当前位置： SCI文献检索 > International Journal of Clinical Oncology期刊下所有文献 > Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.

Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.

Abstract：

PURPOSE:Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT. METHODS:62 adult survivors of a PFT, ascertained from a national register, diagnosed before 5 years of age, and a sibling control, received a single IQ assessment an average of 32 years (range 18-53) after initial diagnosis, using the Weschler Abbreviated Scale of Intelligence. Regression models were fitted to survivor-sibling pair differences on verbal and performance IQ (VIQ and PIQ) scores to investigate whether increasing time between PFT diagnosis and follow-up IQ assessment contributed to survivor-sibling IQ differences. RESULTS:At follow-up, survivors had, on average, VIQ 15 points and PIQ 19 points lower than their siblings. There was no significant effect of time since diagnosis on survivor-sibling VIQ difference. Survivors who received radiotherapy showed no significant effect of time since diagnosis on survivor-sibling PIQ difference. Survivors who did not receive radiotherapy demonstrated a trend for it to reduce. CONCLUSIONS:VIQ and PIQ deficits persist in adulthood, suggesting the effect of a fixed injury imposing on cognitive development, rather than an ongoing pathological process. IMPLICATIONS FOR CANCER SURVIVORS:The findings will help parents and others supporting survivors of an early life PFT to identify and plan for possible cognitive outcomes, and highlight the importance of early interventions to optimize cognitive function during the developmental period.

journal_name

Int J Clin Oncol

journal_title

International journal of clinical oncology

authors

Wagner AP,Carroll C,White SR,Watson P,Spoudeas HA,Hawkins MM,Walker DA,Clare ICH,Holland AJ,Ring H

doi

10.1007/s10147-020-01725-7

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1763-1773

issue

10

eissn

1341-9625

issn

1437-7772

pii

10.1007/s10147-020-01725-7

journal_volume

25

pub_type

杂志文章

相关文献

International Journal of Clinical Oncology文献大全
  • Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer.

    abstract：BACKGROUNDS:The presence of ≥5 circulating tumor cells (CTCs) in 7.5 ml blood is a poor prognostic marker in metastatic breast cancer (MBC). However, the role of human epidermal growth factor receptor 2 (HER2) status in CTCs is not known. METHODS:We prospectively assessed the prognostic value of this parameter for pat...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-011-0260-0

    authors： Hayashi N,Nakamura S,Tokuda Y,Shimoda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NT

    更新日期：2012-04-01 00:00:00

  • Partial nephrectomy for hilar tumors: comparison of conventional open and robot-assisted approaches.

    abstract：BACKGROUND:To characterize clinical advantages in robot-assisted partial nephrectomy (RAPN) for targeting renal hilar tumors, and compare them with those of open PN (OPN). METHODS:This study included 31 consecutive patients with renal hilar tumors, consisting of 15 and 16 who received OPN and RAPN, respectively, betwe...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-015-0783-x

    authors： Miyake H,Hinata N,Imai S,Furukawa J,Tanaka K,Fujisawa M

    更新日期：2015-08-01 00:00:00

  • Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung.

    abstract：BACKGROUND:Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countrie...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0515-4

    authors： Rahman S,Kondo N,Yoneda K,Takuwa T,Hashimoto M,Orui H,Okumura Y,Tanaka F,Kumamoto K,Mostafa MG,Chowdhury GM,Haque A,Hasegawa S

    更新日期：2014-02-01 00:00:00

  • The effect of gemcitabine/paclitaxel chemotherapy on the survival of patients with metastatic urothelial cancers.

    abstract：BACKGROUND:To evaluate the survival benefit of gemcitabine and paclitaxel (GT) chemotherapy for patients with metastatic urothelial cancer (UC), a retrospective analysis was performed to compare the overall survival in two periods: before (group I) and after (group II) the introduction of GT chemotherapy. PATIENTS AND...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0381-0

    authors： Matsui Y,Nishiyama H,Yoshimura K,Xing ND,Sumiyoshi T,Saito R,Inoue T,Kamba T,Ogawa O

    更新日期：2013-04-01 00:00:00

  • 'Trifecta' outcomes of robot-assisted partial nephrectomy: a large Japanese multicenter study.

