A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric cancer.

Abstract:

BACKGROUND:Based on the results of the SPIRITS trial, combination chemotherapy of S-1 plus cisplatin (SP) is now considered the standard treatment for patients with advanced gastric cancer (AGC) in Japan. On the other hand, several non-Japanese studies have shown the efficacy of capecitabine plus cisplatin (XP), which has been used as the reference arm in recent global studies of AGC. METHODS:We retrospectively compared the efficacy and safety of SP and XP in first-line treatment for patients with AGC. RESULTS:From August 2006 to November 2008, 26 AGC patients received XP in the context of 2 global trials (AVAGAST and ToGA), and 50 patients received SP during the same period. The objective response rate was 43.2 % in the SP group and 50 % in the XP group, with no significant difference (p = 0.62). There were also no significant differences in progression-free survival (median 5.8 vs. 5.2 months; p = 0.91) and overall survival (median 13.8 vs. 13.5 months; p = 0.97) between the SP and XP groups. The frequencies of hematological toxicities of grade 3 or more and non-hematological toxicities were not significantly different between the 2 groups. Although grade 1 or 2 hand-foot syndrome was more common in the XP group, no patients experienced grade 3 or more. CONCLUSIONS:Although the retrospective nature of this study and the small number of patients is a major limitation, SP and XP were associated with similar efficacy and safety in patients with AGC.

journal_name

Int J Clin Oncol

authors

Shitara K,Sawaki A,Matsuo K,Kondo C,Takahari D,Ura T,Tajika M,Niwa Y,Muro K

doi

10.1007/s10147-012-0416-6

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

539-46

issue

3

eissn

1341-9625

issn

1437-7772

journal_volume

18

pub_type

杂志文章
  • Loco-regional failures in head and neck cancer: can they be effectively salvaged by nonsurgical therapeutic modalities?

    abstract:BACKGROUND:This retrospective study was carried out to ascertain the extent of efficacy of nonsurgical salvage modalities, mainly chemotherapy (CT) alone or chemoradiotherapy (CTRT), for loco-regional failures in head and neck cancer (HNC). METHODS:Between 1991 and 1999, 131 patients with HNC, mostly stages III and IV...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s101470300004

    authors: Datta NR,Nagar YS,Singh S,Naryan L

    更新日期:2003-02-01 00:00:00

  • The prognostic significance of whole-body and spleen MTV (metabolic tumor volume) scanning for patients with diffuse large B cell lymphoma.

    abstract:BACKGROUND:Positron Emission Tomography-Computed Tomography (PET-CT) has been changing diagnostic and therapeutic strategies for patients with cancers, and several PET-CT-related prognostic factors have been reported. We have focused on metabolic tumor volumes (MTVs) over the whole body and in specific organs using 18F...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01807-6

    authors: Yamanaka S,Miyagawa M,Sugawara Y,Hasebe S,Fujii T,Takeuchi K,Tanaka K,Yakushijin Y

    更新日期:2021-01-01 00:00:00

  • Distribution analysis of hydrogel spacer and evaluation of rectal dose reduction in Japanese prostate cancer patients undergoing stereotactic body radiation therapy.

    abstract:BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01855-y

    authors: Kobayashi H,Eriguchi T,Tanaka T,Ogata T,Ishida M,Nakajima Y,Kumabe A,Kosugi M

    更新日期:2021-01-07 00:00:00

  • Stereotactic body radiotherapy in patients with chronic obstructive pulmonary disease and interstitial pneumonia: a review.

    abstract::Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-019-01432-y

    authors: Doi H,Nakamatsu K,Nishimura Y

    更新日期:2019-08-01 00:00:00

  • Chemotherapy for patients with unresectable or metastatic small bowel adenocarcinoma: a systematic review.

    abstract:BACKGROUND:There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA. METHODS:In accordance with the PRISMA statements,...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01703-z

    authors: Nishikawa Y,Hoshino N,Horimatsu T,Funakoshi T,Hida K,Sakai Y,Muto M,Nakayama T

    更新日期:2020-08-01 00:00:00

  • Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA.

    abstract:BACKGROUND:The clinical impact of monitoring serum p53 antibodies, carbohydrate antigen19-9, and carcinoembryonic antigen in patients with colorectal cancer has not been fully evaluated. METHODS:A total of 420 surgically treated stage II/III colorectal cancer patients were retrospectively analyzed. Among them, 101 pat...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-019-01597-6

    authors: Ushigome M,Shimada H,Miura Y,Yoshida K,Kaneko T,Koda T,Nagashima Y,Suzuki T,Kagami S,Funahashi K

