The microbe electric: conversion of organic matter to electricity.


:Broad application of microbial fuel cells will require substantial increases in current density. A better understanding of the microbiology of these systems may help. Recent studies have greatly expanded the range of microorganisms known to function either as electrode-reducing microorganisms at the anode or as electrode-oxidizing microorganisms at the cathode. Microorganisms that can completely oxidize organic compounds with an electrode serving as the sole electron acceptor are expected to be the primary contributors to power production. Several mechanisms for electron transfer to anodes have been proposed including: direct electron transfer via outer-surface c-type cytochromes, long-range electron transfer via microbial nanowires, electron flow through a conductive biofilm matrix containing cytochromes, and soluble electron shuttles. Which mechanisms are most important depend on the microorganisms and the thickness of the anode biofilm. Emerging systems biology approaches to the study, design, and evolution of microorganisms interacting with electrodes are expected to contribute to improved microbial fuel cells.


Curr Opin Biotechnol


Lovley DR




Has Abstract


2008-12-01 00:00:00














  • Bioremedial potential of microbial mechanisms of metal mobilization and immobilization.

    abstract::Microorganisms play important roles in the environmental fate of toxic metals and radionuclides with a multiplicity of mechanisms effecting transformations between soluble and insoluble forms. These mechanisms are integral components of natural biogeochemical cycles and are of potential for both in situ and ex situ bi...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Gadd GM

    更新日期:2000-06-01 00:00:00

  • Recent work on Alzheimer's disease transgenics.

    abstract::The most significant feature of the current transgenic models of Alzheimer's disease continues to be the amyloid phenotype. In the past year, mice have been more extensively characterized in terms of the effect of amyloid accumulation on downstream events, such as neurodegeneration and behavioral changes, but the resu...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Duff K

    更新日期:1998-12-01 00:00:00

  • Customised nucleic acid libraries for enhanced aptamer selection and performance.

    abstract::Aptamers are short single-stranded oligo(deoxy)nucleotides that are selected to bind to target molecules with high affinity and specificity. Because of their sophisticated characteristics and versatile applicability, aptamers are thought to become universal molecular probes in biotechnological and therapeutic applicat...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Pfeiffer F,Rosenthal M,Siegl J,Ewers J,Mayer G

    更新日期:2017-12-01 00:00:00

  • Mismatch repair and cancer susceptibility.

    abstract::Mismatch-repair systems have been identified in organisms ranging from Escherichia coli to humans. They can repair almost all DNA base pair mismatches as well as small insertion/deletion mismatches. Molecular and biochemical analyses have shown that the core components of eukaryotic mismatch-repair systems are highly ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Kolodner RD,Alani E

    更新日期:1994-12-01 00:00:00

  • Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production.

    abstract::The biosynthesis of the solvents 1-butanol and acetone is restricted to species of the genus Clostridium, a diverse group of Gram-positive, endospore forming anaerobes comprising toxin-producing strains as well as terrestrial non-pathogenic species of biotechnological impact. Among solventogenic clostridia, Clostridiu...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Lütke-Eversloh T,Bahl H

    更新日期:2011-10-01 00:00:00

  • The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem.

    abstract::Chinese hamster ovary (CHO) cell-based bioproduction of recombinant proteins can now routinely achieve >5 g/L titers in fed-batches. This progress is partly due to the rapid adaptability of CHO cells to various genetic manipulations and changing process conditions. An inherently plastic genome allows for this adaptabi...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Dahodwala H,Lee KH

    更新日期:2019-12-01 00:00:00

  • Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility.

    abstract::Thiopeptide antibiotics, which are a class of sulfur-rich and highly modified peptide natural products, exhibit a wide variety of important biological properties. These antibiotics are ribosomally synthesized and arise from post-translational modifications, exemplifying a process through which nature develops the stru...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Lin Z,He Q,Liu W

    更新日期:2017-12-01 00:00:00

  • Advances in optical detection strategies for reporter signal measurements.

    abstract::Many recent advances in bioreporter technology focus on challenges related to bioengineering, yet in many applications implementation of optical signal measurement is equally susceptible to improvement. For bioluminescent bioreporters, one area of effort lies in the development of semiconductor chip-based detector mod...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Wells M

    更新日期:2006-02-01 00:00:00

  • Combined metal catalysis and biocatalysis for an efficient deracemization process.

    abstract::Driven by the demand to enhance the economic balance of chemical processes, the transformation of a racemate into a single stereoisomer (the deracemization process) is one of the most important areas of research. The recent development of the combined use of enzyme and metal catalysis has led to efficient deracemizati...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Pàmies O,Bäckvall JE

