Prognostic factors in patients with uterine carcinosarcoma: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group.

Abstract:

BACKGROUND:Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS:We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopathological, treatment, and outcome information. RESULTS:A total of 486 patients (median age 65 years) were identified-224 (46 %) were stage I, 32 (7 %) were stage II, 139 (28 %) were stage III, and 91 (19 %) were stage IV. Among them, 277 (57 %) had disease recurrence. Median disease-free survival (DFS) was 16.4 months [95 % confidence interval (CI) 15.7-27.2], and median overall survival (OS) was 72.0 months (95 % CI 43.0-not reached). In total, 454 (94 %) patients received adjuvant treatment, and 440 (91 %) received adjuvant chemotherapy. In multivariate analysis, stage III-IV disease, CA-125 level, and lymphovascular space invasion (LVSI) were significantly associated with shorter median DFS. Stage III-IV disease, performance status 2-4, ≥50 % myometrial invasion depth, and postsurgical residual tumor size >1 cm were significantly associated with shorter median OS. Conversely, pelvic lymph node lymphadenectomy was associated with improved DFS and OS. CONCLUSIONS:Stage, performance status, CA-125 level, LVSI, and myometrial invasion were associated with poor prognoses. Pelvic lymphadenectomy was associated with improved survival, and may be necessary for the surgical management of UCS.

journal_name

Int J Clin Oncol

authors

Harano K,Hirakawa A,Yunokawa M,Nakamura T,Satoh T,Nishikawa T,Aoki D,Ito K,Ito K,Nakanishi T,Susumu N,Takehara K,Watanabe Y,Watari H,Saito T

doi

10.1007/s10147-015-0859-7

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

168-76

issue

1

eissn

1341-9625

issn

1437-7772

pii

10.1007/s10147-015-0859-7

journal_volume

21

pub_type

杂志文章,多中心研究
  • Management of retroperitoneal lymph nodes in the treatment of ovarian cancer.

    abstract::The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-007-0672-z

    authors: Ushijima K

    更新日期:2007-06-01 00:00:00

  • Popliteal pseudoaneurysm simulating soft-tissue sarcoma: complication of osteochondroma resection.

    abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/pl00012084

    authors: Otsuka T,Yonezawa M,Kamiyama F,Matusita Y,Matui N

    更新日期:2001-04-01 00:00:00

  • Hepatic resection with or without adjuvant iodine-131-lipiodol for hepatocellular carcinoma: a comparative analysis.

    abstract:BACKGROUND:Resection of hepatocellular carcinoma (HCC) is potentially curative; however, recurrence is common. To date, few or no effective adjuvant therapies have been adequately investigated. This study evaluates the efficacy of adjuvant iodine-131-lipiodol after hepatic resection through the experience of a single-c...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0143-9

    authors: Chua TC,Saxena A,Chu F,Butler SP,Quinn RJ,Glenn D,Morris DL

    更新日期:2011-04-01 00:00:00

  • Complete remission in a patient with metastatic mixed adenocarcinoma/extrapulmonary small cell carcinoma of the prostate.

    abstract::Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0198-2

    authors: Brammer JE,Lulla P,Lynch GR

    更新日期:2011-12-01 00:00:00

  • A survival analysis using physique-adjusted tumor size of non-small cell lung cancer.

    abstract:BACKGROUND:Differences in individual body sizes have not been well considered when analyzing the survival of patients with non-small cell lung cancer (NSCLC). We hypothesized that physique-adjusted tumor size is superior to actual tumor size in predicting the prognosis. METHODS:Eight hundred and forty-two patients who...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-017-1219-6

    authors: Ozeki N,Fukui T,Kawaguchi K,Nakamura S,Hakiri S,Kato T,Hirakawa A,Yokoi K

    更新日期:2018-04-01 00:00:00

  • Novel classification of ovarian metastases originating from colorectal cancer by radiological imaging and macroscopic appearance.

