Objective response with lapatinib in patients with meningitis carcinomatosa derived from HER2/HER1-negative breast cancer.

Abstract:

:A 45-year-old woman with HER2(-)/HER1(-) breast cancer underwent radical mastectomy, followed by radiation and chemotherapy. However, her symptoms progressed rapidly owing to meningitis carcinomatosa and she was fitted with a urethral catheter. She also had difficulty in walking. However, immediately after treatment with lapatinib, her symptoms almost completely disappeared. The catheter was removed and she no longer needed a wheelchair. Unfortunately, after treatment was stopped, the bilateral upper limb skin metastases reappeared, the brain metastases relapsed, and she again experienced symptoms of meningitis carcinomatosa. Lapatinib was restarted, resulting in an immediate improvement in the symptoms and a reduction in the skin and brain metastases. Immunohistochemical staining of the lapatinib-sensitive metastatic skin tumor showed it to be HER2(2+), FISH(-)/HER1(-). This result suggested that the lapatinib-sensitive lesions in the brain and meninges were also HER2-positive. Carcinomatosa meningitis has a very poor prognosis and no effective treatment has yet been developed. Here, we report the first case in which lapatinib has been used to effectively treat meningitis carcinomatosa in HER2(-)/HER1(-) relapsed breast cancer.

journal_name

Int J Clin Oncol

authors

Onishi H,Morisaki T,Nakafusa Y,Nakashima Y,Yokohata K,Katano M

doi

10.1007/s10147-011-0195-5

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

718-21

issue

6

eissn

1341-9625

issn

1437-7772

journal_volume

16

pub_type

杂志文章
  • Current status and perspectives of brachytherapy for cervical cancer.

    abstract::Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-008-0865-0

    authors: Toita T

    更新日期:2009-02-01 00:00:00

  • Clinicopathological study of carcinomas of the lip and the mucosa of the upper and lower lips.

    abstract:BACKGROUND:Lip carcinomas are rare oral tumors, and there have been few reports of lip carcinoma in Japan. METHODS:Of 914 patients with oral carcinomas treated between January 1980 and December 1998, 12 (1.3%) had lip carcinoma and 5 (0.5%) had lip mucosal carcinoma. We investigated the clinicopathological features of...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/pl00012093

    authors: Ogura I,Amagasa T,Iwaki H,Kijima T,Kurabayashi T,Yoshimasu H

    更新日期:2001-06-01 00:00:00

  • Treatment choices and outcomes of non-metastatic hepatocellular carcinoma patients in relationship to neighborhood socioeconomic status: a population-based study.

    abstract:OBJECTIVE:To assess the impact of socioeconomic status (SES) on treatment choices and outcomes of hepatocellular carcinoma (HCC) patients treated with local therapies (ablation or surgery). METHODS:Surveillance, Epidemiology and End Results (SEER) specialized socioeconomic database was accessed. Cases with non-metasta...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01616-x

    authors: Abdel-Rahman O

    更新日期:2020-05-01 00:00:00

  • Acute toxicity of image-guided hypofractionated proton therapy for localized prostate cancer.

    abstract:BACKGROUND:Hypofractionated proton therapy (HFPT) is expected to become an effective treatment approach for localized prostate cancer (PCa). The purpose of this study was to evaluate differences in acute toxicity among patients with localized PCa treated with either conventional fractionated proton therapy (CFPT) or HF...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-017-1209-8

    authors: Nakajima K,Iwata H,Ogino H,Hattori Y,Hashimoto S,Nakanishi M,Toshito T,Umemoto Y,Iwatsuki S,Shibamoto Y,Mizoe JE

    更新日期:2018-04-01 00:00:00

  • Testicular metastasis from an extramedullary plasmacytoma.

    abstract::Plasmacytoma is a blood disease featuring the proliferation of abnormal plasmacytes accompanied by the production of monoclonal immunoglobulins. It usually arises in the medulla; thus, extramedullary plasmacytoma is rare, and metastatic testicular tumors are also infrequent. In this report, we present a case of testic...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-008-0769-z

    authors: Kamisawa H,Akita H,Naiki T,Kato T,Okamura T

    更新日期:2008-10-01 00:00:00

  • Time to biochemical relapse after radical prostatectomy and efficacy of salvage radiotherapy in patients with prostate cancer.

