Abstract:
BACKGROUND:Pulmonary wedge resection is an option for lung cancer patients with limited cardiopulmonary preservation. As the impact of underlying lung status on the prognosis of such patients remains unclear, we assessed this issue. METHODS:A total of 149 borderline surgical candidates with localized lung cancer who had undergone wedge resection were retrospectively investigated. Clinical variables related to perioperative morbidity, local control rate, and oncological outcomes based on underlying lung disease were analyzed. RESULTS:According to the risk analysis of postoperative complications, underlying lung disease did not influence the surgical morbidity. Postoperative recurrence occurred in 65 patients (locoregional recurrence in 36, distant metastasis in 12, and both simultaneously in 17). Multivariate analysis revealed that emphysema on computed tomography (CT) [hazard ratio (HR) 0.45; 95% confidence interval (CI) 0.21-0.99] was an independent indicator of locoregional recurrence. Forty-four patients died of lung cancer and 29 of other causes. Multivariate analysis demonstrated that interstitial lung disease on CT (HR 1.98; 95% CI 1.01-3.89) was a predictor of poor prognosis. CONCLUSION:Pulmonary wedge resection can be safely undergone by lung cancer patients regardless of pulmonary comorbidity, although underlying lung disease may influence the prognosis after wedge resection.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Kawaguchi T,Sawabata N,Miura S,Kawai N,Yasukawa M,Tojo T,Taniguchi Sdoi
10.1007/s10147-018-1367-3subject
Has Abstractpub_date
2019-04-01 00:00:00pages
366-374issue
4eissn
1341-9625issn
1437-7772pii
10.1007/s10147-018-1367-3journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Neuroendocrine carcinoma (NEC) of the esophagus and the stomach is aggressive. The purpose of this study was to determine the optimal therapeutic strategy. METHODS:Both clinicopathological factors and treatment results were examined in 34 patients with immunohistochemically diagnosed NEC of the upper gastro...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01631-y
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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abstract:BACKGROUND:The risk factors of incisional surgical site infection (iSSI) after open radical cystectomy (ORC) have not been fully investigated. The aim of the present study is to examine factors correlated with iSSI development after ORC with intestinal urinary diversion. METHODS:A total of 178 patients who had undergo...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:It is still controversial whether axillary lymph node (ALN) dissection (ALND) can be omitted after negative sentinel lymph node (SLN) biopsy (SLNB) in breast cancer (BC) patients with clinically positive ALNs at presentation treated with neoadjuvant chemotherapy (NAC). The study aim was to analyze whether SL...
journal_title:International journal of clinical oncology
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abstract:BACKGROUND:Six months of adjuvant chemotherapy is regarded as the standard of care for patients with stage III colon cancer. However, whether longer treatment can improve prognosis has not been fully investigated. We conducted a phase III study comparing 6 and 12 months of adjuvant capecitabine chemotherapy for stage I...
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
abstract::Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, suni...
journal_title:International journal of clinical oncology
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doi:10.1007/s10147-010-0116-z
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journal_title:International journal of clinical oncology
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abstract:BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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abstract::5-Fluorouracil (5-FU) has been the most widely accepted and studied chemotherapeutic agent, and many combination chemotherapeutic regimens have been reported. However, until recently, a standard regimen for metastatic gastric cancer had not been established. The combination of S-1 and cisplatin is a good candidate as ...
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pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::We report the case of a 68-year-old Japanese man who presented with postrenal azotemia due to bilateral upper ureteral stenosis. The patient's right kidney was nonfunctional; therefore, right nephroureterectomy was performed for the purpose of pathologic diagnosis. Histopathologic examination revealed follicular lymph...
journal_title:International journal of clinical oncology
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更新日期:2007-12-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2018-06-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Prognostic outcomes and safety following treatment with pembrolizumab in patients with advanced urothelial carcinoma (UC) have not been fully elucidated in clinical practice. The aim of this study was to evaluate the oncological efficacy and safety of pembrolizumab after failure of platinum-based chemotherap...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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abstract::Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade. On histopathological examination, juvenile GCTs are distinct from the adult type of GCT, and have a lower risk...
journal_title:International journal of clinical oncology
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更新日期:2009-02-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2014-04-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2016-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2013-08-01 00:00:00
abstract::Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavily pretreated patients. Paclitaxel has a so-called platelet-sparing effect, but until now it was unknown whether...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00