Versatile stem cells, young and old. A review.

Abstract:

:Both embryonic and somatic stem cells have been studied in recent years with particular regard to their differentiation potential. In vitro studies allow a considerable amplification of such cells in culture as well as the induction of commitment in different directions under proper stimulating factors. Moreover, a surprising versatility has been discovered,which makes possible a ;reprogramming' of stem cells into a lineage pathway which may be completely different from the expected direction: for instance, a production of brain cells from blood progenitors has been obtained. It is thus possible to envisage methods of producing in culture sufficient amounts of stem cells, committed to a certain pathway, which can be transplanted in vivo to replace damaged tissues and organs.

journal_name

Cytotechnology

journal_title

Cytotechnology

authors

Eridani S

doi

10.1023/A:1017526408890

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

137-43

issue

2

eissn

0920-9069

issn

1573-0778

journal_volume

35

pub_type

杂志文章
  • Chemical genomics: massively parallel technologies for rapid lead identification and target validation.

    abstract::Chemical genomics is a new research paradigm with importantapplications in drug discovery. It links genomic targets withsmall-molecule chemistries thereby allowing for efficient targetvalidation and lead compound identification. ACADIA'schemical-genomics platform consists of a large and diverse small-moleculelibrary (...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1021169023731

    authors: Hacksell U,Nash N,Burstein ES,Piu F,Croston G,Brann MR

    更新日期:2002-01-01 00:00:00

  • Inhibition of hepatoma cell invasion beneath mesothelial-cell monolayer by sera from tea- and related component-treated rats and their modes of action.

    abstract::The bioavailability and action of teas on the invasion of a rat ascites hepatoma cell line, AH109A, were determined and their modes of action were by co-culturing the cancer cells with a rat mesentery-derived mesothelial-cell (M-cell) monolayer in the presence of sera from rats orally given teas and their component, (...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1014008129116

    authors: Zhang G,Miura Y,Yagasaki K

    更新日期:2001-07-01 00:00:00

  • Development of a generic transient transfection process at 100 L scale.

    abstract::We have developed a generic transient transfection process at 100 L scale, using HEK293-EBNA cells and PEI as the transfection reagent for the production of recombinant IgG. The process, including large-scale plasmid preparation, expression at bioreactor scale, capture, purification and, if necessary, endotoxin remova...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-008-9135-2

    authors: Tuvesson O,Uhe C,Rozkov A,Lüllau E

    更新日期:2008-02-01 00:00:00

  • Genotypic and phenotypic changes of BHK-21 cells grown in suspension cultures.

    abstract::The propagation of foot-and-mouth disease virus on BHK-21 suspension cells, although economically convenient, may yield a scarcely immunizing antigen. Helpful insights were obtained by investigating a few genotypic and phenotypic features of the cell cultures. The appearance of polyploid populations, higher cell conce...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:

    authors: Amadori M,Berneri C

    更新日期:1993-01-01 00:00:00

  • A new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.

    abstract::In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to stu...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-016-9964-3

    authors: Grenade C,Moniotte N,Rompen E,Vanheusden A,Mainjot A,De Pauw-Gillet MC

    更新日期:2016-12-01 00:00:00

  • Change in growth kinetics of hybridoma cells entrapped in collagen gel affected by alkaline supply.

    abstract::The growth yields for glucose and glutamine of murine hybridoma cells entrapped in collagen gel particles were examined during the growth phase. The immobilized hybridoma cells were cultivated in a fluidized bed fermenter where the medium was circulating to supply oxygen separately. Procedures to supply an alkaline so...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00758178

    authors: Shirai Y,Yamaguchi M,Kobayashi A,Nishi A,Nakamura H,Murakami H

    更新日期:1994-01-01 00:00:00

  • NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells.

    abstract::IL-5 plays important roles in eosinophil differentiation, expansion, and recruitment. The regulation of IL-5 seems critical for the treatment of eosinophil-mediated allergic reactions. However, the precise mechanisms for IL-5 regulation remain unknown. In this study, we investigated how IL-5 production is regulated. T...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-013-9585-z

    authors: Hashiguchi M,Kobayashi A,Kashiwakura Y,Kojima H,Kanno Y,Kurosu A,Tokudome S,Kobata T

