Prognostic scores for evaluating the survival benefit of regorafenib or trifluridine/tipiracil in patients with metastatic colorectal cancer: an exploratory analysis of the REGOTAS study.

abstract：BACKGROUND:Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with...

journal_title：International journal of clinical oncology

authors： Uçar MA,Arikan F,Coşkun HŞ,Kondak Y,Tatlı AM,Göksu SS

更新日期：2020-03-01 00:00:00

abstract：:The fourth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer was published in 2015. The guidelines contain seven chapters and six flow charts. The major changes in this new edition are as follows-(1) the for...

journal_title：International journal of clinical oncology

authors： Komiyama S,Katabuchi H,Mikami M,Nagase S,Okamoto A,Ito K,Morishige K,Suzuki N,Kaneuchi M,Yaegashi N,Udagawa Y,Yoshikawa H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:No investigation of S-1 monotherapy in previously treated advanced non-small-cell lung cancer (NSCLC) patients has yet been reported. We conducted a retrospective study to evaluate the efficacy and tolerability of S-1 in patients with failure of second- or further-line chemotherapy. PATIENTS AND METHODS:The...

journal_title：International journal of clinical oncology

authors： Ono A,Naito T,Murakami H,Takahashi T,Nakamura Y,Tsuya A,Kaira K,Igawa S,Shukuya T,Tamiya A,Kaira R,Endo M,Yamamoto N

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Peripheral sensory neurotoxicity is a frequent adverse effect of oxaliplatin therapy. Calcium and magnesium (Ca/Mg) infusions are frequently used as preventatives, but a recent phase III trial failed to show that they prevent neurotoxicity. We therefore conducted a multicenter randomized phase III trial to c...

journal_title：International journal of clinical oncology

authors： Oki E,Emi Y,Kojima H,Higashijima J,Kato T,Miyake Y,Kon M,Ogata Y,Takahashi K,Ishida H,Saeki H,Sakaguchi Y,Yamanaka T,Kono T,Tomita N,Baba H,Shirabe K,Kakeji Y,Maehara Y

更新日期：2015-08-01 00:00:00

abstract：:Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...

journal_title：International journal of clinical oncology

authors： Lønning PE

更新日期：2002-08-01 00:00:00

abstract：:We report the case of a 62-year-old man with advanced gastric cancer and multiple liver metastases who was successfully treated with combined chemotherapy including S-1. The patient was clinically diagnosed with stage IV (T3 N2 H1 P0) disease and was initially treated with 100 mg/body per day S-1 administered orally f...

journal_title：International journal of clinical oncology

authors： Nakamura R,Saikawa Y,Kumagai K,Kiyota T,Ohashi M,Yoshida M,Kubota T,Kumai K,Kitajima M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Opioids are key drugs for cancer pain relief, but some patients, especially those who have gastroenterological cancers, suffer from severe opioid-induced bowel dysfunction (OBD), which reduces their quality of life. In order to achieve better pain relief, efforts to minimize OBD are required. METHODS:Betwee...

journal_title：International journal of clinical oncology

authors： Matsui T,Kojima T,Kojima H,Iwamoto N,Kure S,Uemura T,Fujimitsu Y,Sakamoto J

更新日期：2009-06-01 00:00:00

abstract：:Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade. On histopathological examination, juvenile GCTs are distinct from the adult type of GCT, and have a lower risk...

journal_title：International journal of clinical oncology

authors： Kaur H,Bagga R,Saha SC,Gainder S,Srinivasan R,Adhya AK,Dhaliwal LK

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. This study summarizes the tumor responses and the acute and late adverse effects of BNCT in the treatment of patients with both recurrent and newly diagnosed T4 salivary gland carcinoma...

journal_title：International journal of clinical oncology

authors： Aihara T,Morita N,Kamitani N,Kumada H,Ono K,Hiratsuka J,Harada T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Sternal resection is occasionally required for patients with malignant tumors, particularly sarcomas, in the sternal region. Few reports have described post-operative respiratory and shoulder function after sternal resection for patients with bone and soft-tissue sarcomas. METHODS:Eight consecutive patients...

journal_title：International journal of clinical oncology

authors： Nishida Y,Tsukushi S,Urakawa H,Toriyama K,Kamei Y,Yokoi K,Ishiguro N

更新日期：2015-12-01 00:00:00

abstract：:We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and...

journal_title：International journal of clinical oncology

authors： Yamada T,Ohtsubo K,Mouri H,Yamashita K,Yasumoto K,Izumi K,Zen Y,Watanabe H,Yano S

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatme...

journal_title：International journal of clinical oncology

authors： Oyakawa T,Muraoka N,Iida K,Kusuhara M,Mori K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Constipation is a common side effect of opioid therapy. An observational study of opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 patients with various tumor types. This post hoc analysis of OIC-J evaluated a subgroup of patients with gastrointestinal (GI) cancer. MET...

journal_title：International journal of clinical oncology

authors： Harada T,Imai H,Fumita S,Noriyuki T,Gamoh M,Okamoto M,Akashi Y,Kizawa Y,Tokoro A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Neuroendocrine carcinoma (NEC) of the esophagus and the stomach is aggressive. The purpose of this study was to determine the optimal therapeutic strategy. METHODS:Both clinicopathological factors and treatment results were examined in 34 patients with immunohistochemically diagnosed NEC of the upper gastro...

