A matched-pair comparison of intensity-modulated radiation therapy with cetuximab versus intensity-modulated radiation therapy with platinum-based chemotherapy for locally advanced head neck cancer.

Abstract:

PURPOSE:We retrospectively compared the efficacy of intensity-modulated radiotherapy (IMRT) and cetuximab (IMRT/cetuximab) versus IMRT and platinum-based chemotherapy (IMRT/platinum) for locally advanced head neck squamous cell carcinoma (LAHNSCC). METHODS:Thirty-one IMRT/cetuximab patients were matched 1:2 with 62 IMRT/platinum patients according to primary site and clinical stage. The primary endpoint was locoregional recurrence (LRR), and secondary endpoints included distant metastasis (DM), cause-specific survival (CSS), and overall survival (OS). RESULTS:Because of inherent selection bias, the IMRT/cetuximab cohort was significantly older and with a higher Charlson Comorbidity Index. IMRT/cetuximab and IMRT/platinum did not have significantly different LRR and DM (33 vs. 23 % at 2 years, P = 0.22; 17 vs. 11 % at 2 years, P = 0.40; respectively). IMRT/cetuximab had significantly worse CSS and OS (67 vs. 84 %, P = 0.04; 58 vs. 83 %, P = 0.001; respectively). However, for the subset of elderly patients ≥65 years old, there is no difference between the two cohorts for all endpoints (all P = NS). CONCLUSION:IMRT/platinum should remain the preferred choice of chemoradiotherapy for LAHNSCC, but IMRT/cetuximab may be a reasonable alternative for elderly patients.

journal_name

Int J Clin Oncol

authors

Huang J,Baschnagel AM,Chen P,Gustafson G,Jaiyesmi I,Folbe M,Ye H,Akervall J,Krauss D

doi

10.1007/s10147-013-0540-y

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

240-6

issue

2

eissn

1341-9625

issn

1437-7772

journal_volume

19

pub_type

杂志文章
  • Gastrectomy and chemotherapy with S-1 for gastric cancer in a patient with acquired immunodeficiency syndrome.

    abstract::Total gastrectomy and chemotherapy with S-1 after surgery were performed in a 50-year-old woman with gastric cancer associated with acquired immunodeficiency syndrome (AIDS). She was given a diagnosis of gastric cancer at the lesser curvature of the body of the stomach, and distal gastrectomy was performed in December...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0114-1

    authors: Suzuki R,Ariizumi S,Araida T,Hayashi K,Yamamoto M

    更新日期:2011-02-01 00:00:00

  • Three-year follow-up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases.

    abstract:BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-018-01389-4

    authors: Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

    更新日期:2019-05-01 00:00:00

  • Sequential chemotherapy using gemcitabine + carboplatin followed by gemcitabine + carboplatin + docetaxel for advanced upper-tract urothelial cancer.

    abstract:BACKGROUND:Retrospective evaluation of the effectiveness and adverse events (AEs) of a sequential chemotherapy regimen using gemcitabine + carboplatin (GCarbo) followed by GCarbo + docetaxel (GCarboD) for advanced upper-tract urothelial carcinoma (UTUC). METHODS:We treated 56 patients with advanced UTUC. Mean patient ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0846-z

    authors: Yoneyama T,Imai A,Hatakeyama S,Hashimoto Y,Koie T,Ohyama C

    更新日期:2015-12-01 00:00:00

  • The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer.

    abstract:BACKGROUND:The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment of cervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). METHODS:Fifty-six patients with squamous cell carc...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0807-6

    authors: Mizunuma M,Yokoyama Y,Futagami M,Aoki M,Takai Y,Mizunuma H

    更新日期:2015-10-01 00:00:00

  • Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria.

    abstract:BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-017-1189-8

    authors: Imura S,Teraoku H,Yoshikawa M,Ishikawa D,Yamada S,Saito Y,Iwahashi S,Ikemoto T,Morine Y,Shimada M

    更新日期:2018-02-01 00:00:00

  • Collagen gel matrix assay as an in vitro chemosensitivity test for malignant astrocytic tumors.

