Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma.

abstract：BACKGROUND:Irinotecan (CPT-11) and bolus 5-fluorouracil (5-FU)/leucovorin (LV) administered weekly for 4 weeks every 42 days (Saltz regimen) is active but substantially toxic in patients with metastatic colorectal cancer (CRC). The efficacy and toxicity of this regimen, however, have not been determined in Japanese pat...

journal_title：International journal of clinical oncology

authors： Fujishima H,Kikuchi I,Miyanaga O,Ueda A,Baba E,Mitsugi K,Harada M,Nakano S

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:We evaluated the relationship between biological behavior and microsatellite instability (MSI) status, with or without p53 status, in sporadic colorectal carcinoma. METHODS:MSI was analyzed with regard to biological features such as cellular proliferation and apoptotic cell death, in addition to clinicopath...

journal_title：International journal of clinical oncology

authors： Mori S,Ogata Y,Shirouzu K

更新日期：2004-08-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, suni...

journal_title：International journal of clinical oncology

authors： Miyake H,Haraguchi T,Takenaka A,Fujisawa M

更新日期：2011-04-01 00:00:00

abstract：:Specific allelic losses in the DNA of tumor cells are potential indicators of postoperative prognosis. Patients whose tumors showed allelic losses at 1p34, 3p25, 8p22, 13q12, 17p13.3, or 17q21.1 had a significantly higher risk of postoperative mortality than women whose tumors retained both alleles at those loci (the ...

journal_title：International journal of clinical oncology

authors： Hirano A,Utada Y,Haga S,Kajiwara T,Sakamoto G,Kasumi F,Nakamura Y,Emi M

更新日期：2001-02-01 00:00:00

abstract：:The identification and validation of putative surrogate endpoints in oncology is a great challenge to medical investigators, statisticians, and regulators. A putative surrogate endpoint must be validated at both individual-level and trial-level before it can be used to replace the clinical endpoint in a future clinica...

journal_title：International journal of clinical oncology

authors： Shi Q,Sargent DJ

更新日期：2009-04-01 00:00:00

abstract：:5-Fluorouracil (5-FU) has been the most widely accepted and studied chemotherapeutic agent, and many combination chemotherapeutic regimens have been reported. However, until recently, a standard regimen for metastatic gastric cancer had not been established. The combination of S-1 and cisplatin is a good candidate as ...

journal_title：International journal of clinical oncology

authors： Yoshida K,Yamaguchi K,Osada S,Kawaguchi Y,Takahashi T,Sakashita F,Tanaka Y

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Malignant change in fibrous dysplasia (FD) is very rare. This study was carried out to establish some characteristic clinical information about this disorder. METHODS:Four cases with a malignant change in FD out of 128 cases with FD were surgically treated and followed up for a median period of 61.3 months....

journal_title：International journal of clinical oncology

authors： Hoshi M,Matsumoto S,Manabe J,Tanizawa T,Shigemitsu T,Izawa N,Takeuchi K,Kawaguchi N

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:We conducted a multiinstitutional analysis to clarify the clinical significance of perioperative chemotherapy, in invasive bladder cancers in Japan, and to identify the patient subpopulations who could benefit from perioperative chemotherapy. METHODS:A total of 913 consecutive patients aged less than 80 yea...

journal_title：International journal of clinical oncology

authors： Matsui Y,Nishiyama H,Watanabe J,Teramukai S,Ono Y,Ohshima S,Fujimoto K,Hirao Y,Fukushima M,Ogawa O

更新日期：2005-04-01 00:00:00

abstract：:We report two cases of the plasmacytoid variant of urothelial carcinoma of urinary bladder in which systemic chemotherapy was effective. In the first case, a 76-year-old man presented with dysphasia. Magnetic resonance imaging (MRI) and computed tomography revealed a brain tumor and a bladder tumor. Resection of the b...

journal_title：International journal of clinical oncology

authors： Hayashi T,Tanigawa G,Fujita K,Imamura R,Nakazawa S,Yamamoto Y,Hosomi M,Shimazu K,Fushimi H,Yamaguchi S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Cyclin E and p27 play pivotal roles in cancer development and progression. We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. METHODS:Tumors from ...

