Prognostic outcomes and safety in patients treated with pembrolizumab for advanced urothelial carcinoma: experience in real-world clinical practice.

abstract：BACKGROUND:Peripheral sensory neurotoxicity is a frequent adverse effect of oxaliplatin therapy. Calcium and magnesium (Ca/Mg) infusions are frequently used as preventatives, but a recent phase III trial failed to show that they prevent neurotoxicity. We therefore conducted a multicenter randomized phase III trial to c...

journal_title：International journal of clinical oncology

authors： Oki E,Emi Y,Kojima H,Higashijima J,Kato T,Miyake Y,Kon M,Ogata Y,Takahashi K,Ishida H,Saeki H,Sakaguchi Y,Yamanaka T,Kono T,Tomita N,Baba H,Shirabe K,Kakeji Y,Maehara Y

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). METHODS:Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemother...

journal_title：International journal of clinical oncology

authors： Urakami S,Yuasa T,Yamamoto S,Sakura M,Tanaka H,Hayashi T,Uehara S,Inoue Y,Fujii Y,Masuda H,Fukui I,Yonese J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The efficacy of carbon-ion radiotherapy (C-ion RT) for lymph node (LN) oligo-recurrence has only been evaluated in limited single-center studies. We aimed to investigate the benefit of C-ion RT for LN oligo-recurrence in a large multi-center study. METHODS:Patients who received C-ion RT between December 199...

journal_title：International journal of clinical oncology

authors： Okonogi N,Kaminuma T,Okimoto T,Shinoto M,Yamamoto N,Yamada S,Murata K,Ohno T,Shioyama Y,Tsuji H,Nakano T,Kamada T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The activity and synergy for the combination treatment of cisplatin and gemcitabine has been identified in a variety of human tumor cells, including ovarian cancer cells, and has been widely approved for the treatment of non-small cell lung cancer, pancreatic cancer and biliary tract cancer. As the gastroint...

journal_title：International journal of clinical oncology

authors： Tomita Y,Saito T,Okadome M,Eto T,Ariyoshi K,Shimamoto K

更新日期：2014-08-01 00:00:00

abstract：:The original article can be found online. ...

journal_title：International journal of clinical oncology

authors： Shigeta K,Kosaka T,Hongo H,Yanai Y,Matsumoto K,Morita S,Mizuno R,Shinojima T,Kikuchi E,Oya M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrosp...

journal_title：International journal of clinical oncology

authors： Kondo T,Hara I,Takagi T,Kodama Y,Hashimoto Y,Kobayashi H,Iizuka J,Omae K,Yoshida K,Tanabe K

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...

journal_title：International journal of clinical oncology

authors： Okano S,Enokida T,Onoe T,Ota Y,Motegi A,Zenda S,Akimoto T,Tahara M

更新日期：2019-07-01 00:00:00

abstract：:Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

journal_title：International journal of clinical oncology

authors： Brammer JE,Lulla P,Lynch GR

更新日期：2011-12-01 00:00:00

abstract：:Poorly differentiated neuroendocrine carcinoma has a poor prognosis, especially when associated with distant metastasis. A 60-year-old man was admitted to a private hospital because of dyspnea at work in 2007. Computed tomography revealed lung infarction and a right adrenal tumor sized 12 cm in diameter that was tight...

journal_title：International journal of clinical oncology

authors： Ochiai T,Komiyama S,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Kikuchi S,Fujiwara H,Sakakura C,Kokuba Y,Sonoyama T,Otsuji E

更新日期：2010-08-01 00:00:00

abstract：:Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...

journal_title：International journal of clinical oncology

authors： Hatoum HA,Abi Saad GS,Otrock ZK,Barada KA,Shamseddine AI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Malignant change in fibrous dysplasia (FD) is very rare. This study was carried out to establish some characteristic clinical information about this disorder. METHODS:Four cases with a malignant change in FD out of 128 cases with FD were surgically treated and followed up for a median period of 61.3 months....

journal_title：International journal of clinical oncology

authors： Hoshi M,Matsumoto S,Manabe J,Tanizawa T,Shigemitsu T,Izawa N,Takeuchi K,Kawaguchi N

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA. METHODS:In accordance with the PRISMA statements,...

journal_title：International journal of clinical oncology

authors： Nishikawa Y,Hoshino N,Horimatsu T,Funakoshi T,Hida K,Sakai Y,Muto M,Nakayama T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...

journal_title：International journal of clinical oncology

authors： Imura S,Teraoku H,Yoshikawa M,Ishikawa D,Yamada S,Saito Y,Iwahashi S,Ikemoto T,Morine Y,Shimada M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Diagnosis of secondary ovarian tumors originating from colorectal cancer has previously been based upon history of malignancy and radiological findings of bilateral masses with a "stained glass appearance." The purpose of this study was to perform a detailed investigation of the radiological and macroscopic ...

journal_title：International journal of clinical oncology

authors： Kato MK,Shida D,Yoneoka Y,Yoshida H,Miyasaka N,Kanemitsu Y,Kato T

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:We retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients. METHODS:The study involved 650 patients who underwen...

journal_title：International journal of clinical oncology

authors： Hara K,Aoyama T,Hayashi T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Yamada T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (ALL). The purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus B19 and Epstein-Barr virus (EBV...

