Cytokine profile in cervical mucosa of Japanese patients with cervical intraepithelial neoplasia.


BACKGROUND:Immune responses in the uterine cervix are considered to play an important role in persistent human papillomavirus (HPV) infection and carcinogenesis, but many aspects of the mechanism are still unclear. The goal of this study was to measure cytokines to analyze immune responses in patients with cervical intraepithelial neoplasia (CIN). MATERIALS AND METHODS:The levels of 17 cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, INF-γ, MCP-1, MIP-1β, and TNFα) in cervical mucus were simultaneously measured using a multiplex immunoassay in 52 high-grade squamous intraepithelial lesion (HSIL) cases and overproduction of IL-1β, IL-8, and MIP-1β was identified. The levels of these 3 cytokines were measured in 130 patients with or without CIN lesions using enzyme-linked immunosorbent assay. The associations of the cytokine levels with the cytology, infecting HPV type, and status of cigarette smoking were investigated. RESULTS:IL-1β and IL-8 levels were associated with the cytology, and these levels were higher in HSIL cases than in NILM (negative for intraepithelial lesion and malignancy) and LSIL (low-grade squamous intraepithelial lesion) cases (P = 0.005, P = 0.001, respectively). The MIP-1β level was significantly lower in smokers (P = 0.018) and high-risk (HR)-HPV-infected patients (P = 0.021). CONCLUSIONS:Enhanced expression of IL-1β and IL-8 indicates that Th2 inflammatory responses become stronger in the local uterine cervical region with the progression of CIN lesions, and a decrease in the MIP-1β level may be advantageous for immunoescape of HPV. Cigarette smoking may further facilitate persistent HPV infection.


Int J Clin Oncol


Iwata T,Fujii T,Morii K,Saito M,Sugiyama J,Nishio H,Morisada T,Tanaka K,Yaguchi T,Kawakami Y,Aoki D




Has Abstract


2015-02-01 00:00:00












  • Opioid-induced constipation in patients with cancer pain in Japan (OIC-J study): a post hoc subgroup analysis of patients with gastrointestinal cancer.

    abstract:BACKGROUND:Constipation is a common side effect of opioid therapy. An observational study of opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 patients with various tumor types. This post hoc analysis of OIC-J evaluated a subgroup of patients with gastrointestinal (GI) cancer. MET...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Harada T,Imai H,Fumita S,Noriyuki T,Gamoh M,Okamoto M,Akashi Y,Kizawa Y,Tokoro A

    更新日期:2021-01-01 00:00:00

  • Debulking metastatic pelvic nodes before radiotherapy in cervical cancer patients: a long-term follow-up result.

    abstract:BACKGROUND:Enlarged pelvic nodes are commonly found during preoperative imaging studies in cervical cancer patients and may represent tumor metastasis. It remains controversial whether debulking of these enlarged nodes prior to definitive radiotherapy offers any survival benefit to the patient. METHODS:Enlarged suspic...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Cheung TH,Lo KW,Yim SF,Yau SH,Yu MM,Yeung WK

    更新日期:2011-10-01 00:00:00

  • Loss of ARID1A expression is associated with poor prognosis in patients with stage I/II clear cell carcinoma of the ovary.

    abstract:BACKGROUND:Recent studies have shown that somatic mutations in the AT-rich interactive domain 1A (SWI-like) gene (ARID1A) are the most common genetic changes in clear cell carcinoma of the ovary (CCC). A gene mutation of ARID1A was found in approximately half of CCC cases, and led to absence of the encoded protein and ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Itamochi H,Oumi N,Oishi T,Shoji T,Fujiwara H,Sugiyama T,Suzuki M,Kigawa J,Harada T

    更新日期:2015-10-01 00:00:00

  • Preplanned safety analysis of the JFMC37-0801 trial: a randomized phase III study of six months versus twelve months of capecitabine as adjuvant chemotherapy for stage III colon cancer.

    abstract:BACKGROUND:Six months of adjuvant chemotherapy is regarded as the standard of care for patients with stage III colon cancer. However, whether longer treatment can improve prognosis has not been fully investigated. We conducted a phase III study comparing 6 and 12 months of adjuvant capecitabine chemotherapy for stage I...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Suto T,Ishiguro M,Hamada C,Kunieda K,Masuko H,Kondo K,Ishida H,Nishimura G,Sasaki K,Morita T,Hazama S,Maeda K,Mishima H,Ike H,Sadahiro S,Sugihara K,Okajima M,Saji S,Sakamoto J,Tomita N

