Apoptosis resistance in tumor cells.

Abstract:

:Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.

journal_name

Cytotechnology

journal_title

Cytotechnology

authors

Mashima T,Seimiya H,Chen Z,Kataoka S,Tsuruo T

doi

10.1023/A:1008058031511

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

293-308

issue

1-3

eissn

0920-9069

issn

1573-0778

journal_volume

27

pub_type

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