journal_title：International journal of clinical oncology

authors： da Conceição Nunes J,de Araujo GV,Viana MT,Sarinho ES

更新日期：2016-10-01 00:00:00

abstract：:Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...

journal_title：International journal of clinical oncology

authors： Doi H,Nakamatsu K,Nishimura Y

更新日期：2019-08-01 00:00:00

abstract：:It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...

journal_title：International journal of clinical oncology

authors： Matsunaga T,Kogawa K,Fujimi A,Takizawa K,Takahira N,Takemoto N,Tanaka I,Akiyama T,Sato T,Takayama T,Terui T,Sakamaki S,Niitsu Y

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:This study aims to investigate the prognostic value of the ratio of hemoglobin-RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Patients with metastatic NCCLC who attended two separate medical oncolo...

journal_title：International journal of clinical oncology

authors： Bozkaya Y,Kurt B,Gürler F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:We aimed to determine the frequency of fibromyalgia syndrome (FM) in operated breast cancer patients and to research the relationship between FM and the severity of fatigue and quality of life in these breast cancer patients. METHODS:The demographic data of 101 operated breast cancer patients were recorded....

journal_title：International journal of clinical oncology

authors： Akkaya N,Atalay NS,Selcuk ST,Alkan H,Catalbas N,Sahin F

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high rate of nodal metastasis. Sentinel lymph node biopsy (SLNB) is used in MCC and other cancers to identify regional node micrometastases in patients with clinically negative nodes; however, whether SLN status is associated with recurrence o...

journal_title：International journal of clinical oncology

authors： Shibayama Y,Imafuku S,Takahashi A,Nakayama J

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

journal_title：International journal of clinical oncology

authors： Matsuo K,Enomoto T,Yamasaki M

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate whether serum alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) trends might be correlated with overall survival rates in patients with recurrent hepatocellular carcinoma (HCC) undergoing trans-catheter arterial chemo-embolization (TACE). METHODS:We pe...

journal_title：International journal of clinical oncology

authors： Arai T,Kobayashi A,Ohya A,Takahashi M,Yokoyama T,Shimizu A,Motoyama H,Furusawa N,Notake T,Kitagawa N,Sakai H,Imamura H,Kadoya M,Miyagawa S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Pulmonary metastasectomy in patients with renal cell carcinoma (RCC) remains controversial. The purpose of our analysis was to explore the outcome of patients with RCC who underwent pulmonary metastasectomy at our institution. METHODS:We reviewed data on 25 patients who underwent resection of lung metastasi...

journal_title：International journal of clinical oncology

authors： Kawashima A,Nakayama M,Oka D,Sato M,Hatano K,Mukai M,Nagahara A,Nakai Y,Takayama H,Inoue M,Shiono H,Nishimura K,Okumura M,Nonomura N

更新日期：2011-12-01 00:00:00

abstract：:Plasmacytoma is a blood disease featuring the proliferation of abnormal plasmacytes accompanied by the production of monoclonal immunoglobulins. It usually arises in the medulla; thus, extramedullary plasmacytoma is rare, and metastatic testicular tumors are also infrequent. In this report, we present a case of testic...

journal_title：International journal of clinical oncology

authors： Kamisawa H,Akita H,Naiki T,Kato T,Okamura T

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:We aimed to compare the impact of systematic uncertainties in patient setup and prostate motion on three different external-beam radiotherapy protocols for prostate cancer. METHODS:To simulate possible near-maximum systematic errors, the isocenter position was shifted to eight points with +/-1.65 SD of the ...

journal_title：International journal of clinical oncology

authors： Zhu SY,Mizowaki T,Norihisa Y,Takayama K,Nagata Y,Hiraoka M

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:The use of adjuvant treatment has not been sufficiently investigated in duodenal adenocarcinoma. This study evaluated the effect of postoperative radiotherapy (PORT) on survival outcomes in this rare malignancy. METHODS:We identified patients who were diagnosed between 2004 and 2013 in the Surveillance, Epidem...

journal_title：International journal of clinical oncology

authors： Lim YJ,Kim K

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The purpose of our study was to evaluate the efficacy of a new combination antiemetic therapy consisting of palonosetron, aprepitant, and dexamethasone in gastric cancer patients undergoing chemotherapy with S-1 plus cisplatin. METHODS:This prospective, multi-institutional observational study assessed patient-...

journal_title：International journal of clinical oncology

authors： Oyama K,Fushida S,Kaji M,Takeda T,Yabushita K,Nezuka H,Kinami S,Kadoya N,Takai Y,Tsukioka Y,Ohyama S,Tsuji K,Tsukada T,Kinoshita J,Fujimura T,Ohta T

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS:The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefe...

journal_title：International journal of clinical oncology

authors： Nakabayashi N,Hirose M,Suzuki R,Suzumiya J,Igawa M

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Most Brenner tumors are benign, with only 1% being malignant. In this study we report on 13 cases with malignant Brenner tumor of the ovary and discuss the clinical, demographic and histologic features. METHOD:Thirteen patients with malignant Brenner tumor of the ovary who were treated at Selçuk University G...

journal_title：International journal of clinical oncology

authors： Gezginç K,Karatayli R,Yazici F,Acar A,Çelik Ç,Çapar M,Tavli L

更新日期：2012-08-01 00:00:00