abstract：BACKGROUND:Although the Onodera's prognosis nutritional index (O-PNI) has been used to predict long-term life expectancy, its use to predict life expectancy within 12 weeks has not been discussed. In this study, we examined the usefulness of the O-PNI to predict short-term life expectancy in patients with end-stage gas...

journal_title：International journal of clinical oncology

authors： Oyama K,Oba M,Oshima Y,Shimada H

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

journal_title：International journal of clinical oncology

authors： Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...

journal_title：International journal of clinical oncology

authors： Kobayashi H,Eriguchi T,Tanaka T,Ogata T,Ishida M,Nakajima Y,Kumabe A,Kosugi M

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:To avoid the loss of fertility, chemotherapy should be chosen as an adjuvant treatment after trachelectomy. Our study evaluated the effectiveness and safety of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer. METHODS:Our institutional review board approved this clinical study, and in...

journal_title：International journal of clinical oncology

authors： Okugawa K,Yahata H,Sonoda K,Kodama K,Yagi H,Ohgami T,Yasunaga M,Onoyama I,Kaneki E,Asanoma K,Kobayashi H,Kato K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Positron Emission Tomography-Computed Tomography (PET-CT) has been changing diagnostic and therapeutic strategies for patients with cancers, and several PET-CT-related prognostic factors have been reported. We have focused on metabolic tumor volumes (MTVs) over the whole body and in specific organs using 18F...

journal_title：International journal of clinical oncology

authors： Yamanaka S,Miyagawa M,Sugawara Y,Hasebe S,Fujii T,Takeuchi K,Tanaka K,Yakushijin Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for urothelial carcinoma of the upper urinary tract (UCUUT) is common. One of the mechanisms driving this is the implantation of cancer cells from the UCUUT at the RNUs. Therefore, their detection after RNU can assist in predicting IVR. Thi...

journal_title：International journal of clinical oncology

authors： Iwata H,Sassa N,Kato M,Murase Y,Seko S,Kawanishi H,Hattori R,Gotoh M,Tsuzuki T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:We proposed a novel treatment strategy, consisting of triweekly cisplatin plus dose-dense weekly paclitaxel before and after radical hysterectomy without adjuvant radiation therapy to treat locally advanced cervical cancer. However, cisplatin-related severe non-hematologic toxicities were frequent during thi...

journal_title：International journal of clinical oncology

authors： Nagao S,Yamamoto K,Oishi T,Yamaguchi S,Takehara K,Shimada M,Kigawa J

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Constipation is a common side effect of opioid therapy. An observational study of opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 patients with various tumor types. This post hoc analysis of OIC-J evaluated a subgroup of patients with gastrointestinal (GI) cancer. MET...

journal_title：International journal of clinical oncology

authors： Harada T,Imai H,Fumita S,Noriyuki T,Gamoh M,Okamoto M,Akashi Y,Kizawa Y,Tokoro A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Intrahepatic cholangiocarcinoma (IHCC) has a poor prognosis, and surgery remains the only effective treatment. However, tumor recurrence after primary hepatectomy is common. We examined the significance of repeat surgery for IHCC. METHODS:We collected data for all patients with IHCC between 1992 and 2018 (n...

journal_title：International journal of clinical oncology

authors： Tokuda K,Morine Y,Saito Y,Yamada S,Miyazaki K,Yamashita S,Okikawa S,Ikemoto T,Imura S,Shimada M

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:To fill the data gap between clinical trials and real-world settings, this study assessed the overall effectiveness and safety of nivolumab in patients with head and neck cancer (HNC) during Japanese real-world clinical practice. METHODS:This was a multicenter, retrospective study in Japanese patients with ...

journal_title：International journal of clinical oncology

authors： Hanai N,Shimizu Y,Kariya S,Yasumatsu R,Yokota T,Fujii T,Tsukahara K,Yoshida M,Hanyu K,Ueda T,Hirakawa H,Takahashi S,Ono T,Sano D,Yamauchi M,Watanabe A,Omori K,Yamazaki T,Monden N,Kudo N,Arai M,Sakurai D,Asakag

更新日期：2020-11-21 00:00:00

abstract：PURPOSE:Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT. METHODS:62 adult survivo...

journal_title：International journal of clinical oncology

authors： Wagner AP,Carroll C,White SR,Watson P,Spoudeas HA,Hawkins MM,Walker DA,Clare ICH,Holland AJ,Ring H

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian. METHODS:We prospectively recruited patients with localized PCa, locat...

journal_title：International journal of clinical oncology

authors： Shoji S,Hiraiwa S,Uemura K,Nitta M,Hasegawa M,Kawamura Y,Hashida K,Hasebe T,Tajiri T,Miyajima A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Diagnosis of secondary ovarian tumors originating from colorectal cancer has previously been based upon history of malignancy and radiological findings of bilateral masses with a "stained glass appearance." The purpose of this study was to perform a detailed investigation of the radiological and macroscopic ...

