Track structure calculations on intracellular targets responsible for signal release in bystander experiments with transfer of irradiated cell-conditioned medium.

abstract：:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

journal_title：International journal of radiation biology

authors： Dörr W,Kummermehr J

更新日期：1992-03-01 00:00:00

abstract：:We used three common fluorescent probes to measure pericentric inversion frequencies in 2.9 Gy 60Co gamma-irradiated human lymphocytes. For a given chromosome, the first probe is specific to one telomeric region, the second probe is specific to one subcentromeric region and the third probe is specific to the centromer...

journal_title：International journal of radiation biology

authors： Lucas JN,Hill FS,Chen AM,Burk CE

更新日期：1997-01-01 00:00:00

abstract：:Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...

journal_title：International journal of radiation biology

authors： Alper T,Mothersill C,Seymour CB

更新日期：1988-10-01 00:00:00

abstract：:Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...

journal_title：International journal of radiation biology

authors： Dikomey E,Franzke J

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:5-Formyluracil (5-foU) is a major derivative of thymine produced in DNA by ionizing radiation and various chemical oxidants. It has been previously shown that 5-foU in template DNA directs misincorporation of nucleotides by DNA polymerases during in vitro DNA synthesis. The present experiments were designed to ...

journal_title：International journal of radiation biology

authors： Miyabe I,Zhang QM,Sugiyama H,Kino K,Yonei S

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To investigate whether extremely low frequency electromagnetic field (ELF-EMF) exposure could induce oxidative stress in workers performing tour-inspection near transformers and distribution power lines. MATERIALS AND METHODS:Occupational short-term 'spot' measurements were performed. In total, 310 inspection ...

journal_title：International journal of radiation biology

authors： Li L,Xiong DF,Liu JW,Li ZX,Zeng GC,Li HL

更新日期：2015-05-01 00:00:00

abstract：:Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

journal_title：International journal of radiation biology

authors： Singh SP,Kesavan PC

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). CONCLUSION:In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RI...

journal_title：International journal of radiation biology

authors： Aypar U,Morgan WF,Baulch JE

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:A key enzyme of polyamine catabolism, spermidine/spermine N(1)-acetyltransferase (SSAT), is responsive to antiproliferative agents. The role of SSAT in cellular responses to X-ray irradiation was examined. MATERIALS AND METHODS:Exponentially growing HeLa S3 cells were irradiated by X-rays, and mRNA levels for ...

journal_title：International journal of radiation biology

authors： Mita K,Fukuchi K,Hamana K,Ichimura S,Nenoi M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To study cell damage and possible apoptosis in K562 human erythroleukemic cells exposed for 2 h to an extremely low frequency (ELF) 50 Hz sinusoidal magnetic field with a magnetic induction of either 1 or 5 mT using high resolution proton nuclear magnetic resonance (1H-NMR) spectroscopy. MATERIALS AND METHODS:...

journal_title：International journal of radiation biology

authors： Santini MT,Ferrante A,Romano R,Rainaldi G,Motta A,Donelli G,Vecchia P,Indovina PL

更新日期：2005-02-01 00:00:00

abstract：:The literature suggests that the function of radiation-induced G2 arrest is to allow repair of potentially lethal damage before cell-entry into, and damage expression in, mitosis. The nature of the damage repaired is not known, but chromosome aberrations have been considered. To examine this possibility in G2 cells, t...

journal_title：International journal of radiation biology

authors： Rowley R

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:This study was undertaken to understand the roles of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of the process following exposure of E. coli to gamma-radiation in vivo. MATERIALS AND METHODS:A plasmid DNA construct, pMTa4, was transformed into isogenic repair proficient (wild)...

journal_title：International journal of radiation biology

authors： Sharan RN,Ryo H,Nomura T

更新日期：2007-02-01 00:00:00

abstract：:The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

journal_title：International journal of radiation biology

authors： Watts ME,Dennis MF,Roberts IJ

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...

journal_title：International journal of radiation biology

authors： Ponomarev AL,Huff J,Cucinotta FA

更新日期：2010-06-01 00:00:00

abstract：:The effects of a low dose (0.1-20 mGy) preirradiation with X-rays followed by a higher dose (2 Gy) of the same radiation on the recovery of the genetic damage induced as dominant lethals in mature oocytes (stage 14) of different strains of Drosophila melanogaster were investigated. The response was shown to be depende...

journal_title：International journal of radiation biology

authors： Schäppi-Büchi C

更新日期：1994-04-01 00:00:00

abstract：PURPOSE:Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies. The effects of the drug on cell survival, alteration of the cell cycle and induction of apoptosis were examined without and in combination with ionizing r...

journal_title：International journal of radiation biology

authors： Cordes N,Plasswilm L,Bamberg M,Rodemann HP

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The hemorrhagic syndrome is a major cause of morbidity and mortality associated with the acute radiation syndrome (ARS). We previously characterized the dose-response relationship for total body irradiation (TBI)-induced ARS in the New Zealand White (NZW) rabbit. Thrombocytopenia, hemorrhage, and anemia were st...

