Monthly paclitaxel and carboplatin with oral estramustine phosphate in patients with hormone-refractory prostate cancer.

abstract：BACKGROUND:The field of immunotherapy has recently focused on cancers with microsatellite instability (MSI). These cancers include both Lynch-syndrome-associated tumors, which are caused by mismatch repair (MMR) germline mutations, and sporadic MSI tumors, which are mainly attributed to MLH1 promoter methylation. The p...

journal_title：International journal of clinical oncology

authors： Yamada R,Yamaguchi T,Iijima T,Wakaume R,Takao M,Koizumi K,Hishima T,Horiguchi SI

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcinoma suggested the recommended dose of docetaxel at 10 mg/m2 and cisplatin at 20 mg/m2. Phase II study of the concurrent chemor...

journal_title：International journal of clinical oncology

authors： Nakahara S,Takenaka Y,Ogawa K,Nishiike S,Yamamoto Y,Seo Y,Isohashi F,Suzuki O,Yoshioka Y,Sumida I,Yoshii T,Tomiyama Y,Inohara H

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and toxicity of third-line gemcitabine monotherapy (Gem) in patients with platinum-resistant advanced urothelial cancer (UC). PATIENTS AND METHODS:From July 2005 to March 2009, 13 patients were enrolled. All patients had previously received methotrexate, vinblastine, doxorubicin, and...

journal_title：International journal of clinical oncology

authors： Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Alternative anti-androgen therapy (AAT) with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. However, no studies have compared enzalutamide without AAT with enzalutamide after AAT with flutamide as treatment for castration-resistant prostat...

journal_title：International journal of clinical oncology

authors： Iguchi T,Tamada S,Kato M,Yasuda S,Otoshi T,Hamada K,Yamasaki T,Nakatani T

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic veracity for disease-specific survival (DSS) of the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis staging system (TNM-8) compared with the seventh edition (TNM-7) in a Chinese populati...

journal_title：International journal of clinical oncology

authors： Zhi J,Wu Y,Hu L,Zhao J,Liu H,Ruan X,Hou X,Zhang J,Zheng X,Gao M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:No investigation of S-1 monotherapy in previously treated advanced non-small-cell lung cancer (NSCLC) patients has yet been reported. We conducted a retrospective study to evaluate the efficacy and tolerability of S-1 in patients with failure of second- or further-line chemotherapy. PATIENTS AND METHODS:The...

journal_title：International journal of clinical oncology

authors： Ono A,Naito T,Murakami H,Takahashi T,Nakamura Y,Tsuya A,Kaira K,Igawa S,Shukuya T,Tamiya A,Kaira R,Endo M,Yamamoto N

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) patients are usually diagnosed in advanced stages which results in high mortality. This study aimed to identify novel circulating miRNAs as biomarkers for the early detection of GC. METHODS:Candidate miRNA was identified after integrated analysis of two Gene Expression Omnibus (GEO) data...

journal_title：International journal of clinical oncology

authors： Shi Y,Wang Z,Zhu X,Chen L,Ma Y,Wang J,Yang X,Liu Z

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:To characterize clinical advantages in robot-assisted partial nephrectomy (RAPN) for targeting renal hilar tumors, and compare them with those of open PN (OPN). METHODS:This study included 31 consecutive patients with renal hilar tumors, consisting of 15 and 16 who received OPN and RAPN, respectively, betwe...

journal_title：International journal of clinical oncology

authors： Miyake H,Hinata N,Imai S,Furukawa J,Tanaka K,Fujisawa M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Malignant change in fibrous dysplasia (FD) is very rare. This study was carried out to establish some characteristic clinical information about this disorder. METHODS:Four cases with a malignant change in FD out of 128 cases with FD were surgically treated and followed up for a median period of 61.3 months....

journal_title：International journal of clinical oncology

authors： Hoshi M,Matsumoto S,Manabe J,Tanizawa T,Shigemitsu T,Izawa N,Takeuchi K,Kawaguchi N

更新日期：2006-06-01 00:00:00

abstract：:A diagnosis of cervical cancer during pregnancy poses difficult management and ethical problems. Survival of the patient is the foremost concern, but fetal viability and well-being must also be addressed. Radical trachelectomy (RT) has recently begun to be performed as a possible treatment modality for early stage inv...

