Phase I study of irinotecan and S-1 combination therapy in patients with metastatic gastric cancer.

abstract：BACKGROUND:To avoid the loss of fertility, chemotherapy should be chosen as an adjuvant treatment after trachelectomy. Our study evaluated the effectiveness and safety of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer. METHODS:Our institutional review board approved this clinical study, and in...

journal_title：International journal of clinical oncology

authors： Okugawa K,Yahata H,Sonoda K,Kodama K,Yagi H,Ohgami T,Yasunaga M,Onoyama I,Kaneki E,Asanoma K,Kobayashi H,Kato K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Japanese physicians' attitudes regarding the education of nurse practitioners (NPs) are not well described. PARTICIPANTS AND METHODS:A survey was mailed to 1,094 board members of the Japanese Society of Clinical Oncology (JSCO) and the Japanese Primary Care Association (JPCA), and the directors of the clini...

journal_title：International journal of clinical oncology

authors： Ishida Y,Hatao M,Fukushima O,Mori M,Isozaki F,Okuyama A

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

journal_title：International journal of clinical oncology

authors： Matsuo K,Enomoto T,Yamasaki M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Although subcutaneous implantable ports have been indicated as venous access for chemotherapy, these devices have not been used routinely for hematological tumors. METHODS:Between May 2006 and April 2009, 39 ports were implanted in 37 patients with hematological tumors and 16 ports were implanted in 14 pati...

journal_title：International journal of clinical oncology

authors： Ohno H,Mizumoto C,Otsuki Y,Oguma S,Yoshida Y

更新日期：2010-04-01 00:00:00

abstract：:Prostate cancer is androgen-dependent, and hormone therapy, mainly achieved by androgen deprivation, has been one of the main treatment modalities in the clinical management of prostate cancer patients for more than six decades. In the 1980s, luteinizing hormone-releasing hormone agonists, which reduce testosterone to...

journal_title：International journal of clinical oncology

authors： Suzuki H,Kamiya N,Imamoto T,Kawamura K,Yano M,Takano M,Utsumi T,Naya Y,Ichikawa T

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The objective was to evaluate the incidence of second primary malignancies (SPMs) in thyroid cancer patients compared to age- and gender-matched controls without thyroid cancer from the general population of the same region. METHODS:Tampere and Oulu University Hospitals treated 910 patients with well-differ...

journal_title：International journal of clinical oncology

authors： Hakala TT,Sand JA,Jukkola A,Huhtala HS,Metso S,Kellokumpu-Lehtinen PL

更新日期：2016-04-01 00:00:00

abstract：:When total mesorectal excision (TME) is accurately performed, dysfunction, theoretically, does not occur. However, there are differences among individuals in the running patterns and the volumes of nerve fibers, and if obesity or a narrow pelvis is present, nerve identification is difficult. Currently, the rate of uri...

journal_title：International journal of clinical oncology

authors： Moriya Y

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Inhibition of Notch by γ-secretase inhibitor (GSI) has been shown to have an antitumor effect in Notch-expressing non-small cell lung cancer (NSCLC) and to induce apoptosis through modulation of Bcl-2 family proteins. In particular, Bim, a BH3-only member of the Bcl-2 family of proteins, has an important rol...

journal_title：International journal of clinical oncology

authors： Sakakibara-Konishi J,Ikezawa Y,Oizumi S,Kikuchi J,Kikuchi E,Mizugaki H,Kinoshita I,Dosaka-Akita H,Nishimura M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate whether class III β-tubulin (TUBB3) expression could predict progression-free survival or overall survival in relapsed non-small cell lung cancer (NSCLC) patients treated with taxene-based chemotherapy. METHODS:Immunohistochemistal staining was used to examine the expres...

journal_title：International journal of clinical oncology

authors： Kaira K,Takahashi T,Murakami H,Shukuya T,Kenmotsu H,Ono A,Naito T,Tsuya A,Nakamura Y,Endo M,Kondo H,Nakajima T,Yamamoto N

更新日期：2013-06-01 00:00:00

abstract：:A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...

journal_title：International journal of clinical oncology

authors： Balleari E,Panarello S,Capello E,Grosso M,Passalia C,Pitto P,Raggi F,Roccatagliata L,Cabiddu F,Ghio R

