Carbohydrate nanotechnology: hierarchical assembly using nature's other information carrying biopolymers.

Abstract:

:Despite their central role in directing some of the most complex biological processes, carbohydrates--nature's other information carrying biopolymer--have been largely ignored as building blocks for synthetic hierarchical assemblies. The non-stoichiometric binding and astronomical diversity characteristic of carbohydrates could lead to tantalizingly complex assembly algorithms, but these attributes simultaneously increase the difficulty of preparing carbohydrate assemblies and anticipating their behavior. Convergences in biotechnology, nanotechnology, polymer chemistry, surface science, and supramolecular chemistry have led to many recent important breakthroughs in glycan microarrays and synthetic carbohydrate receptors, where the idiosyncrasies of carbohydrate structure and binding are increasingly considered. We hope to inspire more researchers to consider carbohydrate structure, diversity, and binding as attractive tools for constructing synthetic hierarchical assemblies.

journal_name

Curr Opin Biotechnol

authors

Han X,Zheng Y,Munro CJ,Ji Y,Braunschweig AB

doi

10.1016/j.copbio.2014.11.016

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

41-7

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(14)00204-3

journal_volume

34

pub_type

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