Abstract:
BACKGROUND:Recent studies have shown the benefits of neoadjuvant therapy with chemotherapy or chemoradiotherapy for resectable locally advanced thoracic esophageal squamous cell carcinoma (ESCC). The aim of our study was to elucidate the use of neoadjuvant therapy for thoracic ESCC in Japan. METHODS:Data on patients with stage IB-III thoracic ESCC were retrieved from the national database of hospital-based cancer registries combined with claims data between 2012 and 2013. These data were analyzed using a mixed-effect logistic regression analysis, with a focus on exploring patterns in the first-line treatment for ESCC, including proportion of patients who received neoadjuvant therapy, and investigating the hospital characteristics and patient factors associated with the use of neoadjuvant therapy. RESULTS:Of the 5016 patients with stage IB-III thoracic ESCC at the 305 participating hospitals, 34.2% received neoadjuvant therapy (neoadjuvant chemotherapy, 29.5%; neoadjuvant chemoradiotherapy, 4.7%). The therapy was less likely to be administered to older patients (≤64 years, 48.8%; 65-70 years, 42.0%; 70-75 years, 33.9%; 75-80 years, 22.2%; 80-85 years, 3.8%; ≥85 years, 1.4%) and at hospitals with a low volume of patients (very high, 42.1%; high, 37.5%; low, 30.7%; and very low, 26.4%). This trend was confirmed by regression analysis. CONCLUSIONS:Based on our results, in Japan, relatively few patients with resectable locally advanced thoracic ESCC receive neoadjuvant therapy, with older patients and patients at lower volume hospitals being less likely than other patients to receive the neoadjuvant therapy. We recommend that the process of treatment decision-making be assessed at both the patient and hospital levels so that patients can consider various treatment options, including neoadjuvant therapy with surgery in Japan.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Tsukada Y,Higashi T,Shimada H,Kikuchi Y,Terahara Adoi
10.1007/s10147-017-1178-ysubject
Has Abstractpub_date
2018-02-01 00:00:00pages
81-91issue
1eissn
1341-9625issn
1437-7772pii
10.1007/s10147-017-1178-yjournal_volume
23pub_type
杂志文章abstract:BACKGROUND:It is expected that cell-free and concentrated ascites reinfusion therapy (CART) will relieve the symptoms caused by ascites. To date, however, no report of objective changes in patients' symptoms has been published. We have therefore evaluated symptom management by CART. METHODS:From April 2011 to July 201...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-014-0750-y
更新日期:2015-06-01 00:00:00
abstract::Recent advances in molecular biology have identified the responsible genes for many hereditary cancer syndromes (familial tumors). Therefore, now, the final diagnosis of familial tumors can be done by molecular methods to detect the genetic alteration in the disease-causing responsible gene(s) in the patient. So-calle...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-004-0421-5
更新日期:2004-08-01 00:00:00
abstract::The original article can be found online. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10147-019-01395-0
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate prognostic factors and develop a prognostic factor-based risk stratification model for disease-specific survival (DSS) in a radical cystectomy (RC) series. METHODS:The patient cohort comprised 194 consecutive patients with bladder cancer treated with RC. Univariate a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0310-7
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:It is often difficult to diagnose large cell neuroendocrine carcinomas (LCNEC) of the lung using small biopsy specimens. Some recent studies attempted to diagnose LCNEC using biopsy specimens; in 2011, the International Association for the Study of Lung Cancer pathological panels suggested possible LCNEC as ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-012-0509-2
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:To avoid the loss of fertility, chemotherapy should be chosen as an adjuvant treatment after trachelectomy. Our study evaluated the effectiveness and safety of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer. METHODS:Our institutional review board approved this clinical study, and in...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01778-8
更新日期:2021-01-01 00:00:00
abstract::We report a patient with avascular necrosis of the bilateral femoral head resulting from long-term steroid administration for radiation pneumonitis that occurred after tangential irradiation of the breast. The patient was a 50-year-old postmenopausal woman with breast cancer, stage IIIB (T4bN0M0) in the right C area. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-006-0607-0
更新日期:2006-12-01 00:00:00
abstract::Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s101470200038
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our ins...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-019-01422-0
更新日期:2019-07-01 00:00:00
abstract::A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s101470050012
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Our aim was to study the efficacy and safety of combination chemotherapy with gemcitabine plus cisplatin (GC) for patients with advanced urothelial carcinoma (UC) after failure of methotrexate, vinblastin, adriamycin, and cisplatin (M-VAC) chemotherapy. METHODS:We studied a total of 33 patients with advance...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-011-0188-4
更新日期:2011-08-01 00:00:00
abstract::Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/pl00012084
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:As cancer therapy can be harmful to spermatogenesis, men are generally advised to cryopreserve sperm before gonadotoxic treatment. Here, we compared fresh and frozen-thawed sperm quality in patients according to cancer type, and reported use rate in subsequent assisted reproductive technology (ART) cycles. ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0330-3
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:To report on our primary experience with the placement of a hydrogel spacer following stereotactic body radiation therapy (SBRT) in low- and intermediate-risk prostate cancer patients and assess its impact on dosimetry as well as acute toxicity. METHODS:A total of 70 patients treated with SBRT (total dose o...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01855-y
