Abstract:
BACKGROUND:Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS:We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopathological, treatment, and outcome information. RESULTS:A total of 486 patients (median age 65 years) were identified-224 (46 %) were stage I, 32 (7 %) were stage II, 139 (28 %) were stage III, and 91 (19 %) were stage IV. Among them, 277 (57 %) had disease recurrence. Median disease-free survival (DFS) was 16.4 months [95 % confidence interval (CI) 15.7-27.2], and median overall survival (OS) was 72.0 months (95 % CI 43.0-not reached). In total, 454 (94 %) patients received adjuvant treatment, and 440 (91 %) received adjuvant chemotherapy. In multivariate analysis, stage III-IV disease, CA-125 level, and lymphovascular space invasion (LVSI) were significantly associated with shorter median DFS. Stage III-IV disease, performance status 2-4, ≥50 % myometrial invasion depth, and postsurgical residual tumor size >1 cm were significantly associated with shorter median OS. Conversely, pelvic lymph node lymphadenectomy was associated with improved DFS and OS. CONCLUSIONS:Stage, performance status, CA-125 level, LVSI, and myometrial invasion were associated with poor prognoses. Pelvic lymphadenectomy was associated with improved survival, and may be necessary for the surgical management of UCS.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Harano K,Hirakawa A,Yunokawa M,Nakamura T,Satoh T,Nishikawa T,Aoki D,Ito K,Ito K,Nakanishi T,Susumu N,Takehara K,Watanabe Y,Watari H,Saito Tdoi
10.1007/s10147-015-0859-7subject
Has Abstractpub_date
2016-02-01 00:00:00pages
168-76issue
1eissn
1341-9625issn
1437-7772pii
10.1007/s10147-015-0859-7journal_volume
21pub_type
杂志文章,多中心研究abstract::The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-007-0672-z
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abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:Resection of hepatocellular carcinoma (HCC) is potentially curative; however, recurrence is common. To date, few or no effective adjuvant therapies have been adequately investigated. This study evaluates the efficacy of adjuvant iodine-131-lipiodol after hepatic resection through the experience of a single-c...
journal_title:International journal of clinical oncology
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pub_type: 临床试验,杂志文章
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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