journal_title：International journal of clinical oncology

authors： Iwami N,Ishioka S,Endo T,Baba T,Nagasawa K,Takahashi M,Sugio A,Takada S,Mariya T,Mizunuma M,Saito T

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:To evaluate the survival benefit of gemcitabine and paclitaxel (GT) chemotherapy for patients with metastatic urothelial cancer (UC), a retrospective analysis was performed to compare the overall survival in two periods: before (group I) and after (group II) the introduction of GT chemotherapy. PATIENTS AND...

journal_title：International journal of clinical oncology

authors： Matsui Y,Nishiyama H,Yoshimura K,Xing ND,Sumiyoshi T,Saito R,Inoue T,Kamba T,Ogawa O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Zoledronic acid treatment reduces the incidence of skeletal-related events (SREs) in patients with bone metastases from breast, lung, and urologic cancers including prostate and renal cancer. The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bla...

journal_title：International journal of clinical oncology

authors： Zaghloul MS,Boutrus R,El-Hossieny H,Kader YA,El-Attar I,Nazmy M

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:We conducted a phase I dose escalation study to determine the maximum tolerated dose (MTD), the recommended dose (RD) and the safety profile of amrubicin (AMR) plus paclitaxel (PTX) combination regimen for patients with previously treated non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:PTX was admi...

journal_title：International journal of clinical oncology

authors： Kaira K,Sunaga N,Imai H,Kamide Y,Koga Y,Ono A,Kuwako T,Masuda T,Hisada T,Ishizuka T,Yamada M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Our aim was to study the efficacy and safety of combination chemotherapy with gemcitabine plus cisplatin (GC) for patients with advanced urothelial carcinoma (UC) after failure of methotrexate, vinblastin, adriamycin, and cisplatin (M-VAC) chemotherapy. METHODS:We studied a total of 33 patients with advance...

journal_title：International journal of clinical oncology

authors： Gondo T,Ohori M,Hamada R,Tanaka A,Satake N,Takeuchi H,Nakashima J,Hatano T,Tachibana M

更新日期：2011-08-01 00:00:00

abstract：:Sarcomas represent a rare and heterogeneous disease and the prognosis of patients remains poor, with a disease-free survival at 5 years of less than 10%. Only a few chemotherapeutic agents, such as doxorubicin and ifosfamide, have been identified to be active with response rates above 20%. The concept of angiostatic t...

journal_title：International journal of clinical oncology

authors： Kasper B,Ho AD,Egerer G

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Neoadjuvant cisplatin-based chemotherapy for patients with muscle-invasive bladder cancer (BC) has better survival benefit than radical cystectomy (RC) alone. However, optimal dosing schedule, including drug selection, number of cycles, and interval between chemotherapy and cystectomy, as well as acceptable ...

journal_title：International journal of clinical oncology

authors： Koie T,Ohyama C,Hashimoto Y,Hatakeyama S,Yamamoto H,Yoneyama T,Kamimura N

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:We performed a retrospective study to clarify the outcome of stage IB2-IIB patients with bulky cervical cancer who underwent neoadjuvant chemotherapy (NAC) followed by radical hysterectomy and adjuvant treatment. METHODS:Sixty-five patients with bulky stage IB2-IIB cervical cancer, treated at Tottori Univer...

journal_title：International journal of clinical oncology

authors： Uegaki K,Shimada M,Sato S,Deura I,Naniwa J,Sato S,Oishi T,Itamochi H,Harada T,Kigawa J

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarker...

journal_title：International journal of clinical oncology

authors： Ruggiero A,De Rosa G,Rizzo D,Leo A,Maurizi P,De Nisco A,Vendittelli F,Zuppi C,Mordente A,Riccardi R

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS:A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) a...

journal_title：International journal of clinical oncology

authors： Sato I,Higuchi A,Yanagisawa T,Murayama S,Kumabe T,Sugiyama K,Mukasa A,Saito N,Sawamura Y,Terasaki M,Shibui S,Takahashi J,Nishikawa R,Ishida Y,Kamibeppu K

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Peripheral sensory neurotoxicity is a frequent adverse effect of oxaliplatin therapy. Calcium and magnesium (Ca/Mg) infusions are frequently used as preventatives, but a recent phase III trial failed to show that they prevent neurotoxicity. We therefore conducted a multicenter randomized phase III trial to c...