    abstract:BACKGROUND:Diagnosis of secondary ovarian tumors originating from colorectal cancer has previously been based upon history of malignancy and radiological findings of bilateral masses with a "stained glass appearance." The purpose of this study was to perform a detailed investigation of the radiological and macroscopic ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01717-7

    authors: Kato MK,Shida D,Yoneoka Y,Yoshida H,Miyasaka N,Kanemitsu Y,Kato T

    更新日期:2020-09-01 00:00:00

  • Clinical significance of thermal detection of soft-tissue tumors.

    abstract:BACKGROUND:Soft-tissue tumors are often accompanied by abnormal temperature distribution detected during palpation. However, the assessment of temperature distribution is subjective, limiting its wide use in cancer screening. The aim of this study was to evaluate the clinical significance of the thermal detection of so...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01658-1

    authors: Shimatani A,Hoshi M,Oebisu N,Iwai T,Takada N,Nakamura H

    更新日期:2020-07-01 00:00:00

  • Sequential chemotherapy using gemcitabine + carboplatin followed by gemcitabine + carboplatin + docetaxel for advanced upper-tract urothelial cancer.

    abstract:BACKGROUND:Retrospective evaluation of the effectiveness and adverse events (AEs) of a sequential chemotherapy regimen using gemcitabine + carboplatin (GCarbo) followed by GCarbo + docetaxel (GCarboD) for advanced upper-tract urothelial carcinoma (UTUC). METHODS:We treated 56 patients with advanced UTUC. Mean patient ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0846-z

    authors: Yoneyama T,Imai A,Hatakeyama S,Hashimoto Y,Koie T,Ohyama C

    更新日期:2015-12-01 00:00:00

  • Current status and perspectives of brachytherapy for cervical cancer.

    abstract::Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-008-0865-0

    authors: Toita T

    更新日期:2009-02-01 00:00:00

  • Use of direct oral anti-coagulants for the treatment of venous thromboembolism in patients with advanced cancer: a prospective observational study.

    abstract:BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatme...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01415-z

    authors: Oyakawa T,Muraoka N,Iida K,Kusuhara M,Mori K

    更新日期:2019-07-01 00:00:00

  • Pancreatic carcinoma-specific immunotherapy using synthesised alpha-galactosyl epitope-activated immune responders: findings from a pilot study.

    abstract:BACKGROUND:Dendritic cell (DC)-based and cytokine-induced killer cell (CIK)-based therapy can induce specific antitumor T-cell responses. This clinical pilot study examined the safety, the feasibility, and the outcome of tumor-specific immunotherapy for patients with advanced pancreatic adenocarcinoma. METHODS:Alpha-G...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-012-0434-4

    authors: Qiu Y,Yun MM,Xu MB,Wang YZ,Yun S

    更新日期:2013-08-01 00:00:00

  • Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil.

    abstract:BACKGROUND:Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0552-7

    authors: Lee SH,Choi EJ,Kim MS,Park JW,Lee YS,Kim SY,Kang CS

    更新日期:2014-04-01 00:00:00

  • A retrospective study of second-line chemotherapy for unresectable or recurrent squamous cell carcinoma of the esophagus refractory to chemotherapy with 5-fluorouracil plus platinum.

    abstract:BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients w...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0738-y

    authors: Yamazaki K,Hironaka S,Boku N,Yasui H,Fukutomi A,Yoshino T,Onozawa Y,Hasuike N,Inui T,Yamaguchi Y,Ono H

    更新日期:2008-04-01 00:00:00

  • Predicting short-term life expectancy of patients with end-stage gastric cancer using Onodera's prognostic nutritional index.

    abstract:BACKGROUND:Although the Onodera's prognosis nutritional index (O-PNI) has been used to predict long-term life expectancy, its use to predict life expectancy within 12 weeks has not been discussed. In this study, we examined the usefulness of the O-PNI to predict short-term life expectancy in patients with end-stage gas...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01808-5

    authors: Oyama K,Oba M,Oshima Y,Shimada H

    更新日期:2021-02-01 00:00:00

  • Combination therapy with PD-1 or PD-L1 inhibitors for cancer.

