Colorectal obstruction is a potential prognostic factor for stage II colorectal cancer.

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The optimal treatment for elderly patients with glioblastoma has not been established. METHODS:We retrospectively analyzed the safety and efficacy of hypofractionated radiotherapy (45 Gy/15 fr) combined with temozolomide (TMZ) followed by bevacizumab (BEV) salvage treatment in 18 glioblastoma patients aged ...

journal_title：International journal of clinical oncology

authors： Matsuda KI,Sakurada K,Nemoto K,Kayama T,Sonoda Y

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:In this phase I/II study, we assessed the safety and initial efficacy of stereotactic body radiotherapy (SBRT) for lung tumors with real-time tumor tracking using CyberKnife based on the Monte Carlo algorithm. METHODS:Study subjects had histologically confirmed primary non-small-cell lung cancer staged as T...

journal_title：International journal of clinical oncology

authors： Iwata H,Ishikura S,Murai T,Iwabuchi M,Inoue M,Tatewaki K,Ohta S,Yokota N,Shibamoto Y

更新日期：2017-08-01 00:00:00

abstract：:5-Fluorouracil (5-FU) has been the most widely accepted and studied chemotherapeutic agent, and many combination chemotherapeutic regimens have been reported. However, until recently, a standard regimen for metastatic gastric cancer had not been established. The combination of S-1 and cisplatin is a good candidate as ...

journal_title：International journal of clinical oncology

authors： Yoshida K,Yamaguchi K,Osada S,Kawaguchi Y,Takahashi T,Sakashita F,Tanaka Y

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment of cervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). METHODS:Fifty-six patients with squamous cell carc...

journal_title：International journal of clinical oncology

authors： Mizunuma M,Yokoyama Y,Futagami M,Aoki M,Takai Y,Mizunuma H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:We conducted a study to validate the influence of the systemic immune-inflammation index (SII) on overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) and to verify whether the implementation of the SII in place of neutrophil and platelet counts within the International Metastatic Re...

journal_title：International journal of clinical oncology

authors： Chrom P,Zolnierek J,Bodnar L,Stec R,Szczylik C

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Surgical complication rates of total laryngectomy vary according to the preoperative treatments performed and patient factors. Wound complications after salvage laryngectomy following concurrent chemoradiotherapy (CCRT) were analyzed. METHODS:Eighty-six patients who had undergone total laryngectomy for lary...

journal_title：International journal of clinical oncology

authors： Furuta Y,Homma A,Oridate N,Suzuki F,Hatakeyama H,Suzuki K,Nishioka T,Shirato H,Fukuda S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for urothelial carcinoma of the upper urinary tract (UCUUT) is common. One of the mechanisms driving this is the implantation of cancer cells from the UCUUT at the RNUs. Therefore, their detection after RNU can assist in predicting IVR. Thi...

journal_title：International journal of clinical oncology

authors： Iwata H,Sassa N,Kato M,Murase Y,Seko S,Kawanishi H,Hattori R,Gotoh M,Tsuzuki T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Previous reports concerning the prevalence of human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) have observed varied results. The aim of this study was to evaluate the prevalence of HPV in oral premalignant lesions (OPL) and OSCC. For accurate HPV detection in oral lesions, comparative analys...

journal_title：International journal of clinical oncology

authors： Ishibashi M,Kishino M,Sato S,Morii E,Ogawa Y,Aozasa K,Kogo M,Toyosawa S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...

journal_title：International journal of clinical oncology

authors： Saikawa M,Kishimoto S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our ins...

journal_title：International journal of clinical oncology

authors： Yamamoto Y,Kanzaki R,Kanou T,Ose N,Funaki S,Shintani Y,Minami M,Outani H,Takenaka S,Hamada K,Yoshikawa H,Okumura M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying cognitive decline after radiotherapy not directed at brain areas remains unclear. We previously suggested that adjuvant breast radiotherapy in breast conservation therapy could lower memory function soon after therapy, and that the process might be partially mediated by plasma inter...

journal_title：International journal of clinical oncology

authors： Shibayama O,Yoshiuchi K,Inagaki M,Matsuoka Y,Yoshikawa E,Sugawara Y,Akechi T,Wada N,Imoto S,Murakami K,Ogawa A,Uchitomi Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

journal_title：International journal of clinical oncology

authors： Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:We retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients. METHODS:The study involved 650 patients who underwen...

journal_title：International journal of clinical oncology

authors： Hara K,Aoyama T,Hayashi T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Yamada T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...

journal_title：International journal of clinical oncology

authors： Miyake H,Matsushita Y,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:We evaluated the relationship between biological behavior and microsatellite instability (MSI) status, with or without p53 status, in sporadic colorectal carcinoma. METHODS:MSI was analyzed with regard to biological features such as cellular proliferation and apoptotic cell death, in addition to clinicopath...

