Abstract:
BACKGROUND:Although the Onodera's prognosis nutritional index (O-PNI) has been used to predict long-term life expectancy, its use to predict life expectancy within 12 weeks has not been discussed. In this study, we examined the usefulness of the O-PNI to predict short-term life expectancy in patients with end-stage gastric cancer. METHODS:Blood samples from 425 patients who underwent surgery for gastric cancer at Toho University Omori Hospital from January 2001 to the end of December 2018 were analyzed. In 184 of 425 patients, a complete set of four blood sampling data were available at 12, 8, 4, and 1 week before death. The cutoff values and c-indices of O-PNI for predicting short-term life expectancy was calculated using the receiver operating characteristic curve. RESULTS:The shorter the life expectancy, the lower the O-PNI. For life expectancy of 8, 4, and 1 week, the optimal cutoff values for O-PNI were 40.4 (sensitivity 80.1%, specificity 44.6%); 38.3 (sensitivity 80.2%, specificity 54.1%); and 35.5 (sensitivity 80.4%, specificity 55.3%), respectively. CONCLUSIONS:In most patients, the O-PNI was below 40.4, 38.3, and 35.5 at 8, 4, and 1 week, respectively, before death, with 80% sensitivities. The O-PNI may be useful for predicting the short-term life expectancy in patients with end-stage gastric cancer.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Oyama K,Oba M,Oshima Y,Shimada Hdoi
10.1007/s10147-020-01808-5subject
Has Abstractpub_date
2021-02-01 00:00:00pages
364-369issue
2eissn
1341-9625issn
1437-7772pii
10.1007/s10147-020-01808-5journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-019-01534-7
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-019-01551-6
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expr...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0593-y
更新日期:2014-08-01 00:00:00
abstract::Among head and neck squamous cell carcinoma (HNSCC), the incidence of oropharyngeal SCC (OPSCC) is increasing in contrast to carcinoma with origin in other subsites. Human papillomavirus (HPV) is now recognized as a significant risk factor of the carcinogenesis of OPSCC. The HPV-related OPSCC patients tend to be relat...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-016-1009-6
更新日期:2016-10-01 00:00:00
abstract::Total gastrectomy and chemotherapy with S-1 after surgery were performed in a 50-year-old woman with gastric cancer associated with acquired immunodeficiency syndrome (AIDS). She was given a diagnosis of gastric cancer at the lesser curvature of the body of the stomach, and distal gastrectomy was performed in December...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0114-1
更新日期:2011-02-01 00:00:00
abstract::We report the case of a 62-year-old man with advanced gastric cancer and multiple liver metastases who was successfully treated with combined chemotherapy including S-1. The patient was clinically diagnosed with stage IV (T3 N2 H1 P0) disease and was initially treated with 100 mg/body per day S-1 administered orally f...
journal_title:International journal of clinical oncology
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doi:10.1007/s10147-006-0648-4
更新日期:2007-08-01 00:00:00
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journal_title:International journal of clinical oncology
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abstract:OBJECTIVE:Cesarean radical hysterectomy (CRH) for invasive cervical cancer during pregnancy is characterized by heavy blood loss. Any surgical modifications made in an attempt to reduce the blood loss are valuable. Our study was designed to evaluate the efficacy of amputating the uterine corpus during CRH. METHODS:All...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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更新日期:2021-01-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
abstract::5-Fluorouracil (5-FU) has been the most widely accepted and studied chemotherapeutic agent, and many combination chemotherapeutic regimens have been reported. However, until recently, a standard regimen for metastatic gastric cancer had not been established. The combination of S-1 and cisplatin is a good candidate as ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-008-0793-z
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The field of immunotherapy has recently focused on cancers with microsatellite instability (MSI). These cancers include both Lynch-syndrome-associated tumors, which are caused by mismatch repair (MMR) germline mutations, and sporadic MSI tumors, which are mainly attributed to MLH1 promoter methylation. The p...
journal_title:International journal of clinical oncology
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doi:10.1007/s10147-018-1238-y
更新日期:2018-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1209-8
更新日期:2018-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-007-0672-z
更新日期:2007-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10147-019-01522-x
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In patients with relapsed ovarian cancer, the objectives of salvage therapy are considered to be maintenance of quality of life and prolongation of patient survival. Chemotherapy using oral agents could be a good choice for salvage therapy. We reassessed the usefulness of oral cyclophosphamide (CPA) salvage ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-010-0094-1
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The correlation between treatment-related factors and lung toxicity has not been sufficiently evaluated in salvage radiotherapy. METHODS:Twenty-one patients with recurrent non-small-cell lung cancer (NSCLC) after lobectomy received salvage radiotherapy to a total dose of 46-60 Gy. The effects of radiotherap...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-005-0542-5
更新日期:2006-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0367-3
更新日期:2013-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,实务指引
doi:10.1007/s10147-016-0985-x
更新日期:2016-06-01 00:00:00
abstract::Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-019-01432-y
更新日期:2019-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:High-risk factors for recurrence of head and neck squamous cell carcinoma after surgical resection include involvement of ≥ 2 regional lymph nodes, extracapsular spread, and microscopic involvement of resected mucosal margins. Adjuvant chemoradiotherapy is thought to improve postoperative locoregional contro...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-013-0532-y
更新日期:2014-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0897-1
更新日期:2016-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s101470050012
更新日期:2000-02-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0283-6
更新日期:2012-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-014-0709-z
更新日期:2015-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-018-1261-z
更新日期:2018-08-01 00:00:00