    更新日期:2020-04-01 00:00:00

  • The current status of perioperative chemotherapy for invasive bladder cancer: a multiinstitutional retrospective study in Japan.

    abstract:BACKGROUND:We conducted a multiinstitutional analysis to clarify the clinical significance of perioperative chemotherapy, in invasive bladder cancers in Japan, and to identify the patient subpopulations who could benefit from perioperative chemotherapy. METHODS:A total of 913 consecutive patients aged less than 80 yea...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-004-0474-5

    authors: Matsui Y,Nishiyama H,Watanabe J,Teramukai S,Ono Y,Ohshima S,Fujimoto K,Hirao Y,Fukushima M,Ogawa O

    更新日期:2005-04-01 00:00:00

  • Successful delivery after vaginal radical trachelectomy for invasive uterine cervical cancer.

    abstract::A 32-year-old Japanese woman was diagnosed as having stage Ib1 adenocarcinoma by diagnostic laser conization at a local hospital. She was admitted to our hospital for fertility-sparing treatment. A radical trachelectomy (RT) was performed using the laparoscopic vaginal procedure. The procedure was started with a lapar...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-005-0536-3

    authors: Ishioka S,Endo T,Hayashi T,Kitajima Y,Sugimura M,Sagae S,Saito T

    更新日期:2006-04-01 00:00:00

  • The evolving role of aromatase inhibitors in breast cancer.

    abstract::Anti-aromatase agents inhibit the cytochrome p-450 component of the aromatase enzyme complex responsible for the final step of estrogen biosynthesis in peripheral tissues. These drugs can be classified into first-generation (e.g., aminoglutethimide), second-generation (e.g., formestane and fadrazole), and third-genera...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s101470200040

    authors: Mokbel K

    更新日期:2002-10-01 00:00:00

  • C(H)OP refractory chronic lymphocytic leukemia patients in whom salvage chemotherapy chosen by evaluating multiple chemotherapeutic drug-resistant factors was remarkably effective.

    abstract::It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-003-0327-7

    authors: Matsunaga T,Kogawa K,Fujimi A,Takizawa K,Takahira N,Takemoto N,Tanaka I,Akiyama T,Sato T,Takayama T,Terui T,Sakamaki S,Niitsu Y

    更新日期:2003-10-01 00:00:00

  • Comparison of chemotherapeutic efficacy between LCNEC diagnosed using large specimens and possible LCNEC diagnosed using small biopsy specimens.

    abstract:BACKGROUND:It is often difficult to diagnose large cell neuroendocrine carcinomas (LCNEC) of the lung using small biopsy specimens. Some recent studies attempted to diagnose LCNEC using biopsy specimens; in 2011, the International Association for the Study of Lung Cancer pathological panels suggested possible LCNEC as ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-012-0509-2

    authors: Tokito T,Kenmotsu H,Watanabe R,Ito I,Shukuya T,Ono A,Nakamura Y,Tsuya A,Naito T,Murakami H,Takahashi T,Ohde Y,Kondo H,Endo M,Kameya T,Nakajima T,Mori K,Yamamoto N

    更新日期:2014-02-01 00:00:00

  • Comparisons of the impact of systematic uncertainties in patient setup and prostate motion on doses to the target among different plans for definitive external-beam radiotherapy for prostate cancer.

    abstract:BACKGROUND:We aimed to compare the impact of systematic uncertainties in patient setup and prostate motion on three different external-beam radiotherapy protocols for prostate cancer. METHODS:To simulate possible near-maximum systematic errors, the isocenter position was shifted to eight points with +/-1.65 SD of the ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-007-0724-4

    authors: Zhu SY,Mizowaki T,Norihisa Y,Takayama K,Nagata Y,Hiraoka M

    更新日期:2008-02-01 00:00:00

  • Comparison of outcomes between overlapping structure-based and non-overlapping structure-based optimization for simultaneous integrated boost IMRT for malignant gliomas.

    abstract:BACKGROUND:Intensity-modulated radiotherapy (IMRT) can deliver different doses to two target volumes with high conformity. The purpose of the present study was to compare outcomes provided by two different optimization methods, overlapping structure-based and non-overlapping structure-based methods, for simultaneous in...

    journal_title:International journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10147-004-0433-1

    authors: Suzuki M,Nakamatsu K,Kanamori S,Okajima K,Okumura M,Nishimura Y

    更新日期:2004-12-01 00:00:00

  • Factors predicting incisional surgical site infection in patients undergoing open radical cystectomy for bladder cancer.

