Abstract:
BACKGROUND:The role and the optimal measurement method of serum HER2 levels are not defined in patients with metastatic breast cancer (MBC). We prospectively assessed the prognostic value of serum HER2 levels in MBC using two methods, enzyme immunoassay (EIA) and chemiluminescence immunoassay (CLIA). METHODS:We collected blood samples from patients with MBC at baseline and at subsequent 3- to 4-week intervals up to 12 weeks. Samples were divided, and serum HER2 levels were determined using EIA and CLIA. We also determined whether serum HER2 levels had decreased by ≥20% at first follow-up. These results were evaluated against overall survival, progression-free survival, and tumor response. RESULTS:We obtained 196 samples from 52 patients. In 59 samples from patients who received trastuzumab, serum HER2 positivity rates were significantly lower for EIA (n = 22) than for CLIA (n = 33, P = 0.042); in 137 samples from patients who did not receive trastuzumab, there was no significant difference in rates of serum HER2 positivity for CLIA (n = 83) and EIA (n = 80). Serum HER2 level at baseline, the level at first follow-up, and a decrease of ≥20% between baseline and first follow-up were not associated with overall survival, progression-free survival, and tumor response. CONCLUSIONS:Chemiluminescence immunoassay was a more sensitive method than EIA for measuring serum HER2 levels in patients who received trastuzumab. However, because serum HER2 levels did not correlate with patient outcome, we do not currently recommend measuring serum HER2 levels by either method for prognostic evaluation in patients with MBC.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Hayashi N,Nakamura S,Tokuda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NTdoi
10.1007/s10147-011-0253-zsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
55-62issue
1eissn
1341-9625issn
1437-7772journal_volume
17pub_type
杂志文章abstract:BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-017-1230-y
更新日期:2018-06-01 00:00:00
abstract::Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-009-0001-9
更新日期:2010-02-01 00:00:00
abstract::A 45-year-old woman with HER2(-)/HER1(-) breast cancer underwent radical mastectomy, followed by radiation and chemotherapy. However, her symptoms progressed rapidly owing to meningitis carcinomatosa and she was fitted with a urethral catheter. She also had difficulty in walking. However, immediately after treatment w...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0195-5
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The correlation between treatment-related factors and lung toxicity has not been sufficiently evaluated in salvage radiotherapy. METHODS:Twenty-one patients with recurrent non-small-cell lung cancer (NSCLC) after lobectomy received salvage radiotherapy to a total dose of 46-60 Gy. The effects of radiotherap...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-005-0542-5
更新日期:2006-02-01 00:00:00
abstract::Primary sarcoma of the fallopian tube is a very rare neoplasm. We report the case of a 69-year-old woman affected with leiomyosarcoma of the left fallopian tube. Her chief complaint was lower abdominal pain. The preoperative diagnosis was a left adnexal malignant tumor based on pelvic examination, abdominal computed t...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0027-z
更新日期:2010-04-01 00:00:00
abstract::In Japan, the National Cancer Center and university hospitals have initiated next-generation sequencing-based in vitro diagnostic testing for cancer patients as a method of clinical sequencing. Based on the molecular alterations detected, physicians can provide approved targeted therapy and access to investigational d...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-018-1378-0
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1189-8
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC). METHODS:MVD was evaluated in tumors (n = 50) from patients with EOC who...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1033-6
更新日期:2017-02-01 00:00:00
abstract::A diagnosis of cervical cancer during pregnancy poses difficult management and ethical problems. Survival of the patient is the foremost concern, but fetal viability and well-being must also be addressed. Radical trachelectomy (RT) has recently begun to be performed as a possible treatment modality for early stage inv...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0209-3
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-009-0016-2
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS:We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-015-0859-7
更新日期:2016-02-01 00:00:00
abstract::We report four patients with pancreatic metastasis of renal cell carcinoma who were successfully treated with radiation therapy. The patients were one woman and three men with a median age of 55 years (range, 49 to 62 years) who underwent radical nephrectomy for primary renal cell carcinoma. The median interval from n...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0833-8
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0907-3
更新日期:2016-04-01 00:00:00
abstract::Combination chemotherapy with cisplatin and pemetrexed is the most active first-line regimen for malignant pleural mesothelioma (MPM). However, no drugs have been approved for second-line treatment of MPM, with effective regimens remaining to be identified for patients in relapse. We have now evaluated the combination...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0064-7
更新日期:2010-10-01 00:00:00
abstract::We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia. The patient reported a swelling in his left lower abdomen over the past 6 months. Magnetic resonance imaging revealed a left inguinal mass extending from the ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0850-7
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Dendritic cell (DC)-based and cytokine-induced killer cell (CIK)-based therapy can induce specific antitumor T-cell responses. This clinical pilot study examined the safety, the feasibility, and the outcome of tumor-specific immunotherapy for patients with advanced pancreatic adenocarcinoma. METHODS:Alpha-G...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-012-0434-4
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0532-y
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:We aimed to determine the frequency of fibromyalgia syndrome (FM) in operated breast cancer patients and to research the relationship between FM and the severity of fatigue and quality of life in these breast cancer patients. METHODS:The demographic data of 101 operated breast cancer patients were recorded....
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0377-9
更新日期:2013-04-01 00:00:00
abstract::Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-005-0514-9
更新日期:2005-12-01 00:00:00
abstract::Recent advances in molecular biology have identified the responsible genes for many hereditary cancer syndromes (familial tumors). Therefore, now, the final diagnosis of familial tumors can be done by molecular methods to detect the genetic alteration in the disease-causing responsible gene(s) in the patient. So-calle...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-004-0421-5
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0839-y
更新日期:2015-12-01 00:00:00
abstract::Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-010-0140-z
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:We aimed to compare the impact of systematic uncertainties in patient setup and prostate motion on three different external-beam radiotherapy protocols for prostate cancer. METHODS:To simulate possible near-maximum systematic errors, the isocenter position was shifted to eight points with +/-1.65 SD of the ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0724-4
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS:The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefe...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-018-1287-2
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the predictive value of preoperative hydronephrosis for pathological outcome and prognosis in patients with upper tract urothelial carcinoma treated with nephroureterectomy. METHODS:167 patients with UTUC treated with nephroureterectomy at our two institutions in Japan between 2002 and 2017 were ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-019-01535-6
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-020-01656-3
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:We performed a multicenter longitudinal study using our neck dissection questionnaire (NDQ) and arm abduction test (AAT) to assess the impact of rehabilitation and surgical modification on postoperative quality of life (QOL). METHODS:Patients who had undergone neck dissection for the treatment of head and n...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-009-0020-6
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The aim of this phase II study was to evaluate the feasibility and safety of a carboplatin and gemcitabine combination regimen in the treatment of completely resected non-small cell lung cancer (NSCLC). METHODS:Patients with completely resected pathologically documented stage IB, II or IIIA NSCLC were treat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0118-x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Opioids are key drugs for cancer pain relief, but some patients, especially those who have gastroenterological cancers, suffer from severe opioid-induced bowel dysfunction (OBD), which reduces their quality of life. In order to achieve better pain relief, efforts to minimize OBD are required. METHODS:Betwee...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0829-4
更新日期:2009-06-01 00:00:00
abstract::We report a rare case of advanced ovarian mucinous adenocarcinoma in a pregnant woman. A 28-year-old pregnant Japanese woman was diagnosed with an ovarian tumor 8 cm in diameter at a local hospital. She was sent to a private hospital at 25 weeks of gestation because of the growing ovarian tumor. Advanced ovarian carci...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0655-0
更新日期:2007-10-01 00:00:00