当前位置： SCI文献检索 > International Journal of Clinical Oncology期刊下所有文献 > Use of direct oral anti-coagulants for the treatment of venous thromboembolism in patients with advanced cancer: a prospective observational study.

Use of direct oral anti-coagulants for the treatment of venous thromboembolism in patients with advanced cancer: a prospective observational study.

Abstract：

BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatment for new-onset VTE between December 2015 and May 2018. Patients were followed for 3 months to evaluate bleeding and VTE recurrences. The primary study endpoint was major and non-major bleeding. RESULTS:One hundred and forty-five of 147 enrolled patients were analyzed. Of these, 8 [5.5%, 95% confidence interval (CI) 2.8-10.5] and 29 patients (20%, 95% CI 14.3-27.2) experienced major and non-major bleeding, respectively. Patients with bleeding were more likely to have a poor performance status (PS) [hazard rate (HR) 2.04, 95% CI 1.15-3.63] and more frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) (HR 2.75, 95% CI 1.62-4.67) relative to those without bleeding. In a multivariate analysis, combined DOAC and NSAID use correlated significantly with bleeding (odds ratio 4.63, 95% CI 1.70-12.9, p = 0.003). Among 105 of 145 patients included in the VTE recurrence assessment, 9 experienced a VTE recurrence (8.6%, 95% CI 4.6-15.5). CONCLUSIONS:Our findings confirm the risk of bleeding during DOAC treatment for VTE in Japanese patients with advanced cancer, particularly those with poor PS and those using NSAIDs. The risk of bleeding in these patients may be reduced by avoiding the combined use of DOACs and NSAIDs.

journal_name

Int J Clin Oncol

journal_title

International journal of clinical oncology

authors

Oyakawa T,Muraoka N,Iida K,Kusuhara M,Mori K

doi

10.1007/s10147-019-01415-z

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

876-881

issue

7

eissn

1341-9625

issn

1437-7772

pii

10.1007/s10147-019-01415-z

journal_volume

24

pub_type

杂志文章

相关文献

International Journal of Clinical Oncology文献大全
  • Employment status and termination among survivors of pediatric brain tumors: a cross-sectional survey.

    abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-018-1279-2

    authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

    更新日期：2018-10-01 00:00:00

  • Correction to: Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration.

    abstract：:The original article can be found online. ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s10147-019-01395-0

    authors： Shigeta K,Kosaka T,Hongo H,Yanai Y,Matsumoto K,Morita S,Mizuno R,Shinojima T,Kikuchi E,Oya M

    更新日期：2019-05-01 00:00:00

  • Phase I studies of nogitecan hydrochloride for Japanese.

    abstract：BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...

    journal_title：International journal of clinical oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s101470200026

    authors： Kobayashi K,Hino M,Fukuoka M,Takeuchi K,Furuse K,Yoneda S,Hasegawa K,Noda K,Kinoshita H,Kimura I,Taguchi T,Kanamaru R,Horikoshi N,Niitani H

    更新日期：2002-06-01 00:00:00

  • The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma.

    abstract：BACKGROUND:Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expr...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-013-0593-y

    authors： Tovuu LO,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Arakawa Y,Mori H,Hanaoka J,Kanamoto M,Sugimoto K,Saito Y,Yamada S,Asanoma M,Shimada M

    更新日期：2014-08-01 00:00:00

  • Trends in oncological CT imaging: clinical application of multidetector-row CT and 3D-CT imaging.

    abstract：:Computed tomography (CT) plays an essential role in oncological imaging as the modality of screening for malignancies, mapping out the treatment strategy at staging, assessing response to the treatment, and following up patient outcome after the treatment. The advent of multidetector-row CT (MDCT) has brought about dr...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-006-0586-1

    authors： Ueda T,Mori K,Minami M,Motoori K,Ito H

    更新日期：2006-08-01 00:00:00

  • Myocardial performance index and biochemical markers for early detection of doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukaemia.

    abstract：BACKGROUND:Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarker...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0458-9

    authors： Ruggiero A,De Rosa G,Rizzo D,Leo A,Maurizi P,De Nisco A,Vendittelli F,Zuppi C,Mordente A,Riccardi R

    更新日期：2013-10-01 00:00:00

  • Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites.

    abstract：:Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade. On histopathological examination, juvenile GCTs are distinct from the adult type of GCT, and have a lower risk...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-008-0805-z

    authors： Kaur H,Bagga R,Saha SC,Gainder S,Srinivasan R,Adhya AK,Dhaliwal LK

    更新日期：2009-02-01 00:00:00

  • Bilateral primary malignant lymphoma of the ureter.

    abstract：:We report the case of a 68-year-old Japanese man who presented with postrenal azotemia due to bilateral upper ureteral stenosis. The patient's right kidney was nonfunctional; therefore, right nephroureterectomy was performed for the purpose of pathologic diagnosis. Histopathologic examination revealed follicular lymph...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-007-0685-7

    authors： Kubota Y,Kawai A,Tsuchiya T,Kozima K,Yokoi S,Deguchi T

    更新日期：2007-12-01 00:00:00

  • Sperm banking and assisted reproductive outcome in men with cancer: a 10 years' experience.

