Can hybrid FDG-PET/CT detect subclinical lymph node metastasis of esophageal cancer appropriately and contribute to radiation treatment planning? A comparison of image-based and pathological findings.

Abstract:

BACKGROUND:We aimed to determine the appropriateness of adding 18F-fluorodeoxyglucose (FDG)-positronemission tomography (PET) to computed tomography (CT) and other pre-existing diagnostic imaging modalities for detecting subclinical lymph node metastasis of esophageal cancer, by comparing images from these modalities with the results of histopathological analysis. METHODS:Twenty patients who received radical surgery for squamous cell carcinoma of the esophagus were examined by PET-CT, and endoscopic ultrasound (EUS) examination before surgery. Based on these diagnostic modalities, the clinical target volume (CTV) was set as the gross tumor volume (GTV) plus a 1-cm margin. Histopathological diagnosis was performed in all patients immediately after resection. RESULTS:Fifty-three (3.0%) of 1764 nodes in the 20 patients were histopathologically positive for cancer cells. The CTV was not adequate to cover these histopathologically detected positive lymph nodes in 8 of 20 patients on CT, 5 of 20 on CT+EUS, 7 of 20 on PET-CT, and 5 of 20 on PET-CT+EUS. CONCLUSION:The detection rate of subclinical lymph node metastasis did not improve with the use of PET-CT, for either the cervical and supraclavicular, mediastinal, or abdominal regions. It is not recommended to use FDG-PET or PET-CT alone as a diagnostic tool to determine CTV if pathologically involved lymphatic regions are to be included in the CTV in the treatment protocol. The accuracy of PET-CT must be further improved in order to better detect positive nodes and improve the definition of the CTV.

journal_name

Int J Clin Oncol

authors

Shimizu S,Hosokawa M,Itoh K,Fujita M,Takahashi H,Shirato H

doi

10.1007/s10147-009-0893-4

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

421-5

issue

5

eissn

1341-9625

issn

1437-7772

journal_volume

14

pub_type

杂志文章
  • The prognostic impact of immune-related adverse events in metastatic renal cell carcinoma patients treated with nivolumab: a real-world multi-institutional retrospective study.

    abstract:BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-021-01872-5

    authors: Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

    更新日期:2021-01-20 00:00:00

  • Focal therapy with high-intensity focused ultrasound for the localized prostate cancer for Asian based on the localization with MRI-TRUS fusion image-guided transperineal biopsy and 12-cores transperineal systematic biopsy: prospective analysis of oncolog

    abstract:BACKGROUND:We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian. METHODS:We prospectively recruited patients with localized PCa, locat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01723-9

    authors: Shoji S,Hiraiwa S,Uemura K,Nitta M,Hasegawa M,Kawamura Y,Hashida K,Hasebe T,Tajiri T,Miyajima A

    更新日期:2020-10-01 00:00:00

  • Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.

    abstract:BACKGROUND:Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcinoma suggested the recommended dose of docetaxel at 10 mg/m2 and cisplatin at 20 mg/m2. Phase II study of the concurrent chemor...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-016-0997-6

    authors: Nakahara S,Takenaka Y,Ogawa K,Nishiike S,Yamamoto Y,Seo Y,Isohashi F,Suzuki O,Yoshioka Y,Sumida I,Yoshii T,Tomiyama Y,Inohara H

    更新日期:2016-12-01 00:00:00

  • Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical

    abstract:PURPOSE:This single-arm, multicenter, phase-II trial evaluated the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) using fine-powder cisplatin and iodized-oil suspension in patients with intermediate- and advanced-stage [Barcelona Clinic Liver Cancer (BCLC) stage-B and stage-C] hepatocellular carci...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-014-0773-4

    authors: Takaki H,Yamakado K,Tsurusaki M,Yasumoto T,Baba Y,Narimatsu Y,Shimohira M,Yamaguchi M,Matsuo K,Inaba Y,Mikami K,Watanabe R,Nishida N,Anai H,Kakizawa H,Hirota S

    更新日期:2015-08-01 00:00:00

  • Current status and perspectives of brachytherapy for cervical cancer.

    abstract::Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-008-0865-0

    authors: Toita T

    更新日期:2009-02-01 00:00:00

  • Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients.

    abstract:BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0907-3

    authors: Tsuruga T,Fujimoto A,Kawana K,Mori M,Hasumi Y,Kino N,Tomio K,Miura S,Tanikawa M,Sone K,Miyamoto Y,Ikeda Y,Kojima S,Adachi K,Nagasaka K,Matsumoto Y,Arimoto T,Oda K,Nakagawa S,Horie K,Yasugi T,Yokota H,Osuga Y,

    更新日期:2016-04-01 00:00:00

  • Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy.

    abstract::Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0001-9

    authors: Makay O,Kazimi M,Aydin U,Nart D,Yilmaz F,Zeytunlu M,Goker E,Coker A

    更新日期:2010-02-01 00:00:00

  • Popliteal pseudoaneurysm simulating soft-tissue sarcoma: complication of osteochondroma resection.

    abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/pl00012084

    authors: Otsuka T,Yonezawa M,Kamiyama F,Matusita Y,Matui N

    更新日期:2001-04-01 00:00:00

  • Liver resection for advanced or aggressive colorectal cancer metastases in the era of effective chemotherapy: a review.

    abstract::Liver surgery has been known to cure metastatic colorectal cancer in a small proportion of patients. However, advances in procedural technique and chemotherapy now allow more patients to have safe, potentially curative surgery. Here we review surgery for unresectable colorectal liver metastases using an expert multidi...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-011-0291-6

    authors: Tanaka K,Ichikawa Y,Endo I

    更新日期:2011-10-01 00:00:00

  • Low-dose chemotherapy with methotrexate and vinblastine for patients with desmoid tumors: relationship to CTNNB1 mutation status.

    abstract:BACKGROUND:This study was conducted to determine the efficacy and safety of low-dose chemotherapy with methotrexate (MTX) and vinblastine (VBL) for patients with desmoid tumors refractory to meloxicam treatment, focusing in particular on the relationship between the efficacy of this chemotherapy and catenin β-1 (CTNNB1...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0829-0

    authors: Nishida Y,Tsukushi S,Urakawa H,Hamada S,Kozawa E,Ikuta K,Ando Y,Ishiguro N

    更新日期:2015-12-01 00:00:00

  • Recent progress and perspectives on prostate cancer biomarkers.

    abstract::The application of prostate-specific antigen (PSA) in prostate cancer (PC) screening, diagnosis, and prognosis has improved the clinical management of PC patients. However, the PSA assay has been faced with criticism due to its potential association with over-diagnosis and subsequent overtreatment of patients with ind...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-016-1049-y

    authors: Hatakeyama S,Yoneyama T,Tobisawa Y,Ohyama C

    更新日期:2017-04-01 00:00:00

  • Glycosylation in bladder cancer.

    abstract::Complex carbohydrates are major components of the cell membrane and they play crucial roles in cell-cell and cell-extracellular matrix interactions, as well as in signal transduction. They consist of three kinds of molecular species; glycoproteins, proteoglycans, and glycosphingolipids. There is a distinct difference ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-008-0809-8

    authors: Ohyama C

    更新日期:2008-08-01 00:00:00

  • Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil.

    abstract:BACKGROUND:Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0552-7

    authors: Lee SH,Choi EJ,Kim MS,Park JW,Lee YS,Kim SY,Kang CS

    更新日期:2014-04-01 00:00:00

  • Correction to: Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration.

    abstract::The original article can be found online. ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10147-019-01395-0

    authors: Shigeta K,Kosaka T,Hongo H,Yanai Y,Matsumoto K,Morita S,Mizuno R,Shinojima T,Kikuchi E,Oya M

    更新日期:2019-05-01 00:00:00

  • Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy.

    abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0014-4

    authors: Matsuo K,Enomoto T,Yamasaki M

    更新日期:2010-02-01 00:00:00

  • Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer.

    abstract::The fourth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer was published in 2015. The guidelines contain seven chapters and six flow charts. The major changes in this new edition are as follows-(1) the for...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,实务指引

    doi:10.1007/s10147-016-0985-x

    authors: Komiyama S,Katabuchi H,Mikami M,Nagase S,Okamoto A,Ito K,Morishige K,Suzuki N,Kaneuchi M,Yaegashi N,Udagawa Y,Yoshikawa H

    更新日期:2016-06-01 00:00:00

  • Effects of cell-free and concentrated ascites reinfusion therapy (CART) on symptom relief of malignancy-related ascites.

    abstract:BACKGROUND:It is expected that cell-free and concentrated ascites reinfusion therapy (CART) will relieve the symptoms caused by ascites. To date, however, no report of objective changes in patients' symptoms has been published. We have therefore evaluated symptom management by CART. METHODS:From April 2011 to July 201...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-014-0750-y

    authors: Ito T,Hanafusa N,Iwase S,Noiri E,Nangaku M,Nakagawa K,Miyagawa K

    更新日期:2015-06-01 00:00:00

  • Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer.

    abstract:BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-019-01418-w

    authors: Okano S,Enokida T,Onoe T,Ota Y,Motegi A,Zenda S,Akimoto T,Tahara M

    更新日期:2019-07-01 00:00:00

  • A retrospective study of second-line chemotherapy for unresectable or recurrent squamous cell carcinoma of the esophagus refractory to chemotherapy with 5-fluorouracil plus platinum.

    abstract:BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients w...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0738-y

    authors: Yamazaki K,Hironaka S,Boku N,Yasui H,Fukutomi A,Yoshino T,Onozawa Y,Hasuike N,Inui T,Yamaguchi Y,Ono H

    更新日期:2008-04-01 00:00:00

  • Phase II study of 5-fluorouracil-leucovorin plus bevacizumab for chemotherapy-naïve older or frail patients with metastatic colorectal cancer (OGSG 0802).