    更新日期:2014-05-01 00:00:00

  • Mechanisms of resistance to alkylating agents.

    abstract::Alkylating agents are the most widely used anticancer drugs whose main target is the DNA, although how exactly the DNA lesions cause cell death is still not clear. The emergence of resistance to this class of drugs as well as to other antitumor agents is one of the major causes of failure of cancer treatment. This pap...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1008060720608

    authors: Damia G,D'Incalci M

    更新日期:1998-09-01 00:00:00

  • Real architecture For 3D Tissue (RAFT™) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells.

    abstract::There is an unmet medical need for the improvement of pancreatic islet maintenance in culture. Due to restricted donor availability it is essential to ameliorate islet viability and graft engraftment. The aim of this study was to compare the standard tissue culture techniques with the advanced Real Architecture For 3D...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-017-0067-6

    authors: Szebeni GJ,Tancos Z,Feher LZ,Alfoldi R,Kobolak J,Dinnyes A,Puskas LG

    更新日期:2017-04-01 00:00:00

  • Development of human monoclonal antibodies: A review.

    abstract::This article describes the current status in the development of human monoclonal antibodies. Over the last ten years a lot of information about the human immune system has emerged. Combining these with the many new (bio-)technologies it is plausible that the long awaited breakthrough of this technology is close. This ...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00365341

    authors: Lindl T

    更新日期:1996-01-01 00:00:00

  • Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells.

    abstract::Chicken egg yolk lipoprotein (YLP) was partially fractionated into some constituents, and the effect of constituents of YLP were examined on the growth and immunoglobulin (IgM and IgG) secretion of a HB4C5 human-human hybridoma cell line cultured in serum-free medium. Among the fractions, YP-1 and YP-2 fractions (LDL-...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00749004

    authors: Shinohara K,Fukushima T,Suzuki M,Tsutsumi M,Kobori M,Kong ZL

    更新日期:1993-01-01 00:00:00

  • Epitope analysis of peanut allergen Ara h1 with human monoclonal IgM antibody 92-2.

    abstract::A human-mouse hybridoma clone 92-2 secreting IgM-class human monoclonal antibody to peanut allergen protein Ara h1 was established. To detect antibody-binding sequences on Ara h1, we synthesized a series of peptides of the Ara h1 protein on a multi-pin apparatus for the pin-peptide ELISA. The 92-2 human monoclonal ant...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-009-9243-7

    authors: Shinmoto H,Matsuo Y,Naganawa Y,Tomita S,Takano-Ishikawa Y

    更新日期:2010-08-01 00:00:00

  • Chaperone and foldase coexpression in the baculovirus-insect cell expression system.

    abstract:CONCLUSIONS:The BEVS has become widely utilized for production of recombinant proteins. However, protein aggregation and inefficient processing often limit yields, especially for secreted and membrane proteins. Since many proteins of pharmaceutical interest require similar posttranslational processing steps, engineerin...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00350396

    authors: Betenbaugh MJ,Ailor E,Whiteley E,Hinderliter P,Hsu TA

    更新日期:1996-01-01 00:00:00

  • Molecular mechanisms of Bombyx batryticatus ethanol extract inducing gastric cancer SGC-7901 cells apoptosis.

    abstract::Bombyx batryticatus is a traditional Chinese medicine. To understand apoptotic effect of B. batryticatus ethanol extract (BBE), we investigated the role of BBE in inducing apoptosis of human gastric cancer cells SGC-7901. Cells treated with BBE and apoptosis was assessed by methyl thiazolyl tetrazolium (MTT) assay, mo...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-017-0102-7

    authors: Wu JY,Sheikho A,Ma H,Li TC,Zhao YQ,Zhang YL,Wang D

    更新日期:2017-12-01 00:00:00

  • Biological response of endothelial cells and its modulation by cytokines: prospects for therapy and bioprocesses.

    abstract::Endothelial cells are involved in important pathological situations. They could be the target for infectious processes as for example in Cowdriosis, an important disease in cattle due to the rickettsia Cowdria ruminantium prevalent in the south of the Sahara. They are also connected to angiogenic processes related to ...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1007928203997

    authors: Marique T,Blankaert D,Hendrick V,Raschella A,Declerck B,Alloin C,Teixera-Guerra I,Sandron D,Cherlet M,Parent D,Kirkpatrick C,Van Vooren JP,Wérenne J

