Impact of biomarker changes during neoadjuvant chemotherapy for clinical response in patients with residual breast cancers.

abstract：BACKGROUND:Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients. METHODS:We identified 38 patients who were evaluated ...

journal_title：International journal of clinical oncology

authors： Matsushima M,Kikuchi E,Akita H,Miyajima A,Oya M,Jinzaki M

更新日期：2017-06-01 00:00:00

abstract：:Primary sarcoma of the fallopian tube is a very rare neoplasm. We report the case of a 69-year-old woman affected with leiomyosarcoma of the left fallopian tube. Her chief complaint was lower abdominal pain. The preoperative diagnosis was a left adnexal malignant tumor based on pelvic examination, abdominal computed t...

journal_title：International journal of clinical oncology

authors： Ueda T,Emoto M,Fukuoka M,Miyahara D,Horiuchi S,Tsujioka H,Kawarabayashi T

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose large cell neuroendocrine carcinomas (LCNEC) of the lung using small biopsy specimens. Some recent studies attempted to diagnose LCNEC using biopsy specimens; in 2011, the International Association for the Study of Lung Cancer pathological panels suggested possible LCNEC as ...

journal_title：International journal of clinical oncology

authors： Tokito T,Kenmotsu H,Watanabe R,Ito I,Shukuya T,Ono A,Nakamura Y,Tsuya A,Naito T,Murakami H,Takahashi T,Ohde Y,Kondo H,Endo M,Kameya T,Nakajima T,Mori K,Yamamoto N

更新日期：2014-02-01 00:00:00

abstract：:A 38-year-old woman underwent mastectomy and axillary lymph node dissection for invasive ductal carcinoma with multiple lymph node involvement. The patient received adriamycin 60 mg/m(2) and cyclophosphamide 600 mg/m(2) followed by weekly paclitaxel 80 mg/m(2) (without interruption) as adjuvant treatment. After receiv...

journal_title：International journal of clinical oncology

authors： Hikino H,Kawashima M,Yamada T,Ozaki N

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The standard of care for treatment of localized muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC). The patient's condition may affect management of MIBC, especially for elderly patients with more comorbid conditions and lower performance status. We retrospectively evaluated the association bet...

journal_title：International journal of clinical oncology

authors： Hara T,Matsuyama H,Kamiryo Y,Hayashida S,Yamamoto N,Nasu T,Joko K,Baba Y,Suga A,Yamamoto M,Aoki A,Takai K,Yoshihiro S,Konishi M,Sakano S,Imoto K,Tei Y,Yamaguchi S,Yano S,Yamaguchi Uro-Onocology Group.

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Because there are few exchanges of doctors and surgical techniques among leading Japanese hospitals, neck dissections in Japan have become so highly diverse that the uniformity and comparability of nonradical neck dissections have become questionable. METHODS:The Japan Neck Dissection Study Group (JNDSG) wa...

journal_title：International journal of clinical oncology

authors： Saikawa M,Kishimoto S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were correlated with favorable clinical outcome in patients with melanoma. However, in metastatic renal cell carcinoma (mRCC) patients, there have been few reports about the correlation between ...

journal_title：International journal of clinical oncology

authors： Kato T,Nagahara A,Kawamura N,Nakata W,Soda T,Matsuzaki K,Hatano K,Kawashima A,Ujike T,Imamura R,Nishimura K,Takada S,Tsujihata M,Yamaguchi S,Takao T,Nishimura K,Nonomura N,Uemura M

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Hypofractionated proton therapy (HFPT) is expected to become an effective treatment approach for localized prostate cancer (PCa). The purpose of this study was to evaluate differences in acute toxicity among patients with localized PCa treated with either conventional fractionated proton therapy (CFPT) or HF...

journal_title：International journal of clinical oncology

authors： Nakajima K,Iwata H,Ogino H,Hattori Y,Hashimoto S,Nakanishi M,Toshito T,Umemoto Y,Iwatsuki S,Shibamoto Y,Mizoe JE

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our ins...