journal_title：International journal of clinical oncology

authors： Oki E,Emi Y,Kojima H,Higashijima J,Kato T,Miyake Y,Kon M,Ogata Y,Takahashi K,Ishida H,Saeki H,Sakaguchi Y,Yamanaka T,Kono T,Tomita N,Baba H,Shirabe K,Kakeji Y,Maehara Y

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated m...

journal_title：International journal of clinical oncology

authors： Feng M,Zhu J,Liang L,Zeng N,Wu Y,Wan C,Shen Y,Wen F

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The clinical impact of monitoring serum p53 antibodies, carbohydrate antigen19-9, and carcinoembryonic antigen in patients with colorectal cancer has not been fully evaluated. METHODS:A total of 420 surgically treated stage II/III colorectal cancer patients were retrospectively analyzed. Among them, 101 pat...

journal_title：International journal of clinical oncology

authors： Ushigome M,Shimada H,Miura Y,Yoshida K,Kaneko T,Koda T,Nagashima Y,Suzuki T,Kagami S,Funahashi K

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Prognostic outcomes and safety following treatment with pembrolizumab in patients with advanced urothelial carcinoma (UC) have not been fully elucidated in clinical practice. The aim of this study was to evaluate the oncological efficacy and safety of pembrolizumab after failure of platinum-based chemotherap...

journal_title：International journal of clinical oncology

authors： Tamura D,Jinnouchi N,Abe M,Ikarashi D,Matsuura T,Kato R,Maekawa S,Kato Y,Kanehira M,Takata R,Obara W

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS:The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefe...

journal_title：International journal of clinical oncology

authors： Nakabayashi N,Hirose M,Suzuki R,Suzumiya J,Igawa M

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Most Brenner tumors are benign, with only 1% being malignant. In this study we report on 13 cases with malignant Brenner tumor of the ovary and discuss the clinical, demographic and histologic features. METHOD:Thirteen patients with malignant Brenner tumor of the ovary who were treated at Selçuk University G...

journal_title：International journal of clinical oncology

authors： Gezginç K,Karatayli R,Yazici F,Acar A,Çelik Ç,Çapar M,Tavli L

更新日期：2012-08-01 00:00:00

abstract：:Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...

journal_title：International journal of clinical oncology

authors： Lønning PE

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The Randomized Phase III Study Comparing Oxaliplatin plus S-1 with Cisplatin plus S-1 in Chemotherapy-naïve Patients with Advanced Gastric Cancer (G-SOX) showed the noninferiority of S-1 (an oral fluoropyrimidine-derivative dihydropyrimidine dehydrogenase inhibitor) plus oxaliplatin combination therapy (SOX)...

journal_title：International journal of clinical oncology

authors： Hamada C,Yamada Y,Azuma M,Nishikawa K,Gotoh M,Bando H,Sugimoto N,Nishina T,Amagai K,Chin K,Niwa Y,Tsuji A,Imamura H,Tsuda M,Yasui H,Fujii H,Yamaguchi K,Yasui H,Hironaka S,Shimada K,Miwa H,Hyodo I

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment of cervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). METHODS:Fifty-six patients with squamous cell carc...

journal_title：International journal of clinical oncology

authors： Mizunuma M,Yokoyama Y,Futagami M,Aoki M,Takai Y,Mizunuma H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The efficacy of carbon-ion radiotherapy (C-ion RT) for lymph node (LN) oligo-recurrence has only been evaluated in limited single-center studies. We aimed to investigate the benefit of C-ion RT for LN oligo-recurrence in a large multi-center study. METHODS:Patients who received C-ion RT between December 199...

journal_title：International journal of clinical oncology

authors： Okonogi N,Kaminuma T,Okimoto T,Shinoto M,Yamamoto N,Yamada S,Murata K,Ohno T,Shioyama Y,Tsuji H,Nakano T,Kamada T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:It is still controversial whether axillary lymph node (ALN) dissection (ALND) can be omitted after negative sentinel lymph node (SLN) biopsy (SLNB) in breast cancer (BC) patients with clinically positive ALNs at presentation treated with neoadjuvant chemotherapy (NAC). The study aim was to analyze whether SL...

journal_title：International journal of clinical oncology

authors： Takei H,Yoshida T,Kurosumi M,Inoue K,Matsumoto H,Hayashi Y,Higuchi T,Uchida S,Ninomiya J,Kubo K,Oba H,Nagai S,Tabei T

更新日期：2013-06-01 00:00:00