    更新日期:1997-11-01 00:00:00

  • Optimization of macrophage isolation from the Persian sturgeon and the Caspian kutum fish: a comparative study.

    abstract::The aim of this research was a comparative study on the isolation and culture of head kidney macrophages derived from Acipenser persicous and Rutilus frisii kutum as teleost and chondrostei species of fish. The macrophages were isolated by density gradient sedimentation, followed by adherence to a plastic surface. The...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-018-0256-y

    authors: Rastgar S,Movahedinia A,Salamat N,Salati A,Zabihi E

    更新日期:2018-12-01 00:00:00

  • Growth, metabolism and baculovirus production in suspension cultures of an Anticarsia gemmatalis cell line.

    abstract::The UFL-AG-286 cell line, established from embryonic tissue of the lepidopteran insect Anticarsia gemmatalis, has been identified as a good candidate to be used as a cellular substrate in the development of a process for in vitro production of the Anticarsia gemmatalis multicapsid nucleopolyhedrovirus, a baculovirus w...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-006-9042-3

    authors: Gioria VV,Jäger V,Claus JD

    更新日期:2006-10-01 00:00:00

  • Study of the cytotoxic activity of Styrax camporum extract and its chemical markers, egonol and homoegonol.

    abstract::The benzofuran lignans egonol and homoegonol are found in all species of the genus Styrax. Since natural products are important sources of new anticancer drugs, this study evaluated the cytotoxic activity of a hydroalcoholic extract of the stems of S. camporum (SCHE) and their chemical markers, egonol (EG) and homoego...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-015-9864-y

    authors: de Oliveira PF,Damasceno JL,Bertanha CS,Araújo AR,Pauletti PM,Tavares DC

    更新日期:2016-08-01 00:00:00

  • Fibroblast growth factor 21 induces lipolysis more efficiently than it suppresses lipogenesis in goat adipocytes.

    abstract::Fibroblast growth factor 21 (FGF21) potentially regulates glucose and lipid metabolism in energy homeostasis. We investigated dynamic changes in goat adipocytes treated with 75 nM FGF21 for 24, 36 and 48 h. Compared to controls, FGF21-treated adipocytes displayed smaller lipid droplets and altered levels of the mRNA t...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-018-0237-1

    authors: Zhang Y,Li L,Wang Q,Zhan S,Wang L,Zhong T,Guo J,Zhang H

    更新日期:2018-10-01 00:00:00

  • Liver stem cells.

    abstract::The capacity of hepatocytes and cholangiocytes to contribute to their own maintenance has long been recognized. More recently, studies have indicated the presence of both intra-hepatic and extra-hepatic stem/progenitor cell populations. The intraorgan compartment probably derives primarily from the biliary tree, most ...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1024826823194

    authors: Theise ND

    更新日期:2003-03-01 00:00:00

  • Eicosapentaenoic acid protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced hepatic toxicity in cultured rat hepatocytes.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent and ubiquitous environmental contaminant. The health impact of TCDD exposure is of great concern to the general public. Recent reports have implied that eicosapentaenoic acid (EPA) might be a potential chemopreventive agent and influence hepatotoxicity. The ai...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-011-9386-1

    authors: Turkez H,Geyikoglu F,Mokhtar YI,Togar B

    更新日期:2012-01-01 00:00:00

  • Echinococcus granulosus protoscoleces promotes proliferation and invasion of hepatocellular carcinoma cells.

    abstract::There may exist a connection between Echinococcus granulosus infection and cancer development. Here, it is aimed to investigate specific effects of E. granulosus protoscoleces (PSCs) on the proliferation and invasion capacities of hepatocellular carcinoma (HCC) cells in vitro and ex vitro. HepG2 cells were cultured wi...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-020-00437-0

    authors: Yasen A,Wang M,Ran B,Lv G,Aji T,Xiao H,Shao Y,Wen H

    更新日期:2021-02-01 00:00:00

  • Productivity enhancement of recombinant protein in CHO cells via specific promoter activation by oncogenes.