    abstract：BACKGROUND:As cancer therapy can be harmful to spermatogenesis, men are generally advised to cryopreserve sperm before gonadotoxic treatment. Here, we compared fresh and frozen-thawed sperm quality in patients according to cancer type, and reported use rate in subsequent assisted reproductive technology (ART) cycles. ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-011-0330-3

    authors： Freour T,Mirallie S,Jean M,Barriere P

    更新日期：2012-12-01 00:00:00

  • Debulking metastatic pelvic nodes before radiotherapy in cervical cancer patients: a long-term follow-up result.

    abstract：BACKGROUND:Enlarged pelvic nodes are commonly found during preoperative imaging studies in cervical cancer patients and may represent tumor metastasis. It remains controversial whether debulking of these enlarged nodes prior to definitive radiotherapy offers any survival benefit to the patient. METHODS:Enlarged suspic...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-011-0225-3

    authors： Cheung TH,Lo KW,Yim SF,Yau SH,Yu MM,Yeung WK

    更新日期：2011-10-01 00:00:00

  • Standardizing the extent of resection in nonradical neck dissections: the final report of the Japan Neck Dissection Study Group prospective study.

    abstract：BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10147-009-0016-2

    authors： Saikawa M,Kishimoto S

    更新日期：2010-02-01 00:00:00

  • Combination therapy with PD-1 or PD-L1 inhibitors for cancer.

    abstract：:Immune checkpoint inhibitors (ICIs)-such as antibodies to programmed cell death-1 (PD-1), to its ligand PD-L1, or to cytotoxic T lymphocyte-associated protein-4 (CTLA-4)-are an evolving treatment option for several types of cancer, but only a limited number of patients benefit from such therapy. Preclinical studies ha...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-019-01548-1

    authors： Hayashi H,Nakagawa K

    更新日期：2020-05-01 00:00:00

  • Distribution analysis of hydrogel spacer and evaluation of rectal dose reduction in Japanese prostate cancer patients undergoing stereotactic body radiation therapy.

    abstract：BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-020-01855-y

    authors： Kobayashi H,Eriguchi T,Tanaka T,Ogata T,Ishida M,Nakajima Y,Kumabe A,Kosugi M

    更新日期：2021-01-07 00:00:00

  • The prognostic impact of immune-related adverse events in metastatic renal cell carcinoma patients treated with nivolumab: a real-world multi-institutional retrospective study.

    abstract：BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-021-01872-5

    authors： Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

    更新日期：2021-01-20 00:00:00

  • Use of preoperative performance status and hemoglobin concentration to predict overall survival for patients aged ≥ 75 years after radical cystectomy for treatment of bladder cancer.

    abstract：BACKGROUND:The standard of care for treatment of localized muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC). The patient's condition may affect management of MIBC, especially for elderly patients with more comorbid conditions and lower performance status. We retrospectively evaluated the association bet...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-015-0857-9

    authors： Hara T,Matsuyama H,Kamiryo Y,Hayashida S,Yamamoto N,Nasu T,Joko K,Baba Y,Suga A,Yamamoto M,Aoki A,Takai K,Yoshihiro S,Konishi M,Sakano S,Imoto K,Tei Y,Yamaguchi S,Yano S,Yamaguchi Uro-Onocology Group.

    更新日期：2016-02-01 00:00:00

  • Impact of microscopically margin-positive resection on survival in children with hepatoblastoma after hepatectomy: a retrospective cohort study.

    abstract：BACKGROUND:Impact of R1 (microscopically margin-positive) resection on survival of patients with hepatoblastoma (HB) remains debatable. This study aimed to compare the long-term outcomes of R0 (microscopically margin-negative) and R1 resection for HB in children after hepatectomy. METHODS:We retrospectively reviewed f...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-019-01573-0

    authors： Ren X,Li H,Diao M,Xu H,Li L

    更新日期：2020-04-01 00:00:00

  • Low-dose chemotherapy with methotrexate and vinblastine for patients with desmoid tumors: relationship to CTNNB1 mutation status.

    abstract：BACKGROUND:This study was conducted to determine the efficacy and safety of low-dose chemotherapy with methotrexate (MTX) and vinblastine (VBL) for patients with desmoid tumors refractory to meloxicam treatment, focusing in particular on the relationship between the efficacy of this chemotherapy and catenin β-1 (CTNNB1...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-015-0829-0

    authors： Nishida Y,Tsukushi S,Urakawa H,Hamada S,Kozawa E,Ikuta K,Ando Y,Ishiguro N

    更新日期：2015-12-01 00:00:00

  • Monthly paclitaxel and carboplatin with oral estramustine phosphate in patients with hormone-refractory prostate cancer.