journal_title：International journal of clinical oncology

authors： Takahashi S,Kamata Y,Tamo W,Koyanagi M,Hatanaka R,Yamada Y,Tsushima T,Takaya S,Fukuda I

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Constipation is a common side effect of opioid therapy. An observational study of opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 patients with various tumor types. This post hoc analysis of OIC-J evaluated a subgroup of patients with gastrointestinal (GI) cancer. MET...

journal_title：International journal of clinical oncology

authors： Harada T,Imai H,Fumita S,Noriyuki T,Gamoh M,Okamoto M,Akashi Y,Kizawa Y,Tokoro A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:UFT is composed of tegafur, a prodrug of 5-fluorouracil, and uracil, at a fixed ratio of 1: 4. UFT is widely used with leucovorin as adjuvant chemotherapy in patients with colon cancer. As reported, UFT/leucovorin should not be taken simultaneously with food because a high fat content will reduce the systemi...

journal_title：International journal of clinical oncology

authors： Furuhata T,Meguro M,Nishidate T,Okita K,Ishiyama G,Iwayama Y,Hosokawa Y,Tsuruma T,Kimura Y,Mizuguchi T,Sasaki K

更新日期：2009-12-01 00:00:00

abstract：:In Japan, the National Cancer Center and university hospitals have initiated next-generation sequencing-based in vitro diagnostic testing for cancer patients as a method of clinical sequencing. Based on the molecular alterations detected, physicians can provide approved targeted therapy and access to investigational d...

journal_title：International journal of clinical oncology

authors： Takeuchi S,Okuda S

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS:We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopat...

journal_title：International journal of clinical oncology

authors： Harano K,Hirakawa A,Yunokawa M,Nakamura T,Satoh T,Nishikawa T,Aoki D,Ito K,Ito K,Nakanishi T,Susumu N,Takehara K,Watanabe Y,Watari H,Saito T

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for urothelial carcinoma of the upper urinary tract (UCUUT) is common. One of the mechanisms driving this is the implantation of cancer cells from the UCUUT at the RNUs. Therefore, their detection after RNU can assist in predicting IVR. Thi...

journal_title：International journal of clinical oncology

authors： Iwata H,Sassa N,Kato M,Murase Y,Seko S,Kawanishi H,Hattori R,Gotoh M,Tsuzuki T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Compared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients wi...

journal_title：International journal of clinical oncology

authors： Miyawaki Y,Sato H,Fujiwara N,Oya S,Sugita H,Hirano Y,Yamane T,Sakuramoto S,Okamoto K,Yamaguchi S,Koyama I

更新日期：2020-04-01 00:00:00

abstract：:We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A...

journal_title：International journal of clinical oncology

authors： Sato S,Koike T,Yamato Y,Yoshiya K,Motono N,Takeshige M,Homma K,Koizumi N,Yokoyama A,Tsukada H

更新日期：2010-06-01 00:00:00

abstract：:Liver surgery has been known to cure metastatic colorectal cancer in a small proportion of patients. However, advances in procedural technique and chemotherapy now allow more patients to have safe, potentially curative surgery. Here we review surgery for unresectable colorectal liver metastases using an expert multidi...

journal_title：International journal of clinical oncology

authors： Tanaka K,Ichikawa Y,Endo I

更新日期：2011-10-01 00:00:00

abstract：:Standard definitive radiotherapy for cervical cancer consists of whole pelvic external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). In Japan, high-dose-rate ICBT (HDR-ICBT) has been utilized in clinical practice for more than 40 years. Several randomized clinical trials demonstrated that HDR-ICBT a...

journal_title：International journal of clinical oncology

authors： Toita T

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate whether class III β-tubulin (TUBB3) expression could predict progression-free survival or overall survival in relapsed non-small cell lung cancer (NSCLC) patients treated with taxene-based chemotherapy. METHODS:Immunohistochemistal staining was used to examine the expres...

