Abstract:
:The updated 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS) has incorporated molecular parameters into pathological diagnosis, for the first time in the molecular era. While it has led to the more precise diagnoses of well-understood entities and the better comprehension of less-understood entities, its practical application has also created some concerns whether or not genotypes predominate over phenotypes in tumor diagnostics. In response to these concerns, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHO (cIMAPCT-NOW) was established under the sponsorship of the International Society of Neuropathology to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. cIMPACT has thus far published five updates on the proposal and clarification of existing and new terms and entities. Also, recent studies have shown that WHO grading based on histology has lost its prognostic relevance, which necessitates novel, improved grading criteria. We herein highlight the current status of clinical application of WHO 2016 classification and cIMPACT proposals, and the future endeavor to incorporate DNA methylation profiling of the CNS tumors for better clinical decision-making to achieve a goal of precision medicine for each patient with brain tumors.
journal_name
Int J Clin Oncoljournal_title
International journal of clinical oncologyauthors
Onizuka H,Masui K,Komori Tdoi
10.1007/s10147-020-01695-wsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
997-1003issue
6eissn
1341-9625issn
1437-7772pii
10.1007/s10147-020-01695-wjournal_volume
25pub_type
杂志文章,评审abstract:BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head an...
journal_title:International journal of clinical oncology
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abstract::A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors,...
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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journal_title:International journal of clinical oncology
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更新日期:2001-04-01 00:00:00
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更新日期:2019-07-01 00:00:00
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章,实务指引
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更新日期:2016-06-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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journal_title:International journal of clinical oncology
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pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:International journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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journal_title:International journal of clinical oncology
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journal_title:International journal of clinical oncology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00