    abstract:BACKGROUND:To investigate the prognostic and therapeutic implications of time to biochemical relapse (BCR) in patients with prostate cancer after radical prostatectomy. METHODS:The records of 3210 consecutive men with prostate cancer who underwent radical prostatectomy between January 1998 and June 2013 were retrospec...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01463-5

    authors: Pak S,You D,Jeong IG,Kim YS,Hong JH,Kim CS,Ahn H

    更新日期:2019-10-01 00:00:00

  • Complete remission in a patient with metastatic mixed adenocarcinoma/extrapulmonary small cell carcinoma of the prostate.

    abstract::Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0198-2

    authors: Brammer JE,Lulla P,Lynch GR

    更新日期:2011-12-01 00:00:00

  • Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.

    abstract:PURPOSE:Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. This study summarizes the tumor responses and the acute and late adverse effects of BNCT in the treatment of patients with both recurrent and newly diagnosed T4 salivary gland carcinoma...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-013-0580-3

    authors: Aihara T,Morita N,Kamitani N,Kumada H,Ono K,Hiratsuka J,Harada T

    更新日期:2014-01-01 00:00:00

  • Focal therapy with high-intensity focused ultrasound for the localized prostate cancer for Asian based on the localization with MRI-TRUS fusion image-guided transperineal biopsy and 12-cores transperineal systematic biopsy: prospective analysis of oncolog

    abstract:BACKGROUND:We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian. METHODS:We prospectively recruited patients with localized PCa, locat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01723-9

    authors: Shoji S,Hiraiwa S,Uemura K,Nitta M,Hasegawa M,Kawamura Y,Hashida K,Hasebe T,Tajiri T,Miyajima A

    更新日期:2020-10-01 00:00:00

  • Preoperatively undetected solitary bile duct hamartoma (von Meyenburg complex) associated with esophageal carcinoma.

    abstract::Bile duct hamartomas, also known as von Meyenburg complexes, are benign neoplasms consisting of cystic dilatation of the bile duct surrounded by fibrous stroma. We report a rare case in a 60-year-old man who presented with coexistent von Meyenburg complex and esophageal carcinoma. Preoperative computed tomography did ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0747-x

    authors: Mimatsu K,Oida T,Kawasaki A,Aramaki O,Kuboi Y,Katsura Y,Amano S

    更新日期:2008-08-01 00:00:00

  • Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer.

    abstract:BACKGROUND:Inhibition of Notch by γ-secretase inhibitor (GSI) has been shown to have an antitumor effect in Notch-expressing non-small cell lung cancer (NSCLC) and to induce apoptosis through modulation of Bcl-2 family proteins. In particular, Bim, a BH3-only member of the Bcl-2 family of proteins, has an important rol...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-016-1060-3

    authors: Sakakibara-Konishi J,Ikezawa Y,Oizumi S,Kikuchi J,Kikuchi E,Mizugaki H,Kinoshita I,Dosaka-Akita H,Nishimura M

    更新日期:2017-04-01 00:00:00

  • The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer.

    abstract:BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-019-01551-6

    authors: Yoshida K,Kajiyama H,Yoshihara M,Tamauchi S,Ikeda Y,Yoshikawa N,Nishino K,Niimi K,Suzuki S,Kikkawa F

    更新日期:2020-02-01 00:00:00

  • Risk stratification of survival by lymphovascular invasion, pathological stage, and surgical margin in patients with bladder cancer treated with radical cystectomy.

    abstract:BACKGROUND:The aim of this study was to investigate prognostic factors and develop a prognostic factor-based risk stratification model for disease-specific survival (DSS) in a radical cystectomy (RC) series. METHODS:The patient cohort comprised 194 consecutive patients with bladder cancer treated with RC. Univariate a...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0310-7

    authors: Gondo T,Nakashima J,Ozu C,Ohno Y,Horiguchi Y,Namiki K,Yoshioka K,Ohori M,Hatano T,Tachibana M