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcinoma suggested the recommended dose of docetaxel at 10 mg/m2 and cisplatin at 20 mg/m2. Phase II study of the concurrent chemor...

journal_title：International journal of clinical oncology

authors： Nakahara S,Takenaka Y,Ogawa K,Nishiike S,Yamamoto Y,Seo Y,Isohashi F,Suzuki O,Yoshioka Y,Sumida I,Yoshii T,Tomiyama Y,Inohara H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...

journal_title：International journal of clinical oncology

authors： Tsuruga T,Fujimoto A,Kawana K,Mori M,Hasumi Y,Kino N,Tomio K,Miura S,Tanikawa M,Sone K,Miyamoto Y,Ikeda Y,Kojima S,Adachi K,Nagasaka K,Matsumoto Y,Arimoto T,Oda K,Nakagawa S,Horie K,Yasugi T,Yokota H,Osuga Y,

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The efficacy of carbon-ion radiotherapy (C-ion RT) for lymph node (LN) oligo-recurrence has only been evaluated in limited single-center studies. We aimed to investigate the benefit of C-ion RT for LN oligo-recurrence in a large multi-center study. METHODS:Patients who received C-ion RT between December 199...

journal_title：International journal of clinical oncology

authors： Okonogi N,Kaminuma T,Okimoto T,Shinoto M,Yamamoto N,Yamada S,Murata K,Ohno T,Shioyama Y,Tsuji H,Nakano T,Kamada T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Sternal resection is occasionally required for patients with malignant tumors, particularly sarcomas, in the sternal region. Few reports have described post-operative respiratory and shoulder function after sternal resection for patients with bone and soft-tissue sarcomas. METHODS:Eight consecutive patients...

journal_title：International journal of clinical oncology

authors： Nishida Y,Tsukushi S,Urakawa H,Toriyama K,Kamei Y,Yokoi K,Ishiguro N

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:As cancer therapy can be harmful to spermatogenesis, men are generally advised to cryopreserve sperm before gonadotoxic treatment. Here, we compared fresh and frozen-thawed sperm quality in patients according to cancer type, and reported use rate in subsequent assisted reproductive technology (ART) cycles. ...

journal_title：International journal of clinical oncology

authors： Freour T,Mirallie S,Jean M,Barriere P

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Cancer patients are at high risk of developing a second cancer after the treatment of initial cancers. Understanding the characteristics of multiple primary cancer is important to establish an effective surveillance program for the early detection of second cancers. METHODS:We analyzed the cancer registry r...

journal_title：International journal of clinical oncology

authors： Ueno M,Muto T,Oya M,Ota H,Azekura K,Yamaguchi T

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:An association between inflammation and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the influence of preoperative biliary drainage-related inflammation in patients with biliary tract cancer. METHODS:The clinical data of 97 patients who underwent surg...

journal_title：International journal of clinical oncology

authors： Kurahara H,Maemura K,Mataki Y,Sakoda M,Iino S,Kawasaki Y,Arigami T,Uenosono Y,Kijima Y,Shinchi H,Takao S,Natsugoe S

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Pulmonary wedge resection is an option for lung cancer patients with limited cardiopulmonary preservation. As the impact of underlying lung status on the prognosis of such patients remains unclear, we assessed this issue. METHODS:A total of 149 borderline surgical candidates with localized lung cancer who h...

journal_title：International journal of clinical oncology

authors： Kawaguchi T,Sawabata N,Miura S,Kawai N,Yasukawa M,Tojo T,Taniguchi S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Peripheral sensory neurotoxicity is a frequent adverse effect of oxaliplatin therapy. Calcium and magnesium (Ca/Mg) infusions are frequently used as preventatives, but a recent phase III trial failed to show that they prevent neurotoxicity. We therefore conducted a multicenter randomized phase III trial to c...

journal_title：International journal of clinical oncology

authors： Oki E,Emi Y,Kojima H,Higashijima J,Kato T,Miyake Y,Kon M,Ogata Y,Takahashi K,Ishida H,Saeki H,Sakaguchi Y,Yamanaka T,Kono T,Tomita N,Baba H,Shirabe K,Kakeji Y,Maehara Y

