Abstract:
BACKGROUND:Evaluation of the prognosis in patients with spinal metastases is important in decision making regarding surgical treatment. The purpose of this study was to investigate overall survival in patients with spinal metastases from lung cancer by histological subtype, and to investigate prognostic factors in patients treated with and without epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). METHODS:The data from 135 patients diagnosed with spinal metastases from lung cancer were retrospectively evaluated. The 88 patients with adenocarcinoma were divided into two groups according to whether the lung cancer was treated with or without EGFR-TKIs-the EGFR-TKI group (n = 43) and the non-EGFR-TKI group (n = 45). RESULTS:The overall median survival time was 11.3 months for those with adenocarcinoma, 5.3 months for squamous cell carcinoma, and 3.9 months for small cell carcinoma. Overall survival in the EGFR-TKI group (median 21.4 months) was significantly longer than in the non-EGFR-TKI group (median 6.1 months). In univariate analysis, poor performance status was a poor prognostic factor in the non-EGFR-TKI group. However, performance status and other variables were not significant prognostic factors in the EGFR-TKI group. CONCLUSIONS:Median overall survival was longer in patients with spinal metastases from lung cancer treated with EGFR-TKIs compared with those treated without EGFR-TKIs. Poor performance status or other prognostic factors were not associated with poor overall survival in the group treated with EGFR-TKIs.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Dohzono S,Sasaoka R,Takamatsu K,Nakamura Hdoi
10.1007/s10147-017-1116-zsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
698-705issue
4eissn
1341-9625issn
1437-7772pii
10.1007/s10147-017-1116-zjournal_volume
22pub_type
杂志文章abstract:BACKGROUND:The aim of this study was to investigate the screening rate for hepatitis B virus (HBV) infection, which is recommended by some guidelines for the prevention of HBV reactivation, in patients undergoing chemotherapy for malignancy in Japan. METHODS:The study subjects were 3302 patients who had received first...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-0995-8
更新日期:2016-12-01 00:00:00
abstract:BACKGROUNDS:The presence of ≥5 circulating tumor cells (CTCs) in 7.5 ml blood is a poor prognostic marker in metastatic breast cancer (MBC). However, the role of human epidermal growth factor receptor 2 (HER2) status in CTCs is not known. METHODS:We prospectively assessed the prognostic value of this parameter for pat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0260-0
更新日期:2012-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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abstract::Ovarian cancer is the leading cause of death in women with gynecological cancer. Most patients are diagnosed at an advanced stage with a poor prognosis. Currently, surgical tumor debulking followed by chemotherapy based on platinum and taxane is the standard treatment for advanced disease. However, these patients rema...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-012-0459-8
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarker...
journal_title:International journal of clinical oncology
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更新日期:2013-10-01 00:00:00
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journal_title:International journal of clinical oncology
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doi:10.1007/s10147-006-0625-y
更新日期:2007-02-01 00:00:00
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journal_title:International journal of clinical oncology
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abstract:BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-009-0016-2
更新日期:2010-02-01 00:00:00
abstract::A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...
journal_title:International journal of clinical oncology
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更新日期:2007-06-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2020-04-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2006-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-016-1049-y
更新日期:2017-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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journal_title:International journal of clinical oncology
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更新日期:2008-08-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2002-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-03-01 00:00:00
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更新日期:2017-04-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2013-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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