journal_title：International journal of clinical oncology

authors： Morita M,Taguchi K,Kagawa M,Nakanoko T,Uehara H,Sugiyama M,Ota M,Ikebe M,Sugimachi K,Esaki T,Toh Y

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment of cervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). METHODS:Fifty-six patients with squamous cell carc...

journal_title：International journal of clinical oncology

authors： Mizunuma M,Yokoyama Y,Futagami M,Aoki M,Takai Y,Mizunuma H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Early tumor shrinkage (ETS) is a response-related endpoint of clinical trials of chemotherapy (CHT) of patients with metastatic colorectal cancer (mCRC). It identifies a dimensional reduction of tumor size by at least 20-30% after 6-8 weeks of CHT. METHODS:A literature search of randomized trials of systemi...

journal_title：International journal of clinical oncology

authors： Colloca GA,Venturino A,Guarneri D

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:In patients with relapsed ovarian cancer, the objectives of salvage therapy are considered to be maintenance of quality of life and prolongation of patient survival. Chemotherapy using oral agents could be a good choice for salvage therapy. We reassessed the usefulness of oral cyclophosphamide (CPA) salvage ...

journal_title：International journal of clinical oncology

authors： Watanabe Y,Etoh T,Koike E,Mizuno Y,Wang WM,Hoshiai H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：:Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

journal_title：International journal of clinical oncology

authors： Brammer JE,Lulla P,Lynch GR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The influence of resection of the primary lesion on the prognosis of patients with incurable stage IV colorectal cancer is unclear. METHODS:We retrospectively analyzed 158 asymptomatic patients with incurable stage IV colorectal cancer who received systemic chemotherapy in our center from 2002 to 2009, eith...

journal_title：International journal of clinical oncology

authors： Watanabe A,Yamazaki K,Kinugasa Y,Tsukamoto S,Yamaguchi T,Shiomi A,Tsushima T,Yokota T,Todaka A,Machida N,Fukutomi A,Onozawa Y,Yasui H

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Most Brenner tumors are benign, with only 1% being malignant. In this study we report on 13 cases with malignant Brenner tumor of the ovary and discuss the clinical, demographic and histologic features. METHOD:Thirteen patients with malignant Brenner tumor of the ovary who were treated at Selçuk University G...

journal_title：International journal of clinical oncology

authors： Gezginç K,Karatayli R,Yazici F,Acar A,Çelik Ç,Çapar M,Tavli L

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS:The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefe...

journal_title：International journal of clinical oncology

authors： Nakabayashi N,Hirose M,Suzuki R,Suzumiya J,Igawa M

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Although several studies have reported the incidence of KIT and PDGFRA gene mutations in cutaneous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is an uncommon neoplasm compared with countries with Caucasian populations. METHODS:In this study, p...

journal_title：International journal of clinical oncology

authors： Terada T

更新日期：2010-10-01 00:00:00

abstract：:A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors,...

journal_title：International journal of clinical oncology

authors： Kaneko G,Kikuchi E,Hasegawa M,Miyajima A,Nakagawa K,Kameyama K,Oya M

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:We retrospectively compared the efficacy of intensity-modulated radiotherapy (IMRT) and cetuximab (IMRT/cetuximab) versus IMRT and platinum-based chemotherapy (IMRT/platinum) for locally advanced head neck squamous cell carcinoma (LAHNSCC). METHODS:Thirty-one IMRT/cetuximab patients were matched 1:2 with 62 IM...

journal_title：International journal of clinical oncology

authors： Huang J,Baschnagel AM,Chen P,Gustafson G,Jaiyesmi I,Folbe M,Ye H,Akervall J,Krauss D

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

journal_title：International journal of clinical oncology

authors： Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Set-up errors represent a source of uncertainty in head and neck (H&N) cancer radiotherapy. The present study evaluated set-up accuracy with the use of cone-beam computed tomography (CBCT) in order to establish the proper clinical target volume (CTV) to planning target volume (PTV) margins to be adopted. ME...

journal_title：International journal of clinical oncology

authors： Dionisi F,Palazzi MF,Bracco F,Brambilla MG,Carbonini C,Asnaghi DD,Monti AF,Torresin A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...

journal_title：International journal of clinical oncology

authors： Urakami S,Yuasa T,Yamamoto S,Sakura M,Tanaka H,Hayashi T,Uehara S,Inoue Y,Fujii Y,Masuda H,Fukui I,Yonese J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Liver resection is the most effective procedure for colorectal cancer liver metastasis (CRLM); however, early recurrence is an important problem that affects the postoperative prognoses of patients with CRLM. We previously suggested a therapeutic algorithm for CRLM using fluorodeoxyglucose-positron emission ...

journal_title：International journal of clinical oncology

authors： Watanabe A,Harimoto N,Yokobori T,Araki K,Kubo N,Igarashi T,Tsukagoshi M,Ishii N,Yamanaka T,Handa T,Oyama T,Higuchi T,Shirabe K

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Despite increasing interest in minimally invasive surgery, prevalence data are completely absent. Our objective was to analyze clinico-epidemiological variations of surgery for renal malignancy in Japan with emphasis on annual trends and regional gaps, and to analyze factors affecting choice of open versus m...

journal_title：International journal of clinical oncology

authors： Sugihara T,Yasunaga H,Horiguchi H,Tsuru N,Fujimura T,Nishimatsu H,Kume H,Ohe K,Matsuda S,Fushimi K,Homma Y

更新日期：2013-12-01 00:00:00