Abstract:
BACKGROUND:Hormone receptor status has been one of the most important factors in predicting the response to endocrine therapy in breast cancer patients. However, half of those patients with estrogen receptor-positive tumors do not respond to endocrine therapy. There have been no universal factors for predicting resistance to endocrine therapy in this population. Recently, p53 status has been extensively used as a predictive factor for response to systemic therapy, because tumor cells lacking p53 function do not respond to systemic therapy due to a failure in apoptosis. We therefore studied the relationship between the efficacy of endocrine therapy and biological factors, including p53. METHODS:The expression of p53, Ki67, and human epidermal growth factor receptor (HER)2 was examined by immunostaining in the primary tumors of 53 patients who received endocrine therapy for recurrent or advanced breast cancer. The following clinical factors were also analyzed: site treated, disease-free interval, and response to first-line endocrine therapy. To evaluate the significance of these factors, time to endocrine therapy failure (TTEF), or the total duration of sequential endocrine therapies was adopted as representing the clinical outcome. RESULTS:The median TTEF was 16.1 months (range, 2.5-89.9 months). Multivariate analysis showed significantly reduced TTEF associated with no response to first-line endocrine therapy (P = 0.006 and P = 0.002 in all patients and in recurrent patients, respectively) and associated with positive p53 expression (P = 0.066 and P = 0.004, respectively). CONCLUSION:p53 expression status was a significant molecular marker as well as the response to first-line endocrine therapy for predicting TTEF in recurrent breast cancer with hormone-sensitive disease.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Kai K,Nishimura R,Arima N,Miyayama H,Iwase Hdoi
10.1007/s10147-006-0601-6subject
Has Abstractpub_date
2006-12-01 00:00:00pages
426-33issue
6eissn
1341-9625issn
1437-7772journal_volume
11pub_type
杂志文章abstract::We report the case of a 68-year-old Japanese man who presented with postrenal azotemia due to bilateral upper ureteral stenosis. The patient's right kidney was nonfunctional; therefore, right nephroureterectomy was performed for the purpose of pathologic diagnosis. Histopathologic examination revealed follicular lymph...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0685-7
更新日期:2007-12-01 00:00:00
abstract::Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2021-01-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0769-z
更新日期:2008-10-01 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2000-02-01 00:00:00
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更新日期:2021-01-07 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-004-0466-5
更新日期:2005-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0439-z
更新日期:2013-08-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2010-08-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 历史文章,杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2013-08-01 00:00:00