    abstract::Immune checkpoint inhibitors (ICIs)-such as antibodies to programmed cell death-1 (PD-1), to its ligand PD-L1, or to cytotoxic T lymphocyte-associated protein-4 (CTLA-4)-are an evolving treatment option for several types of cancer, but only a limited number of patients benefit from such therapy. Preclinical studies ha...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-019-01548-1

    authors: Hayashi H,Nakagawa K

    更新日期:2020-05-01 00:00:00

  • Phase I studies of nogitecan hydrochloride for Japanese.

    abstract:BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s101470200026

    authors: Kobayashi K,Hino M,Fukuoka M,Takeuchi K,Furuse K,Yoneda S,Hasegawa K,Noda K,Kinoshita H,Kimura I,Taguchi T,Kanamaru R,Horikoshi N,Niitani H

    更新日期:2002-06-01 00:00:00

  • Treatment strategies for neuroendocrine carcinoma of the upper digestive tract.

    abstract:BACKGROUND:Neuroendocrine carcinoma (NEC) of the esophagus and the stomach is aggressive. The purpose of this study was to determine the optimal therapeutic strategy. METHODS:Both clinicopathological factors and treatment results were examined in 34 patients with immunohistochemically diagnosed NEC of the upper gastro...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01631-y

    authors: Morita M,Taguchi K,Kagawa M,Nakanoko T,Uehara H,Sugiyama M,Ota M,Ikebe M,Sugimachi K,Esaki T,Toh Y

    更新日期:2020-05-01 00:00:00

  • Association of the primary tumor's SUVmax with survival after surgery for clinical stage IA esophageal cancer: a single-center retrospective study.

    abstract:BACKGROUND:Compared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients wi...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01606-8

    authors: Miyawaki Y,Sato H,Fujiwara N,Oya S,Sugita H,Hirano Y,Yamane T,Sakuramoto S,Okamoto K,Yamaguchi S,Koyama I

    更新日期:2020-04-01 00:00:00

  • Fertility in testicular cancer patients: a single-centre study in Turkey.

    abstract:BACKGROUND:Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01534-7

    authors: Uçar MA,Arikan F,Coşkun HŞ,Kondak Y,Tatlı AM,Göksu SS

    更新日期:2020-03-01 00:00:00

  • Reconstruction surgery for patients with musculoskeletal tumor, using a pasteurized autogenous bone graft.

    abstract:BACKGROUND:The pasteurized autogenous bone graft (PABG) is a new method to reuse resected and diseased autogenous bones after heat treatment at a comparatively low temperature (60 degrees C-65 degrees C). METHODS:The subjects of this study were ten patients with musculoskeletal tumor who underwent surgery with a PABG ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-004-0391-7

    authors: Sakayama K,Kidani T,Fujibuchi T,Kamogawa J,Yamamoto H,Shibata T

    更新日期:2004-06-01 00:00:00

  • Effects of cell-free and concentrated ascites reinfusion therapy (CART) on symptom relief of malignancy-related ascites.

    abstract:BACKGROUND:It is expected that cell-free and concentrated ascites reinfusion therapy (CART) will relieve the symptoms caused by ascites. To date, however, no report of objective changes in patients' symptoms has been published. We have therefore evaluated symptom management by CART. METHODS:From April 2011 to July 201...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-014-0750-y

    authors: Ito T,Hanafusa N,Iwase S,Noiri E,Nangaku M,Nakagawa K,Miyagawa K

    更新日期:2015-06-01 00:00:00

  • Cardiac metastasis from renal cell carcinoma without inferior vena involvement: a review of the literature based on a case report. Two different patterns of spread?

    abstract::We report the case of a 59-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, treated with radical nephrectomy, palliative radiotherapy for bone metastasis, and medical therapy for bone and lung metastases. The patient died of cardiac arrest after evidence of massive m...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-007-0730-6

    authors: Zustovich F,Gottardo F,De Zorzi L,Cecchetto A,Dal Bianco M,Mauro E,Cartei G