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Alternative anti-androgen therapy (AAT) with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. However, no studies have compared enzalutamide without AAT with enzalutamide after AAT with flutamide as treatment for castration-resistant prostat...

journal_title：International journal of clinical oncology

authors： Iguchi T,Tamada S,Kato M,Yasuda S,Otoshi T,Hamada K,Yamasaki T,Nakatani T

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Whether the administration of calcium (Ca) and magnesium (Mg) can reduce oxaliplatin-related neurotoxicity remains controversial. In addition, little is known about the effects of Ca/Mg on the blood level of platinum or objective tumor progression. PATIENTS AND METHODS:Patients receiving modified FOLFOX6 fo...

journal_title：International journal of clinical oncology

authors： Ishibashi K,Okada N,Miyazaki T,Sano M,Ishida H

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:We retrospectively investigated the efficacy and safety profile of weekly low-dose docetaxel (DTX) with estramustine in comparison with triweekly standard-dose DTX treatment for Japanese patients with castration-resistant prostate cancer (CRPC). METHODS:Between April 2002 and January 2011, 75 CRPC patients ...

journal_title：International journal of clinical oncology

authors： Nakai Y,Nishimura K,Nakayama M,Uemura M,Takayama H,Nonomura N,Tsujimura A,Osaka CRPC Clinical Study Collaboration.

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Panitumumab is a fully human, monoclonal antibody against the epidermal growth factor receptor. Previous studies in non-Japanese patients with solid tumors showed that panitumumab exhibited nonlinear pharmacokinetics, was well tolerated (skin toxicities were the most common treatment-related adverse events),...

journal_title：International journal of clinical oncology

authors： Doi T,Ohtsu A,Tahara M,Tamura T,Shirao K,Yamada Y,Otani S,Yang BB,Ohkura M,Ohtsu T

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:It is still controversial whether axillary lymph node (ALN) dissection (ALND) can be omitted after negative sentinel lymph node (SLN) biopsy (SLNB) in breast cancer (BC) patients with clinically positive ALNs at presentation treated with neoadjuvant chemotherapy (NAC). The study aim was to analyze whether SL...

journal_title：International journal of clinical oncology

authors： Takei H,Yoshida T,Kurosumi M,Inoue K,Matsumoto H,Hayashi Y,Higuchi T,Uchida S,Ninomiya J,Kubo K,Oba H,Nagai S,Tabei T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...

journal_title：International journal of clinical oncology

authors： Saikawa M,Kishimoto S

更新日期：2010-02-01 00:00:00

abstract：:Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what is the optima...

journal_title：International journal of clinical oncology

authors： Gradishar WJ,O'Regan RM

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Based on the results of the SPIRITS trial, combination chemotherapy of S-1 plus cisplatin (SP) is now considered the standard treatment for patients with advanced gastric cancer (AGC) in Japan. On the other hand, several non-Japanese studies have shown the efficacy of capecitabine plus cisplatin (XP), which ...

journal_title：International journal of clinical oncology

authors： Shitara K,Sawaki A,Matsuo K,Kondo C,Takahari D,Ura T,Tajika M,Niwa Y,Muro K

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Set-up errors represent a source of uncertainty in head and neck (H&N) cancer radiotherapy. The present study evaluated set-up accuracy with the use of cone-beam computed tomography (CBCT) in order to establish the proper clinical target volume (CTV) to planning target volume (PTV) margins to be adopted. ME...

journal_title：International journal of clinical oncology

authors： Dionisi F,Palazzi MF,Bracco F,Brambilla MG,Carbonini C,Asnaghi DD,Monti AF,Torresin A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...

journal_title：International journal of clinical oncology

authors： Yokota T,Onitsuka T,Kusafuka K,Ogawa H,Onozawa Y,Nakagawa M,Iida Y,Kamijo T,Nishimura T,Nakajima T,Boku N,Yasui H

更新日期：2014-02-01 00:00:00

abstract：:We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and...

journal_title：International journal of clinical oncology

authors： Yamada T,Ohtsubo K,Mouri H,Yamashita K,Yasumoto K,Izumi K,Zen Y,Watanabe H,Yano S

更新日期：2009-10-01 00:00:00