journal_title：International journal of clinical oncology

authors： Kato MK,Shida D,Yoneoka Y,Yoshida H,Miyasaka N,Kanemitsu Y,Kato T

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA. METHODS:In accordance with the PRISMA statements,...

journal_title：International journal of clinical oncology

authors： Nishikawa Y,Hoshino N,Horimatsu T,Funakoshi T,Hida K,Sakai Y,Muto M,Nakayama T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Soft-tissue tumors are often accompanied by abnormal temperature distribution detected during palpation. However, the assessment of temperature distribution is subjective, limiting its wide use in cancer screening. The aim of this study was to evaluate the clinical significance of the thermal detection of so...

journal_title：International journal of clinical oncology

authors： Shimatani A,Hoshi M,Oebisu N,Iwai T,Takada N,Nakamura H

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：:The updated 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS) has incorporated molecular parameters into pathological diagnosis, for the first time in the molecular era. While it has led to the more precise diagnoses of well-understood entities and the better comprehens...

journal_title：International journal of clinical oncology

authors： Onizuka H,Masui K,Komori T

更新日期：2020-06-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs)-such as antibodies to programmed cell death-1 (PD-1), to its ligand PD-L1, or to cytotoxic T lymphocyte-associated protein-4 (CTLA-4)-are an evolving treatment option for several types of cancer, but only a limited number of patients benefit from such therapy. Preclinical studies ha...

journal_title：International journal of clinical oncology

authors： Hayashi H,Nakagawa K

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Prognostic outcomes and safety following treatment with pembrolizumab in patients with advanced urothelial carcinoma (UC) have not been fully elucidated in clinical practice. The aim of this study was to evaluate the oncological efficacy and safety of pembrolizumab after failure of platinum-based chemotherap...

journal_title：International journal of clinical oncology

authors： Tamura D,Jinnouchi N,Abe M,Ikarashi D,Matsuura T,Kato R,Maekawa S,Kato Y,Kanehira M,Takata R,Obara W

更新日期：2020-05-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The ...

journal_title：International journal of clinical oncology

authors： Kawakami Y,Ohta S,Sayem MA,Tsukamoto N,Yaguchi T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Neuroendocrine carcinoma (NEC) of the esophagus and the stomach is aggressive. The purpose of this study was to determine the optimal therapeutic strategy. METHODS:Both clinicopathological factors and treatment results were examined in 34 patients with immunohistochemically diagnosed NEC of the upper gastro...

journal_title：International journal of clinical oncology

authors： Morita M,Taguchi K,Kagawa M,Nakanoko T,Uehara H,Sugiyama M,Ota M,Ikebe M,Sugimachi K,Esaki T,Toh Y

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:To assess the impact of socioeconomic status (SES) on treatment choices and outcomes of hepatocellular carcinoma (HCC) patients treated with local therapies (ablation or surgery). METHODS:Surveillance, Epidemiology and End Results (SEER) specialized socioeconomic database was accessed. Cases with non-metasta...

journal_title：International journal of clinical oncology

authors： Abdel-Rahman O

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Compared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients wi...

journal_title：International journal of clinical oncology

authors： Miyawaki Y,Sato H,Fujiwara N,Oya S,Sugita H,Hirano Y,Yamane T,Sakuramoto S,Okamoto K,Yamaguchi S,Koyama I

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The clinical impact of monitoring serum p53 antibodies, carbohydrate antigen19-9, and carcinoembryonic antigen in patients with colorectal cancer has not been fully evaluated. METHODS:A total of 420 surgically treated stage II/III colorectal cancer patients were retrospectively analyzed. Among them, 101 pat...

journal_title：International journal of clinical oncology

authors： Ushigome M,Shimada H,Miura Y,Yoshida K,Kaneko T,Koda T,Nagashima Y,Suzuki T,Kagami S,Funahashi K

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Although regorafenib or trifluridine/tipiracil (FTD/TPI) has been recognized as a later-line standard treatment in patients with metastatic colorectal cancer (mCRC), not all patients have beneficial outcomes. This study aimed to develop a prognostic scoring system for evaluating the overall survival (OS) ben...

journal_title：International journal of clinical oncology

authors： Moriwaki T,Fukuoka S,Masuishi T,Takashima A,Kumekawa Y,Kajiwara T,Yamazaki K,Esaki T,Makiyama A,Denda T,Hatachi Y,Suto T,Sugimoto N,Enomoto M,Ishikawa T,Kashiwada T,Oki E,Komatsu Y,Tsuji A,Tsuchihashi K,Sakai D,

