Abstract:
:Chromatography is undoubtedly the workhorse of downstream processes, affording high resolution for bioseparations. At the same time, it has the notoriety of being the single largest cost center in downstream processing and of being a low-throughput operation. Consequently, 'chromatography alternatives' are an attractive proposition, even if only a reduction in the extent of use of packed beds can be realized. This paper reviews the current state of unit operations posing as chromatography alternatives--including membrane filtration, aqueous two-phase extraction, three-phase partitioning, precipitation, crystallization, monoliths and membrane chromatography--and their potential to do the unthinkable.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Przybycien TM,Pujar NS,Steele LMdoi
10.1016/j.copbio.2004.08.008subject
Has Abstractpub_date
2004-10-01 00:00:00pages
469-78issue
5eissn
0958-1669issn
1879-0429pii
S0958-1669(04)00114-4journal_volume
15pub_type
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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