    abstract：BACKGROUND:We aimed to determine the safety and efficacy of monthly paclitaxel and carboplatin with oral estramustine phosphate in patients with hormone-refractory prostate cancer (HRPC). METHODS:Patients with prostate cancer that was progressing despite androgen ablation therapy were treated with i.v. paclitaxel, 175...

    journal_title：International journal of clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10147-005-0513-x

    authors： Segawa T,Kamoto T,Kinoshita H,Kunishima Y,Yoshimura K,Ito A,Takahashi T,Higashi S,Nakamura E,Nishiyama H,Ito N,Yamamoto S,Habuchi T,Ogawa O

    更新日期：2005-10-01 00:00:00

  • Platelet-sparing effect of paclitaxel in heavily pretreated ovarian cancer patients.

    abstract：:Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavily pretreated patients. Paclitaxel has a so-called platelet-sparing effect, but until now it was unknown whether...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s101470200050

    authors： Ishikawa H,Fujiwara K,Suzuki S,Tanaka Y,Kohno I

    更新日期：2002-10-01 00:00:00

  • The effect of gemcitabine/paclitaxel chemotherapy on the survival of patients with metastatic urothelial cancers.

    abstract：BACKGROUND:To evaluate the survival benefit of gemcitabine and paclitaxel (GT) chemotherapy for patients with metastatic urothelial cancer (UC), a retrospective analysis was performed to compare the overall survival in two periods: before (group I) and after (group II) the introduction of GT chemotherapy. PATIENTS AND...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0381-0

    authors： Matsui Y,Nishiyama H,Yoshimura K,Xing ND,Sumiyoshi T,Saito R,Inoue T,Kamba T,Ogawa O

    更新日期：2013-04-01 00:00:00

  • Metastatic collecting duct carcinoma of the kidney responded to sunitinib.

    abstract：:Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, suni...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-010-0116-z

    authors： Miyake H,Haraguchi T,Takenaka A,Fujisawa M

    更新日期：2011-04-01 00:00:00

  • A new therapeutic approach in patients with advanced sarcoma.

    abstract：:Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-005-0514-9

    authors： Kasper B,Ho AD,Egerer G

    更新日期：2005-12-01 00:00:00

  • Comparison between cancer specialists and general physicians regarding the education of nurse practitioners in Japan: a postal survey of the Japanese Society of Clinical Oncology.

    abstract：BACKGROUND:Japanese physicians' attitudes regarding the education of nurse practitioners (NPs) are not well described. PARTICIPANTS AND METHODS:A survey was mailed to 1,094 board members of the Japanese Society of Clinical Oncology (JSCO) and the Japanese Primary Care Association (JPCA), and the directors of the clini...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0460-2

    authors： Ishida Y,Hatao M,Fukushima O,Mori M,Isozaki F,Okuyama A

    更新日期：2013-10-01 00:00:00

  • 'Trifecta' outcomes of robot-assisted partial nephrectomy: a large Japanese multicenter study.

    abstract：OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10147-019-01565-0

    authors： Furukawa J,Kanayama H,Azuma H,Inoue K,Kobayashi Y,Kashiwagi A,Segawa T,Takahashi Y,Horie S,Ogawa O,Takenaka A,Shiroki R,Tanabe K,Fujisawa M

    更新日期：2020-02-01 00:00:00

  • Metastasis of colorectal carcinoma to the testes: clinical presentation and possible pathways.

    abstract：:Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-010-0140-z

    authors： Hatoum HA,Abi Saad GS,Otrock ZK,Barada KA,Shamseddine AI

    更新日期：2011-06-01 00:00:00

  • Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer.

    abstract：BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...

    journal_title：International journal of clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10147-019-01418-w

    authors： Okano S,Enokida T,Onoe T,Ota Y,Motegi A,Zenda S,Akimoto T,Tahara M

    更新日期：2019-07-01 00:00:00

  • Colorectal obstruction is a potential prognostic factor for stage II colorectal cancer.

    abstract：BACKGROUND:Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. METHODS:Data were retrospectively reviewed from ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-018-1307-2

    authors： Okuda Y,Shimura T,Yamada T,Hirata Y,Yamaguchi R,Sakamoto E,Kataoka H

    更新日期：2018-12-01 00:00:00

  • Progress in systemic adjuvant therapy of early-stage breast cancer.

    abstract：:Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what is the optima...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-003-0338-4

    authors： Gradishar WJ,O'Regan RM

    更新日期：2003-08-01 00:00:00

  • Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung.

    abstract：BACKGROUND:Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countrie...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0515-4

    authors： Rahman S,Kondo N,Yoneda K,Takuwa T,Hashimoto M,Orui H,Okumura Y,Tanaka F,Kumamoto K,Mostafa MG,Chowdhury GM,Haque A,Hasegawa S

    更新日期：2014-02-01 00:00:00

  • The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer.

    abstract：BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...

    journal_title：International journal of clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10147-019-01551-6

    authors： Yoshida K,Kajiyama H,Yoshihara M,Tamauchi S,Ikeda Y,Yoshikawa N,Nishino K,Niimi K,Suzuki S,Kikkawa F

    更新日期：2020-02-01 00:00:00