Thinking twice before abandoning first-line chemotherapy in ovarian cancer: report of two cases and literature review. Passing from tri-weekly to weekly regimens.

abstract：BACKGROUND:The field of immunotherapy has recently focused on cancers with microsatellite instability (MSI). These cancers include both Lynch-syndrome-associated tumors, which are caused by mismatch repair (MMR) germline mutations, and sporadic MSI tumors, which are mainly attributed to MLH1 promoter methylation. The p...

journal_title：International journal of clinical oncology

authors： Yamada R,Yamaguchi T,Iijima T,Wakaume R,Takao M,Koizumi K,Hishima T,Horiguchi SI

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Liver resection is the most effective procedure for colorectal cancer liver metastasis (CRLM); however, early recurrence is an important problem that affects the postoperative prognoses of patients with CRLM. We previously suggested a therapeutic algorithm for CRLM using fluorodeoxyglucose-positron emission ...

journal_title：International journal of clinical oncology

authors： Watanabe A,Harimoto N,Yokobori T,Araki K,Kubo N,Igarashi T,Tsukagoshi M,Ishii N,Yamanaka T,Handa T,Oyama T,Higuchi T,Shirabe K

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Our aim was to study the efficacy and safety of combination chemotherapy with gemcitabine plus cisplatin (GC) for patients with advanced urothelial carcinoma (UC) after failure of methotrexate, vinblastin, adriamycin, and cisplatin (M-VAC) chemotherapy. METHODS:We studied a total of 33 patients with advance...

journal_title：International journal of clinical oncology

authors： Gondo T,Ohori M,Hamada R,Tanaka A,Satake N,Takeuchi H,Nakashima J,Hatano T,Tachibana M

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Differences in individual body sizes have not been well considered when analyzing the survival of patients with non-small cell lung cancer (NSCLC). We hypothesized that physique-adjusted tumor size is superior to actual tumor size in predicting the prognosis. METHODS:Eight hundred and forty-two patients who...

journal_title：International journal of clinical oncology

authors： Ozeki N,Fukui T,Kawaguchi K,Nakamura S,Hakiri S,Kato T,Hirakawa A,Yokoi K

更新日期：2018-04-01 00:00:00

abstract：:We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A...

journal_title：International journal of clinical oncology

authors： Sato S,Koike T,Yamato Y,Yoshiya K,Motono N,Takeshige M,Homma K,Koizumi N,Yokoyama A,Tsukada H

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:We have performed 26 vaginal radical trachelectomies (RTs) for patients with early invasive uterine cervical cancer since 2003 and, to date, have experienced 8 deliveries. The procedure has a high risk for preterm labor and the subsequent occurrence of preterm premature rupture of membranes (pPROM). We repor...

journal_title：International journal of clinical oncology

authors： Takada S,Ishioka S,Endo T,Baba T,Morishita M,Akashi Y,Mizuuchi M,Adachi H,Kim M,Saito T

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cancer patients are at high risk of developing a second cancer after the treatment of initial cancers. Understanding the characteristics of multiple primary cancer is important to establish an effective surveillance program for the early detection of second cancers. METHODS:We analyzed the cancer registry r...

journal_title：International journal of clinical oncology

authors： Ueno M,Muto T,Oya M,Ota H,Azekura K,Yamaguchi T

更新日期：2003-06-01 00:00:00

abstract：:Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what is the optima...

journal_title：International journal of clinical oncology

authors： Gradishar WJ,O'Regan RM

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:In patients with relapsed ovarian cancer, the objectives of salvage therapy are considered to be maintenance of quality of life and prolongation of patient survival. Chemotherapy using oral agents could be a good choice for salvage therapy. We reassessed the usefulness of oral cyclophosphamide (CPA) salvage ...

journal_title：International journal of clinical oncology

authors： Watanabe Y,Etoh T,Koike E,Mizuno Y,Wang WM,Hoshiai H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The aim of this phase II study was to evaluate the feasibility and safety of a carboplatin and gemcitabine combination regimen in the treatment of completely resected non-small cell lung cancer (NSCLC). METHODS:Patients with completely resected pathologically documented stage IB, II or IIIA NSCLC were treat...