    abstract:BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-020-01656-3

    authors: Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

    更新日期:2020-07-01 00:00:00

  • A prognostic parameter in advanced non-small cell lung cancer: the ratio of hemoglobin-to-red cell distribution width.

    abstract:BACKGROUND:This study aims to investigate the prognostic value of the ratio of hemoglobin-RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Patients with metastatic NCCLC who attended two separate medical oncolo...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01417-x

    authors: Bozkaya Y,Kurt B,Gürler F

    更新日期:2019-07-01 00:00:00

  • Progress in systemic adjuvant therapy of early-stage breast cancer.

    abstract::Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what is the optima...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-003-0338-4

    authors: Gradishar WJ,O'Regan RM

    更新日期:2003-08-01 00:00:00

  • Effectiveness of repeat surgery for recurrence after primary hepatectomy in patients with intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (IHCC) has a poor prognosis, and surgery remains the only effective treatment. However, tumor recurrence after primary hepatectomy is common. We examined the significance of repeat surgery for IHCC. METHODS:We collected data for all patients with IHCC between 1992 and 2018 (n...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01775-x

    authors: Tokuda K,Morine Y,Saito Y,Yamada S,Miyazaki K,Yamashita S,Okikawa S,Ikemoto T,Imura S,Shimada M

    更新日期:2020-12-01 00:00:00

  • Effects of a low-fat meal on the oral bioavailability of UFT and leucovorin in patients with colorectal cancer.

    abstract:BACKGROUND:UFT is composed of tegafur, a prodrug of 5-fluorouracil, and uracil, at a fixed ratio of 1: 4. UFT is widely used with leucovorin as adjuvant chemotherapy in patients with colon cancer. As reported, UFT/leucovorin should not be taken simultaneously with food because a high fat content will reduce the systemi...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10147-009-0919-y

    authors: Furuhata T,Meguro M,Nishidate T,Okita K,Ishiyama G,Iwayama Y,Hosokawa Y,Tsuruma T,Kimura Y,Mizuguchi T,Sasaki K

    更新日期:2009-12-01 00:00:00

  • Management of retroperitoneal lymph nodes in the treatment of ovarian cancer.

    abstract::The mechanisms and clinical significance of lymph node involvement in ovarian cancer have been revealed since the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new clinical staging including retroperitoneal lymph node status. The multiple directions of the lymph drainage pathway in ovarian...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-007-0672-z

    authors: Ushijima K

    更新日期:2007-06-01 00:00:00

  • Performance of outpatient regimen of S-1 in combination with fractional cisplatin for advanced or recurrent gastric cancers: a phase I study.

    abstract:BACKGROUND:We designed an outpatient regimen consisting of fractional cisplatin in combination with S-1, a novel oral fluoropyrimidine derivative for the treatment of recurrent or advanced gastric cancer and conducted a phase I study to determine the dose limiting toxicities (DLTs) and recommended dose (RD). METHODS:E...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-005-0505-x

    authors: Shimoyama S,Imamura K,Hiki N,Yamaguchi H,Mafune K,Kaminishi M

    更新日期:2005-08-01 00:00:00

  • Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma.

    abstract:BACKGROUND:The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our ins...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01422-0

    authors: Yamamoto Y,Kanzaki R,Kanou T,Ose N,Funaki S,Shintani Y,Minami M,Outani H,Takenaka S,Hamada K,Yoshikawa H,Okumura M

    更新日期:2019-07-01 00:00:00

  • Aggressive estrogen-receptor-positive breast cancer arising in patients with elevated body mass index.

    abstract:BACKGROUND:Obese women with estrogen receptor (ER)-positive breast cancer may experience worse disease-free and overall survival. We hypothesize that this observation is due to intrinsically aggressive disease and that obesity will be associated with higher histologic grade and Ki67. METHODS:A sequential cohort of wom...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-014-0712-4

    authors: Santa-Maria CA,Yan J,Xie XJ,Euhus DM

    更新日期:2015-04-01 00:00:00

  • Comparison of outcomes between overlapping structure-based and non-overlapping structure-based optimization for simultaneous integrated boost IMRT for malignant gliomas.

    abstract:BACKGROUND:Intensity-modulated radiotherapy (IMRT) can deliver different doses to two target volumes with high conformity. The purpose of the present study was to compare outcomes provided by two different optimization methods, overlapping structure-based and non-overlapping structure-based methods, for simultaneous in...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-004-0433-1

    authors: Suzuki M,Nakamatsu K,Kanamori S,Okajima K,Okumura M,Nishimura Y

    更新日期:2004-12-01 00:00:00

  • Complete remission in a patient with metastatic mixed adenocarcinoma/extrapulmonary small cell carcinoma of the prostate.

    abstract::Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0198-2

    authors: Brammer JE,Lulla P,Lynch GR

    更新日期:2011-12-01 00:00:00