Abstract:
:Congenital diseases that could result in hyperphosphatemia at an early age include hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) and congenital hypoparathyroidism/pseudohypoparathyroidism due to the insufficient activity of fibroblast growth factor (FGF) 23 and parathyroid hormone. HFTC/HHS is a rare autosomal recessive disease caused by inactivating mutations in the FGF23, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), or Klotho (KL) genes, resulting in the excessive cleavage of active intact FGF23 (FGF23, GALNT3) or increased resistance to the action of FGF23 (KL). Massive ectopic calcification, known as tumoral calcinosis (TC), is seen in periarticular soft tissues, typically in the hip, elbow, and shoulder in HFTC/HHS, reducing the range of motion. However, other regions, such as the eye, intestine, vasculature, and testis, are also targets of ectopic calcification. The other symptoms of HFTC/HHS are painful hyperostosis of the lower legs, dental abnormalities, and systemic inflammation. Low phosphate diets, phosphate binders, and phosphaturic reagents such as acetazolamide are the treatment options for HFTC/HHS and have various consequences, which warrant the development of novel therapeutics involving recombinant FGF23.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Ito N,Fukumoto Sdoi
10.1007/s00223-020-00659-6subject
Has Abstractpub_date
2021-01-01 00:00:00pages
104-115issue
1eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-020-00659-6journal_volume
108pub_type
杂志文章,评审abstract::The present study examined calcium phosphate precipitation in aqueous suspensions of multilamellar liposomes as a possible in vitro model for matrix vesicle mineralization. Liposomes were prepared by dispersing CHCl3-evaporated thin films of 7:2:1 and 7:1:1 molar mixtures of phosphatidylcholine, dicetyl phosphate, and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405354
更新日期:1984-07-01 00:00:00
abstract::The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral and skeletal changes were assessed by biochemical methods and by histomorphometric analysis of endosteal bone ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405119
更新日期:1983-09-01 00:00:00
abstract::The current studies were intended to determine whether the anabolic effects of calcitonin (CT) on human osteoblast-line cells were (1) unique to osteosarcoma cells or also evident in osteoblast-line cells derived from normal human bone; and/or (2) associated with effects on several insulin-like growth factor (IGF) sys...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001112
更新日期:2000-09-01 00:00:00
abstract::Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00793-1
更新日期:2021-01-09 00:00:00
abstract::Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1098-2
更新日期:2004-02-01 00:00:00
abstract::Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied. Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month. The re...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00298606
更新日期:1995-03-01 00:00:00
abstract::Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555167
更新日期:1988-07-01 00:00:00
abstract::Quantitative trait locus analysis can be used to identify genes critically involved in biological processes. No such analysis has been applied to identifying genes that control bone fracture healing. To determine the feasibility of such an approach, healing of femur fractures was measured between C57BL/6, DBA/2, and C...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9144-3
更新日期:2008-06-01 00:00:00
abstract::A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555993
更新日期:1990-08-01 00:00:00
abstract::In vitro models of osteogenesis are essential for investigating bone biology and the effects of pharmaceutical, chemical, and physical cues on bone formation. Osteogenesis takes place in a complex three-dimensional (3D) environment with cells from both mesenchymal and hematopoietic origins. Existing in vitro models of...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9467-3
更新日期:2011-05-01 00:00:00
abstract::The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556340
更新日期:1988-02-01 00:00:00
abstract::Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0420-6
更新日期:2018-09-01 00:00:00
abstract::To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310252
更新日期:1995-09-01 00:00:00
abstract::Ultrasound measurements of the calcaneus are related to incidence of osteoporotic fracture. Such measurements are generally made at fixed coordinates relative to a footplate. This study compares measurements at an anatomically located region of interest (ROIanat) and at fixed coordinates (ROIfixed), with bone mineral ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298991
更新日期:1995-07-01 00:00:00
abstract::The current study is based on our earlier investigation carried out in 1999, where bone mineral density (BMD) of 35 neurofibromatosis type 1 (NF1) patients was measured and osteoporosis was shown to be common in NF1. The findings have been confirmed by a number of later publications. The purpose of the current longitu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9661-y
更新日期:2013-01-01 00:00:00
abstract::Radiation therapy (RT) is an established treatment modality for malignant neoplasms. RT induces tissue damage that may lead to osteoradionecrosis in more severe cases. Suitable animal models to study RT-induced changes in membranous craniofacial bone are currently not available. The aim of this study was therefore to ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9217-y
更新日期:2009-05-01 00:00:00
abstract::Recent evidence of the occurrence of brushite in newly formed bone mineral prompted a study of the solubility properties of brushite:apatite mixtures under physiological conditions and the influence on them of pH, lactate, pyruvate, and, particularly, noncollagenous bone proteins (NCBPs). Brushite alone was surprising...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411226
更新日期:1982-03-01 00:00:00
abstract::Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010042
更新日期:2001-12-01 00:00:00
abstract::The goals of internal fixation are an accurate reduction and stable fixation in the presence of adequate bony vascularity. This can be achieved by a variety of means including plate fixation. A certain amount of periosteal stripping is necessary for proper open reduction of a fracture and for proper plate application....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900080
更新日期:1996-07-01 00:00:00
abstract::A simple method for determining histamine and polyamines in various tissues was devised. The method, however, could not be applied to calcified tissues, because the high concentration of Ca2+ in the extract interferes with the chromatographic separation of these amines. By treating the extracts from calcified tissues ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296220
更新日期:1992-07-01 00:00:00
abstract::The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555250
更新日期:1987-08-01 00:00:00
abstract::To evaluate the associations of sarcopenia and previous falls with 2-year major osteoporotic fractures (MOFs) in community-dwelling older adults. Four thousand Chinese men and women ≥ 65 years recruited from Hong Kong communities were prospectively followed up. Measures of muscle mass, grip strength, gait speed and fa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00709-z
更新日期:2020-08-01 00:00:00
abstract::Conventional transmission electron microscopy requires an effective dehydration of the tissue specimens under investigation. This dehydration, for which ethanol most often is used, may influence the solubility of the slightly soluble calcium phosphates. To study the behavior of calcium phosphates in ethanol, stable ne...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554840
更新日期:1985-03-01 00:00:00
abstract::The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0275-x
更新日期:2005-07-01 00:00:00
abstract::Regular tennis play is associated with impressive asymmetries in bone strength in favor of the racquet arm, particularly in the humerus. However, the relative effects of service and ground strokes are not known. Serendipitously, we encountered a 46-year-old regular tennis player who has played service and ground strok...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9995-3
更新日期:2015-08-01 00:00:00
abstract::ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900148
更新日期:1996-11-01 00:00:00
abstract::Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223001103
更新日期:2000-07-01 00:00:00
abstract::Several studies have shown an association between circulating leptin concentration and bone mineral density. but most studies are cross-sectional in design and report findings in women only. We per-formed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0017-x
更新日期:2004-05-01 00:00:00
abstract::Patients with systemic lupus erythematosus (SLE), a chronic inflammatory disease characterized by loss of T- and B-cell tolerance to autoantigens, are at increased risk for osteoporosis and fractures. Mice deficient in Fc gamma receptor IIb (FcγRIIB) exhibit spontaneous SLE and its restoration rescues the disease. To ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0464-7
更新日期:2018-12-01 00:00:00
abstract::Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength). Based on the FRAX studies suggesting that the questions without bone mineral density can be used to screen for osteoporosis, there is now a valid simple questionnaire...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-0022-5
更新日期:2016-04-01 00:00:00