A prospective, randomized, placebo-controlled trial of zoledronic acid in bony metastatic bladder cancer.

abstract：OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...

journal_title：International journal of clinical oncology

authors： Furukawa J,Kanayama H,Azuma H,Inoue K,Kobayashi Y,Kashiwagi A,Segawa T,Takahashi Y,Horie S,Ogawa O,Takenaka A,Shiroki R,Tanabe K,Fujisawa M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Recent studies have shown the benefits of neoadjuvant therapy with chemotherapy or chemoradiotherapy for resectable locally advanced thoracic esophageal squamous cell carcinoma (ESCC). The aim of our study was to elucidate the use of neoadjuvant therapy for thoracic ESCC in Japan. METHODS:Data on patients w...

journal_title：International journal of clinical oncology

authors： Tsukada Y,Higashi T,Shimada H,Kikuchi Y,Terahara A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications ...

journal_title：International journal of clinical oncology

authors： Lee SH,Choi EJ,Kim MS,Park JW,Lee YS,Kim SY,Kang CS

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Irinotecan plus intravenous 5-fluorouracil with leucovorin is effective against gastrointestinal cancer. S-1 is an oral fluoropyrimidine derivative combining tegafur with the modulators 5-chloro-2,4-dihydroxypyrimidine (a potent dihydropyrimidine dehydrogenase inhibitor), and potassium oxonate (an orotate ph...

journal_title：International journal of clinical oncology

authors： Yamada Y,Yasui H,Goto A,Arai T,Ura T,Hamaguchi T,Muro K,Shimada Y,Shirao K

更新日期：2003-12-01 00:00:00

abstract：:Recent advances in molecular biology have identified the responsible genes for many hereditary cancer syndromes (familial tumors). Therefore, now, the final diagnosis of familial tumors can be done by molecular methods to detect the genetic alteration in the disease-causing responsible gene(s) in the patient. So-calle...

journal_title：International journal of clinical oncology

authors： Tomita N,Oto M

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:To investigate the prognostic and therapeutic implications of time to biochemical relapse (BCR) in patients with prostate cancer after radical prostatectomy. METHODS:The records of 3210 consecutive men with prostate cancer who underwent radical prostatectomy between January 1998 and June 2013 were retrospec...

journal_title：International journal of clinical oncology

authors： Pak S,You D,Jeong IG,Kim YS,Hong JH,Kim CS,Ahn H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the screening rate for hepatitis B virus (HBV) infection, which is recommended by some guidelines for the prevention of HBV reactivation, in patients undergoing chemotherapy for malignancy in Japan. METHODS:The study subjects were 3302 patients who had received first...

journal_title：International journal of clinical oncology

authors： Ikeda M,Yamamoto H,Kaneko M,Oshima H,Takahashi H,Umemoto K,Watanabe K,Hashimoto Y,Ohno I,Mitsunaga S,Okusaka T

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:We conducted a multiinstitutional analysis to clarify the clinical significance of perioperative chemotherapy, in invasive bladder cancers in Japan, and to identify the patient subpopulations who could benefit from perioperative chemotherapy. METHODS:A total of 913 consecutive patients aged less than 80 yea...

journal_title：International journal of clinical oncology

authors： Matsui Y,Nishiyama H,Watanabe J,Teramukai S,Ono Y,Ohshima S,Fujimoto K,Hirao Y,Fukushima M,Ogawa O

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countrie...

journal_title：International journal of clinical oncology

authors： Rahman S,Kondo N,Yoneda K,Takuwa T,Hashimoto M,Orui H,Okumura Y,Tanaka F,Kumamoto K,Mostafa MG,Chowdhury GM,Haque A,Hasegawa S

更新日期：2014-02-01 00:00:00

abstract：:A 38-year-old woman underwent mastectomy and axillary lymph node dissection for invasive ductal carcinoma with multiple lymph node involvement. The patient received adriamycin 60 mg/m(2) and cyclophosphamide 600 mg/m(2) followed by weekly paclitaxel 80 mg/m(2) (without interruption) as adjuvant treatment. After receiv...

journal_title：International journal of clinical oncology

authors： Hikino H,Kawashima M,Yamada T,Ozaki N

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The objective was to evaluate the incidence of second primary malignancies (SPMs) in thyroid cancer patients compared to age- and gender-matched controls without thyroid cancer from the general population of the same region. METHODS:Tampere and Oulu University Hospitals treated 910 patients with well-differ...

journal_title：International journal of clinical oncology

authors： Hakala TT,Sand JA,Jukkola A,Huhtala HS,Metso S,Kellokumpu-Lehtinen PL

更新日期：2016-04-01 00:00:00

abstract：:Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

journal_title：International journal of clinical oncology

authors： Brammer JE,Lulla P,Lynch GR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Evaluation of the prognosis in patients with spinal metastases is important in decision making regarding surgical treatment. The purpose of this study was to investigate overall survival in patients with spinal metastases from lung cancer by histological subtype, and to investigate prognostic factors in pati...

journal_title：International journal of clinical oncology

authors： Dohzono S,Sasaoka R,Takamatsu K,Nakamura H

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Retrospective evaluation of the effectiveness and adverse events (AEs) of a sequential chemotherapy regimen using gemcitabine + carboplatin (GCarbo) followed by GCarbo + docetaxel (GCarboD) for advanced upper-tract urothelial carcinoma (UTUC). METHODS:We treated 56 patients with advanced UTUC. Mean patient ...