    更新日期:2008-06-01 00:00:00

  • A matched-pair comparison of intensity-modulated radiation therapy with cetuximab versus intensity-modulated radiation therapy with platinum-based chemotherapy for locally advanced head neck cancer.

    abstract:PURPOSE:We retrospectively compared the efficacy of intensity-modulated radiotherapy (IMRT) and cetuximab (IMRT/cetuximab) versus IMRT and platinum-based chemotherapy (IMRT/platinum) for locally advanced head neck squamous cell carcinoma (LAHNSCC). METHODS:Thirty-one IMRT/cetuximab patients were matched 1:2 with 62 IM...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0540-y

    authors: Huang J,Baschnagel AM,Chen P,Gustafson G,Jaiyesmi I,Folbe M,Ye H,Akervall J,Krauss D

    更新日期:2014-04-01 00:00:00

  • Evaluation of the efficacy of palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin.

    abstract:PURPOSE:The purpose of our study was to evaluate the efficacy of a new combination antiemetic therapy consisting of palonosetron, aprepitant, and dexamethasone in gastric cancer patients undergoing chemotherapy with S-1 plus cisplatin. METHODS:This prospective, multi-institutional observational study assessed patient-...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-015-0916-2

    authors: Oyama K,Fushida S,Kaji M,Takeda T,Yabushita K,Nezuka H,Kinami S,Kadoya N,Takai Y,Tsukioka Y,Ohyama S,Tsuji K,Tsukada T,Kinoshita J,Fujimura T,Ohta T

    更新日期:2016-06-01 00:00:00

  • International pediatric liver cancer pathological classification: current trend.

    abstract::This review describes the pathological classification of pediatric liver cancer types and subtypes proposed at the recent international symposium (March 2011, Los Angeles, USA) and meetings involving pathologists serving as central reviewers for the Children's Oncology Group, Société Internationale d'Oncologie Pédiatr...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-013-0624-8

    authors: Tanaka Y,Inoue T,Horie H

    更新日期:2013-12-01 00:00:00

  • Factors predicting incisional surgical site infection in patients undergoing open radical cystectomy for bladder cancer.

    abstract:BACKGROUND:The risk factors of incisional surgical site infection (iSSI) after open radical cystectomy (ORC) have not been fully investigated. The aim of the present study is to examine factors correlated with iSSI development after ORC with intestinal urinary diversion. METHODS:A total of 178 patients who had undergo...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0646-2

    authors: Gondo T,Ohno Y,Nakashima J,Hashimoto T,Takizawa I,Tanaka A,Shimodaira K,Satake N,Takeuchi H,Nakagami Y,Ohori M,Tachibana M

    更新日期:2014-10-01 00:00:00

  • Gastrointestinal stromal tumors: their origin and cause.

    abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, we found that GISTs expressed KIT, a receptor tyrosine kinase encoded by the protooncogene c-kit. We propose that GISTs may originate from interstitial cells of Cajal (ICCs), which are considered to ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/pl00012072

    authors: Hirota S

    更新日期:2001-02-01 00:00:00

  • Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy.

    abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0014-4

    authors: Matsuo K,Enomoto T,Yamasaki M

    更新日期:2010-02-01 00:00:00

  • Clinical trials and future potential of targeted therapy for ovarian cancer.

    abstract::Ovarian cancer is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at an advanced stage with a poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced disease. However, these patients rema...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-012-0459-8

    authors: Itamochi H,Kigawa J

    更新日期:2012-10-01 00:00:00

  • A prospective, randomized, placebo-controlled trial of zoledronic acid in bony metastatic bladder cancer.

    abstract:BACKGROUND:Zoledronic acid treatment reduces the incidence of skeletal-related events (SREs) in patients with bone metastases from breast, lung, and urologic cancers including prostate and renal cancer. The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bla...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10147-010-0074-5

    authors: Zaghloul MS,Boutrus R,El-Hossieny H,Kader YA,El-Attar I,Nazmy M

    更新日期:2010-08-01 00:00:00