Abstract:
BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients with unresectable or recurrent squamous cell carcinoma of the esophagus refractory to prior chemotherapy with 5-fluorouracil plus platinum. METHODS:Nedaplatin was administered at 90 mg/m(2) intravenously on day 1, and vindesine was administered at 3 mg/m(2) intravenously on days 1 and 8 every 28 days. Docetaxel 60 mg/m(2) or 70 mg/m(2) was administered intravenously every 21 days. We analyzed the response rate, overall survival time, progression-free survival time, and toxicity in 24 patients treated with nedaplatin plus vindesine and 28 patients treated with docetaxel. RESULTS:In patients treated with nedaplatin plus vindesine, the response rate of the 13 patients with measurable lesions was 8% (1/13), the median progression-free survival time was 1.8 months, and the median survival time was 5.5 months. In patients treated with docetaxel, the response rate of the 17 patients with measurable lesions was 18% (3/17), the median progression-free survival time was 2.1 months, and the median survival time was 5.1 months. The most frequent toxicity was neutropenia (grade 4; 13% in the group with nedaplatin plus vindesine and 50% in the docetaxel group), and febrile neutropenia (grade 3; 4% and 18%, respectively). CONCLUSION:The efficacy of the two regimens for unresectable or recurrent squamous cell carcinoma of the esophagus refractory to chemotherapy with 5-fluorouracil plus platinum was unsatisfactory. New, more effective therapies are needed.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Yamazaki K,Hironaka S,Boku N,Yasui H,Fukutomi A,Yoshino T,Onozawa Y,Hasuike N,Inui T,Yamaguchi Y,Ono Hdoi
10.1007/s10147-007-0738-ysubject
Has Abstractpub_date
2008-04-01 00:00:00pages
150-5issue
2eissn
1341-9625issn
1437-7772journal_volume
13pub_type
杂志文章abstract:BACKGROUND:We have performed 26 vaginal radical trachelectomies (RTs) for patients with early invasive uterine cervical cancer since 2003 and, to date, have experienced 8 deliveries. The procedure has a high risk for preterm labor and the subsequent occurrence of preterm premature rupture of membranes (pPROM). We repor...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0479-4
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abstract:BACKGROUND:Hormone receptor status has been one of the most important factors in predicting the response to endocrine therapy in breast cancer patients. However, half of those patients with estrogen receptor-positive tumors do not respond to endocrine therapy. There have been no universal factors for predicting resista...
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doi:10.1007/s10147-006-0601-6
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abstract:BACKGROUND:Zoledronic acid treatment reduces the incidence of skeletal-related events (SREs) in patients with bone metastases from breast, lung, and urologic cancers including prostate and renal cancer. The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bla...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:This study aims to investigate the prognostic value of the ratio of hemoglobin-RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Patients with metastatic NCCLC who attended two separate medical oncolo...
journal_title:International journal of clinical oncology
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abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly in comparison to that of HNSCC, which is associated with the use of tobacco or alcohol or both. This increase has resulted mainly from the global rise in...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:Hypofractionated proton therapy (HFPT) is expected to become an effective treatment approach for localized prostate cancer (PCa). The purpose of this study was to evaluate differences in acute toxicity among patients with localized PCa treated with either conventional fractionated proton therapy (CFPT) or HF...
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journal_title:International journal of clinical oncology
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pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00
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更新日期:2014-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2005-08-01 00:00:00
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:We conducted a multiinstitutional analysis to clarify the clinical significance of perioperative chemotherapy, in invasive bladder cancers in Japan, and to identify the patient subpopulations who could benefit from perioperative chemotherapy. METHODS:A total of 913 consecutive patients aged less than 80 yea...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-004-0474-5
更新日期:2005-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-006-0625-y
更新日期:2007-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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