Clinicopathological study of carcinomas of the lip and the mucosa of the upper and lower lips.

abstract：BACKGROUND:We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian. METHODS:We prospectively recruited patients with localized PCa, locat...

journal_title：International journal of clinical oncology

authors： Shoji S,Hiraiwa S,Uemura K,Nitta M,Hasegawa M,Kawamura Y,Hashida K,Hasebe T,Tajiri T,Miyajima A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:This retrospective study was carried out to ascertain the extent of efficacy of nonsurgical salvage modalities, mainly chemotherapy (CT) alone or chemoradiotherapy (CTRT), for loco-regional failures in head and neck cancer (HNC). METHODS:Between 1991 and 1999, 131 patients with HNC, mostly stages III and IV...

journal_title：International journal of clinical oncology

authors： Datta NR,Nagar YS,Singh S,Naryan L

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:An association between inflammation and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the influence of preoperative biliary drainage-related inflammation in patients with biliary tract cancer. METHODS:The clinical data of 97 patients who underwent surg...

journal_title：International journal of clinical oncology

authors： Kurahara H,Maemura K,Mataki Y,Sakoda M,Iino S,Kawasaki Y,Arigami T,Uenosono Y,Kijima Y,Shinchi H,Takao S,Natsugoe S

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...

journal_title：International journal of clinical oncology

authors： Okano S,Enokida T,Onoe T,Ota Y,Motegi A,Zenda S,Akimoto T,Tahara M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The role and the optimal measurement method of serum HER2 levels are not defined in patients with metastatic breast cancer (MBC). We prospectively assessed the prognostic value of serum HER2 levels in MBC using two methods, enzyme immunoassay (EIA) and chemiluminescence immunoassay (CLIA). METHODS:We collec...

journal_title：International journal of clinical oncology

authors： Hayashi N,Nakamura S,Tokuda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NT

更新日期：2012-02-01 00:00:00

abstract：:Liver surgery has been known to cure metastatic colorectal cancer in a small proportion of patients. However, advances in procedural technique and chemotherapy now allow more patients to have safe, potentially curative surgery. Here we review surgery for unresectable colorectal liver metastases using an expert multidi...

journal_title：International journal of clinical oncology

authors： Tanaka K,Ichikawa Y,Endo I

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The pasteurized autogenous bone graft (PABG) is a new method to reuse resected and diseased autogenous bones after heat treatment at a comparatively low temperature (60 degrees C-65 degrees C). METHODS:The subjects of this study were ten patients with musculoskeletal tumor who underwent surgery with a PABG ...

journal_title：International journal of clinical oncology

authors： Sakayama K,Kidani T,Fujibuchi T,Kamogawa J,Yamamoto H,Shibata T

更新日期：2004-06-01 00:00:00

abstract：:Anti-aromatase agents inhibit the cytochrome p-450 component of the aromatase enzyme complex responsible for the final step of estrogen biosynthesis in peripheral tissues. These drugs can be classified into first-generation (e.g., aminoglutethimide), second-generation (e.g., formestane and fadrazole), and third-genera...

journal_title：International journal of clinical oncology

authors： Mokbel K

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Although several reports have discussed the potential of the indocyanine green (ICG) fluorescence technique, its effectiveness and limitations have not been fully evaluated. For the accurate detection of sentinel lymph node (SLN) in cutaneous melanoma, which can arise in a wide variety of sites throughout th...

journal_title：International journal of clinical oncology

authors： Namikawa K,Tsutsumida A,Tanaka R,Kato J,Yamazaki N

更新日期：2014-02-01 00:00:00

abstract：:A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses...

journal_title：International journal of clinical oncology

authors： Tsujimura H,Takagi T,Tamaru J,Sakai C

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate the prognostic significance of thymidylate synthase (TS) expression in the tumor tissue of patients with metastatic colorectal cancer (CRC) who received protracted venous infusions of 5-fluorouracil (5-FU). METHODS:We retrospectively analyzed the prognostic value of TS e...

journal_title：International journal of clinical oncology

authors： Hosokawa A,Yamada Y,Shimada Y,Muro K,Hamaguchi T,Morita H,Araake M,Orita H,Shirao K

更新日期：2004-10-01 00:00:00

abstract：:Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

journal_title：International journal of clinical oncology

authors： Brammer JE,Lulla P,Lynch GR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Irinotecan (CPT-11) and bolus 5-fluorouracil (5-FU)/leucovorin (LV) administered weekly for 4 weeks every 42 days (Saltz regimen) is active but substantially toxic in patients with metastatic colorectal cancer (CRC). The efficacy and toxicity of this regimen, however, have not been determined in Japanese pat...

journal_title：International journal of clinical oncology

authors： Fujishima H,Kikuchi I,Miyanaga O,Ueda A,Baba E,Mitsugi K,Harada M,Nakano S

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathologica...

