Abstract：
:We have previously noted that a relatively large load (150 N) is required to induce a strain on the cortex of rat vertebrae similar to that induced on weight-bearing bones by normal mechanical usage. It seems unlikely that the musculature of the tail normally imposes loads of this magnitude, and this suggests that the quantity of bone in caudal vertebrae is maintained at a higher level than would be expected for the mechanical environment to which it is exposed. This high bone mass could represent a genetically determined minimum, or could be maintained through increased sensitivity to mechanical stimuli. To distinguish between these two possibilities, we denervated the tails of 13-week-old rats by neurectomy at L6, and assessed the response of the caudal vertebrae to mechanical disuse. We found that caudal neurectomy caused a reduction in the cancellous bone formation rate in the eighth caudal vertebrae to 12% of that seen in sham-operated animals. The cancellous bone formation rate in the thoracic vertebrae of neurectomized rats, which are not mechanically disused by caudal neurectomy, was not significantly reduced. This suggests that the cancellous bone formation rate in vertebrae is maintained by substantially less intense mechanical environments than those prevailing in weight-bearing bones, raising the possibility that bones may differ in their sensitivity to mechanical strain.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Chow JW,Jagger CJ,Chambers TJdoi
10.1007/s002239900097subject
Has Abstractpub_date
1996-08-01 00:00:00pages
117-20issue
2eissn
0171-967Xissn
1432-0827journal_volume
59pub_type
杂志文章abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900492
更新日期：1998-07-01 00:00:00
abstract：:Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 1...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1106-y
更新日期：2002-11-01 00:00:00
abstract：:Fracture healing is a natural process that recapitulates embryonic skeletal development. In the early phase after fracture, reactive oxygen species (ROS) are produced under inflammatory and ischemic conditions due to vessel injury and soft tissue damage, leading to cell death. Usually, such damage during the course of...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00576-3
更新日期：2019-10-01 00:00:00
abstract：:The potassium pyroantimonate technique was utilized for the selective subcellular localization of calcium in the mandibular condylar cartilage of 1-day-old rats. Electron dense calcium pyroantimonate precipitates were localized principally in mitochondria and at the cell membrane of the chondrocytes. In addition, smal...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408603
更新日期：1980-01-01 00:00:00
abstract：:The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) aged 3-12 yrs, after a median period of 14 mo.s is reported. Children wi...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02556381
更新日期：1991-04-01 00:00:00
abstract：:Irrespective of the method used for noninvasive bone mass determination, data comparison between different centers is a major problem as significant interunit variation may occur. We, therefore, have employed mobile densitometry units to reduce interunit variability in two large epidemiologic studies in Germany. Two c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00301682
更新日期：1994-03-01 00:00:00
abstract：:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound mea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0216-8
更新日期：2004-11-01 00:00:00
abstract：:Mechanical forces applied to cultured bone cells induce the production of cAMP via stimulation of the formation of prostaglandin E2 (PGE2) and its release into the medium, resulting in stimulation of adenylate cyclase. In this paper we show that either the antibiotic gentamycin (100 micrograms/ml) or antiphospholipid ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553753
更新日期：1988-04-01 00:00:00
abstract：:We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone loss. The PTHR1 gene, including its 14 exons, their exon-intron boundaries, and 1,50...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9072-7
更新日期：2007-10-01 00:00:00
abstract：:Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-017-0369-x
更新日期：2018-02-01 00:00:00
abstract：:Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m2) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m2 for men and < 0.512 m2 for women. We report normative ALM/BMI values for Australian adults, and compare the pe...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0506-1
更新日期：2019-04-01 00:00:00
abstract：:It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900185
更新日期：1997-01-01 00:00:00
abstract：:The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-018-0424-2
更新日期：2018-09-01 00:00:00
abstract：:Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with D...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900574
更新日期：1999-01-01 00:00:00
abstract：:Dual-photon absorptiometry (153Gd) was used to measure bone mineral of the total body and major anatomical areas. Patients with osteoporosis (male = 11, female = 18) and with renal osteodystrophy (n = 17) were significantly below (20%) normal females (n = 72) and males (n = 13) at most sites. In the osteoporotic patie...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405287
更新日期：1984-01-01 00:00:00
abstract：:Raf-1, the product of proto-oncogene c-raf-1, has key roles in the signal transduction pathways within the cell. The molecular mechanisms of tooth development in the mouse embryo are not known in detail. We examined the expression of Raf-1 during subsequent tooth development by immunohistochemical analysis. In mouse e...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02509547
更新日期：1996-01-01 00:00:00
abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To clarify this mechanism, we investigated the effects o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-0021-1
更新日期：2004-05-01 00:00:00
abstract：:Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230001212
更新日期：2001-06-01 00:00:00
abstract：:The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555250
更新日期：1987-08-01 00:00:00
abstract：:Carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) in serum has recently been proposed as a new biochemical marker of bone resorption. In the present study we compared serum ICTP with radiopharmaceutical and histomorphometric measurements of bone turnover in postmenopausal women with mild...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00316286
更新日期：1994-01-01 00:00:00
abstract：:The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0358-0
更新日期：2018-03-01 00:00:00
abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405032
更新日期：1983-01-01 00:00:00
abstract：:The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0500-7
更新日期：2019-04-01 00:00:00
abstract：:The diphosphonates dichloromethanediphosphonate (Cl2MDP) and to a minor degree 1-hydroxyethane-1,1-diphosphonate (EDHP) increased the glycogen content in cultured cartilage cells of rabbit ear. This effect was not due to different concentrations of glucose in the medium. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408621
更新日期：1980-01-01 00:00:00
abstract：:Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900301
更新日期：1997-08-01 00:00:00
abstract：:Newly developed fuzzy logic-derived structural parameters were used to characterize trabecular bone architecture in high-resolution magnetic resonance imaging (HR-MRI) of human cadaver calcaneus specimens. These parameters were compared to standard histomorphological structural measures and analyzed concerning perform...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9058-5
更新日期：2007-10-01 00:00:00
abstract：:The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1096-4
更新日期：2003-12-01 00:00:00
abstract：:The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553763
更新日期：1989-04-01 00:00:00
abstract：:Peritubular dentin (PTD) is a relatively dense mineralized tissue surrounding tooth dentin tubules, whose composition and mode of formation are still unclear. Fourier transform infrared microspectroscopic studies of the organic and mineral components of the highly developed horse PTD indicate that the peritubular matr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-2108-5
更新日期：2002-08-01 00:00:00
abstract：:We describe a tall-statured 14-year-old boy who illustrated the full phenotypic and radiographic features of Stickler syndrome type I. A bone biopsy showed evidence of reduced bone mass and bone turnover, such as reduced BV/TV (-43%), TbTh (-29%), and OS/BS (-48%), Ob.S/BS (-27%), and Oc/BS (-47%) compared to "age-mat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9324-9
更新日期：2010-02-01 00:00:00