journal_title：International journal of clinical oncology

authors： Kaira K,Takahashi T,Murakami H,Shukuya T,Kenmotsu H,Ono A,Naito T,Tsuya A,Nakamura Y,Endo M,Kondo H,Nakajima T,Yamamoto N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The correlation between treatment-related factors and lung toxicity has not been sufficiently evaluated in salvage radiotherapy. METHODS:Twenty-one patients with recurrent non-small-cell lung cancer (NSCLC) after lobectomy received salvage radiotherapy to a total dose of 46-60 Gy. The effects of radiotherap...

journal_title：International journal of clinical oncology

authors： Uno T,Isobe K,Kawakami H,Ueno N,Kawata T,Yamamoto S,Sekine Y,Iyoda A,Iizasa T,Fujisawa T,Shigematsu N,Ito H

更新日期：2006-02-01 00:00:00

abstract：:The two main malignant hepatic tumors in children are hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). The past two decades have brought significant improvement to the outcomes of children diagnosed with malignant hepatic tumors, especially HBL, due to improvements in diagnosis and treatment. Histological ...

journal_title：International journal of clinical oncology

authors： Hiyama E

更新日期：2013-12-01 00:00:00

abstract：:Distant metastasis from colorectal carcinoma most often occurs in the liver and lungs. Metastasis to bones, adrenals, lymph nodes, brain, and skin has also been reported. Metastatic colorectal carcinoma to the testes is very uncommon. Even more uncommon is testicular metastasis from rectal carcinoma. Researchers throu...

journal_title：International journal of clinical oncology

authors： Hatoum HA,Abi Saad GS,Otrock ZK,Barada KA,Shamseddine AI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The activity and synergy for the combination treatment of cisplatin and gemcitabine has been identified in a variety of human tumor cells, including ovarian cancer cells, and has been widely approved for the treatment of non-small cell lung cancer, pancreatic cancer and biliary tract cancer. As the gastroint...

journal_title：International journal of clinical oncology

authors： Tomita Y,Saito T,Okadome M,Eto T,Ariyoshi K,Shimamoto K

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...

journal_title：International journal of clinical oncology

authors： Matsuo K,Enomoto T,Yamasaki M

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and toxicity of third-line gemcitabine monotherapy (Gem) in patients with platinum-resistant advanced urothelial cancer (UC). PATIENTS AND METHODS:From July 2005 to March 2009, 13 patients were enrolled. All patients had previously received methotrexate, vinblastine, doxorubicin, and...

journal_title：International journal of clinical oncology

authors： Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Panitumumab is a fully human, monoclonal antibody against the epidermal growth factor receptor. Previous studies in non-Japanese patients with solid tumors showed that panitumumab exhibited nonlinear pharmacokinetics, was well tolerated (skin toxicities were the most common treatment-related adverse events),...

journal_title：International journal of clinical oncology

authors： Doi T,Ohtsu A,Tahara M,Tamura T,Shirao K,Yamada Y,Otani S,Yang BB,Ohkura M,Ohtsu T

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Despite increasing interest in minimally invasive surgery, prevalence data are completely absent. Our objective was to analyze clinico-epidemiological variations of surgery for renal malignancy in Japan with emphasis on annual trends and regional gaps, and to analyze factors affecting choice of open versus m...

journal_title：International journal of clinical oncology

authors： Sugihara T,Yasunaga H,Horiguchi H,Tsuru N,Fujimura T,Nishimatsu H,Kume H,Ohe K,Matsuda S,Fushimi K,Homma Y

更新日期：2013-12-01 00:00:00

abstract：:A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma. At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made. Unfortuna...

journal_title：International journal of clinical oncology

authors： Balleari E,Panarello S,Capello E,Grosso M,Passalia C,Pitto P,Raggi F,Roccatagliata L,Cabiddu F,Ghio R

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head an...

journal_title：International journal of clinical oncology

authors： Nakamura K,Sasaki M,Kunitake N,Kimura M,Watanabe T,Sasaki T,Terashima H,Kuwabara Y,Sakai S,Masuda K

更新日期：2001-12-01 00:00:00