    更新日期:2003-08-01 00:00:00

  • Strategies for the aerobic co-metabolism of chlorinated solvents.

    abstract::Recent field and laboratory studies have evaluated the potential for aerobic co-metabolism of chlorinated solvents. Different co-metabolic substrates and different methods of application have been tried, including growing indigenous microbes in situ, and injecting into the soil subsurface strains grown in subsurface r...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Semprini L

    更新日期:1997-06-01 00:00:00

  • Recent advances in single-cell studies of gene regulation.

    abstract::A mechanistic understanding of gene regulatory network dynamics requires quantitative single-cell data of multiple network components in response to well-defined perturbations. Recent advances in the development of fluorescent biomarkers for proteins, detection of RNA and interactions, microfluidic technology, and hig...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Selimkhanov J,Hasty J,Tsimring LS

    更新日期:2012-02-01 00:00:00

  • Fluorescence spectroscopy as a tool to investigate protein interactions.

    abstract::Recent advances in the use of fluorescence spectroscopy to study protein interactions have primarily involved combinations of classic fluorescence techniques, novel probe and coupling chemistries, and advances in laser excitation and detection capabilities. For example, new coupling strategies for fluorescent probes h...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章


    authors: Brown MP,Royer C

    更新日期:1997-02-01 00:00:00

  • Antibody discovery: phage display.

    abstract::Phage display has proven to be a robust and convenient technology for the selection of high-quality human antibodies from diverse libraries. Besides enabling the identification of antibodies in a fast, high-throughput mode, which allows comprehensive protein expression analyses, phage display has been used to identify...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Kretzschmar T,von Rüden T

    更新日期:2002-12-01 00:00:00

  • Microbial production of diols as platform chemicals: recent progresses.

    abstract::Diols are chemicals with two hydroxyl groups which have a wide range of appealing applications as chemicals and fuels. In particular, four diol compounds, namely 1,3-propanediol (1,3-PDO), 1,2-propanediol (1,2-PDO), 2,3-butanediol (2,3-BDO) and 1,4-butanediol (1,4-BDO) can be biotechnologically produced by direct micr...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Zeng AP,Sabra W

    更新日期:2011-12-01 00:00:00

  • Bioavailability of pollutants and chemotaxis.

    abstract::The exposure of bacteria to pollutants induces frequently chemoattraction or chemorepellent reactions. Recent research suggests that the capacity to degrade a toxic compound has co-evolved in some bacteria with the capacity to chemotactically react to it. There is an increasing amount of data which show that chemoattr...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Krell T,Lacal J,Reyes-Darias JA,Jimenez-Sanchez C,Sungthong R,Ortega-Calvo JJ

    更新日期:2013-06-01 00:00:00

  • Towards better understanding of industrial cell factories: novel approaches for 13C metabolic flux analysis in complex nutrient environments.

    abstract::The quantification of intracellular fluxes via 13C metabolic flux analysis has become one of the major techniques to support systems-based metabolic engineering of industrial production hosts. Commonly, 13C studies are conducted using minimal media, however, a great variety of industrial processes rely on complex medi...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Schwechheimer SK,Becker J,Wittmann C

    更新日期:2018-12-01 00:00:00

  • Pathway elucidation and engineering of plant-derived diterpenoids.

    abstract::Plant-derived diterpenoids are indispensable to plant development, stress-resistance and interaction with environmental microorganisms. Besides significant roles in plant fitness and adaption, many bioactivities beneficial to human beings are also found in diterpenoids from terrestrial plants. However, these high-valu...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Shao J,Sun Y,Liu H,Wang Y

    更新日期:2020-10-05 00:00:00

  • Fragment-based approaches to enzyme inhibition.

    abstract::Fragment-based approaches have provided a new paradigm for small-molecule drug discovery. The methodology is complementary to high-throughput screening approaches, starting from fragments of low molecular complexity and high ligand efficiency, and building up to more potent inhibitors. The approach, which depends heav...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Ciulli A,Abell C

    更新日期:2007-12-01 00:00:00

  • Microbial biocatalyst developments to upgrade fossil fuels.

    abstract::Steady increases in the average sulfur content of petroleum and stricter environmental regulations concerning the sulfur content have promoted studies of bioprocessing to upgrade fossil fuels. Bioprocesses can potentially provide a solution to the need for improved and expanded fuel upgrading worldwide, because biopro...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Kilbane JJ 2nd

    更新日期:2006-06-01 00:00:00

  • Gene expression using Xenopus oocytes.