    abstract::To construct a recombinant protein highly producing cell lines, we have previously developed the Oncogene Activated Production (OAP) system by using BHK-21 cells. Here we verified the availability of the OAP system in CHO cells. We firstly generated 'primed' ras amplified CHO cells, ras clone I, by introducing human c...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1008048928053

    authors: Katakura Y,Seto P,Miura T,Ohashi H,Teruya K,Shirahata S

    更新日期:1999-09-01 00:00:00

  • High-level expression of a foreign gene by a recombinant baculovirus with an expanded host range.

    abstract::The usefulness of host range expanded viruses as an expressionvector system was investigated by following the expression ofthe E. coli lacZ gene. The host range expanded recombinantviruses were obtained from Sf-21 or BmN-4 cells coinfected withAutographa californica and Bombyx mori nuclearpolyhedrosis viruses. Among t...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1023/A:1008166310368

    authors: Kim HS,Woo SD,Kim WJ,Choi JY,Kang SK

    更新日期:2000-02-01 00:00:00

  • Expression of anchorin CII mRNA by cultured chondrocytes.

    abstract::The establishment of a cell culture system promoting chondrocyte differentiation has been utilized to better characterize phenotypic stages of chondrogenesis at the cellular level. Although the expression of the type II collagen gene has been studied during "in vitro" chondrocyte differentiation, little is known about...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00736804

    authors: Castagnola P,Cancedda R

    更新日期:1991-02-01 00:00:00

  • Pig testis extract augments adiponectin expression and secretion through the peroxisome proliferator-activated receptor signaling pathway in 3T3-L1 adipocytes.

    abstract::Adiponectin is a key molecule whose upregulation may ameliorate symptoms of type 2 diabetes mellitus and disorders of lipid metabolism. Several plant-derived components have been shown to enhance adiponectin secretion; however, there have been no reports on the effects of animal-derived products. Therefore, in the cur...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-018-0213-9

    authors: Kadooka K,Sato M,Matsumoto T,Kuhara S,Katakura Y,Fujimura T

    更新日期:2018-06-01 00:00:00

  • Immunonucleochemistry: a new method for in situ detection of antigens in the nucleus of cells in culture.

    abstract::The advancement of immunocytochemistry (ICC) allows one to observe detailed spatial distribution of cellular antigens, but, with some limitations. Using conventional ICC, it is difficult to distinguish the nuclear localization from cytoplasm, as two large subcellular compartments overlap on the z-axis. In this study, ...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-010-9266-0

    authors: Moon IS,Lee H,Park SD,Seog DH

    更新日期:2010-04-01 00:00:00

  • Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties.

    abstract::The efficacy of hepatocellular carcinoma (HCC) treatment is very low because of the high percentage of recurrence and resistance to anticancer agents. Hepatic cancer stem cells (HCSCs) are considered the origin of such recurrence and resistance. Our aim was to evaluate the stemness of doxorubicin and 5-fluorouracil re...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-012-9511-9

    authors: Vu NB,Nguyen TT,Tran LC,Do CD,Nguyen BH,Phan NK,Pham PV

    更新日期:2013-08-01 00:00:00

  • Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes.

    abstract::Numerous challenges remain in the successful clinical translation of cell-based therapeutic studies for skeletal tissue repair, including appropriate cell sources and viable cell delivery systems. Poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) amphiphilic block copolymers have been extensively explored in micros...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/s10616-012-9450-5

    authors: Zhang D,Tong A,Zhou L,Fang F,Guo G

    更新日期:2012-12-01 00:00:00

  • A two-compartment cell entrapment bioreactor with three different holding times for cells, high and low molecular weight compounds.

    abstract::A new bioreactor for animal cell cultivation employs two compartments for cells and medium respectively. The two chambers are separated by an ultrafiltration membrane. Cells and solution of collagen or collagen/chitosan mixture were loaded to the cell chamber and were allowed to form gel inside. Contraction of the cel...

    journal_title:Cytotechnology

    pub_type: 杂志文章

    doi:10.1007/BF00365093

    authors: Scholz M,Hu WS

    更新日期:1990-09-01 00:00:00