    abstract：OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10147-019-01565-0

    authors： Furukawa J,Kanayama H,Azuma H,Inoue K,Kobayashi Y,Kashiwagi A,Segawa T,Takahashi Y,Horie S,Ogawa O,Takenaka A,Shiroki R,Tanabe K,Fujisawa M

    更新日期：2020-02-01 00:00:00

  • Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases.

    abstract：BACKGROUND:Cyclin E and p27 play pivotal roles in cancer development and progression. We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. METHODS:Tumors from ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s101470200053

    authors： Takahashi S,Kamata Y,Tamo W,Koyanagi M,Hatanaka R,Yamada Y,Tsushima T,Takaya S,Fukuda I

    更新日期：2002-12-01 00:00:00

  • Treatment outcomes of hypofractionated radiotherapy combined with temozolomide followed by bevacizumab salvage therapy in glioblastoma patients aged > 75 years.

    abstract：BACKGROUND:The optimal treatment for elderly patients with glioblastoma has not been established. METHODS:We retrospectively analyzed the safety and efficacy of hypofractionated radiotherapy (45 Gy/15 fr) combined with temozolomide (TMZ) followed by bevacizumab (BEV) salvage treatment in 18 glioblastoma patients aged ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-018-1298-z

    authors： Matsuda KI,Sakurada K,Nemoto K,Kayama T,Sonoda Y

    更新日期：2018-10-01 00:00:00

  • Assessment of the prognostic value and N1b changes of the eighth TNM/AJCC staging system for differentiated thyroid carcinoma.

    abstract：BACKGROUND:The aim of this study was to evaluate the prognostic veracity for disease-specific survival (DSS) of the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis staging system (TNM-8) compared with the seventh edition (TNM-7) in a Chinese populati...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10147-019-01522-x

    authors： Zhi J,Wu Y,Hu L,Zhao J,Liu H,Ruan X,Hou X,Zhang J,Zheng X,Gao M

    更新日期：2020-01-01 00:00:00

  • Bilateral primary malignant lymphoma of the ureter.

    abstract：:We report the case of a 68-year-old Japanese man who presented with postrenal azotemia due to bilateral upper ureteral stenosis. The patient's right kidney was nonfunctional; therefore, right nephroureterectomy was performed for the purpose of pathologic diagnosis. Histopathologic examination revealed follicular lymph...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-007-0685-7

    authors： Kubota Y,Kawai A,Tsuchiya T,Kozima K,Yokoi S,Deguchi T

    更新日期：2007-12-01 00:00:00

  • Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients.

    abstract：BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-015-0907-3

    authors： Tsuruga T,Fujimoto A,Kawana K,Mori M,Hasumi Y,Kino N,Tomio K,Miura S,Tanikawa M,Sone K,Miyamoto Y,Ikeda Y,Kojima S,Adachi K,Nagasaka K,Matsumoto Y,Arimoto T,Oda K,Nakagawa S,Horie K,Yasugi T,Yokota H,Osuga Y,

    更新日期：2016-04-01 00:00:00

  • Multiple lymphomatous polyposis overexpressing cyclin D1.

    abstract：:A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s101470050012

    authors： Tsujimura H,Takagi T,Tamaru J,Sakai C

    更新日期：2000-02-01 00:00:00

  • Radiotherapy for thoracic tumors: association between subclinical interstitial lung disease and fatal radiation pneumonitis.

    abstract：BACKGROUND:We evaluated the association between subclinical interstitial lung disease (ILD) and fatal radiation pneumonitis (RP) in patients with thoracic tumors treated with thoracic radiotherapy (RT). METHODS:Sixty-two consecutive patients with thoracic tumors treated with thoracic RT were retrospectively analyzed. ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-014-0679-1

    authors： Yamaguchi S,Ohguri T,Matsuki Y,Yahara K,Oki H,Imada H,Narisada H,Korogi Y

    更新日期：2015-02-01 00:00:00

  • Molecular genetic diagnosis of familial tumors.

    abstract：:Recent advances in molecular biology have identified the responsible genes for many hereditary cancer syndromes (familial tumors). Therefore, now, the final diagnosis of familial tumors can be done by molecular methods to detect the genetic alteration in the disease-causing responsible gene(s) in the patient. So-calle...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-004-0421-5

    authors： Tomita N,Oto M

    更新日期：2004-08-01 00:00:00

  • Is extracapsular tumour spread a prognostic factor in patients with early breast cancer?

