Abstract:
:Multidrug resistance (MDR) is a major problem in cancer chemotherapy. As P-glycoprotein is the key molecule in MDR, many investigators have constructed anti-P-glycoprotein monoclonal antibodies (MAbs). Those antibodies, including MRK16 and C219, were used for elucidation of the mechanism of MDR and for overcoming of MDR. This article describes the characterization of the antibodies against the P-glycoprotein and other proteins of multidrug-resistant tumor cells, and discusses the therapeutic implication of the antibodies.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Heike Y,Tsuruo Tdoi
10.1007/BF00744659subject
Has Abstractpub_date
1993-01-01 00:00:00pages
91-107issue
1-3eissn
0920-9069issn
1573-0778journal_volume
12pub_type
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