    abstract::Xenopus oocytes have been used as a surrogate genetic system for the study of many facets of gene expression. Some recent salient examples where injected oocytes proved to be indispensable for the analysis of transcription, translation, RNA/protein transport, and ion channel formation are described. ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章


    authors: Richter JD

    更新日期:1991-10-01 00:00:00

  • Engineering microbial cell morphology and membrane homeostasis toward industrial applications.

    abstract::Microbial cell factory performance is significantly affected by the cell morphology and membrane homeostasis. It is important to ensure that cell factories are able to regulate cell morphology and maintain membrane homeostasis. Cell morphology can be controlled by regulating the formation of elongasomes and divisomes,...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Guo L,Pang Z,Gao C,Chen X,Liu L

    更新日期:2020-12-01 00:00:00

  • Engineered minichromosomes in plants.

    abstract::Genetic engineering for complex or combined traits requires the simultaneous expression of multiple genes, and has been considered as the bottleneck for the next generation of genetic engineering in plants. Minichromosome technology provides one solution to the stable expression and maintenance of multiple transgenes ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Yu W,Han F,Birchler JA

    更新日期:2007-10-01 00:00:00

  • Bacteriophage endolysins: applications for food safety.

    abstract::Bacteriophage endolysins (peptidoglycan hydrolases) have emerged as a new class of antimicrobial agents useful for controlling bacterial infection or other unwanted contaminations in various fields, particularly in the light of the worldwide increasing frequency of drug-resistant pathogens. This review summarizes and ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Schmelcher M,Loessner MJ

    更新日期:2016-02-01 00:00:00

  • Nano-spectroscopic imaging of proteins with near-field scanning optical microscopy (NSOM).

    abstract::Understanding the hierarchical structure of proteins at their fundamental length scales is essential to get insights into their functions and roles in fundamental biological processes. Near-field scanning optical microscopy (NSOM), which overcomes the diffraction limits of conventional optics, provides a powerful anal...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Yong YC,Wang YZ,Zhong JJ

    更新日期:2018-12-01 00:00:00

  • Population-level approaches reveal novel aspects of lignin biosynthesis, content, composition and structure.

    abstract::Population-level studies enabled by high-throughput phenotyping have revealed significant variation in lignin characteristics including content, S:G:H ratio, inter-unit linkage distributions, and molecular weights across multiple plant species. Coupled with genome-wide association mapping studies (GWAS) targeted at li...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Tuskan GA,Muchero W,Tschaplinski TJ,Ragauskas AJ

    更新日期:2019-04-01 00:00:00

  • Receptor-Fc fusion therapeutics, traps, and MIMETIBODY technology.

    abstract::Fc fusion proteins are molecules in which the immunoglobulin Fc is fused genetically to a protein of interest, such as an extracellular domain of a receptor, ligand, enzyme, or peptide. Fc fusion proteins have some antibody-like properties such as long serum half-life and easy expression and purification, making them ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Huang C

    更新日期:2009-12-01 00:00:00

  • Nucleic acids in the environment.

    abstract::The past year has witnessed several excellent advances in basic and applied research on nucleic acids in the environment. Improved methods for extracting nucleic acids from environmental samples have been published, as well as information on the use of reporter genes in bacteria, natural genetic transformation in soil...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Trevors JT

    更新日期:1996-06-01 00:00:00

  • Molecular and biotechnological approaches to fish vaccines.

    abstract::Global aquaculture is projected to grow from 10 million to 20 million metric tons by the year 2000. To meet this projection, the aquaculture industry must bring some of its infectious disease problems under control without relying on antibiotics and chemotherapeutics. Thus, vaccines for fish and shellfish are being so...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Leong JA

    更新日期:1993-06-01 00:00:00

  • Emerging protein delivery methods.

    abstract::The efficient and safe delivery of therapeutic proteins is the key to commercial success and, in some cases, the demonstration of efficacy in current and future biotechnology products. Numerous delivery technologies and companies have evolved over the past year. To critically evaluate the available options, each metho...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Cleland JL,Daugherty A,Mrsny R

    更新日期:2001-04-01 00:00:00

  • The electric picnic: synergistic requirements for exoelectrogenic microbial communities.

    abstract::Characterization of the various microbial populations present in exoelectrogenic biofilms provides insight into the processes required to convert complex organic matter in wastewater streams into electrical current in bioelectrochemical systems (BESs). Analysis of the community profiles of exoelectrogenic microbial co...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章


    authors: Kiely PD,Regan JM,Logan BE

    更新日期:2011-06-01 00:00:00