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Impact of R1 (microscopically margin-positive) resection on survival of patients with hepatoblastoma (HB) remains debatable. This study aimed to compare the long-term outcomes of R0 (microscopically margin-negative) and R1 resection for HB in children after hepatectomy. METHODS:We retrospectively reviewed f...

journal_title：International journal of clinical oncology

authors： Ren X,Li H,Diao M,Xu H,Li L

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:We retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients. METHODS:The study involved 650 patients who underwen...

journal_title：International journal of clinical oncology

authors： Hara K,Aoyama T,Hayashi T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Yamada T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-04-01 00:00:00

abstract：:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this disease. Oncogenic PIK3CA mutation, which activates the PIK3CA/AKT/mTOR signaling pathway, is a promising druggable ...

journal_title：International journal of clinical oncology

authors： Kuroda T,Kohno T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with...

journal_title：International journal of clinical oncology

authors： Uçar MA,Arikan F,Coşkun HŞ,Kondak Y,Tatlı AM,Göksu SS

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the predictive value of preoperative hydronephrosis for pathological outcome and prognosis in patients with upper tract urothelial carcinoma treated with nephroureterectomy. METHODS:167 patients with UTUC treated with nephroureterectomy at our two institutions in Japan between 2002 and 2017 were ...

journal_title：International journal of clinical oncology

authors： Fukui T,Kanno T,Kobori G,Moroi S,Yamada H

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Liver resection is the most effective procedure for colorectal cancer liver metastasis (CRLM); however, early recurrence is an important problem that affects the postoperative prognoses of patients with CRLM. We previously suggested a therapeutic algorithm for CRLM using fluorodeoxyglucose-positron emission ...

journal_title：International journal of clinical oncology

authors： Watanabe A,Harimoto N,Yokobori T,Araki K,Kubo N,Igarashi T,Tsukagoshi M,Ishii N,Yamanaka T,Handa T,Oyama T,Higuchi T,Shirabe K

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...

journal_title：International journal of clinical oncology

authors： Yoshida K,Kajiyama H,Yoshihara M,Tamauchi S,Ikeda Y,Yoshikawa N,Nishino K,Niimi K,Suzuki S,Kikkawa F

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...

journal_title：International journal of clinical oncology

authors： Furukawa J,Kanayama H,Azuma H,Inoue K,Kobayashi Y,Kashiwagi A,Segawa T,Takahashi Y,Horie S,Ogawa O,Takenaka A,Shiroki R,Tanabe K,Fujisawa M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic veracity for disease-specific survival (DSS) of the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis staging system (TNM-8) compared with the seventh edition (TNM-7) in a Chinese populati...

journal_title：International journal of clinical oncology

authors： Zhi J,Wu Y,Hu L,Zhao J,Liu H,Ruan X,Hou X,Zhang J,Zheng X,Gao M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) patients are usually diagnosed in advanced stages which results in high mortality. This study aimed to identify novel circulating miRNAs as biomarkers for the early detection of GC. METHODS:Candidate miRNA was identified after integrated analysis of two Gene Expression Omnibus (GEO) data...

journal_title：International journal of clinical oncology

authors： Shi Y,Wang Z,Zhu X,Chen L,Ma Y,Wang J,Yang X,Liu Z

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathologica...

journal_title：International journal of clinical oncology

authors： Kano M,Hihara J,Kaneko M,Uemura K,Ohge H,Sueda T

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine if quantitative SUV-related, volumetric FDG PET parameters, and texture features (SPs, VPs, and TFs, respectively) were useful to evaluate and predict response and recurrence after chemotherapy in follicular lymphoma (FL). METHODS:Pre- and posttreatment FDG PET examin...

journal_title：International journal of clinical oncology

authors： Tatsumi M,Isohashi K,Matsunaga K,Watabe T,Kato H,Kanakura Y,Hatazawa J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:To investigate the prognostic and therapeutic implications of time to biochemical relapse (BCR) in patients with prostate cancer after radical prostatectomy. METHODS:The records of 3210 consecutive men with prostate cancer who underwent radical prostatectomy between January 1998 and June 2013 were retrospec...

journal_title：International journal of clinical oncology

authors： Pak S,You D,Jeong IG,Kim YS,Hong JH,Kim CS,Ahn H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The efficacy of carbon-ion radiotherapy (C-ion RT) for lymph node (LN) oligo-recurrence has only been evaluated in limited single-center studies. We aimed to investigate the benefit of C-ion RT for LN oligo-recurrence in a large multi-center study. METHODS:Patients who received C-ion RT between December 199...

journal_title：International journal of clinical oncology

authors： Okonogi N,Kaminuma T,Okimoto T,Shinoto M,Yamamoto N,Yamada S,Murata K,Ohno T,Shioyama Y,Tsuji H,Nakano T,Kamada T

更新日期：2019-09-01 00:00:00