Abstract：
:The biosynthesis of the solvents 1-butanol and acetone is restricted to species of the genus Clostridium, a diverse group of Gram-positive, endospore forming anaerobes comprising toxin-producing strains as well as terrestrial non-pathogenic species of biotechnological impact. Among solventogenic clostridia, Clostridium acetobutylicum represents the model organism and general but yet important genetic tools were established only recently to investigate and understand the complex life cycle-accompanied physiology and its regulatory mechanisms. Since clostridial butanol production regained much interest in the past few years, different metabolic engineering approaches were conducted--although promising and in part successful strategies were employed, the major breakthrough to generate an optimum phenotype with superior butanol titer, yield and productivity still remains to be expected.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Lütke-Eversloh T,Bahl Hdoi
10.1016/j.copbio.2011.01.011subject
Has Abstractpub_date
2011-10-01 00:00:00pages
634-47issue
5eissn
0958-1669issn
1879-0429pii
S0958-1669(11)00025-5journal_volume
22pub_type
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