A new therapeutic approach in patients with advanced sarcoma.

abstract：:Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The ...

journal_title：International journal of clinical oncology

authors： Kawakami Y,Ohta S,Sayem MA,Tsukamoto N,Yaguchi T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS:We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopat...

journal_title：International journal of clinical oncology

authors： Harano K,Hirakawa A,Yunokawa M,Nakamura T,Satoh T,Nishikawa T,Aoki D,Ito K,Ito K,Nakanishi T,Susumu N,Takehara K,Watanabe Y,Watari H,Saito T

更新日期：2016-02-01 00:00:00

abstract：:Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pat...

journal_title：International journal of clinical oncology

authors： Makay O,Kazimi M,Aydin U,Nart D,Yilmaz F,Zeytunlu M,Goker E,Coker A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Indocyanine green (ICG), an agent for measuring liver function, becomes fluorescent under near-infrared (NIR) light after binding to serum proteins. Hepatocellular carcinoma (HCC) with a deposit of preoperatively administered ICG becomes clearly detectable under ICG fluorography; however, it remains unclear ...

journal_title：International journal of clinical oncology

authors： Morita Y,Sakaguchi T,Unno N,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Baba S,Takehara Y,Suzuki S,Konno H

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Neoplastic cardiac tamponade (NCT) is a life-threatening complication of cancer. The interval between cancer diagnosis and NCT onset and the prognosis after pericardiocentesis may differ according to cancer type. METHODS AND RESULTS:We performed a retrospective study of 113 patients (54 % male) with NCT who...

journal_title：International journal of clinical oncology

authors： Takayama T,Okura Y,Okada Y,Honma K,Nashimoto A,Sato N,Yokoyama A,Minamino T

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:When soft-tissue sarcomas occur near neurovascular structures, preoperative images cannot always reveal the accurate relationship between the tumor and these structures. Therefore, in some patients, neurovascular structures are sacrificed unnecessarily. In other patients, neurovascular structures are preserv...

journal_title：International journal of clinical oncology

authors： Matsumoto S,Kawaguchi N,Manabe J,Matsushita Y

更新日期：2002-02-01 00:00:00

abstract：:Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...

journal_title：International journal of clinical oncology

authors： Hatoum HA,Abi Saad GS,Otrock ZK,Barada KA,Shamseddine AI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...

journal_title：International journal of clinical oncology

authors： Saikawa M,Kishimoto S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:This multi-center, phase III trial assesses the efficacy of daikenchuto (TU-100) on gastrointestinal disorders after hepatic resection (UMIN Registration No. 000003103). MATERIALS AND METHODS:A total of 231 patients, who underwent hepatic resection at 26 Japanese centers, were enrolled. Patients were random...

journal_title：International journal of clinical oncology

authors： Shimada M,Morine Y,Nagano H,Hatano E,Kaiho T,Miyazaki M,Kono T,Kamiyama T,Morita S,Sakamoto J,Kusano M,Saji S,Kanematsu T,Kitajima M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Differences in individual body sizes have not been well considered when analyzing the survival of patients with non-small cell lung cancer (NSCLC). We hypothesized that physique-adjusted tumor size is superior to actual tumor size in predicting the prognosis. METHODS:Eight hundred and forty-two patients who...

journal_title：International journal of clinical oncology

authors： Ozeki N,Fukui T,Kawaguchi K,Nakamura S,Hakiri S,Kato T,Hirakawa A,Yokoi K

更新日期：2018-04-01 00:00:00

abstract：:We report four patients with pancreatic metastasis of renal cell carcinoma who were successfully treated with radiation therapy. The patients were one woman and three men with a median age of 55 years (range, 49 to 62 years) who underwent radical nephrectomy for primary renal cell carcinoma. The median interval from n...

journal_title：International journal of clinical oncology

authors： Saito J,Yamanaka K,Sato M,Mori N,Sekii K,Yoshioka T,Itatani H,Nakatsuka S