journal_title：International journal of clinical oncology

authors： Yamamoto Y,Kanzaki R,Kanou T,Ose N,Funaki S,Shintani Y,Minami M,Outani H,Takenaka S,Hamada K,Yoshikawa H,Okumura M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Irinotecan (CPT-11) and bolus 5-fluorouracil (5-FU)/leucovorin (LV) administered weekly for 4 weeks every 42 days (Saltz regimen) is active but substantially toxic in patients with metastatic colorectal cancer (CRC). The efficacy and toxicity of this regimen, however, have not been determined in Japanese pat...

journal_title：International journal of clinical oncology

authors： Fujishima H,Kikuchi I,Miyanaga O,Ueda A,Baba E,Mitsugi K,Harada M,Nakano S

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:We conducted a phase I dose escalation study to determine the maximum tolerated dose (MTD), the recommended dose (RD) and the safety profile of amrubicin (AMR) plus paclitaxel (PTX) combination regimen for patients with previously treated non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:PTX was admi...

journal_title：International journal of clinical oncology

authors： Kaira K,Sunaga N,Imai H,Kamide Y,Koga Y,Ono A,Kuwako T,Masuda T,Hisada T,Ishizuka T,Yamada M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Immune responses in the uterine cervix are considered to play an important role in persistent human papillomavirus (HPV) infection and carcinogenesis, but many aspects of the mechanism are still unclear. The goal of this study was to measure cytokines to analyze immune responses in patients with cervical int...

journal_title：International journal of clinical oncology

authors： Iwata T,Fujii T,Morii K,Saito M,Sugiyama J,Nishio H,Morisada T,Tanaka K,Yaguchi T,Kawakami Y,Aoki D

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Neoplastic cardiac tamponade (NCT) is a life-threatening complication of cancer. The interval between cancer diagnosis and NCT onset and the prognosis after pericardiocentesis may differ according to cancer type. METHODS AND RESULTS:We performed a retrospective study of 113 patients (54 % male) with NCT who...

journal_title：International journal of clinical oncology

authors： Takayama T,Okura Y,Okada Y,Honma K,Nashimoto A,Sato N,Yokoyama A,Minamino T

更新日期：2015-10-01 00:00:00

abstract：:We report the case of a 62-year-old man with advanced gastric cancer and multiple liver metastases who was successfully treated with combined chemotherapy including S-1. The patient was clinically diagnosed with stage IV (T3 N2 H1 P0) disease and was initially treated with 100 mg/body per day S-1 administered orally f...

journal_title：International journal of clinical oncology

authors： Nakamura R,Saikawa Y,Kumagai K,Kiyota T,Ohashi M,Yoshida M,Kubota T,Kumai K,Kitajima M

更新日期：2007-08-01 00:00:00

abstract：:Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...

journal_title：International journal of clinical oncology

authors： Lønning PE

更新日期：2002-08-01 00:00:00

abstract：:A 32-year-old Japanese woman was diagnosed as having stage Ib1 adenocarcinoma by diagnostic laser conization at a local hospital. She was admitted to our hospital for fertility-sparing treatment. A radical trachelectomy (RT) was performed using the laparoscopic vaginal procedure. The procedure was started with a lapar...

journal_title：International journal of clinical oncology

authors： Ishioka S,Endo T,Hayashi T,Kitajima Y,Sugimura M,Sagae S,Saito T

更新日期：2006-04-01 00:00:00

abstract：:Specific allelic losses in the DNA of tumor cells are potential indicators of postoperative prognosis. Patients whose tumors showed allelic losses at 1p34, 3p25, 8p22, 13q12, 17p13.3, or 17q21.1 had a significantly higher risk of postoperative mortality than women whose tumors retained both alleles at those loci (the ...

journal_title：International journal of clinical oncology

authors： Hirano A,Utada Y,Haga S,Kajiwara T,Sakamoto G,Kasumi F,Nakamura Y,Emi M

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:To analyze the impact of sunitinib treatment on health-related quality of life (HRQOL) in Japanese patients with metastatic renal cell carcinoma (mRCC). METHODS:This study prospectively included 90 consecutive patients with mRCC treated with sunitinib for at least 3 months. HRQOL in these patients was asses...

