Abstract：
:To study the risk of fractures associated with anxiolytics, sedatives, and hypnotics, we conducted a case-control study. Cases were all subjects with any fracture during the year 2000 (n = 124,655). For each case, three controls (n = 373,962) matched on age and gender were randomly drawn from the background population. The exposure was use of any anxiolytic, sedative, or hypnotics. Adjustments were made for a number of potential confounders. Most anxiolytics, sedatives, and hypnotics were associated with a limited increase in the risk of fractures. There was a dose-response relationship, and drugs with a half-life longer than 24 h were associated with a trend toward a higher relative risk of fractures than drugs with a shorter half-life. Both current use (last use <1 year ago) and past use (last use more than one year ago) were associated with an increased risk of fractures. We conclude that anxiolytics, sedatives, and hypnotics are associated with a limited increase in the risk of fractures. For most drugs a dose-response relationship was present, and drugs with a half-life >24 h tended to be associated with a higher risk of fractures than drugs with a shorter half-life. This points to a dose-dependent risk of, for example, falls leading to fractures. However, the increased risk of fractures with past use may suggest an effect of the condition for which the drug was prescribed rather than the drug per se (confounding by indication).
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Vestergaard P,Rejnmark L,Mosekilde Ldoi
10.1007/s00223-007-9095-0subject
Has Abstractpub_date
2008-01-01 00:00:00pages
34-43issue
1eissn
0171-967Xissn
1432-0827journal_volume
82pub_type
杂志文章abstract：:To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0134-9
更新日期：2005-02-01 00:00:00
abstract：:Cortical bone can be modeled as a complex hierarchical composite interrelating both structure and material properties on four levels of structural organization: molecular, ultrastructural, microscopic, and macroscopic. In young animals, the microstructural systems are long parallel lamellar units, plexiform bone, whic...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02406131
更新日期：1984-01-01 00:00:00
abstract：:To characterize osteopenic changes in ovariectomized (OVX) rats as a function of time, female Sprague Dawley rats (240 g body weight, 90 days old) were subjected to bilateral ovariectomy or sham surgery and killed at various times from 14-180 days postovariectomy. The proximal tibial metaphysis was processed undecalci...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02571317
更新日期：1988-09-01 00:00:00
abstract：:A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556215
更新日期：1991-10-01 00:00:00
abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900505
更新日期：1998-08-01 00:00:00
abstract：:We conducted a case-control study on fracture risk associated with the use of orally administered prednisolone/prednisone, budesonide, methylprednisolone, and hydrocortisone to assess if the various preparations were associated with different fracture patterns. Cases were all subjects with any fracture sustained durin...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9124-7
更新日期：2008-04-01 00:00:00
abstract：:There are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum le...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00301626
更新日期：1992-04-01 00:00:00
abstract：:The absorption kinetics of intranasal salmon calcitonin were assessed in 4 normal subjects and 9 patients with Klinefelter's syndrome. After administration, absorption occurred within 5 minutes. There was a highly significant correlation between the amount administered and the amount absorbed (r = -0.83, P less than 0...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556097
更新日期：1990-02-01 00:00:00
abstract：:Recent evidence of the occurrence of brushite in newly formed bone mineral prompted a study of the solubility properties of brushite:apatite mixtures under physiological conditions and the influence on them of pH, lactate, pyruvate, and, particularly, noncollagenous bone proteins (NCBPs). Brushite alone was surprising...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411226
更新日期：1982-03-01 00:00:00
abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405386
更新日期：1984-12-01 00:00:00
abstract：:We examined differences in patients' survival after hip fracture (HF) and risk for subsequent HF among patients treated with oral and intravenous bisphosphonates (oBPs, iBPs), denosumab (DMAB), and patients without therapy. We used data from all patients in Austria aged ≥ 50 who sustained a HF between 2012 and 2017 an...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-019-00611-3
更新日期：2019-12-01 00:00:00
abstract：:The purpose of this work was to extend to long bones the study on the ossification of human fetal skeleton in relation to conceptual age by a quantitative methodological approach. Postero-anterior scans were performed on 29 dried fetal femora (from 11.5 weeks of conceptual age to term) by a Hologic QDR 1000 X-ray dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900591
更新日期：1999-02-01 00:00:00
