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Evaluation of S-1 as third- or further-line chemotherapy in advanced non-small-cell lung cancer.

Abstract：

BACKGROUND:No investigation of S-1 monotherapy in previously treated advanced non-small-cell lung cancer (NSCLC) patients has yet been reported. We conducted a retrospective study to evaluate the efficacy and tolerability of S-1 in patients with failure of second- or further-line chemotherapy. PATIENTS AND METHODS:The records of NSCLC patients who had received S-1 monotherapy between January 2005 and November 2006 with the following eligibility criteria were reviewed: previously treated with at least two regimens including platinum and docetaxel in the case of nonadenocarcinoma patients, and including platinum, docetaxel and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in the case of adenocarcinoma patients. S-1 was administered for 28 consecutive days, followed by a 14-day drug-free period (42 days in one course). The drug was administered in two divided doses daily at 80 mg/day for patients with a body surface area <1.25 m(2), 100 mg/day for those with a body surface area of 1.25-1.5 m(2), and 120 mg/day for those with a body surface area > or = 1.5 m(2). RESULTS:Thirty-five patients were registered. The median number of courses administered per patient was 2 (range 1-9). The toxicity profile was mild, and grade 3 or more severe toxicity was rare. The overall response and disease control rates were 5.7% and 40%, respectively. The median survival time was 208 days. CONCLUSION:S-1 exhibits modest activity and acceptable toxicity when used as a third or subsequent line of chemotherapy in patients with advanced NSCLC.

journal_name

Int J Clin Oncol

journal_title

International journal of clinical oncology

authors

Ono A,Naito T,Murakami H,Takahashi T,Nakamura Y,Tsuya A,Kaira K,Igawa S,Shukuya T,Tamiya A,Kaira R,Endo M,Yamamoto N

doi

10.1007/s10147-010-0034-0

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

161-5

issue

2

eissn

1341-9625

issn

1437-7772

journal_volume

15

pub_type

杂志文章

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