journal_title：International journal of radiation biology

authors： Jackson IL,Gurung G,Ayompe E,Fown ER,Triesler S,Mali B,Casildo A,Gibbs A,Poirier Y,Cohen EP,Newman D,Vujaskovic Z

更新日期：2020-10-16 00:00:00

abstract：PURPOSE:To analyze the direct and transgenerational effects of exposure to low-dose 1 GHz (mobile phone/wireless telecommunication range) and 10 GHz (radar/satellite communication range) radiofrequency electromagnetic fields (RF-EMF) on the motility of ciliates Spirostomum ambiguum. MATERIALS AND METHODS:S. ambiguum w...

journal_title：International journal of radiation biology

authors： Sarapultseva EI,Igolkina JV,Tikhonov VN,Dubrova YE

更新日期：2014-03-01 00:00:00

abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

journal_title：International journal of radiation biology

authors： Hall EJ

更新日期：1991-03-01 00:00:00

abstract：:Purpose: To evaluate the antioxidant and radio-protective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) on radiation-induced oxidative stress in brain tissue.Materials and methods: Fifty-four Sprague-Dawley rats were divided into six groups to test the radio-protective effectiveness of Nigella sativa oil a...

journal_title：International journal of radiation biology

authors： Demir E,Taysi S,Ulusal H,Kaplan DS,Cinar K,Tarakcioglu M

更新日期：2020-02-01 00:00:00

abstract：:We have compared the repair kinetics of X-ray-induced sublethal damage (SLD) and potentially lethal damage (PLD) in V79 cells during postirradiation incubation in growth medium at 37 degrees C. Kinetics of SLD repair were studied by dose fractionation (D1 + D2 = 2 + 2, 4 + 2, 4 + 4, 10 + 4 and 10 + 7 Gy). Kinetics of ...

journal_title：International journal of radiation biology

authors： Reddy NM,Lange CS

更新日期：1989-09-01 00:00:00

abstract：:Recently, it has been demonstrated that two different thermal resistant states found in Chinese hamster cells, one transient, associated with thermotolerance, and the other permanent, associated with the increased expression of the cognate member of the hsp 70 family, are characterized by faster recovery from heat-ind...

journal_title：International journal of radiation biology

authors： Laszlo A,Davidson T,Hu A,Landry J,Bedford J

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a re...

journal_title：International journal of radiation biology

authors： Vandevoorde C,Depuydt J,Veldeman L,De Neve W,Sebastià N,Wieme G,Baert A,De Langhe S,Philippé J,Thierens H,Vral A

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To evaluate whether immunotherapy based on adoptively transferred cytotoxic T-cells (CTL) can improve the antitumour efficacy of irradiation. MATERIAL AND METHODS:The experiments were performed using the human squamous cell carcinoma line UT-SCC-15, which expresses human leukocyte antigen (HLA)-A2. The UT-SCC-...

journal_title：International journal of radiation biology

authors： Krause M,Schmitz M,Noessner E,Skrablin PS,Wehner R,Rieber EP,Baumann M

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To evaluate and compare cytotoxic and mutational effects of graded doses of gamma-rays and 4He++ ions at different LET values (nominally 80 and 123 keV/microm) in V79 cells. MATERIALS AND METHODS:4He++ ion beams at 80 and 123 keV/microm were supplied by the 7 MV Van de Graaff CN accelerator of the INFN-LNL in ...

journal_title：International journal of radiation biology

authors： Cherubinit R,Canova S,Favaretto S,Bruna V,Battivelli P,Celotti L

更新日期：2002-09-01 00:00:00

abstract：:The mitogen phytohemagglutinin (PHA) works well in both human and cynomolgus monkey (Macaca fascicularis) lymphocyte cultures to stimulate T cell proliferation. T cells from rhesus monkeys (Macaca mulatta) are less responsive than human cells, producing few metaphases when thousands are required, e.g. in biological do...

journal_title：International journal of radiation biology

authors： Hill FS,Cox AB,Salmon YL,Cantu AO,Lucas JN

更新日期：1994-10-01 00:00:00

abstract：:The relative efficiencies of two types of densely ionizing particles were compared for the induction of mutations at two distinct genetic loci in human cells. Mutations to 6-thioguanine resistance (hgprt locus) or to trifluorothymidine resistance (tk) locus were scored in TK6 human lymphoblastoid cells exposed to grad...

journal_title：International journal of radiation biology

authors： Kronenberg A,Little JB

更新日期：1989-06-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

journal_title：International journal of radiation biology

authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To study the influence of TGF-beta1 and TGF-beta-neutralizing antibodies on the clonogenic activity and terminal differentiation of rat lung fibroblasts following radiation exposure. MATERIAL AND METHODS:Early passage rat lung fibroblasts were used in this study. Colony formation assays were applied to determi...

journal_title：International journal of radiation biology

authors： Hakenjos L,Bamberg M,Rodemann HP

更新日期：2000-04-01 00:00:00