journal_title：International journal of clinical oncology

authors： Usami N,Yokoi K,Hasegawa Y,Taniguchi H,Shindo J,Yamamoto M,Suzuki R,Imaizumi K,Kondo M,Shimokata K,Central Japan Lung Study Group.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:To investigate the prognostic and therapeutic implications of time to biochemical relapse (BCR) in patients with prostate cancer after radical prostatectomy. METHODS:The records of 3210 consecutive men with prostate cancer who underwent radical prostatectomy between January 1998 and June 2013 were retrospec...

journal_title：International journal of clinical oncology

authors： Pak S,You D,Jeong IG,Kim YS,Hong JH,Kim CS,Ahn H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

journal_title：International journal of clinical oncology

authors： Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify the role of Bcl-2 protein and adrenomedullin (AM) expression in relation to apoptosis in the neoplastic changes of squamous epithelium of the uterine cervix. METHODS:Apoptosis in sections of normal cervical epithelium, cervical intraepithelial neoplasia (CIN), and i...

journal_title：International journal of clinical oncology

authors： Li Z,Takeuchi S,Ohara N,Maruo T

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Although subcutaneous implantable ports have been indicated as venous access for chemotherapy, these devices have not been used routinely for hematological tumors. METHODS:Between May 2006 and April 2009, 39 ports were implanted in 37 patients with hematological tumors and 16 ports were implanted in 14 pati...

journal_title：International journal of clinical oncology

authors： Ohno H,Mizumoto C,Otsuki Y,Oguma S,Yoshida Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Opioids are key drugs for cancer pain relief, but some patients, especially those who have gastroenterological cancers, suffer from severe opioid-induced bowel dysfunction (OBD), which reduces their quality of life. In order to achieve better pain relief, efforts to minimize OBD are required. METHODS:Betwee...

journal_title：International journal of clinical oncology

authors： Matsui T,Kojima T,Kojima H,Iwamoto N,Kure S,Uemura T,Fujimitsu Y,Sakamoto J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The Randomized Phase III Study Comparing Oxaliplatin plus S-1 with Cisplatin plus S-1 in Chemotherapy-naïve Patients with Advanced Gastric Cancer (G-SOX) showed the noninferiority of S-1 (an oral fluoropyrimidine-derivative dihydropyrimidine dehydrogenase inhibitor) plus oxaliplatin combination therapy (SOX)...

journal_title：International journal of clinical oncology

authors： Hamada C,Yamada Y,Azuma M,Nishikawa K,Gotoh M,Bando H,Sugimoto N,Nishina T,Amagai K,Chin K,Niwa Y,Tsuji A,Imamura H,Tsuda M,Yasui H,Fujii H,Yamaguchi K,Yasui H,Hironaka S,Shimada K,Miwa H,Hyodo I

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatme...

journal_title：International journal of clinical oncology

authors： Oyakawa T,Muraoka N,Iida K,Kusuhara M,Mori K

更新日期：2019-07-01 00:00:00

abstract：:It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...

journal_title：International journal of clinical oncology

authors： Matsunaga T,Kogawa K,Fujimi A,Takizawa K,Takahira N,Takemoto N,Tanaka I,Akiyama T,Sato T,Takayama T,Terui T,Sakamaki S,Niitsu Y

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Sternal resection is occasionally required for patients with malignant tumors, particularly sarcomas, in the sternal region. Few reports have described post-operative respiratory and shoulder function after sternal resection for patients with bone and soft-tissue sarcomas. METHODS:Eight consecutive patients...

journal_title：International journal of clinical oncology

authors： Nishida Y,Tsukushi S,Urakawa H,Toriyama K,Kamei Y,Yokoi K,Ishiguro N

更新日期：2015-12-01 00:00:00

abstract：:We report two cases of the plasmacytoid variant of urothelial carcinoma of urinary bladder in which systemic chemotherapy was effective. In the first case, a 76-year-old man presented with dysphasia. Magnetic resonance imaging (MRI) and computed tomography revealed a brain tumor and a bladder tumor. Resection of the b...