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Despite increasing interest in minimally invasive surgery, prevalence data are completely absent. Our objective was to analyze clinico-epidemiological variations of surgery for renal malignancy in Japan with emphasis on annual trends and regional gaps, and to analyze factors affecting choice of open versus m...

journal_title：International journal of clinical oncology

authors： Sugihara T,Yasunaga H,Horiguchi H,Tsuru N,Fujimura T,Nishimatsu H,Kume H,Ohe K,Matsuda S,Fushimi K,Homma Y

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:The purpose of our study was to evaluate the efficacy of a new combination antiemetic therapy consisting of palonosetron, aprepitant, and dexamethasone in gastric cancer patients undergoing chemotherapy with S-1 plus cisplatin. METHODS:This prospective, multi-institutional observational study assessed patient-...

journal_title：International journal of clinical oncology

authors： Oyama K,Fushida S,Kaji M,Takeda T,Yabushita K,Nezuka H,Kinami S,Kadoya N,Takai Y,Tsukioka Y,Ohyama S,Tsuji K,Tsukada T,Kinoshita J,Fujimura T,Ohta T

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Although regorafenib or trifluridine/tipiracil (FTD/TPI) has been recognized as a later-line standard treatment in patients with metastatic colorectal cancer (mCRC), not all patients have beneficial outcomes. This study aimed to develop a prognostic scoring system for evaluating the overall survival (OS) ben...

journal_title：International journal of clinical oncology

authors： Moriwaki T,Fukuoka S,Masuishi T,Takashima A,Kumekawa Y,Kajiwara T,Yamazaki K,Esaki T,Makiyama A,Denda T,Hatachi Y,Suto T,Sugimoto N,Enomoto M,Ishikawa T,Kashiwada T,Oki E,Komatsu Y,Tsuji A,Tsuchihashi K,Sakai D,

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT. METHODS:62 adult survivo...

journal_title：International journal of clinical oncology

authors： Wagner AP,Carroll C,White SR,Watson P,Spoudeas HA,Hawkins MM,Walker DA,Clare ICH,Holland AJ,Ring H

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The influence of resection of the primary lesion on the prognosis of patients with incurable stage IV colorectal cancer is unclear. METHODS:We retrospectively analyzed 158 asymptomatic patients with incurable stage IV colorectal cancer who received systemic chemotherapy in our center from 2002 to 2009, eith...

journal_title：International journal of clinical oncology

authors： Watanabe A,Yamazaki K,Kinugasa Y,Tsukamoto S,Yamaguchi T,Shiomi A,Tsushima T,Yokota T,Todaka A,Machida N,Fukutomi A,Onozawa Y,Yasui H

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:To characterize clinical advantages in robot-assisted partial nephrectomy (RAPN) for targeting renal hilar tumors, and compare them with those of open PN (OPN). METHODS:This study included 31 consecutive patients with renal hilar tumors, consisting of 15 and 16 who received OPN and RAPN, respectively, betwe...

journal_title：International journal of clinical oncology

authors： Miyake H,Hinata N,Imai S,Furukawa J,Tanaka K,Fujisawa M

更新日期：2015-08-01 00:00:00

abstract：:When total mesorectal excision (TME) is accurately performed, dysfunction, theoretically, does not occur. However, there are differences among individuals in the running patterns and the volumes of nerve fibers, and if obesity or a narrow pelvis is present, nerve identification is difficult. Currently, the rate of uri...

journal_title：International journal of clinical oncology

authors： Moriya Y

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Evaluation of the prognosis in patients with spinal metastases is important in decision making regarding surgical treatment. The purpose of this study was to investigate overall survival in patients with spinal metastases from lung cancer by histological subtype, and to investigate prognostic factors in pati...

journal_title：International journal of clinical oncology

authors： Dohzono S,Sasaoka R,Takamatsu K,Nakamura H

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate whether class III β-tubulin (TUBB3) expression could predict progression-free survival or overall survival in relapsed non-small cell lung cancer (NSCLC) patients treated with taxene-based chemotherapy. METHODS:Immunohistochemistal staining was used to examine the expres...

