Metastasis of colorectal carcinoma to the testes: clinical presentation and possible pathways.

abstract：BACKGROUND:We designed an outpatient regimen consisting of fractional cisplatin in combination with S-1, a novel oral fluoropyrimidine derivative for the treatment of recurrent or advanced gastric cancer and conducted a phase I study to determine the dose limiting toxicities (DLTs) and recommended dose (RD). METHODS:E...

journal_title：International journal of clinical oncology

authors： Shimoyama S,Imamura K,Hiki N,Yamaguchi H,Mafune K,Kaminishi M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcinoma suggested the recommended dose of docetaxel at 10 mg/m2 and cisplatin at 20 mg/m2. Phase II study of the concurrent chemor...

journal_title：International journal of clinical oncology

authors： Nakahara S,Takenaka Y,Ogawa K,Nishiike S,Yamamoto Y,Seo Y,Isohashi F,Suzuki O,Yoshioka Y,Sumida I,Yoshii T,Tomiyama Y,Inohara H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Despite increasing interest in minimally invasive surgery, prevalence data are completely absent. Our objective was to analyze clinico-epidemiological variations of surgery for renal malignancy in Japan with emphasis on annual trends and regional gaps, and to analyze factors affecting choice of open versus m...

journal_title：International journal of clinical oncology

authors： Sugihara T,Yasunaga H,Horiguchi H,Tsuru N,Fujimura T,Nishimatsu H,Kume H,Ohe K,Matsuda S,Fushimi K,Homma Y

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:To investigate the prognostic and therapeutic implications of time to biochemical relapse (BCR) in patients with prostate cancer after radical prostatectomy. METHODS:The records of 3210 consecutive men with prostate cancer who underwent radical prostatectomy between January 1998 and June 2013 were retrospec...

journal_title：International journal of clinical oncology

authors： Pak S,You D,Jeong IG,Kim YS,Hong JH,Kim CS,Ahn H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head an...

journal_title：International journal of clinical oncology

authors： Nakamura K,Sasaki M,Kunitake N,Kimura M,Watanabe T,Sasaki T,Terashima H,Kuwabara Y,Sakai S,Masuda K

更新日期：2001-12-01 00:00:00

abstract：:We report the case of a 59-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, treated with radical nephrectomy, palliative radiotherapy for bone metastasis, and medical therapy for bone and lung metastases. The patient died of cardiac arrest after evidence of massive m...

journal_title：International journal of clinical oncology

authors： Zustovich F,Gottardo F,De Zorzi L,Cecchetto A,Dal Bianco M,Mauro E,Cartei G

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...

journal_title：International journal of clinical oncology

authors： Yokota T,Onitsuka T,Kusafuka K,Ogawa H,Onozawa Y,Nakagawa M,Iida Y,Kamijo T,Nishimura T,Nakajima T,Boku N,Yasui H

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose large cell neuroendocrine carcinomas (LCNEC) of the lung using small biopsy specimens. Some recent studies attempted to diagnose LCNEC using biopsy specimens; in 2011, the International Association for the Study of Lung Cancer pathological panels suggested possible LCNEC as ...

journal_title：International journal of clinical oncology

authors： Tokito T,Kenmotsu H,Watanabe R,Ito I,Shukuya T,Ono A,Nakamura Y,Tsuya A,Naito T,Murakami H,Takahashi T,Ohde Y,Kondo H,Endo M,Kameya T,Nakajima T,Mori K,Yamamoto N

更新日期：2014-02-01 00:00:00

abstract：:A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors,...

journal_title：International journal of clinical oncology

authors： Kaneko G,Kikuchi E,Hasegawa M,Miyajima A,Nakagawa K,Kameyama K,Oya M

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To assess the impact of socioeconomic status (SES) on treatment choices and outcomes of hepatocellular carcinoma (HCC) patients treated with local therapies (ablation or surgery). METHODS:Surveillance, Epidemiology and End Results (SEER) specialized socioeconomic database was accessed. Cases with non-metasta...

journal_title：International journal of clinical oncology

authors： Abdel-Rahman O

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Residual cancer burden or Ki67 expression levels in residual tumors reportedly provided significant prognostic information for a non-pathological complete response subset after neoadjuvant chemotherapy (NAC). However, the significance of Ki67 reduction for clinical response during chemotherapy in each subtyp...

journal_title：International journal of clinical oncology

authors： Enomoto Y,Morimoto T,Nishimukai A,Higuchi T,Yanai A,Miyagawa Y,Murase K,Imamura M,Takatsuka Y,Nomura T,Takeda M,Watanabe T,Hirota S,Miyoshi Y

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Recombinant human soluble thrombomodulin (rTM) has been established and introduced in the clinic as a standard treatment for disseminated intravascular coagulation (DIC). However, the efficacy and safety of rTM for DIC associated with solid tumors (DIC-STs) have not been fully established. Here, we performed...

journal_title：International journal of clinical oncology

authors： Ouchi K,Takahashi S,Chikamatsu S,Ito S,Takahashi Y,Kawai S,Okita A,Kasahara Y,Okada Y,Imai H,Komine K,Saijo K,Takahashi M,Shirota H,Takahashi M,Gamoh M,Ishioka C