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Neoadjuvant cisplatin-based chemotherapy for patients with muscle-invasive bladder cancer (BC) has better survival benefit than radical cystectomy (RC) alone. However, optimal dosing schedule, including drug selection, number of cycles, and interval between chemotherapy and cystectomy, as well as acceptable ...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-012-0447-z
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Prognostic outcomes and safety following treatment with pembrolizumab in patients with advanced urothelial carcinoma (UC) have not been fully elucidated in clinical practice. The aim of this study was to evaluate the oncological efficacy and safety of pembrolizumab after failure of platinum-based chemotherap...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-019-01613-9
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Soft-tissue tumors are often accompanied by abnormal temperature distribution detected during palpation. However, the assessment of temperature distribution is subjective, limiting its wide use in cancer screening. The aim of this study was to evaluate the clinical significance of the thermal detection of so...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-020-01658-1
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Recent studies have shown that somatic mutations in the AT-rich interactive domain 1A (SWI-like) gene (ARID1A) are the most common genetic changes in clear cell carcinoma of the ovary (CCC). A gene mutation of ARID1A was found in approximately half of CCC cases, and led to absence of the encoded protein and ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-015-0811-x
更新日期:2015-10-01 00:00:00
abstract::Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The ...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-019-01611-x
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Whether the administration of calcium (Ca) and magnesium (Mg) can reduce oxaliplatin-related neurotoxicity remains controversial. In addition, little is known about the effects of Ca/Mg on the blood level of platinum or objective tumor progression. PATIENTS AND METHODS:Patients receiving modified FOLFOX6 fo...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s10147-009-0015-3
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Our previous nonrandomized prospective study showed that template-based lymphadenectomy improved survival among patients with renal pelvic cancer but not among patients with ureteral cancer. However, regional node sites vary according to the tumor's location in relation to the ureter. Therefore, this retrosp...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-016-1024-7
更新日期:2017-02-01 00:00:00
abstract::Background. We aimed to evaluate the clinical usefulness of measurement of the free-to-total (F/T) ratio of prostate-specific antigen (PSA) for the differentiation of prostate cancer from benign prostate hyperplasia (BPH) and for the staging of prostate cancer. Values for PSA density (PSAD) and PSAD adjusted to the tr...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s101470050002
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:In Japan, chemotherapeutic agents that have been approved for the treatment of esophageal cancer include cisplatin, nedaplatin, 5-fluorouracil, vindesine, and docetaxel. We retrospectively investigated the efficacy and toxicity of a combination of nedaplatin plus vindesine, or docetaxel alone, for patients w...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-007-0738-y
更新日期:2008-04-01 00:00:00
abstract::Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) a...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-019-01432-y
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated m...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,meta分析
doi:10.1007/s10147-016-1073-y
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Previous reports concerning the prevalence of human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) have observed varied results. The aim of this study was to evaluate the prevalence of HPV in oral premalignant lesions (OPL) and OSCC. For accurate HPV detection in oral lesions, comparative analys...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-011-0236-0
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:The use of adjuvant treatment has not been sufficiently investigated in duodenal adenocarcinoma. This study evaluated the effect of postoperative radiotherapy (PORT) on survival outcomes in this rare malignancy. METHODS:We identified patients who were diagnosed between 2004 and 2013 in the Surveillance, Epidem...
journal_title:International journal of clinical oncology
pub_type: 杂志文章
doi:10.1007/s10147-017-1226-7
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The standard treatment for cervical cancer is chemoradiation although some patients showed treatment resistance. The purpose of this study was to investigate the clinical efficacy of surgery after chemoradiation for cervical cancer. METHODS:Patients with FIGO stage IB2 to IIB cervical cancer were included i...
journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s10147-019-01551-6
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The Randomized Phase III Study Comparing Oxaliplatin plus S-1 with Cisplatin plus S-1 in Chemotherapy-naïve Patients with Advanced Gastric Cancer (G-SOX) showed the noninferiority of S-1 (an oral fluoropyrimidine-derivative dihydropyrimidine dehydrogenase inhibitor) plus oxaliplatin combination therapy (SOX)...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10147-015-0938-9
更新日期:2016-08-01 00:00:00
abstract::The identification and validation of putative surrogate endpoints in oncology is a great challenge to medical investigators, statisticians, and regulators. A putative surrogate endpoint must be validated at both individual-level and trial-level before it can be used to replace the clinical endpoint in a future clinica...
journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1007/s10147-009-0885-4
更新日期:2009-04-01 00:00:00