    更新日期:2017-06-01 00:00:00

  • Natural course of asymptomatic abnormal prostate findings incidentally detected by CT after intravesical BCG therapy.

    abstract:BACKGROUND:Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients. METHODS:We identified 38 patients who were evaluated ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Matsushima M,Kikuchi E,Akita H,Miyajima A,Oya M,Jinzaki M

    更新日期:2017-06-01 00:00:00

  • Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer.

    abstract:BACKGROUND:In treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN), the use of docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by high-dose cisplatin chemoradiotherapy (CRT) carries concerns over toxicity. We evaluated the feasibility of TPF as induction chemotherapy (IC) to Japane...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章


    authors: Okano S,Enokida T,Onoe T,Ota Y,Motegi A,Zenda S,Akimoto T,Tahara M

    更新日期:2019-07-01 00:00:00

  • Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis.

    abstract:BACKGROUND:Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated m...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,meta分析


    authors: Feng M,Zhu J,Liang L,Zeng N,Wu Y,Wan C,Shen Y,Wen F

    更新日期:2017-04-01 00:00:00

  • Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer.

    abstract:BACKGROUNDS:The presence of ≥5 circulating tumor cells (CTCs) in 7.5 ml blood is a poor prognostic marker in metastatic breast cancer (MBC). However, the role of human epidermal growth factor receptor 2 (HER2) status in CTCs is not known. METHODS:We prospectively assessed the prognostic value of this parameter for pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Hayashi N,Nakamura S,Tokuda Y,Shimoda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NT

    更新日期:2012-04-01 00:00:00

  • Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer.

    abstract:BACKGROUND:Cancer patients are at high risk of developing a second cancer after the treatment of initial cancers. Understanding the characteristics of multiple primary cancer is important to establish an effective surveillance program for the early detection of second cancers. METHODS:We analyzed the cancer registry r...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Ueno M,Muto T,Oya M,Ota H,Azekura K,Yamaguchi T

    更新日期:2003-06-01 00:00:00

  • No significant impact of response to prior androgen receptor-axis-targeted agents on the efficacy of subsequent docetaxel in patients with metastatic castration-resistant prostate cancer.

    abstract:BACKGROUND:To investigate whether the response to an androgen receptor-axis-targeted (ARAT) agent is associated with the efficacy of subsequent docetaxel in metastatic castration-resistant prostate cancer (mCRPC) patients. METHODS:This study included 114 consecutive mCRPC patients, comprising 54 and 60 patients who pr...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章


    authors: Miyake H,Matsushita Y,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

    更新日期:2018-06-01 00:00:00

  • Phase I studies of nogitecan hydrochloride for Japanese.

    abstract:BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kobayashi K,Hino M,Fukuoka M,Takeuchi K,Furuse K,Yoneda S,Hasegawa K,Noda K,Kinoshita H,Kimura I,Taguchi T,Kanamaru R,Horikoshi N,Niitani H

    更新日期:2002-06-01 00:00:00

  • Overall survival and prognostic factors in patients with spinal metastases from lung cancer treated with and without epidermal growth factor receptor tyrosine kinase inhibitors.

    abstract:BACKGROUND:Evaluation of the prognosis in patients with spinal metastases is important in decision making regarding surgical treatment. The purpose of this study was to investigate overall survival in patients with spinal metastases from lung cancer by histological subtype, and to investigate prognostic factors in pati...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Dohzono S,Sasaoka R,Takamatsu K,Nakamura H

    更新日期:2017-08-01 00:00:00

  • Chemotherapy for patients with unresectable or metastatic small bowel adenocarcinoma: a systematic review.

    abstract:BACKGROUND:There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA. METHODS:In accordance with the PRISMA statements,...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Nishikawa Y,Hoshino N,Horimatsu T,Funakoshi T,Hida K,Sakai Y,Muto M,Nakayama T

    更新日期:2020-08-01 00:00:00

  • Use of preoperative performance status and hemoglobin concentration to predict overall survival for patients aged ≥ 75 years after radical cystectomy for treatment of bladder cancer.

    abstract:BACKGROUND:The standard of care for treatment of localized muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC). The patient's condition may affect management of MIBC, especially for elderly patients with more comorbid conditions and lower performance status. We retrospectively evaluated the association bet...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Hara T,Matsuyama H,Kamiryo Y,Hayashida S,Yamamoto N,Nasu T,Joko K,Baba Y,Suga A,Yamamoto M,Aoki A,Takai K,Yoshihiro S,Konishi M,Sakano S,Imoto K,Tei Y,Yamaguchi S,Yano S,Yamaguchi Uro-Onocology Group.

