Abstract:
:The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian cancer have been recognized. The incidence and pattern of lymph node involvement depends on the extent of disease progression and the histological type. Thus, it is difficult to specify a single node as the sentinel node. As a surgical approach, systemic lymphadenectomy is necessary to obtain accurate clinical stage, and it has obvious diagnostic value. Nevertheless, a recent large randomized trial in patients with advanced ovarian cancer revealed that systemic lymphadenectomy had no impact on survival compared with removing only macroscopic lymph nodes. Other factors, such as chemosensitivity, histological grade, and the size of residuals have also influenced survival in ovarian cancer. From the viewpoint of adverse effects and survival benefit, the efficacy of lymphadenectomy remains controversial. Therefore, further accumulation of clinical data is needed to establish the indications for lymph node dissection; when this procedure is done, it should be performed by experienced gynecologic oncologists at selected institutions.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Ushijima Kdoi
10.1007/s10147-007-0672-zsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
181-6issue
3eissn
1341-9625issn
1437-7772journal_volume
12pub_type
杂志文章,评审abstract:BACKGROUND:Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expr...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0593-y
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (IHCC) has a poor prognosis, and surgery remains the only effective treatment. However, tumor recurrence after primary hepatectomy is common. We examined the significance of repeat surgery for IHCC. METHODS:We collected data for all patients with IHCC between 1992 and 2018 (n...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01775-x
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. PATIENTS AND METHODS:Between 1986 and 2011, as a regional population-based study, clinicopathological data...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0645-3
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-009-0014-4
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The Randomized Phase III Study Comparing Oxaliplatin plus S-1 with Cisplatin plus S-1 in Chemotherapy-naïve Patients with Advanced Gastric Cancer (G-SOX) showed the noninferiority of S-1 (an oral fluoropyrimidine-derivative dihydropyrimidine dehydrogenase inhibitor) plus oxaliplatin combination therapy (SOX)...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10147-015-0938-9
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS:We began to perform abdominal trachelectomy in 2005. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1059-9
更新日期:2017-04-01 00:00:00
abstract::We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0869-9
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:We aimed to find the prognostic factors predicting overall survival (OS) in patients with castration-resistant prostate cancer (CRPC) who had docetaxel (DTX) chemotherapy, and to construct a model predicting the optimum number of cycles of DTX. METHODS:A total of 279 CRPC patients who received DTX (≥50 mg/m...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0638-2
更新日期:2014-10-01 00:00:00
abstract::Bile duct hamartomas, also known as von Meyenburg complexes, are benign neoplasms consisting of cystic dilatation of the bile duct surrounded by fibrous stroma. We report a rare case in a 60-year-old man who presented with coexistent von Meyenburg complex and esophageal carcinoma. Preoperative computed tomography did ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0747-x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Radiofrequency ablation (RFA) can be a minimally invasive therapeutic option in patients with lung metastasis from colorectal caner. We aimed to elucidate the safety and survival benefit of computed tomography (CT)-guided percutaneous RFA for lung metastasis from colorectal cancer. METHODS:A total 188 lesio...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-018-1357-5
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate prognostic factors and develop a prognostic factor-based risk stratification model for disease-specific survival (DSS) in a radical cystectomy (RC) series. METHODS:The patient cohort comprised 194 consecutive patients with bladder cancer treated with RC. Univariate a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0310-7
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients w...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0738-y
更新日期:2008-04-01 00:00:00
abstract::Ovarian cancer is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at an advanced stage with a poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced disease. However, these patients rema...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-012-0459-8
更新日期:2012-10-01 00:00:00
abstract::The two main malignant hepatic tumors in children are hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). The past two decades have brought significant improvement to the outcomes of children diagnosed with malignant hepatic tumors, especially HBL, due to improvements in diagnosis and treatment. Histological ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0607-9
更新日期:2013-12-01 00:00:00
abstract::We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia. The patient reported a swelling in his left lower abdomen over the past 6 months. Magnetic resonance imaging revealed a left inguinal mass extending from the ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0850-7
更新日期:2009-08-01 00:00:00
abstract::Combination chemotherapy with cisplatin and pemetrexed is the most active first-line regimen for malignant pleural mesothelioma (MPM). However, no drugs have been approved for second-line treatment of MPM, with effective regimens remaining to be identified for patients in relapse. We have now evaluated the combination...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0064-7
更新日期:2010-10-01 00:00:00
abstract::Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-010-0140-z
更新日期:2011-06-01 00:00:00
abstract::5-Fluorouracil (5-FU) has been the most widely accepted and studied chemotherapeutic agent, and many combination chemotherapeutic regimens have been reported. However, until recently, a standard regimen for metastatic gastric cancer had not been established. The combination of S-1 and cisplatin is a good candidate as ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-008-0793-z
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The pasteurized autogenous bone graft (PABG) is a new method to reuse resected and diseased autogenous bones after heat treatment at a comparatively low temperature (60 degrees C-65 degrees C). METHODS:The subjects of this study were ten patients with musculoskeletal tumor who underwent surgery with a PABG ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-004-0391-7
更新日期:2004-06-01 00:00:00
abstract::Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-019-01611-x
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-019-01565-0
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC). METHODS:MVD was evaluated in tumors (n = 50) from patients with EOC who...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1033-6
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Set-up errors represent a source of uncertainty in head and neck (H&N) cancer radiotherapy. The present study evaluated set-up accuracy with the use of cone-beam computed tomography (CBCT) in order to establish the proper clinical target volume (CTV) to planning target volume (PTV) margins to be adopted. ME...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0395-7
更新日期:2013-06-01 00:00:00
abstract::Brachytherapy is an important radio-therapeutic modality for a variety of malignancies, including prostate cancer, cervix cancer, breast cancer, vagina cancer, endometrium cancer, head and neck cancer, and many more. This technique has been shown to be an effective and safe non-pharmaceutical treatment with fewer seri...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-017-1155-5
更新日期:2017-08-01 00:00:00
abstract::A primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is an extremely rare lesion. To date, only 49 cases have been reported. The presence of mural nodules in a PRMC may indicate a worse prognosis. We report the case of a 40-year-old Japanese woman with a PRMC with mural nodules. Microscopic examination reveale...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0313-4
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:To analyze the impact of sunitinib treatment on health-related quality of life (HRQOL) in Japanese patients with metastatic renal cell carcinoma (mRCC). METHODS:This study prospectively included 90 consecutive patients with mRCC treated with sunitinib for at least 3 months. HRQOL in these patients was asses...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0364-6
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-018-01389-4
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:To avoid the loss of fertility, chemotherapy should be chosen as an adjuvant treatment after trachelectomy. Our study evaluated the effectiveness and safety of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer. METHODS:Our institutional review board approved this clinical study, and in...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01778-8
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Soft-tissue tumors are often accompanied by abnormal temperature distribution detected during palpation. However, the assessment of temperature distribution is subjective, limiting its wide use in cancer screening. The aim of this study was to evaluate the clinical significance of the thermal detection of so...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01658-1
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. This study summarizes the tumor responses and the acute and late adverse effects of BNCT in the treatment of patients with both recurrent and newly diagnosed T4 salivary gland carcinoma...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-013-0580-3
更新日期:2014-01-01 00:00:00