    更新日期:2012-10-01 00:00:00

  • Hepatic resection with or without adjuvant iodine-131-lipiodol for hepatocellular carcinoma: a comparative analysis.

    abstract:BACKGROUND:Resection of hepatocellular carcinoma (HCC) is potentially curative; however, recurrence is common. To date, few or no effective adjuvant therapies have been adequately investigated. This study evaluates the efficacy of adjuvant iodine-131-lipiodol after hepatic resection through the experience of a single-c...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0143-9

    authors: Chua TC,Saxena A,Chu F,Butler SP,Quinn RJ,Glenn D,Morris DL

    更新日期:2011-04-01 00:00:00

  • Natural course of asymptomatic abnormal prostate findings incidentally detected by CT after intravesical BCG therapy.

    abstract:BACKGROUND:Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients. METHODS:We identified 38 patients who were evaluated ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-017-1096-z

    authors: Matsushima M,Kikuchi E,Akita H,Miyajima A,Oya M,Jinzaki M

    更新日期:2017-06-01 00:00:00

  • Comparison between cancer specialists and general physicians regarding the education of nurse practitioners in Japan: a postal survey of the Japanese Society of Clinical Oncology.

    abstract:BACKGROUND:Japanese physicians' attitudes regarding the education of nurse practitioners (NPs) are not well described. PARTICIPANTS AND METHODS:A survey was mailed to 1,094 board members of the Japanese Society of Clinical Oncology (JSCO) and the Japanese Primary Care Association (JPCA), and the directors of the clini...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-012-0460-2

    authors: Ishida Y,Hatao M,Fukushima O,Mori M,Isozaki F,Okuyama A

    更新日期:2013-10-01 00:00:00

  • Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001).

    abstract:BACKGROUND:This multi-center, phase III trial assesses the efficacy of daikenchuto (TU-100) on gastrointestinal disorders after hepatic resection (UMIN Registration No. 000003103). MATERIALS AND METHODS:A total of 231 patients, who underwent hepatic resection at 26 Japanese centers, were enrolled. Patients were random...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s10147-014-0678-2

    authors: Shimada M,Morine Y,Nagano H,Hatano E,Kaiho T,Miyazaki M,Kono T,Kamiyama T,Morita S,Sakamoto J,Kusano M,Saji S,Kanematsu T,Kitajima M

    更新日期:2015-02-01 00:00:00

  • Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer.

    abstract:BACKGROUNDS:The presence of ≥5 circulating tumor cells (CTCs) in 7.5 ml blood is a poor prognostic marker in metastatic breast cancer (MBC). However, the role of human epidermal growth factor receptor 2 (HER2) status in CTCs is not known. METHODS:We prospectively assessed the prognostic value of this parameter for pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0260-0

    authors: Hayashi N,Nakamura S,Tokuda Y,Shimoda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NT

    更新日期:2012-04-01 00:00:00

  • Aggressive angiomyxoma mimicking inguinal hernia in a man.

    abstract::We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia. The patient reported a swelling in his left lower abdomen over the past 6 months. Magnetic resonance imaging revealed a left inguinal mass extending from the ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-008-0850-7

    authors: Minagawa T,Matsushita K,Shimada R,Takayama H,Hiraga R,Uehara T,Murata Y

    更新日期:2009-08-01 00:00:00

  • First case of vaginal radical trachelectomy in a pregnant Japanese woman.

    abstract::A diagnosis of cervical cancer during pregnancy poses difficult management and ethical problems. Survival of the patient is the foremost concern, but fetal viability and well-being must also be addressed. Radical trachelectomy (RT) has recently begun to be performed as a possible treatment modality for early stage inv...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0209-3

    authors: Iwami N,Ishioka S,Endo T,Baba T,Nagasawa K,Takahashi M,Sugio A,Takada S,Mariya T,Mizunuma M,Saito T

