Abstract:
:Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m2) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m2 for men and < 0.512 m2 for women. We report normative ALM/BMI values for Australian adults, and compare the performance of cutpoints derived from reference values for this population with FNIH values for identifying low lean mass. Body composition was measured by DXA (Lunar) for 1411 men and 960 women, aged 20-93 years, from the Geelong Osteoporosis Study, a population-based study in Australia. Sex-stratified means and standard deviations for DXA-derived ALM/BMI were generated for each age-decade, and cutpoints equivalent to T-scores of - 2.0 were derived using reference data for 374 men and 308 women aged 20-39 years. Mean ALM/BMI values were greater for men than women, and decreased with age in both sexes. Cutpoints for ALM/BMI corresponding to T-scores of - 2.0 were 0.827 m2 for men and 0.518 m2 for women. For individuals aged 65+ years, cross-classification of low lean mass according to FNIH criteria (ALM/BMI < 0.789 m2 men and < 0.512 m2 women) in comparison with our cutpoints for ALM/BMI showed overall agreement of 94.6% for men and 99.0% for women (κ 0.73 and 0.89, respectively). We report good agreement for low ALM indexed to BMI, particularly for women, between classifications based on recommendations from the FNIH Sarcopenia Project for identifying clinically significant weakness, with low values identified within our population distribution of ALM/BMI.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Pasco JA,Holloway-Kew KL,Tembo MC,Sui SX,Anderson KB,Rufus-Membere P,Hyde NK,Williams LJ,Kotowicz MAdoi
10.1007/s00223-018-0506-1keywords:
["Appendicular lean mass","Body composition","Muscle mass","Reference data","Sarcopenia"]subject
Has Abstractpub_date
2019-04-01 00:00:00pages
475-479issue
4eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-018-0506-1journal_volume
104pub_type
杂志文章abstract::Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9981-9
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abstract::Ribbon-like crystals, from developing enamel of human fetuses, were studied by high resolution electron microscopy. These crystals were classically described as the first organized mineral formed during amelogenesis. They were characterized by a mean width-to-thickness ratio (W.T-1) of 9.5, and 40% were bent. On latti...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00334485
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555127
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journal_title:Calcified tissue international
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abstract::Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0060-5
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abstract::The interaction between estrogens and androgens, with their protective effects in bone, and parathyroid hormone (PTH), a calcitropic peptide hormone, is complex but may be better understood with murine models. The purpose of this study was to characterize skeletal phenotypes of mice deficient in estrogen receptor alph...
journal_title:Calcified tissue international
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doi:10.1007/s00223-004-0119-8
更新日期:2004-07-01 00:00:00
abstract::The perilacunar areas of low mineral density in microradiographs from cortical bone of patients with hypophosphatemic (vitamin D-resistant) rickets are not evenly distributed throughout the bone tissue. Their frequency and distribution were determined in bone from 9 patients with this disease. It was found that the le...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441169
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299317
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555226
更新日期:1987-11-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-1110-2
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journal_title:Calcified tissue international
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doi:10.1007/s00223-015-9985-5
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abstract::Ascorbic acid is a required cofactor in the hydroxylations of lysine and proline necessary for collagen formation; its role in bone cell differentiation and formation is less well characterized. This study examines the cross-sectional relation between dietary vitamin C intake and bone mineral density (BMD) in women fr...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002239900512
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408528
更新日期:1980-01-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02406131
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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abstract::The accompanying article by Drs. Lian and Stein describes current thinking on how genes are organized in the nucleus and suggests that subnuclear localization is critical for the control of gene expression in bone. In particular, it is proposed that a major function of the osteoblast transcription factor, Runx2, is to...
journal_title:Calcified tissue international
pub_type: 评论,杂志文章,评审
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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