journal_title：International journal of clinical oncology

authors： Kano M,Hihara J,Kaneko M,Uemura K,Ohge H,Sueda T

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Despite increasing interest in minimally invasive surgery, prevalence data are completely absent. Our objective was to analyze clinico-epidemiological variations of surgery for renal malignancy in Japan with emphasis on annual trends and regional gaps, and to analyze factors affecting choice of open versus m...

journal_title：International journal of clinical oncology

authors： Sugihara T,Yasunaga H,Horiguchi H,Tsuru N,Fujimura T,Nishimatsu H,Kume H,Ohe K,Matsuda S,Fushimi K,Homma Y

更新日期：2013-12-01 00:00:00

abstract：:A 45-year-old woman with HER2(-)/HER1(-) breast cancer underwent radical mastectomy, followed by radiation and chemotherapy. However, her symptoms progressed rapidly owing to meningitis carcinomatosa and she was fitted with a urethral catheter. She also had difficulty in walking. However, immediately after treatment w...

journal_title：International journal of clinical oncology

authors： Onishi H,Morisaki T,Nakafusa Y,Nakashima Y,Yokohata K,Katano M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The efficacy of individual chemotherapy based on chemosensitivity has scarcely been studied. METHODS:We examined the chemosensitivites for four anticancer agents - 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), carboplatin, cisplatin, and etoposide - of 43 ma...

journal_title：International journal of clinical oncology

authors： Ono A,Kanno H,Hayashi A,Nishimura S,Kyuma Y,Sato H,Ito S,Shimizu N,Chang CC,Gondo G,Yamamoto I,Sasaki T,Tanaka M

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated m...

journal_title：International journal of clinical oncology

authors： Feng M,Zhu J,Liang L,Zeng N,Wu Y,Wan C,Shen Y,Wen F

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:This study aims to investigate the prognostic value of the ratio of hemoglobin-RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Patients with metastatic NCCLC who attended two separate medical oncolo...

journal_title：International journal of clinical oncology

authors： Bozkaya Y,Kurt B,Gürler F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The CpG island methylator phenotype (CIMP) with multiple promoter methylated loci has been observed in a subset of human colorectal cancer (CRC) cases. CIMP status, which is closely associated with specific clinicopathological and molecular characteristics, is considered a potential predictive biomarker for ...

journal_title：International journal of clinical oncology

authors： Zhang X,Shimodaira H,Soeda H,Komine K,Takahashi H,Ouchi K,Inoue M,Takahashi M,Takahashi S,Ishioka C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...

journal_title：International journal of clinical oncology

authors： Miyake H,Matsushita Y,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:We retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients. METHODS:The study involved 650 patients who underwen...

journal_title：International journal of clinical oncology

authors： Hara K,Aoyama T,Hayashi T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Yamada T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The efficacy of direct oral anti-coagulants (DOACs) for the treatment of venous thromboembolism (VTE) in Japanese patients with advanced cancer is largely unknown. METHODS:This prospective single-center observational study enrolled Japanese patients with unresectable advanced cancer who started DOAC treatme...

journal_title：International journal of clinical oncology

authors： Oyakawa T,Muraoka N,Iida K,Kusuhara M,Mori K

更新日期：2019-07-01 00:00:00

abstract：:Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavily pretreated patients. Paclitaxel has a so-called platelet-sparing effect, but until now it was unknown whether...

journal_title：International journal of clinical oncology

authors： Ishikawa H,Fujiwara K,Suzuki S,Tanaka Y,Kohno I

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Inhibition of Notch by γ-secretase inhibitor (GSI) has been shown to have an antitumor effect in Notch-expressing non-small cell lung cancer (NSCLC) and to induce apoptosis through modulation of Bcl-2 family proteins. In particular, Bim, a BH3-only member of the Bcl-2 family of proteins, has an important rol...

journal_title：International journal of clinical oncology

authors： Sakakibara-Konishi J,Ikezawa Y,Oizumi S,Kikuchi J,Kikuchi E,Mizugaki H,Kinoshita I,Dosaka-Akita H,Nishimura M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Total pharyngolaryngectomy (TPL) is a conventional and standard surgical method for locoregional control of advanced hypopharyngeal cancer (HPC). This study aimed to define the clinicopathological prognostic factors of TPL by evaluating our surgical experience of TPL in the treatment of HPCs. METHODS:We ret...

journal_title：International journal of clinical oncology

authors： Omura G,Ando M,Saito Y,Kobayashi K,Yamasoba T,Asakage T

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. METHODS:Data were retrospectively reviewed from ...

journal_title：International journal of clinical oncology

authors： Okuda Y,Shimura T,Yamada T,Hirata Y,Yamaguchi R,Sakamoto E,Kataoka H

更新日期：2018-12-01 00:00:00

abstract：:Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...

journal_title：International journal of clinical oncology

authors： Kasper B,Ho AD,Egerer G

更新日期：2005-12-01 00:00:00