Abstract:
BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head and neck who had achieved clinical remission after radiation therapy and/or chemotherapy were followed with a strict follow-up strategy (consisting of a schedule of frequent office visits, imaging studies, and blood tests, even if the patient was asymptomatic). RESULTS:Thirty-nine patients relapsed after remission. Twenty-two (56.4%) of the relapses were associated with symptoms. In the 17 patients with asymptomatic relapses (43.6%), an abnormal physical examination result initially indicated relapse in 10 patients. The other tests that initially indicated relapse included scheduled computed tomography scans (3 patients), scheduled gallium scans (2 patients), and serum lactate dehydrogenase levels (2 patients). According to the Ann Arbor stage at relapse, 72.7% of the patients with symptomatic relapses were stage III or IV, while 70.6% of the patients with asymptomatic relapses were stage I or II. CONCLUSIONS:These results indicate that a strict follow-up procedure is effective in detecting asymptomatic relapses, which generally involve a smaller tumor load than symptomatic relapses.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Nakamura K,Sasaki M,Kunitake N,Kimura M,Watanabe T,Sasaki T,Terashima H,Kuwabara Y,Sakai S,Masuda Kdoi
10.1007/s10147-001-8032-xsubject
Has Abstractpub_date
2001-12-01 00:00:00pages
302-5issue
6eissn
1341-9625issn
1437-7772journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Although several studies have reported the incidence of KIT and PDGFRA gene mutations in cutaneous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is an uncommon neoplasm compared with countries with Caucasian populations. METHODS:In this study, p...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0087-0
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Whether the administration of calcium (Ca) and magnesium (Mg) can reduce oxaliplatin-related neurotoxicity remains controversial. In addition, little is known about the effects of Ca/Mg on the blood level of platinum or objective tumor progression. PATIENTS AND METHODS:Patients receiving modified FOLFOX6 fo...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-02-01 00:00:00
abstract::We report the case of a 59-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, treated with radical nephrectomy, palliative radiotherapy for bone metastasis, and medical therapy for bone and lung metastases. The patient died of cardiac arrest after evidence of massive m...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-007-0730-6
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abstract:BACKGROUND:Zoledronic acid treatment reduces the incidence of skeletal-related events (SREs) in patients with bone metastases from breast, lung, and urologic cancers including prostate and renal cancer. The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bla...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-01 00:00:00
abstract::Among head and neck squamous cell carcinoma (HNSCC), the incidence of oropharyngeal SCC (OPSCC) is increasing in contrast to carcinoma with origin in other subsites. Human papillomavirus (HPV) is now recognized as a significant risk factor of the carcinogenesis of OPSCC. The HPV-related OPSCC patients tend to be relat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
abstract::Recent advances in molecular biology have identified the responsible genes for many hereditary cancer syndromes (familial tumors). Therefore, now, the final diagnosis of familial tumors can be done by molecular methods to detect the genetic alteration in the disease-causing responsible gene(s) in the patient. So-calle...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-004-0421-5
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:The field of immunotherapy has recently focused on cancers with microsatellite instability (MSI). These cancers include both Lynch-syndrome-associated tumors, which are caused by mismatch repair (MMR) germline mutations, and sporadic MSI tumors, which are mainly attributed to MLH1 promoter methylation. The p...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-018-1238-y
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Although several reports have discussed the potential of the indocyanine green (ICG) fluorescence technique, its effectiveness and limitations have not been fully evaluated. For the accurate detection of sentinel lymph node (SLN) in cutaneous melanoma, which can arise in a wide variety of sites throughout th...
journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-014-0712-4
更新日期:2015-04-01 00:00:00
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journal_title:International journal of clinical oncology
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doi:10.1007/s10147-012-0418-4
更新日期:2013-06-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The activity and synergy for the combination treatment of cisplatin and gemcitabine has been identified in a variety of human tumor cells, including ovarian cancer cells, and has been widely approved for the treatment of non-small cell lung cancer, pancreatic cancer and biliary tract cancer. As the gastroint...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0599-5
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:We aimed to determine the appropriateness of adding 18F-fluorodeoxyglucose (FDG)-positronemission tomography (PET) to computed tomography (CT) and other pre-existing diagnostic imaging modalities for detecting subclinical lymph node metastasis of esophageal cancer, by comparing images from these modalities w...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-009-0893-4
更新日期:2009-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:International journal of clinical oncology
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更新日期:2013-04-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2020-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0532-y
更新日期:2014-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-005-0542-5
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatme...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-019-01415-z
更新日期:2019-07-01 00:00:00
abstract::We report a rare case of advanced ovarian mucinous adenocarcinoma in a pregnant woman. A 28-year-old pregnant Japanese woman was diagnosed with an ovarian tumor 8 cm in diameter at a local hospital. She was sent to a private hospital at 25 weeks of gestation because of the growing ovarian tumor. Advanced ovarian carci...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0655-0
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:We proposed a novel treatment strategy, consisting of triweekly cisplatin plus dose-dense weekly paclitaxel before and after radical hysterectomy without adjuvant radiation therapy to treat locally advanced cervical cancer. However, cisplatin-related severe non-hematologic toxicities were frequent during thi...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1226-7
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:To evaluate the survival benefit of gemcitabine and paclitaxel (GT) chemotherapy for patients with metastatic urothelial cancer (UC), a retrospective analysis was performed to compare the overall survival in two periods: before (group I) and after (group II) the introduction of GT chemotherapy. PATIENTS AND...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0381-0
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the efficacy and safety of low-dose chemotherapy with methotrexate (MTX) and vinblastine (VBL) for patients with desmoid tumors refractory to meloxicam treatment, focusing in particular on the relationship between the efficacy of this chemotherapy and catenin β-1 (CTNNB1...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00