Abstract:
:A 45-year-old woman with HER2(-)/HER1(-) breast cancer underwent radical mastectomy, followed by radiation and chemotherapy. However, her symptoms progressed rapidly owing to meningitis carcinomatosa and she was fitted with a urethral catheter. She also had difficulty in walking. However, immediately after treatment with lapatinib, her symptoms almost completely disappeared. The catheter was removed and she no longer needed a wheelchair. Unfortunately, after treatment was stopped, the bilateral upper limb skin metastases reappeared, the brain metastases relapsed, and she again experienced symptoms of meningitis carcinomatosa. Lapatinib was restarted, resulting in an immediate improvement in the symptoms and a reduction in the skin and brain metastases. Immunohistochemical staining of the lapatinib-sensitive metastatic skin tumor showed it to be HER2(2+), FISH(-)/HER1(-). This result suggested that the lapatinib-sensitive lesions in the brain and meninges were also HER2-positive. Carcinomatosa meningitis has a very poor prognosis and no effective treatment has yet been developed. Here, we report the first case in which lapatinib has been used to effectively treat meningitis carcinomatosa in HER2(-)/HER1(-) relapsed breast cancer.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Onishi H,Morisaki T,Nakafusa Y,Nakashima Y,Yokohata K,Katano Mdoi
10.1007/s10147-011-0195-5subject
Has Abstractpub_date
2011-12-01 00:00:00pages
718-21issue
6eissn
1341-9625issn
1437-7772journal_volume
16pub_type
杂志文章abstract:BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0532-y
更新日期:2014-02-01 00:00:00
abstract::We report the case of a 68-year-old Japanese man who presented with postrenal azotemia due to bilateral upper ureteral stenosis. The patient's right kidney was nonfunctional; therefore, right nephroureterectomy was performed for the purpose of pathologic diagnosis. Histopathologic examination revealed follicular lymph...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0685-7
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Early tumor shrinkage (ETS) is a response-related endpoint of clinical trials of chemotherapy (CHT) of patients with metastatic colorectal cancer (mCRC). It identifies a dimensional reduction of tumor size by at least 20-30% after 6-8 weeks of CHT. METHODS:A literature search of randomized trials of systemi...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,meta分析
doi:10.1007/s10147-019-01405-1
更新日期:2019-03-01 00:00:00
abstract::We report four patients with pancreatic metastasis of renal cell carcinoma who were successfully treated with radiation therapy. The patients were one woman and three men with a median age of 55 years (range, 49 to 62 years) who underwent radical nephrectomy for primary renal cell carcinoma. The median interval from n...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0833-8
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Neoplastic cardiac tamponade (NCT) is a life-threatening complication of cancer. The interval between cancer diagnosis and NCT onset and the prognosis after pericardiocentesis may differ according to cancer type. METHODS AND RESULTS:We performed a retrospective study of 113 patients (54 % male) with NCT who...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0794-7
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:We retrospectively investigated the efficacy and safety profile of weekly low-dose docetaxel (DTX) with estramustine in comparison with triweekly standard-dose DTX treatment for Japanese patients with castration-resistant prostate cancer (CRPC). METHODS:Between April 2002 and January 2011, 75 CRPC patients ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0536-7
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. METHODS:Data were retrospectively reviewed from ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-018-1307-2
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Hormone receptor status has been one of the most important factors in predicting the response to endocrine therapy in breast cancer patients. However, half of those patients with estrogen receptor-positive tumors do not respond to endocrine therapy. There have been no universal factors for predicting resista...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-006-0601-6
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Irinotecan (CPT-11) and bolus 5-fluorouracil (5-FU)/leucovorin (LV) administered weekly for 4 weeks every 42 days (Saltz regimen) is active but substantially toxic in patients with metastatic colorectal cancer (CRC). The efficacy and toxicity of this regimen, however, have not been determined in Japanese pat...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-003-0371-3
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Recent studies have shown the benefits of neoadjuvant therapy with chemotherapy or chemoradiotherapy for resectable locally advanced thoracic esophageal squamous cell carcinoma (ESCC). The aim of our study was to elucidate the use of neoadjuvant therapy for thoracic ESCC in Japan. METHODS:Data on patients w...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1178-y
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Although several reports have discussed the potential of the indocyanine green (ICG) fluorescence technique, its effectiveness and limitations have not been fully evaluated. For the accurate detection of sentinel lymph node (SLN) in cutaneous melanoma, which can arise in a wide variety of sites throughout th...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0524-y
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify the role of Bcl-2 protein and adrenomedullin (AM) expression in relation to apoptosis in the neoplastic changes of squamous epithelium of the uterine cervix. METHODS:Apoptosis in sections of normal cervical epithelium, cervical intraepithelial neoplasia (CIN), and i...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s101470300015
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:We performed a retrospective study to clarify the outcome of stage IB2-IIB patients with bulky cervical cancer who underwent neoadjuvant chemotherapy (NAC) followed by radical hysterectomy and adjuvant treatment. METHODS:Sixty-five patients with bulky stage IB2-IIB cervical cancer, treated at Tottori Univer...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0559-0
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-009-0016-2
更新日期:2010-02-01 00:00:00
abstract::Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0198-2
更新日期:2011-12-01 00:00:00
abstract::It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-003-0327-7
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS:We began to perform abdominal trachelectomy in 2005. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1059-9
更新日期:2017-04-01 00:00:00
abstract::Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-008-0865-0
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrosp...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1024-7
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the ability of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to detect upper urinary tract urothelial carcinomas (UTUC) compared with pathological examination of tissues obtained by ureteroscopic biopsy and split cytologic analysis of...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0817-4
更新日期:2015-10-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0034-0
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Although regorafenib or trifluridine/tipiracil (FTD/TPI) has been recognized as a later-line standard treatment in patients with metastatic colorectal cancer (mCRC), not all patients have beneficial outcomes. This study aimed to develop a prognostic scoring system for evaluating the overall survival (OS) ben...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
abstract::Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s101470200038
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-019-01418-w
更新日期:2019-07-01 00:00:00
abstract::We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0043-z
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The mechanisms underlying cognitive decline after radiotherapy not directed at brain areas remains unclear. We previously suggested that adjuvant breast radiotherapy in breast conservation therapy could lower memory function soon after therapy, and that the process might be partially mediated by plasma inter...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-018-1330-3
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:It is expected that cell-free and concentrated ascites reinfusion therapy (CART) will relieve the symptoms caused by ascites. To date, however, no report of objective changes in patients' symptoms has been published. We have therefore evaluated symptom management by CART. METHODS:From April 2011 to July 201...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-014-0750-y
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-019-01551-6
更新日期:2020-02-01 00:00:00
abstract::Total gastrectomy and chemotherapy with S-1 after surgery were performed in a 50-year-old woman with gastric cancer associated with acquired immunodeficiency syndrome (AIDS). She was given a diagnosis of gastric cancer at the lesser curvature of the body of the stomach, and distal gastrectomy was performed in December...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0114-1
更新日期:2011-02-01 00:00:00
abstract::We present the case of a 62-year-old Japanese man whose histological diagnosis was adenoendocrine cell carcinoma of the gallbladder at autopsy, but whose antemortem diagnosis was squamous cell carcinoma. The patient was admitted to hospital with complaints of occasional vomiting and abdominal pain. Abdominal computed ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-008-0810-2
更新日期:2009-04-01 00:00:00