    abstract：BACKGROUND:This study searched for extra capsular tumour spread (ECS) as a prognostic factor for recurrence in terms of Disease Free Survival (DFS) and Overall Survival (OS). PATIENTS AND METHODS:For this study, from a retrospective database of the Doubs cancer registry, 823 eligible women with node positive breast ca...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-012-0439-z

    authors： Dobi E,Bazan F,Dufresne A,Demarchi M,Villanueva C,Chaigneau L,Montcuquet P,Ivanaj A,Sautière JL,Maisonnette-Escot Y,Cals L,Algros MP,Woronoff AS,Pivot X

    更新日期：2013-08-01 00:00:00

  • Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma.

    abstract：BACKGROUND:The purpose of this study was to identify the role of Bcl-2 protein and adrenomedullin (AM) expression in relation to apoptosis in the neoplastic changes of squamous epithelium of the uterine cervix. METHODS:Apoptosis in sections of normal cervical epithelium, cervical intraepithelial neoplasia (CIN), and i...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s101470300015

    authors： Li Z,Takeuchi S,Ohara N,Maruo T

    更新日期：2003-04-01 00:00:00

  • The prognostic impact of immune-related adverse events in metastatic renal cell carcinoma patients treated with nivolumab: a real-world multi-institutional retrospective study.

    abstract：BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-021-01872-5

    authors： Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

    更新日期：2021-01-20 00:00:00

  • No significant impact of response to prior androgen receptor-axis-targeted agents on the efficacy of subsequent docetaxel in patients with metastatic castration-resistant prostate cancer.

    abstract：BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...

    journal_title：International journal of clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10147-017-1230-y

    authors： Miyake H,Matsushita Y,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

    更新日期：2018-06-01 00:00:00

  • Optimal use of anthracycline-free perioperative chemotherapy in HER2-positive breast cancer patients.

    abstract：PURPOSE:In adjuvant settings of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, anthracycline-based chemotherapy followed by taxane and trastuzumab is a standard regimen. Recent studies have reported the use of anthracycline-free adjuvant chemotherapy in selected HER2-positive breast cancer pati...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-019-01420-2

    authors： Watanuki R,Hayashida T,Kawai Y,Kikuchi M,Nakashoji A,Yokoe T,Toyota T,Seki T,Takahashi M,Kitagawa Y

    更新日期：2019-07-01 00:00:00

  • Salvage chemotherapy for recurrent or persistent clear cell carcinoma of the ovary: a single-institution experience for a series of 20 patients.

    abstract：BACKGROUND:Recurrent or persistent clear cell carcinoma (CCC) of the ovary is particularly chemotherapy resistant. The purpose of this study was to review our extensive institutional experiences with recurrent or persistent CCC with the aim of finding a more effective chemotherapy regimen. METHODS:The medical records ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-011-0357-5

    authors： Yoshino K,Enomoto T,Fujita M,Ueda Y,Kimura T,Kobayashi E,Tsutsui T,Kimura T

    更新日期：2013-02-01 00:00:00

  • Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001).

    abstract：BACKGROUND:This multi-center, phase III trial assesses the efficacy of daikenchuto (TU-100) on gastrointestinal disorders after hepatic resection (UMIN Registration No. 000003103). MATERIALS AND METHODS:A total of 231 patients, who underwent hepatic resection at 26 Japanese centers, were enrolled. Patients were random...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s10147-014-0678-2

    authors： Shimada M,Morine Y,Nagano H,Hatano E,Kaiho T,Miyazaki M,Kono T,Kamiyama T,Morita S,Sakamoto J,Kusano M,Saji S,Kanematsu T,Kitajima M

    更新日期：2015-02-01 00:00:00

  • Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma: an immunohistochemical and molecular genetic study of Japanese cases.

    abstract：BACKGROUND:Although several studies have reported the incidence of KIT and PDGFRA gene mutations in cutaneous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is an uncommon neoplasm compared with countries with Caucasian populations. METHODS:In this study, p...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-010-0087-0

    authors： Terada T

    更新日期：2010-10-01 00:00:00

  • Loss of ARID1A expression is associated with poor prognosis in patients with stage I/II clear cell carcinoma of the ovary.