abstract：:Calcaneus bone mineral density (BMD) of 738 Japanese women (605 healthy and 133 with osteoporosis) was measured using single X-ray absorptiometry (SXA). A reference range of calcaneus BMD values for healthy Japanese women was established and the usefulness of this method for screening and diagnosis of osteoporosis was...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900665
更新日期：1999-08-01 00:00:00
abstract：:Bone and mineral metabolism has been reported to affect the development of the ossification of the posterior longitudinal ligament (OPLL). The aim of this study was to compare bone mineral densities (BMD) and rate of osteoporosis between cervical OPLL and a matched control group. We also investigated the correlation o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9662-x
更新日期：2013-01-01 00:00:00
abstract：:We studied the acute phase response, including specific cytokine production, [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF alpha)] following a single dose of Aredia (disodium pamidronate) in patients with increased bone turnover and, in vitro, the role played by specific cytokines in the...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s002239900353
更新日期：1997-11-01 00:00:00
abstract：:We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 microM was cytotoxic....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00301951
更新日期：1995-12-01 00:00:00
abstract：:Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s002239900378
更新日期：1997-01-01 00:00:00
abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (2.3 x 10(-12) - 1.4 x 10(-6) [M]) on alkaline phosphatase, collagen, and cell proliferation were examined in primary cultured hypertrophic chondrocytes prepared from the distal epiphyseal growth plate of the tibias of 12-day chick embryos. 1,25(OH)2D3 showed time-...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296776
更新日期：1992-05-01 00:00:00
abstract：:Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00770-8
更新日期：2020-10-17 00:00:00
abstract：:We have used in situ hybridization to examine expression of collagen type I, II, and X mRNA and osteonectin mRNA in the chick epiphysis. Tissue samples from the proximal tibial growth cartilage were fixed in modified Carnoy's solution, dehydrated in ethanol, and embedded in paraffin. Longitudinal and transverse sectio...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556062
更新日期：1989-09-01 00:00:00
abstract：:The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556340
更新日期：1988-02-01 00:00:00
abstract：:The effect of the degree of carboxylation of osteocalcin (OC) on the properties of bone is unclear. The aim of this study was to relate serum concentrations of total OC (tOC) and undercarboxylated OC (ucOC), measured with a two-site immunoassay, to bone mineral density (BMD) at the femoral neck and ultrasonic transmit...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002239900432
更新日期：1998-04-01 00:00:00
abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02561408
更新日期：1989-08-01 00:00:00
abstract：:Melorheostosis is an exceptionally rare sclerosing hyperostosis that typically affects the appendicular skeleton in a limited segmental fashion. It occasionally occurs on a background of another benign generalised sclerosing bone condition, known as osteopoikilosis caused by germline mutations in LEMD3, encoding the i...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00543-y
更新日期：2019-05-01 00:00:00
abstract：:The values of in vivo T1 relaxation time (T1) of phosphorus atoms of wrist bone have been measured by phosphorus-31 magnetic resonance spectroscopy (MRS) in 65 menopausal women separated into three groups: (1) age-matched women without any paraclinical or clinical osteoporosis; (2) patients with paraclinical osteoporo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298583
更新日期：1995-06-01 00:00:00
abstract：:Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00297297
更新日期：1992-01-01 00:00:00
abstract：:A comparative polarized light (PLM), scanning (SEM), and transmission (TEM) electron microscopy study was carried out on cross- and longitudinal sections of human lamellar bone in the tibiae of four male subjects aged 9, 23, 45, and 70 years. SEM analysis was also performed on rectangular-prismatic samples in order to...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01673402
更新日期：1993-01-01 00:00:00
abstract：:Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9556-3
更新日期：2012-02-01 00:00:00
abstract：:Using both low microwave power and weak magnetic field modulation, we have shown that the asymmetric signal arising in X-irradiated tooth enamel as well as in A-type carbonated apatite exposed to X-rays or to excited oxygen has an orthorhombic character and must be attributed to CO2-. Effectively, the mean values foun...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409421
更新日期：1981-01-01 00:00:00
abstract：:The effect of the configuration of porous cylindrical hydroxyapatite (HA) scaffold and laminin preparation of the scaffold on bone formation was estimated. HA scaffolds with a hollow center of 2 or 4 mm in diameter and those without a hollow center were used. The scaffolds were immersed in laminin solution or in cultu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9157-y
更新日期：2008-08-01 00:00:00