    更新日期:2016-02-01 00:00:00

  • Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: a retrospective study.

    abstract:BACKGROUND:Alternative anti-androgen therapy (AAT) with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. However, no studies have compared enzalutamide without AAT with enzalutamide after AAT with flutamide as treatment for castration-resistant prostat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Iguchi T,Tamada S,Kato M,Yasuda S,Otoshi T,Hamada K,Yamasaki T,Nakatani T

    更新日期:2019-07-01 00:00:00

  • Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria.

    abstract:BACKGROUND:Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Imura S,Teraoku H,Yoshikawa M,Ishikawa D,Yamada S,Saito Y,Iwahashi S,Ikemoto T,Morine Y,Shimada M

    更新日期:2018-02-01 00:00:00

  • Phase II study of carboplatin and gemcitabine as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: a report from the Central Japan Lung Study Group, CJLSG 0503 trial.

    abstract:BACKGROUND:The aim of this phase II study was to evaluate the feasibility and safety of a carboplatin and gemcitabine combination regimen in the treatment of completely resected non-small cell lung cancer (NSCLC). METHODS:Patients with completely resected pathologically documented stage IB, II or IIIA NSCLC were treat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Usami N,Yokoi K,Hasegawa Y,Taniguchi H,Shindo J,Yamamoto M,Suzuki R,Imaizumi K,Kondo M,Shimokata K,Central Japan Lung Study Group.

    更新日期:2010-12-01 00:00:00

  • Value of free-to-total prostate-specific antigen ratio for detection and staging of prostate cancer.

    abstract::Background. We aimed to evaluate the clinical usefulness of measurement of the free-to-total (F/T) ratio of prostate-specific antigen (PSA) for the differentiation of prostate cancer from benign prostate hyperplasia (BPH) and for the staging of prostate cancer. Values for PSA density (PSAD) and PSAD adjusted to the tr...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Furuya Y,Akakura K,Ito H

    更新日期:2000-02-01 00:00:00

  • Hepatic resection with or without adjuvant iodine-131-lipiodol for hepatocellular carcinoma: a comparative analysis.

    abstract:BACKGROUND:Resection of hepatocellular carcinoma (HCC) is potentially curative; however, recurrence is common. To date, few or no effective adjuvant therapies have been adequately investigated. This study evaluates the efficacy of adjuvant iodine-131-lipiodol after hepatic resection through the experience of a single-c...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Chua TC,Saxena A,Chu F,Butler SP,Quinn RJ,Glenn D,Morris DL

    更新日期:2011-04-01 00:00:00

  • Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma.

    abstract:BACKGROUND:The purpose of this study was to identify the role of Bcl-2 protein and adrenomedullin (AM) expression in relation to apoptosis in the neoplastic changes of squamous epithelium of the uterine cervix. METHODS:Apoptosis in sections of normal cervical epithelium, cervical intraepithelial neoplasia (CIN), and i...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Li Z,Takeuchi S,Ohara N,Maruo T

    更新日期:2003-04-01 00:00:00

  • Quality of life after neck dissection: a multicenter longitudinal study by the Japanese Clinical Study Group on Standardization of Treatment for Lymph Node Metastasis of Head and Neck Cancer.

    abstract:BACKGROUND:We performed a multicenter longitudinal study using our neck dissection questionnaire (NDQ) and arm abduction test (AAT) to assess the impact of rehabilitation and surgical modification on postoperative quality of life (QOL). METHODS:Patients who had undergone neck dissection for the treatment of head and n...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Nibu K,Ebihara Y,Ebihara M,Kawabata K,Onitsuka T,Fujii T,Saikawa M

    更新日期:2010-02-01 00:00:00

  • Popliteal pseudoaneurysm simulating soft-tissue sarcoma: complication of osteochondroma resection.

    abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Otsuka T,Yonezawa M,Kamiyama F,Matusita Y,Matui N