    abstract：BACKGROUND:Recent studies have shown that somatic mutations in the AT-rich interactive domain 1A (SWI-like) gene (ARID1A) are the most common genetic changes in clear cell carcinoma of the ovary (CCC). A gene mutation of ARID1A was found in approximately half of CCC cases, and led to absence of the encoded protein and ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-015-0811-x

    authors： Itamochi H,Oumi N,Oishi T,Shoji T,Fujiwara H,Sugiyama T,Suzuki M,Kigawa J,Harada T

    更新日期：2015-10-01 00:00:00

  • Current topics and perspectives relating to hormone therapy for prostate cancer.

    abstract：:Prostate cancer is androgen-dependent, and hormone therapy, mainly achieved by androgen deprivation, has been one of the main treatment modalities in the clinical management of prostate cancer patients for more than six decades. In the 1980s, luteinizing hormone-releasing hormone agonists, which reduce testosterone to...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-008-0830-y

    authors： Suzuki H,Kamiya N,Imamoto T,Kawamura K,Yano M,Takano M,Utsumi T,Naya Y,Ichikawa T

    更新日期：2008-10-01 00:00:00

  • Aggressive estrogen-receptor-positive breast cancer arising in patients with elevated body mass index.

    abstract：BACKGROUND:Obese women with estrogen receptor (ER)-positive breast cancer may experience worse disease-free and overall survival. We hypothesize that this observation is due to intrinsically aggressive disease and that obesity will be associated with higher histologic grade and Ki67. METHODS:A sequential cohort of wom...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-014-0712-4

    authors： Santa-Maria CA,Yan J,Xie XJ,Euhus DM

    更新日期：2015-04-01 00:00:00

  • Complete remission in a patient with metastatic mixed adenocarcinoma/extrapulmonary small cell carcinoma of the prostate.

    abstract：:Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-011-0198-2

    authors： Brammer JE,Lulla P,Lynch GR

    更新日期：2011-12-01 00:00:00

  • Preplanned safety analysis of the JFMC37-0801 trial: a randomized phase III study of six months versus twelve months of capecitabine as adjuvant chemotherapy for stage III colon cancer.

    abstract：BACKGROUND:Six months of adjuvant chemotherapy is regarded as the standard of care for patients with stage III colon cancer. However, whether longer treatment can improve prognosis has not been fully investigated. We conducted a phase III study comparing 6 and 12 months of adjuvant capecitabine chemotherapy for stage I...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10147-016-1083-9

    authors： Suto T,Ishiguro M,Hamada C,Kunieda K,Masuko H,Kondo K,Ishida H,Nishimura G,Sasaki K,Morita T,Hazama S,Maeda K,Mishima H,Ike H,Sadahiro S,Sugihara K,Okajima M,Saji S,Sakamoto J,Tomita N

    更新日期：2017-06-01 00:00:00

  • Postoperative D-dimer elevation affects tumor recurrence and the long-term survival in gastric cancer patients who undergo gastrectomy.

    abstract：INTRODUCTION:We retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients. METHODS:The study involved 650 patients who underwen...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-019-01603-x

    authors： Hara K,Aoyama T,Hayashi T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Yamada T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

    更新日期：2020-04-01 00:00:00

  • Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria.

    abstract：BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-017-1189-8

    authors： Imura S,Teraoku H,Yoshikawa M,Ishikawa D,Yamada S,Saito Y,Iwahashi S,Ikemoto T,Morine Y,Shimada M

    更新日期：2018-02-01 00:00:00

  • Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis.

    abstract：BACKGROUND:We evaluated the relationship between biological behavior and microsatellite instability (MSI) status, with or without p53 status, in sporadic colorectal carcinoma. METHODS:MSI was analyzed with regard to biological features such as cellular proliferation and apoptotic cell death, in addition to clinicopath...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s10147-004-0406-4

    authors： Mori S,Ogata Y,Shirouzu K

    更新日期：2004-08-01 00:00:00

  • Strategies for dealing with fraud in clinical trials.

    abstract：:Research misconduct and fraud in clinical research is an increasing problem facing the scientific community. This problem is expected to increase due to discoveries in central statistical monitoring and with the increase in first-time clinical trial investigators in the increasingly global reach of oncology clinical t...

    journal_title：International journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s10147-015-0876-6

    authors： Herson J

    更新日期：2016-02-01 00:00:00