Abstract:
BACKGROUND:Surgical complication rates of total laryngectomy vary according to the preoperative treatments performed and patient factors. Wound complications after salvage laryngectomy following concurrent chemoradiotherapy (CCRT) were analyzed. METHODS:Eighty-six patients who had undergone total laryngectomy for laryngeal cancer at Hokkaido University Hospital, Japan, between 1990 and 2006 were divided into three groups according to preoperative treatments received: group I (n = 35) without radiotherapy (RT) or CCRT, group II (n = 17) RT alone, and group III (n = 34) low-dose CCRT. Salvage total laryngectomy was performed as a consequence of residual or recurrent disease after completion of the treatments. Wound complications such as pharyngocutaneous fistulas, bleeding, infections, and skin necrosis were retrospectively analyzed in each group. RESULTS:A considerable (not statistically significant) difference in the incidence of major wound complications was observed between groups I and III (11.4% vs 29.4%, P = 0.078), but not between groups II and III. In stage III/IV patients, a significant increase in the incidence of wound complications was observed in group III compared to group I. Pharyngocutaneous fistulas were the most common complication, occurring in 8/34 (23.5%) of the group III patients. Additional pharyngeal reconstruction surgery was performed in 5 of the 8 (62.5%) group III patients with pha ryngocutaneous fistulas, while no such patients (0/3) in group I required reconstruction surgery. CONCLUSION:There was an increased risk of wound complications in patients undergoing salvage laryngectomy following CCRT. Patients who developed pharyngocutaneous fistulas after CCRT tended to require surgical reintervention for repair. These findings should be taken into account before the initiation of CCRT and salvage surgery.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Furuta Y,Homma A,Oridate N,Suzuki F,Hatakeyama H,Suzuki K,Nishioka T,Shirato H,Fukuda Sdoi
10.1007/s10147-008-0787-xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
521-7issue
6eissn
1341-9625issn
1437-7772journal_volume
13pub_type
杂志文章abstract:PURPOSE:Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. This study summarizes the tumor responses and the acute and late adverse effects of BNCT in the treatment of patients with both recurrent and newly diagnosed T4 salivary gland carcinoma...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-013-0580-3
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. METHODS:A total of 308 patients diagnosed with stag...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
abstract:PURPOSE:Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT. METHODS:62 adult survivo...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2009-08-01 00:00:00
abstract::We report four patients with hepatocellular carcinoma (all men, with liver cirrhosis and hepatitis C virus infections) who showed spontaneous regression of the tumor. When the spontaneous regression occurred all of the patients were over age 67 years. They showed a rapid increase of serum alpha-fetoprotein levels just...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-12-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrosp...
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pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS:We began to perform abdominal trachelectomy in 2005. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1059-9
更新日期:2017-04-01 00:00:00
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更新日期:2019-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
abstract::We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and...
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pub_type: 杂志文章
doi:10.1007/s10147-012-0460-2
更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10147-014-0712-4
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1060-3
更新日期:2017-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-019-01514-x
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0381-0
更新日期:2013-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1096-z
更新日期:2017-06-01 00:00:00