    更新日期:2001-04-01 00:00:00

  • Granulocytic sarcoma: an unusual cause of spinal cord compression.

    abstract::A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Balleari E,Panarello S,Capello E,Grosso M,Passalia C,Pitto P,Raggi F,Roccatagliata L,Cabiddu F,Ghio R

    更新日期:2007-06-01 00:00:00

  • Sentinel lymph node biopsy after neoadjuvant chemotherapy predicts pathological axillary lymph node status in breast cancer patients with clinically positive axillary lymph nodes at presentation.

    abstract:BACKGROUND:It is still controversial whether axillary lymph node (ALN) dissection (ALND) can be omitted after negative sentinel lymph node (SLN) biopsy (SLNB) in breast cancer (BC) patients with clinically positive ALNs at presentation treated with neoadjuvant chemotherapy (NAC). The study aim was to analyze whether SL...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Takei H,Yoshida T,Kurosumi M,Inoue K,Matsumoto H,Hayashi Y,Higuchi T,Uchida S,Ninomiya J,Kubo K,Oba H,Nagai S,Tabei T

    更新日期:2013-06-01 00:00:00

  • Knowledge base toward understanding actionable alterations and realizing precision oncology.

    abstract::In Japan, the National Cancer Center and university hospitals have initiated next-generation sequencing-based in vitro diagnostic testing for cancer patients as a method of clinical sequencing. Based on the molecular alterations detected, physicians can provide approved targeted therapy and access to investigational d...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Takeuchi S,Okuda S

    更新日期:2019-02-01 00:00:00

  • Three-year follow-up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases.

    abstract:BACKGROUND:Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC. METHODS:Patients with symptomatic m...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Uemura H,Uemura H,Nagamori S,Wakumoto Y,Kimura G,Kikukawa H,Yokomizo A,Mizokami A,Kosaka T,Masumori N,Kawasaki Y,Yonese J,Nasu Y,Fukasawa S,Sugiyama T,Kinuya S,Hosono M,Yamaguchi I,Akagawa T,Matsubara N

    更新日期:2019-05-01 00:00:00

  • A phase I/II study of S-1 plus cisplatin in patients with advanced gastric cancer: 2-week S-1 administration regimen.

    abstract:BACKGROUND:The combination of a new oral dihydropyrimidine dehydrogenase-inhibitory fluoropyrimidine (S-1) and cisplatin (CDDP) is one of the most active chemotherapy regimens for gastric cancer. However, the optimum schedule for this combination has not yet been determined. This study was conducted to establish the ma...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章


    authors: Sato Y,Kondo H,Honda K,Takahari D,Sumiyoshi T,Tsuji Y,Yoshizaki N,Niitsu Y

    更新日期:2005-02-01 00:00:00

  • Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance.

    abstract:OBJECTIVE:The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC). METHODS:MVD was evaluated in tumors (n = 50) from patients with EOC who...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Krishna Priya S,Kumar K,Hiran KR,Bindhu MR,Nagare RP,Vijaykumar DK,Ganesan TS

    更新日期:2017-02-01 00:00:00

  • Evaluation of the efficacy of palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin.

    abstract:PURPOSE:The purpose of our study was to evaluate the efficacy of a new combination antiemetic therapy consisting of palonosetron, aprepitant, and dexamethasone in gastric cancer patients undergoing chemotherapy with S-1 plus cisplatin. METHODS:This prospective, multi-institutional observational study assessed patient-...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Oyama K,Fushida S,Kaji M,Takeda T,Yabushita K,Nezuka H,Kinami S,Kadoya N,Takai Y,Tsukioka Y,Ohyama S,Tsuji K,Tsukada T,Kinoshita J,Fujimura T,Ohta T

    更新日期:2016-06-01 00:00:00

  • The safety and efficacy of cisplatin plus gemcitabine in recurrent ovarian cancer.

    abstract:BACKGROUND:The activity and synergy for the combination treatment of cisplatin and gemcitabine has been identified in a variety of human tumor cells, including ovarian cancer cells, and has been widely approved for the treatment of non-small cell lung cancer, pancreatic cancer and biliary tract cancer. As the gastroint...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章


    authors: Tomita Y,Saito T,Okadome M,Eto T,Ariyoshi K,Shimamoto K

    更新日期:2014-08-01 00:00:00