Abstract:
:Combination chemotherapy with cisplatin and pemetrexed is the most active first-line regimen for malignant pleural mesothelioma (MPM). However, no drugs have been approved for second-line treatment of MPM, with effective regimens remaining to be identified for patients in relapse. We have now evaluated the combination of cisplatin and pemetrexed for retreatment of patients with recurrent MPM. Four men with MPM, all of whom received initial treatment with cisplatin and pemetrexed, underwent retreatment with this drug combination. Two of the patients achieved an objective response to the first-line chemotherapy with no evidence of disease progression for 6.4 or 11.4 months, respectively. The other two patients had stable disease with a duration of 7.8 or 5.0 months, respectively. The two patients who showed an objective response to first-line chemotherapy showed a partial response to retreatment, with a time to progression of 5.0 or 8.2 months, whereas the other two patients had progressive disease with a time to progression of 1.0 or 1.4 months, respectively. Retreatment with cisplatin plus pemetrexed was generally well tolerated. Retreatment with cisplatin and pemetrexed is a potential therapeutic option for certain patients with recurrent epithelioid MPM, possibly including those who show tumor regression with a time to progression of 6 months or more after the initial chemotherapy. Further studies are warranted to evaluate the efficacy of such retreatment and to clarify the criteria for patient selection.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Hayashi H,Okamoto I,Ichikawa Y,Miyazaki M,Yoshioka H,Kunimasa K,Nakagawa Kdoi
10.1007/s10147-010-0064-7subject
Has Abstractpub_date
2010-10-01 00:00:00pages
497-9issue
5eissn
1341-9625issn
1437-7772journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Alternative anti-androgen therapy (AAT) with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. However, no studies have compared enzalutamide without AAT with enzalutamide after AAT with flutamide as treatment for castration-resistant prostat...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrosp...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2020-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of clinical oncology
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更新日期:2010-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2010-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
abstract::This review describes the pathological classification of pediatric liver cancer types and subtypes proposed at the recent international symposium (March 2011, Los Angeles, USA) and meetings involving pathologists serving as central reviewers for the Children's Oncology Group, Société Internationale d'Oncologie Pédiatr...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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abstract::The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00