journal_title：International journal of clinical oncology

authors： Hayashi T,Tanigawa G,Fujita K,Imamura R,Nakazawa S,Yamamoto Y,Hosomi M,Shimazu K,Fushimi H,Yamaguchi S

更新日期：2011-12-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at an advanced stage with a poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced disease. However, these patients rema...

journal_title：International journal of clinical oncology

authors： Itamochi H,Kigawa J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Inhibition of Notch by γ-secretase inhibitor (GSI) has been shown to have an antitumor effect in Notch-expressing non-small cell lung cancer (NSCLC) and to induce apoptosis through modulation of Bcl-2 family proteins. In particular, Bim, a BH3-only member of the Bcl-2 family of proteins, has an important rol...

journal_title：International journal of clinical oncology

authors： Sakakibara-Konishi J,Ikezawa Y,Oizumi S,Kikuchi J,Kikuchi E,Mizugaki H,Kinoshita I,Dosaka-Akita H,Nishimura M

更新日期：2017-04-01 00:00:00

abstract：:We report four patients with pancreatic metastasis of renal cell carcinoma who were successfully treated with radiation therapy. The patients were one woman and three men with a median age of 55 years (range, 49 to 62 years) who underwent radical nephrectomy for primary renal cell carcinoma. The median interval from n...

journal_title：International journal of clinical oncology

authors： Saito J,Yamanaka K,Sato M,Mori N,Sekii K,Yoshioka T,Itatani H,Nakatsuka S

更新日期：2009-06-01 00:00:00

abstract：:Among head and neck squamous cell carcinoma (HNSCC), the incidence of oropharyngeal SCC (OPSCC) is increasing in contrast to carcinoma with origin in other subsites. Human papillomavirus (HPV) is now recognized as a significant risk factor of the carcinogenesis of OPSCC. The HPV-related OPSCC patients tend to be relat...

journal_title：International journal of clinical oncology

authors： Okami K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Constipation is a common side effect of opioid therapy. An observational study of opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 patients with various tumor types. This post hoc analysis of OIC-J evaluated a subgroup of patients with gastrointestinal (GI) cancer. MET...

journal_title：International journal of clinical oncology

authors： Harada T,Imai H,Fumita S,Noriyuki T,Gamoh M,Okamoto M,Akashi Y,Kizawa Y,Tokoro A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

journal_title：International journal of clinical oncology

authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate whether serum alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) trends might be correlated with overall survival rates in patients with recurrent hepatocellular carcinoma (HCC) undergoing trans-catheter arterial chemo-embolization (TACE). METHODS:We pe...

journal_title：International journal of clinical oncology

authors： Arai T,Kobayashi A,Ohya A,Takahashi M,Yokoyama T,Shimizu A,Motoyama H,Furusawa N,Notake T,Kitagawa N,Sakai H,Imamura H,Kadoya M,Miyagawa S

更新日期：2014-10-01 00:00:00

abstract：:Computed tomography (CT) plays an essential role in oncological imaging as the modality of screening for malignancies, mapping out the treatment strategy at staging, assessing response to the treatment, and following up patient outcome after the treatment. The advent of multidetector-row CT (MDCT) has brought about dr...

journal_title：International journal of clinical oncology

authors： Ueda T,Mori K,Minami M,Motoori K,Ito H

更新日期：2006-08-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, suni...

journal_title：International journal of clinical oncology

authors： Miyake H,Haraguchi T,Takenaka A,Fujisawa M

更新日期：2011-04-01 00:00:00

abstract：:Prostate cancer is androgen-dependent, and hormone therapy, mainly achieved by androgen deprivation, has been one of the main treatment modalities in the clinical management of prostate cancer patients for more than six decades. In the 1980s, luteinizing hormone-releasing hormone agonists, which reduce testosterone to...

journal_title：International journal of clinical oncology

authors： Suzuki H,Kamiya N,Imamoto T,Kawamura K,Yano M,Takano M,Utsumi T,Naya Y,Ichikawa T

更新日期：2008-10-01 00:00:00