Abstract:
BACKGROUND:Whether the administration of calcium (Ca) and magnesium (Mg) can reduce oxaliplatin-related neurotoxicity remains controversial. In addition, little is known about the effects of Ca/Mg on the blood level of platinum or objective tumor progression. PATIENTS AND METHODS:Patients receiving modified FOLFOX6 for metastatic colorectal cancer were double-blinded and randomized to receive additional treatment with Ca/Mg or placebo before and after the administration of oxaliplatin. The plasma and ultrafiltrable concentrations of platinum during the first and fifth cycles of treatment were determined using inductively coupled plasma spectrometry. RESULTS:Patients were randomized to receive Ca/Mg (Ca/Mg group, n = 17) or placebo (placebo group, n = 16) before and after the administration of oxaliplatin (85 mg/m(2)). The incidence of neurotoxicity after six cycles was not significantly different between the two groups. Blood concentrations of platinum at each time and the area under the curve were also not significantly different between the two groups. Furthermore, the response rate (RR) and disease control rate (DCR) did not differ significantly between the two groups (Ca/Mg group: RR 36%, DCR 73%. Placebo group: RR 40%, DCR 70%, P > 0.99). The median progression-free survival time was 9.2 months in the Ca/Mg group and 8.1 months in the control group; these survival times were not significantly different (P = 0.56). CONCLUSION:These data are insufficient to conclude with any certainty that the administration of Ca/Mg is not neuroprotective; however, the administration of Ca/Mg may not have any influence on antitumor activity and the blood concentration profile of platinum in patients receiving oxaliplatin-based chemotherapy.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Ishibashi K,Okada N,Miyazaki T,Sano M,Ishida Hdoi
10.1007/s10147-009-0015-3subject
Has Abstractpub_date
2010-02-01 00:00:00pages
82-7issue
1eissn
1341-9625issn
1437-7772journal_volume
15pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The role and the optimal measurement method of serum HER2 levels are not defined in patients with metastatic breast cancer (MBC). We prospectively assessed the prognostic value of serum HER2 levels in MBC using two methods, enzyme immunoassay (EIA) and chemiluminescence immunoassay (CLIA). METHODS:We collec...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0253-z
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s101470200026
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:We have performed 26 vaginal radical trachelectomies (RTs) for patients with early invasive uterine cervical cancer since 2003 and, to date, have experienced 8 deliveries. The procedure has a high risk for preterm labor and the subsequent occurrence of preterm premature rupture of membranes (pPROM). We repor...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0479-4
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The activity and synergy for the combination treatment of cisplatin and gemcitabine has been identified in a variety of human tumor cells, including ovarian cancer cells, and has been widely approved for the treatment of non-small cell lung cancer, pancreatic cancer and biliary tract cancer. As the gastroint...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0599-5
更新日期:2014-08-01 00:00:00
abstract::Adenoid cystic carcinoma of the uterine cervix is a rare and peculiar variant of adenocarcinoma. This tumor represents 3% of all primary cervical adenocarcinomas, and it is locally aggressive and capable of metastasis to other organs even in its early stage. We report a case of adenoid cystic carcinoma stage IIIb that...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-004-0466-5
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abstract::We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0869-9
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Although several studies have reported the incidence of KIT and PDGFRA gene mutations in cutaneous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is an uncommon neoplasm compared with countries with Caucasian populations. METHODS:In this study, p...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0087-0
更新日期:2010-10-01 00:00:00
abstract::In Japan, the first actual survey of morbidity from cancer was conducted by Dr. Mitsuo Segi in Miyagi Prefecture from 1951 to 1953. Population-based cancer registries were started in 1957 in Hiroshima and 1958 in Nagasaki for the follow-up of survivors of the atomic bombings. Public population-based cancer registries,...
journal_title:International journal of clinical oncology
pub_type: 历史文章,杂志文章
doi:10.1007/s10147-008-0759-1
更新日期:2008-04-01 00:00:00
abstract::Brachytherapy is an important radio-therapeutic modality for a variety of malignancies, including prostate cancer, cervix cancer, breast cancer, vagina cancer, endometrium cancer, head and neck cancer, and many more. This technique has been shown to be an effective and safe non-pharmaceutical treatment with fewer seri...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-017-1155-5
更新日期:2017-08-01 00:00:00
abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1096-z
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Based on the results of the SPIRITS trial, combination chemotherapy of S-1 plus cisplatin (SP) is now considered the standard treatment for patients with advanced gastric cancer (AGC) in Japan. On the other hand, several non-Japanese studies have shown the efficacy of capecitabine plus cisplatin (XP), which ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0416-6
更新日期:2013-06-01 00:00:00
abstract::We report a rare case of advanced ovarian mucinous adenocarcinoma in a pregnant woman. A 28-year-old pregnant Japanese woman was diagnosed with an ovarian tumor 8 cm in diameter at a local hospital. She was sent to a private hospital at 25 weeks of gestation because of the growing ovarian tumor. Advanced ovarian carci...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0655-0
更新日期:2007-10-01 00:00:00
abstract::It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-003-0327-7
更新日期:2003-10-01 00:00:00
abstract::Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-008-0865-0
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01855-y
更新日期:2021-01-07 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0646-2
更新日期:2014-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0116-z
更新日期:2011-04-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2003-04-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2010-04-01 00:00:00