    abstract:BACKGROUND:The risk factors of incisional surgical site infection (iSSI) after open radical cystectomy (ORC) have not been fully investigated. The aim of the present study is to examine factors correlated with iSSI development after ORC with intestinal urinary diversion. METHODS:A total of 178 patients who had undergo...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0646-2

    authors: Gondo T,Ohno Y,Nakashima J,Hashimoto T,Takizawa I,Tanaka A,Shimodaira K,Satake N,Takeuchi H,Nakagami Y,Ohori M,Tachibana M

    更新日期:2014-10-01 00:00:00

  • Popliteal pseudoaneurysm simulating soft-tissue sarcoma: complication of osteochondroma resection.

    abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/pl00012084

    authors: Otsuka T,Yonezawa M,Kamiyama F,Matusita Y,Matui N

    更新日期:2001-04-01 00:00:00

  • Value of free-to-total prostate-specific antigen ratio for detection and staging of prostate cancer.

    abstract::Background. We aimed to evaluate the clinical usefulness of measurement of the free-to-total (F/T) ratio of prostate-specific antigen (PSA) for the differentiation of prostate cancer from benign prostate hyperplasia (BPH) and for the staging of prostate cancer. Values for PSA density (PSAD) and PSAD adjusted to the tr...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s101470050002

    authors: Furuya Y,Akakura K,Ito H

    更新日期:2000-02-01 00:00:00

  • Cardiac metastasis from renal cell carcinoma without inferior vena involvement: a review of the literature based on a case report. Two different patterns of spread?

    abstract::We report the case of a 59-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, treated with radical nephrectomy, palliative radiotherapy for bone metastasis, and medical therapy for bone and lung metastases. The patient died of cardiac arrest after evidence of massive m...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-007-0730-6

    authors: Zustovich F,Gottardo F,De Zorzi L,Cecchetto A,Dal Bianco M,Mauro E,Cartei G

    更新日期:2008-06-01 00:00:00

  • The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly in comparison to that of HNSCC, which is associated with the use of tobacco or alcohol or both. This increase has resulted mainly from the global rise in...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10147-016-1005-x

    authors: Sano D,Oridate N

    更新日期:2016-10-01 00:00:00

  • Serum HER2 levels determined by two methods in patients with metastatic breast cancer.

    abstract:BACKGROUND:The role and the optimal measurement method of serum HER2 levels are not defined in patients with metastatic breast cancer (MBC). We prospectively assessed the prognostic value of serum HER2 levels in MBC using two methods, enzyme immunoassay (EIA) and chemiluminescence immunoassay (CLIA). METHODS:We collec...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0253-z

    authors: Hayashi N,Nakamura S,Tokuda Y,Yagata H,Yoshida A,Ota H,Hortobagyi GN,Cristofanilli M,Ueno NT

    更新日期:2012-02-01 00:00:00

  • The duration of functioning of a subcutaneous implantable port for the treatment of hematological tumors: a single institution-based study.

    abstract:BACKGROUND:Although subcutaneous implantable ports have been indicated as venous access for chemotherapy, these devices have not been used routinely for hematological tumors. METHODS:Between May 2006 and April 2009, 39 ports were implanted in 37 patients with hematological tumors and 16 ports were implanted in 14 pati...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0039-8

    authors: Ohno H,Mizumoto C,Otsuki Y,Oguma S,Yoshida Y

    更新日期:2010-04-01 00:00:00

  • Post-operative pulmonary and shoulder function after sternal reconstruction for patients with chest wall sarcomas.

    abstract:BACKGROUND:Sternal resection is occasionally required for patients with malignant tumors, particularly sarcomas, in the sternal region. Few reports have described post-operative respiratory and shoulder function after sternal resection for patients with bone and soft-tissue sarcomas. METHODS:Eight consecutive patients...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-015-0844-1

    authors: Nishida Y,Tsukushi S,Urakawa H,Toriyama K,Kamei Y,Yokoi K,Ishiguro N

    更新日期:2015-12-01 00:00:00

  • Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil.

    abstract:BACKGROUND:Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications ...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-013-0552-7

    authors: Lee SH,Choi EJ,Kim MS,Park JW,Lee YS,Kim SY,Kang CS

    更新日期:2014-04-01 00:00:00

  • Preoperative serum oxidative stress marker as a strong indicator of nodal involvement in clinical stage I lung adenocarcinoma.