    abstract:BACKGROUND:The efficacy of individual chemotherapy based on chemosensitivity has scarcely been studied. METHODS:We examined the chemosensitivites for four anticancer agents - 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), carboplatin, cisplatin, and etoposide - of 43 ma...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-006-0636-8

    authors: Ono A,Kanno H,Hayashi A,Nishimura S,Kyuma Y,Sato H,Ito S,Shimizu N,Chang CC,Gondo G,Yamamoto I,Sasaki T,Tanaka M

    更新日期:2007-04-01 00:00:00

  • Management of retroperitoneal lymph nodes in the treatment of ovarian cancer.

    abstract::The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-007-0672-z

    authors: Ushijima K

    更新日期:2007-06-01 00:00:00

  • Phase II study of carboplatin and gemcitabine as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: a report from the Central Japan Lung Study Group, CJLSG 0503 trial.

    abstract:BACKGROUND:The aim of this phase II study was to evaluate the feasibility and safety of a carboplatin and gemcitabine combination regimen in the treatment of completely resected non-small cell lung cancer (NSCLC). METHODS:Patients with completely resected pathologically documented stage IB, II or IIIA NSCLC were treat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0118-x

    authors: Usami N,Yokoi K,Hasegawa Y,Taniguchi H,Shindo J,Yamamoto M,Suzuki R,Imaizumi K,Kondo M,Shimokata K,Central Japan Lung Study Group.

    更新日期:2010-12-01 00:00:00

  • Set-up errors and planning target volume margins in head and neck cancer radiotherapy: a clinical study of image guidance with on-line cone-beam computed tomography.

    abstract:BACKGROUND:Set-up errors represent a source of uncertainty in head and neck (H&N) cancer radiotherapy. The present study evaluated set-up accuracy with the use of cone-beam computed tomography (CBCT) in order to establish the proper clinical target volume (CTV) to planning target volume (PTV) margins to be adopted. ME...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-012-0395-7

    authors: Dionisi F,Palazzi MF,Bracco F,Brambilla MG,Carbonini C,Asnaghi DD,Monti AF,Torresin A

    更新日期:2013-06-01 00:00:00

  • Clinical response to induction chemotherapy predicts improved survival outcome in urothelial carcinoma with clinical lymph nodal metastasis treated by consolidative surgery.

    abstract:BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0839-y

    authors: Urakami S,Yuasa T,Yamamoto S,Sakura M,Tanaka H,Hayashi T,Uehara S,Inoue Y,Fujii Y,Masuda H,Fukui I,Yonese J

    更新日期:2015-12-01 00:00:00

  • Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical

    abstract:PURPOSE:This single-arm, multicenter, phase-II trial evaluated the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) using fine-powder cisplatin and iodized-oil suspension in patients with intermediate- and advanced-stage [Barcelona Clinic Liver Cancer (BCLC) stage-B and stage-C] hepatocellular carci...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-014-0773-4

    authors: Takaki H,Yamakado K,Tsurusaki M,Yasumoto T,Baba Y,Narimatsu Y,Shimohira M,Yamaguchi M,Matsuo K,Inaba Y,Mikami K,Watanabe R,Nishida N,Anai H,Kakizawa H,Hirota S

    更新日期:2015-08-01 00:00:00

  • Preplanned safety analysis of the JFMC37-0801 trial: a randomized phase III study of six months versus twelve months of capecitabine as adjuvant chemotherapy for stage III colon cancer.

    abstract:BACKGROUND:Six months of adjuvant chemotherapy is regarded as the standard of care for patients with stage III colon cancer. However, whether longer treatment can improve prognosis has not been fully investigated. We conducted a phase III study comparing 6 and 12 months of adjuvant capecitabine chemotherapy for stage I...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10147-016-1083-9

    authors: Suto T,Ishiguro M,Hamada C,Kunieda K,Masuko H,Kondo K,Ishida H,Nishimura G,Sasaki K,Morita T,Hazama S,Maeda K,Mishima H,Ike H,Sadahiro S,Sugihara K,Okajima M,Saji S,Sakamoto J,Tomita N

    更新日期:2017-06-01 00:00:00

  • The prognostic impact of immune-related adverse events in metastatic renal cell carcinoma patients treated with nivolumab: a real-world multi-institutional retrospective study.

    abstract:BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-021-01872-5

    authors: Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

    更新日期:2021-01-20 00:00:00

  • Assessment of the prognostic value and N1b changes of the eighth TNM/AJCC staging system for differentiated thyroid carcinoma.