journal_title：International journal of clinical oncology

authors： Mori S,Ogata Y,Shirouzu K

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expr...

journal_title：International journal of clinical oncology

authors： Tovuu LO,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Arakawa Y,Mori H,Hanaoka J,Kanamoto M,Sugimoto K,Saito Y,Yamada S,Asanoma M,Shimada M

更新日期：2014-08-01 00:00:00

abstract：:We report the case of a 59-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, treated with radical nephrectomy, palliative radiotherapy for bone metastasis, and medical therapy for bone and lung metastases. The patient died of cardiac arrest after evidence of massive m...

journal_title：International journal of clinical oncology

authors： Zustovich F,Gottardo F,De Zorzi L,Cecchetto A,Dal Bianco M,Mauro E,Cartei G

更新日期：2008-06-01 00:00:00

abstract：:We report a rare case of advanced ovarian mucinous adenocarcinoma in a pregnant woman. A 28-year-old pregnant Japanese woman was diagnosed with an ovarian tumor 8 cm in diameter at a local hospital. She was sent to a private hospital at 25 weeks of gestation because of the growing ovarian tumor. Advanced ovarian carci...

journal_title：International journal of clinical oncology

authors： Ishioka S,Hayashi T,Endo T,Baba T,Honma H,Saito T

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:We aimed to determine the appropriateness of adding 18F-fluorodeoxyglucose (FDG)-positronemission tomography (PET) to computed tomography (CT) and other pre-existing diagnostic imaging modalities for detecting subclinical lymph node metastasis of esophageal cancer, by comparing images from these modalities w...

journal_title：International journal of clinical oncology

authors： Shimizu S,Hosokawa M,Itoh K,Fujita M,Takahashi H,Shirato H

更新日期：2009-10-01 00:00:00

abstract：:A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors,...

journal_title：International journal of clinical oncology

authors： Kaneko G,Kikuchi E,Hasegawa M,Miyajima A,Nakagawa K,Kameyama K,Oya M

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

journal_title：International journal of clinical oncology

authors： Matsuo K,Enomoto T,Yamasaki M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the efficacy and safety of low-dose chemotherapy with methotrexate (MTX) and vinblastine (VBL) for patients with desmoid tumors refractory to meloxicam treatment, focusing in particular on the relationship between the efficacy of this chemotherapy and catenin β-1 (CTNNB1...

journal_title：International journal of clinical oncology

authors： Nishida Y,Tsukushi S,Urakawa H,Hamada S,Kozawa E,Ikuta K,Ando Y,Ishiguro N

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine if quantitative SUV-related, volumetric FDG PET parameters, and texture features (SPs, VPs, and TFs, respectively) were useful to evaluate and predict response and recurrence after chemotherapy in follicular lymphoma (FL). METHODS:Pre- and posttreatment FDG PET examin...

journal_title：International journal of clinical oncology

authors： Tatsumi M,Isohashi K,Matsunaga K,Watabe T,Kato H,Kanakura Y,Hatazawa J

更新日期：2019-10-01 00:00:00

abstract：:In Japan, the National Cancer Center and university hospitals have initiated next-generation sequencing-based in vitro diagnostic testing for cancer patients as a method of clinical sequencing. Based on the molecular alterations detected, physicians can provide approved targeted therapy and access to investigational d...

journal_title：International journal of clinical oncology

authors： Takeuchi S,Okuda S

更新日期：2019-02-01 00:00:00

abstract：:We report four patients with hepatocellular carcinoma (all men, with liver cirrhosis and hepatitis C virus infections) who showed spontaneous regression of the tumor. When the spontaneous regression occurred all of the patients were over age 67 years. They showed a rapid increase of serum alpha-fetoprotein levels just...

journal_title：International journal of clinical oncology

authors： Kondo S,Okusaka T,Ueno H,Ikeda M,Morizane C

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the screening rate for hepatitis B virus (HBV) infection, which is recommended by some guidelines for the prevention of HBV reactivation, in patients undergoing chemotherapy for malignancy in Japan. METHODS:The study subjects were 3302 patients who had received first...

journal_title：International journal of clinical oncology

authors： Ikeda M,Yamamoto H,Kaneko M,Oshima H,Takahashi H,Umemoto K,Watanabe K,Hashimoto Y,Ohno I,Mitsunaga S,Okusaka T

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Compared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients wi...

journal_title：International journal of clinical oncology

authors： Miyawaki Y,Sato H,Fujiwara N,Oya S,Sugita H,Hirano Y,Yamane T,Sakuramoto S,Okamoto K,Yamaguchi S,Koyama I

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

journal_title：International journal of clinical oncology

authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

更新日期：2018-10-01 00:00:00