Abstract:
BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrospective study examined the therapeutic role of lymphadenectomy for ureteral cancer according to tumor location. METHODS:Between January 1988 and September 2015, we performed nephroureterectomy for 154 patients with nonmetastatic urothelial carcinoma of the ureter at two Japanese institutions. The tumors' locations were classified as the lower ureter or the upper/middle ureter (before the cranial crossing of the common iliac artery). The appropriate regional nodes were identified based on our previous mapping study. Dissection was classified as complete lymphadenectomy (all regional sites were dissected), incomplete lymphadenectomy (not all sites were dissected), or no lymphadenectomy. We focused the analyses on patients with ≥pT2 disease to clarify the effect of the lymphadenectomy. RESULTS:Among the 48 patients with upper/middle ureteral cancer, recurrence-free and cancer-specific survival were significantly higher in the complete lymphadenectomy group (vs. the incomplete or no lymphadenectomy groups). However, there were no differences in recurrence-free and cancer-specific survivals among the 56 patients with lower ureteral cancer. In the patients with upper/middle ureteral cancer, multivariate analysis revealed that template-based lymphadenectomy was independently associated with a reduced risk of cancer-specific mortality. CONCLUSIONS:Template-based lymphadenectomy has a therapeutic benefit for treating patients with upper/middle ureteral cancer but not for treating patients with lower ureteral cancer.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Kondo T,Hara I,Takagi T,Kodama Y,Hashimoto Y,Kobayashi H,Iizuka J,Omae K,Yoshida K,Tanabe Kdoi
10.1007/s10147-016-1024-7subject
Has Abstractpub_date
2017-02-01 00:00:00pages
145-152issue
1eissn
1341-9625issn
1437-7772pii
10.1007/s10147-016-1024-7journal_volume
22pub_type
杂志文章abstract:BACKGROUND:Although regorafenib or trifluridine/tipiracil (FTD/TPI) has been recognized as a later-line standard treatment in patients with metastatic colorectal cancer (mCRC), not all patients have beneficial outcomes. This study aimed to develop a prognostic scoring system for evaluating the overall survival (OS) ben...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical oncology
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pub_type: 杂志文章,评审
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