journal_title：International journal of clinical oncology

authors： Kaira K,Takahashi T,Murakami H,Shukuya T,Kenmotsu H,Ono A,Naito T,Tsuya A,Nakamura Y,Endo M,Kondo H,Nakajima T,Yamamoto N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate the prognostic significance of thymidylate synthase (TS) expression in the tumor tissue of patients with metastatic colorectal cancer (CRC) who received protracted venous infusions of 5-fluorouracil (5-FU). METHODS:We retrospectively analyzed the prognostic value of TS e...

journal_title：International journal of clinical oncology

authors： Hosokawa A,Yamada Y,Shimada Y,Muro K,Hamaguchi T,Morita H,Araake M,Orita H,Shirao K

更新日期：2004-10-01 00:00:00

abstract：:We report a patient with avascular necrosis of the bilateral femoral head resulting from long-term steroid administration for radiation pneumonitis that occurred after tangential irradiation of the breast. The patient was a 50-year-old postmenopausal woman with breast cancer, stage IIIB (T4bN0M0) in the right C area. ...

journal_title：International journal of clinical oncology

authors： Kosaka Y,Mitsumori M,Araki N,Yamauchi C,Nagata Y,Hiraoka M,Kodama H

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

journal_title：International journal of clinical oncology

authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:We performed a multicenter longitudinal study using our neck dissection questionnaire (NDQ) and arm abduction test (AAT) to assess the impact of rehabilitation and surgical modification on postoperative quality of life (QOL). METHODS:Patients who had undergone neck dissection for the treatment of head and n...

journal_title：International journal of clinical oncology

authors： Nibu K,Ebihara Y,Ebihara M,Kawabata K,Onitsuka T,Fujii T,Saikawa M

更新日期：2010-02-01 00:00:00

abstract：:Background. We aimed to evaluate the clinical usefulness of measurement of the free-to-total (F/T) ratio of prostate-specific antigen (PSA) for the differentiation of prostate cancer from benign prostate hyperplasia (BPH) and for the staging of prostate cancer. Values for PSA density (PSAD) and PSAD adjusted to the tr...

journal_title：International journal of clinical oncology

authors： Furuya Y,Akakura K,Ito H

更新日期：2000-02-01 00:00:00

abstract：:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this disease. Oncogenic PIK3CA mutation, which activates the PIK3CA/AKT/mTOR signaling pathway, is a promising druggable ...

journal_title：International journal of clinical oncology

authors： Kuroda T,Kohno T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...

journal_title：International journal of clinical oncology

authors： Yoshida K,Kajiyama H,Yoshihara M,Tamauchi S,Ikeda Y,Yoshikawa N,Nishino K,Niimi K,Suzuki S,Kikkawa F

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...

journal_title：International journal of clinical oncology

authors： Tsuruga T,Fujimoto A,Kawana K,Mori M,Hasumi Y,Kino N,Tomio K,Miura S,Tanikawa M,Sone K,Miyamoto Y,Ikeda Y,Kojima S,Adachi K,Nagasaka K,Matsumoto Y,Arimoto T,Oda K,Nakagawa S,Horie K,Yasugi T,Yokota H,Osuga Y,

更新日期：2016-04-01 00:00:00

abstract：:Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavily pretreated patients. Paclitaxel has a so-called platelet-sparing effect, but until now it was unknown whether...

journal_title：International journal of clinical oncology

authors： Ishikawa H,Fujiwara K,Suzuki S,Tanaka Y,Kohno I

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Recurrent or persistent clear cell carcinoma (CCC) of the ovary is particularly chemotherapy resistant. The purpose of this study was to review our extensive institutional experiences with recurrent or persistent CCC with the aim of finding a more effective chemotherapy regimen. METHODS:The medical records ...

journal_title：International journal of clinical oncology

authors： Yoshino K,Enomoto T,Fujita M,Ueda Y,Kimura T,Kobayashi E,Tsutsui T,Kimura T

更新日期：2013-02-01 00:00:00