Abstract:
BACKGROUND:Recombinant human soluble thrombomodulin (rTM) has been established and introduced in the clinic as a standard treatment for disseminated intravascular coagulation (DIC). However, the efficacy and safety of rTM for DIC associated with solid tumors (DIC-STs) have not been fully established. Here, we performed a retrospective analysis of the clinical outcomes of rTM for DIC-STs and considered a treatment strategy with rTM for DIC-STs. METHODS:Patients with DIC-STs between November 2009 and March 2016 in 2 cancer core hospitals were retrospectively analyzed. Data, including patient background, treatment course, and clinical outcomes of rTM for DIC-STs, were extracted. The clinical outcomes were evaluated by comparing the DIC score, resolution rate, and overall survival (OS) duration. RESULTS:The study included 123 patients with DIC-STs. The median OS in all patients was 41 days. The DIC resolution rate was 35.2%. DIC scores and DIC-related blood test data (fibrin degradation product and prothrombin time-international normalized ratio) significantly improved at the end of rTM administration (P < 0.001). The OS duration was longer in patients who were treated with chemotherapy after DIC onset than in those who were not treated with chemotherapy (median, 178 days vs. 17 days, P < 0.001). In both univariate and multivariate analyses, chemotherapy after DIC onset showed the strongest association with OS. CONCLUSIONS:rTM can at least temporarily improve or maintain the state of DIC-STs. It is suggested that prolongation of survival can be expected when control of DIC and treatment of the underlying disease are compatible.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Ouchi K,Takahashi S,Chikamatsu S,Ito S,Takahashi Y,Kawai S,Okita A,Kasahara Y,Okada Y,Imai H,Komine K,Saijo K,Takahashi M,Shirota H,Takahashi M,Gamoh M,Ishioka Cdoi
10.1007/s10147-018-1261-zsubject
Has Abstractpub_date
2018-08-01 00:00:00pages
790-798issue
4eissn
1341-9625issn
1437-7772pii
10.1007/s10147-018-1261-zjournal_volume
23pub_type
杂志文章abstract::Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-005-0514-9
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1189-8
更新日期:2018-02-01 00:00:00
abstract::We report two cases of the plasmacytoid variant of urothelial carcinoma of urinary bladder in which systemic chemotherapy was effective. In the first case, a 76-year-old man presented with dysphasia. Magnetic resonance imaging (MRI) and computed tomography revealed a brain tumor and a bladder tumor. Resection of the b...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0240-4
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abstract::A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Compared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients wi...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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abstract::The fourth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer was published in 2015. The guidelines contain seven chapters and six flow charts. The major changes in this new edition are as follows-(1) the for...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,实务指引
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abstract:BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2008-08-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0599-5
更新日期:2014-08-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2005-08-01 00:00:00
abstract::Brachytherapy is an important radio-therapeutic modality for a variety of malignancies, including prostate cancer, cervix cancer, breast cancer, vagina cancer, endometrium cancer, head and neck cancer, and many more. This technique has been shown to be an effective and safe non-pharmaceutical treatment with fewer seri...
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-006-0608-z
更新日期:2006-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-020-01695-w
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA. METHODS:In accordance with the PRISMA statements,...
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更新日期:2020-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s101470200053
更新日期:2002-12-01 00:00:00
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更新日期:2015-08-01 00:00:00
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journal_title:International journal of clinical oncology
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