journal_title：International journal of clinical oncology

authors： Miyake H,Harada K,Kusuda Y,Fujisawa M

更新日期：2013-04-01 00:00:00

abstract：:Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...

journal_title：International journal of clinical oncology

authors： Kasper B,Ho AD,Egerer G

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the efficacy and safety of low-dose chemotherapy with methotrexate (MTX) and vinblastine (VBL) for patients with desmoid tumors refractory to meloxicam treatment, focusing in particular on the relationship between the efficacy of this chemotherapy and catenin β-1 (CTNNB1...

journal_title：International journal of clinical oncology

authors： Nishida Y,Tsukushi S,Urakawa H,Hamada S,Kozawa E,Ikuta K,Ando Y,Ishiguro N

更新日期：2015-12-01 00:00:00

abstract：:Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...

journal_title：International journal of clinical oncology

authors： Hatoum HA,Abi Saad GS,Otrock ZK,Barada KA,Shamseddine AI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarker...

journal_title：International journal of clinical oncology

authors： Ruggiero A,De Rosa G,Rizzo D,Leo A,Maurizi P,De Nisco A,Vendittelli F,Zuppi C,Mordente A,Riccardi R

更新日期：2013-10-01 00:00:00

abstract：:The fourth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer was published in 2015. The guidelines contain seven chapters and six flow charts. The major changes in this new edition are as follows-(1) the for...

journal_title：International journal of clinical oncology

authors： Komiyama S,Katabuchi H,Mikami M,Nagase S,Okamoto A,Ito K,Morishige K,Suzuki N,Kaneuchi M,Yaegashi N,Udagawa Y,Yoshikawa H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

journal_title：International journal of clinical oncology

authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

更新日期：2018-10-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, we found that GISTs expressed KIT, a receptor tyrosine kinase encoded by the protooncogene c-kit. We propose that GISTs may originate from interstitial cells of Cajal (ICCs), which are considered to ...

journal_title：International journal of clinical oncology

authors： Hirota S

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for urothelial carcinoma of the upper urinary tract (UCUUT) is common. One of the mechanisms driving this is the implantation of cancer cells from the UCUUT at the RNUs. Therefore, their detection after RNU can assist in predicting IVR. Thi...

journal_title：International journal of clinical oncology

authors： Iwata H,Sassa N,Kato M,Murase Y,Seko S,Kawanishi H,Hattori R,Gotoh M,Tsuzuki T

更新日期：2021-01-01 00:00:00

abstract：:The application of prostate-specific antigen (PSA) in prostate cancer (PC) screening, diagnosis, and prognosis has improved the clinical management of PC patients. However, the PSA assay has been faced with criticism due to its potential association with over-diagnosis and subsequent overtreatment of patients with ind...

journal_title：International journal of clinical oncology

authors： Hatakeyama S,Yoneyama T,Tobisawa Y,Ohyama C

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

journal_title：International journal of clinical oncology

authors： Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Older or frail patients are often underrepresented in clinical trials for metastatic colorectal cancer (mCRC). We here assessed the efficacy and safety of 5-fluorouracil (5-FU)-leucovorin plus bevacizumab in such patients. METHODS:The study (OGSG 0802) was designed as a single-arm, open-label, multicenter p...

journal_title：International journal of clinical oncology

authors： Ohta T,Kato T,Kawakami H,Miyake Y,Goto M,Iwamoto S,Otsuji T,Nakamura M,Sugimoto N,Okamura S,Kotaka M,Tsujie M,Tokunaga Y,Mishima H,Hata T,Shimokawa T,Kurokawa Y,Satoh T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high rate of nodal metastasis. Sentinel lymph node biopsy (SLNB) is used in MCC and other cancers to identify regional node micrometastases in patients with clinically negative nodes; however, whether SLN status is associated with recurrence o...

journal_title：International journal of clinical oncology

authors： Shibayama Y,Imafuku S,Takahashi A,Nakayama J

更新日期：2015-02-01 00:00:00