    更新日期:2011-12-01 00:00:00

  • Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy.

    abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0014-4

    authors: Matsuo K,Enomoto T,Yamasaki M

    更新日期:2010-02-01 00:00:00

  • A phase I/II study of S-1 plus cisplatin in patients with advanced gastric cancer: 2-week S-1 administration regimen.

    abstract:BACKGROUND:The combination of a new oral dihydropyrimidine dehydrogenase-inhibitory fluoropyrimidine (S-1) and cisplatin (CDDP) is one of the most active chemotherapy regimens for gastric cancer. However, the optimum schedule for this combination has not yet been determined. This study was conducted to establish the ma...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-004-0451-z

    authors: Sato Y,Kondo H,Honda K,Takahari D,Sumiyoshi T,Tsuji Y,Yoshizaki N,Niitsu Y

    更新日期:2005-02-01 00:00:00

  • Feasibility study of direct fentanyl patch introduction without prior opioid titration.

    abstract:BACKGROUND:Opioids are key drugs for cancer pain relief, but some patients, especially those who have gastroenterological cancers, suffer from severe opioid-induced bowel dysfunction (OBD), which reduces their quality of life. In order to achieve better pain relief, efforts to minimize OBD are required. METHODS:Betwee...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-008-0829-4

    authors: Matsui T,Kojima T,Kojima H,Iwamoto N,Kure S,Uemura T,Fujimitsu Y,Sakamoto J

    更新日期:2009-06-01 00:00:00

  • Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis.

    abstract:BACKGROUND:We evaluated the relationship between biological behavior and microsatellite instability (MSI) status, with or without p53 status, in sporadic colorectal carcinoma. METHODS:MSI was analyzed with regard to biological features such as cellular proliferation and apoptotic cell death, in addition to clinicopath...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-004-0406-4

    authors: Mori S,Ogata Y,Shirouzu K

    更新日期:2004-08-01 00:00:00

  • Inhibition of TMEM16A suppresses growth and induces apoptosis in hepatocellular carcinoma.

    abstract:BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01653-6

    authors: Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

    更新日期:2020-06-01 00:00:00

  • Phase II study of 5-fluorouracil-leucovorin plus bevacizumab for chemotherapy-naïve older or frail patients with metastatic colorectal cancer (OGSG 0802).

    abstract:BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-020-01656-3

    authors: Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

    更新日期:2020-07-01 00:00:00

  • Relapse patterns of localized non-Hodgkin's lymphoma of the head and neck after clinical remission: results of a strict follow-up procedure.

    abstract:BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head an...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-001-8032-x

    authors: Nakamura K,Sasaki M,Kunitake N,Kimura M,Watanabe T,Sasaki T,Terashima H,Kuwabara Y,Sakai S,Masuda K

    更新日期:2001-12-01 00:00:00

  • Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy.

    abstract::Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-009-0001-9

    authors: Makay O,Kazimi M,Aydin U,Nart D,Yilmaz F,Zeytunlu M,Goker E,Coker A

    更新日期:2010-02-01 00:00:00

  • Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA.

    abstract:BACKGROUND:The clinical impact of monitoring serum p53 antibodies, carbohydrate antigen19-9, and carcinoembryonic antigen in patients with colorectal cancer has not been fully evaluated. METHODS:A total of 420 surgically treated stage II/III colorectal cancer patients were retrospectively analyzed. Among them, 101 pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01597-6

    authors: Ushigome M,Shimada H,Miura Y,Yoshida K,Kaneko T,Koda T,Nagashima Y,Suzuki T,Kagami S,Funahashi K

    更新日期:2020-04-01 00:00:00

  • Is postoperative adjuvant chemoradiotherapy necessary for high-risk oropharyngeal squamous cell carcinoma?

    abstract:BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0532-y

    authors: Yokota T,Onitsuka T,Kusafuka K,Ogawa H,Onozawa Y,Nakagawa M,Iida Y,Kamijo T,Nishimura T,Nakajima T,Boku N,Yasui H

    更新日期:2014-02-01 00:00:00