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Total pharyngolaryngectomy (TPL) is a conventional and standard surgical method for locoregional control of advanced hypopharyngeal cancer (HPC). This study aimed to define the clinicopathological prognostic factors of TPL by evaluating our surgical experience of TPL in the treatment of HPCs. METHODS:We ret...

journal_title：International journal of clinical oncology

authors： Omura G,Ando M,Saito Y,Kobayashi K,Yamasoba T,Asakage T

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarker...

journal_title：International journal of clinical oncology

authors： Ruggiero A,De Rosa G,Rizzo D,Leo A,Maurizi P,De Nisco A,Vendittelli F,Zuppi C,Mordente A,Riccardi R

更新日期：2013-10-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, we found that GISTs expressed KIT, a receptor tyrosine kinase encoded by the protooncogene c-kit. We propose that GISTs may originate from interstitial cells of Cajal (ICCs), which are considered to ...

journal_title：International journal of clinical oncology

authors： Hirota S

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:To analyze the impact of sunitinib treatment on health-related quality of life (HRQOL) in Japanese patients with metastatic renal cell carcinoma (mRCC). METHODS:This study prospectively included 90 consecutive patients with mRCC treated with sunitinib for at least 3 months. HRQOL in these patients was asses...

journal_title：International journal of clinical oncology

authors： Miyake H,Harada K,Kusuda Y,Fujisawa M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

journal_title：International journal of clinical oncology

authors： Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Obese women with estrogen receptor (ER)-positive breast cancer may experience worse disease-free and overall survival. We hypothesize that this observation is due to intrinsically aggressive disease and that obesity will be associated with higher histologic grade and Ki67. METHODS:A sequential cohort of wom...

journal_title：International journal of clinical oncology

authors： Santa-Maria CA,Yan J,Xie XJ,Euhus DM

更新日期：2015-04-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The ...

journal_title：International journal of clinical oncology

authors： Kawakami Y,Ohta S,Sayem MA,Tsukamoto N,Yaguchi T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The risk factors of incisional surgical site infection (iSSI) after open radical cystectomy (ORC) have not been fully investigated. The aim of the present study is to examine factors correlated with iSSI development after ORC with intestinal urinary diversion. METHODS:A total of 178 patients who had undergo...

journal_title：International journal of clinical oncology

authors： Gondo T,Ohno Y,Nakashima J,Hashimoto T,Takizawa I,Tanaka A,Shimodaira K,Satake N,Takeuchi H,Nakagami Y,Ohori M,Tachibana M

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Although the Onodera's prognosis nutritional index (O-PNI) has been used to predict long-term life expectancy, its use to predict life expectancy within 12 weeks has not been discussed. In this study, we examined the usefulness of the O-PNI to predict short-term life expectancy in patients with end-stage gas...

journal_title：International journal of clinical oncology

authors： Oyama K,Oba M,Oshima Y,Shimada H

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Lip carcinomas are rare oral tumors, and there have been few reports of lip carcinoma in Japan. METHODS:Of 914 patients with oral carcinomas treated between January 1980 and December 1998, 12 (1.3%) had lip carcinoma and 5 (0.5%) had lip mucosal carcinoma. We investigated the clinicopathological features of...

journal_title：International journal of clinical oncology

authors： Ogura I,Amagasa T,Iwaki H,Kijima T,Kurabayashi T,Yoshimasu H

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Pulmonary wedge resection is an option for lung cancer patients with limited cardiopulmonary preservation. As the impact of underlying lung status on the prognosis of such patients remains unclear, we assessed this issue. METHODS:A total of 149 borderline surgical candidates with localized lung cancer who h...

journal_title：International journal of clinical oncology

authors： Kawaguchi T,Sawabata N,Miura S,Kawai N,Yasukawa M,Tojo T,Taniguchi S

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the predictive value of preoperative hydronephrosis for pathological outcome and prognosis in patients with upper tract urothelial carcinoma treated with nephroureterectomy. METHODS:167 patients with UTUC treated with nephroureterectomy at our two institutions in Japan between 2002 and 2017 were ...

journal_title：International journal of clinical oncology

authors： Fukui T,Kanno T,Kobori G,Moroi S,Yamada H

更新日期：2020-03-01 00:00:00

abstract：:Liver surgery has been known to cure metastatic colorectal cancer in a small proportion of patients. However, advances in procedural technique and chemotherapy now allow more patients to have safe, potentially curative surgery. Here we review surgery for unresectable colorectal liver metastases using an expert multidi...

journal_title：International journal of clinical oncology

authors： Tanaka K,Ichikawa Y,Endo I

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with...

journal_title：International journal of clinical oncology

authors： Uçar MA,Arikan F,Coşkun HŞ,Kondak Y,Tatlı AM,Göksu SS

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...

journal_title：International journal of clinical oncology

authors： Urakami S,Yuasa T,Yamamoto S,Sakura M,Tanaka H,Hayashi T,Uehara S,Inoue Y,Fujii Y,Masuda H,Fukui I,Yonese J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...

journal_title：International journal of clinical oncology

authors： Miyake H,Matsushita Y,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and toxicity of third-line gemcitabine monotherapy (Gem) in patients with platinum-resistant advanced urothelial cancer (UC). PATIENTS AND METHODS:From July 2005 to March 2009, 13 patients were enrolled. All patients had previously received methotrexate, vinblastine, doxorubicin, and...

journal_title：International journal of clinical oncology

authors： Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-08-01 00:00:00