    abstract:BACKGROUND:The aim of this study was to evaluate the prognostic veracity for disease-specific survival (DSS) of the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis staging system (TNM-8) compared with the seventh edition (TNM-7) in a Chinese populati...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-019-01522-x

    authors: Zhi J,Wu Y,Hu L,Zhao J,Liu H,Ruan X,Hou X,Zhang J,Zheng X,Gao M

    更新日期:2020-01-01 00:00:00

  • Liver resection for advanced or aggressive colorectal cancer metastases in the era of effective chemotherapy: a review.

    abstract::Liver surgery has been known to cure metastatic colorectal cancer in a small proportion of patients. However, advances in procedural technique and chemotherapy now allow more patients to have safe, potentially curative surgery. Here we review surgery for unresectable colorectal liver metastases using an expert multidi...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-011-0291-6

    authors: Tanaka K,Ichikawa Y,Endo I

    更新日期:2011-10-01 00:00:00

  • Preoperatively undetected solitary bile duct hamartoma (von Meyenburg complex) associated with esophageal carcinoma.

    abstract::Bile duct hamartomas, also known as von Meyenburg complexes, are benign neoplasms consisting of cystic dilatation of the bile duct surrounded by fibrous stroma. We report a rare case in a 60-year-old man who presented with coexistent von Meyenburg complex and esophageal carcinoma. Preoperative computed tomography did ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0747-x

    authors: Mimatsu K,Oida T,Kawasaki A,Aramaki O,Kuboi Y,Katsura Y,Amano S

    更新日期:2008-08-01 00:00:00

  • Preoperative hydronephrosis as a predictor of postnephroureterectomy survival in patients with upper tract urothelial carcinoma: a two-center study in Japan.

    abstract:OBJECTIVE:To evaluate the predictive value of preoperative hydronephrosis for pathological outcome and prognosis in patients with upper tract urothelial carcinoma treated with nephroureterectomy. METHODS:167 patients with UTUC treated with nephroureterectomy at our two institutions in Japan between 2002 and 2017 were ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-019-01535-6

    authors: Fukui T,Kanno T,Kobori G,Moroi S,Yamada H

    更新日期:2020-03-01 00:00:00

  • How asymptomatic are early cancer patients of five organs based on registry data in Japan.

    abstract:BACKGROUND:One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS:The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefe...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-018-1287-2

    authors: Nakabayashi N,Hirose M,Suzuki R,Suzumiya J,Igawa M

    更新日期:2018-10-01 00:00:00

  • Treatment strategies for neuroendocrine carcinoma of the upper digestive tract.

    abstract:BACKGROUND:Neuroendocrine carcinoma (NEC) of the esophagus and the stomach is aggressive. The purpose of this study was to determine the optimal therapeutic strategy. METHODS:Both clinicopathological factors and treatment results were examined in 34 patients with immunohistochemically diagnosed NEC of the upper gastro...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01631-y

    authors: Morita M,Taguchi K,Kagawa M,Nakanoko T,Uehara H,Sugiyama M,Ota M,Ikebe M,Sugimachi K,Esaki T,Toh Y

    更新日期:2020-05-01 00:00:00

  • Clinical trials and future potential of targeted therapy for ovarian cancer.

    abstract::Ovarian cancer is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at an advanced stage with a poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced disease. However, these patients rema...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-012-0459-8

    authors: Itamochi H,Kigawa J

    更新日期:2012-10-01 00:00:00

  • Granulocytic sarcoma: an unusual cause of spinal cord compression.

    abstract::A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-006-0645-7

    authors: Balleari E,Panarello S,Capello E,Grosso M,Passalia C,Pitto P,Raggi F,Roccatagliata L,Cabiddu F,Ghio R

    更新日期:2007-06-01 00:00:00

  • Efficacies and safety of neoadjuvant gemcitabine plus carboplatin followed by immediate cystectomy in patients with muscle-invasive bladder cancer, including those unfit for cisplatin: a prospective single-arm study.

    abstract:BACKGROUND:Neoadjuvant cisplatin-based chemotherapy for patients with muscle-invasive bladder cancer (BC) has better survival benefit than radical cystectomy (RC) alone. However, optimal dosing schedule, including drug selection, number of cycles, and interval between chemotherapy and cystectomy, as well as acceptable ...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-012-0447-z

    authors: Koie T,Ohyama C,Hashimoto Y,Hatakeyama S,Yamamoto H,Yoneyama T,Kamimura N

