Abstract:
:Despite their central role in directing some of the most complex biological processes, carbohydrates--nature's other information carrying biopolymer--have been largely ignored as building blocks for synthetic hierarchical assemblies. The non-stoichiometric binding and astronomical diversity characteristic of carbohydrates could lead to tantalizingly complex assembly algorithms, but these attributes simultaneously increase the difficulty of preparing carbohydrate assemblies and anticipating their behavior. Convergences in biotechnology, nanotechnology, polymer chemistry, surface science, and supramolecular chemistry have led to many recent important breakthroughs in glycan microarrays and synthetic carbohydrate receptors, where the idiosyncrasies of carbohydrate structure and binding are increasingly considered. We hope to inspire more researchers to consider carbohydrate structure, diversity, and binding as attractive tools for constructing synthetic hierarchical assemblies.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Han X,Zheng Y,Munro CJ,Ji Y,Braunschweig ABdoi
10.1016/j.copbio.2014.11.016subject
Has Abstractpub_date
2015-08-01 00:00:00pages
41-7eissn
0958-1669issn
1879-0429pii
S0958-1669(14)00204-3journal_volume
34pub_type
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