journal_title：International journal of clinical oncology

authors： Yoneyama T,Imai A,Hatakeyama S,Hashimoto Y,Koie T,Ohyama C

更新日期：2015-12-01 00:00:00

abstract：:A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses...

journal_title：International journal of clinical oncology

authors： Tsujimura H,Takagi T,Tamaru J,Sakai C

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Enlarged pelvic nodes are commonly found during preoperative imaging studies in cervical cancer patients and may represent tumor metastasis. It remains controversial whether debulking of these enlarged nodes prior to definitive radiotherapy offers any survival benefit to the patient. METHODS:Enlarged suspic...

journal_title：International journal of clinical oncology

authors： Cheung TH,Lo KW,Yim SF,Yau SH,Yu MM,Yeung WK

更新日期：2011-10-01 00:00:00

abstract：:A 32-year-old Japanese woman was diagnosed as having stage Ib1 adenocarcinoma by diagnostic laser conization at a local hospital. She was admitted to our hospital for fertility-sparing treatment. A radical trachelectomy (RT) was performed using the laparoscopic vaginal procedure. The procedure was started with a lapar...

journal_title：International journal of clinical oncology

authors： Ishioka S,Endo T,Hayashi T,Kitajima Y,Sugimura M,Sagae S,Saito T

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC). METHODS:MVD was evaluated in tumors (n = 50) from patients with EOC who...

journal_title：International journal of clinical oncology

authors： Krishna Priya S,Kumar K,Hiran KR,Bindhu MR,Nagare RP,Vijaykumar DK,Ganesan TS

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In this phase I/II study, we assessed the safety and initial efficacy of stereotactic body radiotherapy (SBRT) for lung tumors with real-time tumor tracking using CyberKnife based on the Monte Carlo algorithm. METHODS:Study subjects had histologically confirmed primary non-small-cell lung cancer staged as T...

journal_title：International journal of clinical oncology

authors： Iwata H,Ishikura S,Murai T,Iwabuchi M,Inoue M,Tatewaki K,Ohta S,Yokota N,Shibamoto Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Data supporting the safety and feasibility of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis (TPC-IPAA) and total colectomy with ileorectal anastomosis (TC-IRA) for patients with familial adenomatous polyposis (FAP) are limited. The aim of this study was to clarify the feasibility and m...

journal_title：International journal of clinical oncology

authors： Konishi T,Ishida H,Ueno H,Kobayashi H,Hinoi T,Inoue Y,Ishida F,Kanemitsu Y,Yamaguchi T,Tomita N,Matsubara N,Watanabe T,Sugihara K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathologica...

journal_title：International journal of clinical oncology

authors： Kano M,Hihara J,Kaneko M,Uemura K,Ohge H,Sueda T

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The efficacy of individual chemotherapy based on chemosensitivity has scarcely been studied. METHODS:We examined the chemosensitivites for four anticancer agents - 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), carboplatin, cisplatin, and etoposide - of 43 ma...

journal_title：International journal of clinical oncology

authors： Ono A,Kanno H,Hayashi A,Nishimura S,Kyuma Y,Sato H,Ito S,Shimizu N,Chang CC,Gondo G,Yamamoto I,Sasaki T,Tanaka M

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Although subcutaneous implantable ports have been indicated as venous access for chemotherapy, these devices have not been used routinely for hematological tumors. METHODS:Between May 2006 and April 2009, 39 ports were implanted in 37 patients with hematological tumors and 16 ports were implanted in 14 pati...

journal_title：International journal of clinical oncology

authors： Ohno H,Mizumoto C,Otsuki Y,Oguma S,Yoshida Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Diagnosis of secondary ovarian tumors originating from colorectal cancer has previously been based upon history of malignancy and radiological findings of bilateral masses with a "stained glass appearance." The purpose of this study was to perform a detailed investigation of the radiological and macroscopic ...

journal_title：International journal of clinical oncology

authors： Kato MK,Shida D,Yoneoka Y,Yoshida H,Miyasaka N,Kanemitsu Y,Kato T

更新日期：2020-09-01 00:00:00

abstract：:We report the case of a 62-year-old man with advanced gastric cancer and multiple liver metastases who was successfully treated with combined chemotherapy including S-1. The patient was clinically diagnosed with stage IV (T3 N2 H1 P0) disease and was initially treated with 100 mg/body per day S-1 administered orally f...

journal_title：International journal of clinical oncology

authors： Nakamura R,Saikawa Y,Kumagai K,Kiyota T,Ohashi M,Yoshida M,Kubota T,Kumai K,Kitajima M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:We designed an outpatient regimen consisting of fractional cisplatin in combination with S-1, a novel oral fluoropyrimidine derivative for the treatment of recurrent or advanced gastric cancer and conducted a phase I study to determine the dose limiting toxicities (DLTs) and recommended dose (RD). METHODS:E...

journal_title：International journal of clinical oncology

authors： Shimoyama S,Imamura K,Hiki N,Yamaguchi H,Mafune K,Kaminishi M

更新日期：2005-08-01 00:00:00

abstract：:Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...

journal_title：International journal of clinical oncology

authors： Doi H,Nakamatsu K,Nishimura Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

journal_title：International journal of clinical oncology

authors： Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

更新日期：2019-05-01 00:00:00