Abstract:
BACKGROUND:Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue. METHODS:Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups. RESULTS:Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time. CONCLUSION:Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Tovuu LO,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Arakawa Y,Mori H,Hanaoka J,Kanamoto M,Sugimoto K,Saito Y,Yamada S,Asanoma M,Shimada Mdoi
10.1007/s10147-013-0593-ysubject
Has Abstractpub_date
2014-08-01 00:00:00pages
622-8issue
4eissn
1341-9625issn
1437-7772journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients. METHODS:We identified 38 patients who were evaluated ...
journal_title:International journal of clinical oncology
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-01 00:00:00
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更新日期:2014-02-01 00:00:00