    abstract:BACKGROUND:Reactive oxygen species stimulate lymphatic metastasis by accelerating epithelial-to-mesenchymal transition and lymphangiogenesis in the tumor microenvironment. Hence, systemic oxidative stress level may correlate with nodal involvement in patients with a malignant tumor. METHODS:We examined 46 patients wit...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0283-6

    authors: Tsukioka T,Nishiyama N,Iwata T,Nagano K,Tei K,Suehiro S

    更新日期:2012-06-01 00:00:00

  • A case report of metastatic neuroendocrine carcinoma of the right adrenal gland successfully treated with chemotherapy and surgery.

    abstract::Poorly differentiated neuroendocrine carcinoma has a poor prognosis, especially when associated with distant metastasis. A 60-year-old man was admitted to a private hospital because of dyspnea at work in 2007. Computed tomography revealed lung infarction and a right adrenal tumor sized 12 cm in diameter that was tight...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0051-z

    authors: Ochiai T,Komiyama S,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Kikuchi S,Fujiwara H,Sakakura C,Kokuba Y,Sonoyama T,Otsuji E

    更新日期:2010-08-01 00:00:00

  • Role of sentinel lymph node biopsy in patients with Merkel cell carcinoma: statistical analysis of 403 reported cases.

    abstract:BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high rate of nodal metastasis. Sentinel lymph node biopsy (SLNB) is used in MCC and other cancers to identify regional node micrometastases in patients with clinically negative nodes; however, whether SLN status is associated with recurrence o...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-014-0685-3

    authors: Shibayama Y,Imafuku S,Takahashi A,Nakayama J

    更新日期:2015-02-01 00:00:00

  • 'Trifecta' outcomes of robot-assisted partial nephrectomy: a large Japanese multicenter study.

    abstract:OBJECTIVE:The objective of this study was to evaluate the early surgical outcomes of robot-assisted partial nephrectomy (RAPN) for small renal masses in a large Japanese multicenter series. METHODS:A total of 804 consecutive cases of RAPN were examined at 42 institutes between 2011 and 2016. Medical records for clinic...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10147-019-01565-0

    authors: Furukawa J,Kanayama H,Azuma H,Inoue K,Kobayashi Y,Kashiwagi A,Segawa T,Takahashi Y,Horie S,Ogawa O,Takenaka A,Shiroki R,Tanabe K,Fujisawa M

    更新日期:2020-02-01 00:00:00

  • Debulking metastatic pelvic nodes before radiotherapy in cervical cancer patients: a long-term follow-up result.

    abstract:BACKGROUND:Enlarged pelvic nodes are commonly found during preoperative imaging studies in cervical cancer patients and may represent tumor metastasis. It remains controversial whether debulking of these enlarged nodes prior to definitive radiotherapy offers any survival benefit to the patient. METHODS:Enlarged suspic...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0225-3

    authors: Cheung TH,Lo KW,Yim SF,Yau SH,Yu MM,Yeung WK

    更新日期:2011-10-01 00:00:00

  • A case of rapidly growing pulmonary carcinosarcoma.

    abstract::We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-010-0043-z

    authors: Sato S,Koike T,Yamato Y,Yoshiya K,Motono N,Takeshige M,Homma K,Koizumi N,Yokoyama A,Tsukada H

    更新日期:2010-06-01 00:00:00

  • Pulmonary metastasectomy in patients with renal cell carcinoma: a single-institution experience.

    abstract:BACKGROUND:Pulmonary metastasectomy in patients with renal cell carcinoma (RCC) remains controversial. The purpose of our analysis was to explore the outcome of patients with RCC who underwent pulmonary metastasectomy at our institution. METHODS:We reviewed data on 25 patients who underwent resection of lung metastasi...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-011-0244-0

    authors: Kawashima A,Nakayama M,Oka D,Sato M,Hatano K,Mukai M,Nagahara A,Nakai Y,Takayama H,Inoue M,Shiono H,Nishimura K,Okumura M,Nonomura N

    更新日期:2011-12-01 00:00:00

  • Inhibition of TMEM16A suppresses growth and induces apoptosis in hepatocellular carcinoma.

    abstract:BACKGROUND:Increase of the Ca2+-activated chloride channel TMEM16A is contribute to tumorigenesis. However, the expression level of TMEM16A and its underlying molecular mechanism for TMEM16Apromotingliver carcinogenesis is remains unknown. METHODS:In the present study, the expression of TMEM16A in hepatocellular carci...

    journal_title:International journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s10147-020-01653-6

    authors: Zhang C,Liu J,Han Z,Cui X,Peng D,Xing Y

    更新日期:2020-06-01 00:00:00