    更新日期:2013-08-01 00:00:00

  • Radiotherapy for thoracic tumors: association between subclinical interstitial lung disease and fatal radiation pneumonitis.

    abstract:BACKGROUND:We evaluated the association between subclinical interstitial lung disease (ILD) and fatal radiation pneumonitis (RP) in patients with thoracic tumors treated with thoracic radiotherapy (RT). METHODS:Sixty-two consecutive patients with thoracic tumors treated with thoracic RT were retrospectively analyzed. ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-014-0679-1

    authors: Yamaguchi S,Ohguri T,Matsuki Y,Yahara K,Oki H,Imada H,Narisada H,Korogi Y

    更新日期:2015-02-01 00:00:00

  • A retrospective study of second-line chemotherapy for unresectable or recurrent squamous cell carcinoma of the esophagus refractory to chemotherapy with 5-fluorouracil plus platinum.

    abstract:BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients w...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0738-y

    authors: Yamazaki K,Hironaka S,Boku N,Yasui H,Fukutomi A,Yoshino T,Onozawa Y,Hasuike N,Inui T,Yamaguchi Y,Ono H

    更新日期:2008-04-01 00:00:00

  • Non-muscle invasive bladder cancer with concomitant vaginal urothelial carcinoma: a case report and review of the literature.

    abstract::A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors,...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0097-y

    authors: Kaneko G,Kikuchi E,Hasegawa M,Miyajima A,Nakagawa K,Kameyama K,Oya M

    更新日期:2010-12-01 00:00:00

  • Severe gustatory disorder caused by cisplatin and etoposide.

    abstract::A 48-year-old woman with small-cell lung cancer received combined chemotherapy consisting of cisplatin (CDDP) and etoposide (Vp-16). Although the gustatory threshold in the glossopharyngeal nerve area was normal (14 dB) before chemotherapy, it rose to 22 dB on day 8 of chemotherapy, and it could not be measured, becau...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s101470200017

    authors: Minakata Y,Yamagata T,Nakanishi H,Nishimoto T,Nakanishi M,Mune M,Yukawa S

    更新日期:2002-04-01 00:00:00

  • A history of the cancer registration system in Japan.

    abstract::In Japan, the first actual survey of morbidity from cancer was conducted by Dr. Mitsuo Segi in Miyagi Prefecture from 1951 to 1953. Population-based cancer registries were started in 1957 in Hiroshima and 1958 in Nagasaki for the follow-up of survivors of the atomic bombings. Public population-based cancer registries,...

    journal_title:International journal of clinical oncology

    pub_type: 历史文章,杂志文章

    doi:10.1007/s10147-008-0759-1

    authors: Okamoto N

    更新日期:2008-04-01 00:00:00

  • Detection of hepatocellular carcinomas with near-infrared fluorescence imaging using indocyanine green: its usefulness and limitation.

    abstract:BACKGROUND:Indocyanine green (ICG), an agent for measuring liver function, becomes fluorescent under near-infrared (NIR) light after binding to serum proteins. Hepatocellular carcinoma (HCC) with a deposit of preoperatively administered ICG becomes clearly detectable under ICG fluorography; however, it remains unclear ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0367-3

    authors: Morita Y,Sakaguchi T,Unno N,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Baba S,Takehara Y,Suzuki S,Konno H

    更新日期:2013-04-01 00:00:00

  • Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy.

    abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0014-4

    authors: Matsuo K,Enomoto T,Yamasaki M

    更新日期:2010-02-01 00:00:00

  • Adenoid cystic carcinoma of the uterine cervix.

    abstract::Adenoid cystic carcinoma of the uterine cervix is a rare and peculiar variant of adenocarcinoma. This tumor represents 3% of all primary cervical adenocarcinomas, and it is locally aggressive and capable of metastasis to other organs even in its early stage. We report a case of adenoid cystic carcinoma stage IIIb that...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-004-0466-5

    authors: Nishida M,Nasu K,Takai N,Miyakawa I,Kashima K

    更新日期:2005-06-01 00:00:00